TR199802025T2 - Yeni s�bstit�e edilmi� $2-(1-piperazinil)-etoksi]metil bile�ikleri. - Google Patents
Yeni s�bstit�e edilmi� $2-(1-piperazinil)-etoksi]metil bile�ikleri.Info
- Publication number
- TR199802025T2 TR199802025T2 TR1998/02025T TR9802025T TR199802025T2 TR 199802025 T2 TR199802025 T2 TR 199802025T2 TR 1998/02025 T TR1998/02025 T TR 1998/02025T TR 9802025 T TR9802025 T TR 9802025T TR 199802025 T2 TR199802025 T2 TR 199802025T2
- Authority
- TR
- Turkey
- Prior art keywords
- piperazinyl
- ethoxy
- radical
- compounds
- ikleri
- Prior art date
Links
- 210000000941 bile Anatomy 0.000 title 1
- YZGQDNOIGFBYKF-UHFFFAOYSA-N Ethoxyacetic acid Chemical compound CCOCC(O)=O YZGQDNOIGFBYKF-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
- -1 [2- (1-piperazinyl) ethoxy] methyl compounds Chemical class 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE9600310A BE1010094A3 (fr) | 1996-04-10 | 1996-04-10 | Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199802025T2 true TR199802025T2 (xx) | 1999-01-18 |
Family
ID=3889663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1998/02025T TR199802025T2 (xx) | 1996-04-10 | 1997-03-28 | Yeni s�bstit�e edilmi� $2-(1-piperazinil)-etoksi]metil bile�ikleri. |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6140501A (en, 2012) |
| EP (1) | EP0927173B1 (en, 2012) |
| JP (1) | JP2000508634A (en, 2012) |
| CN (1) | CN1072661C (en, 2012) |
| AR (1) | AR006761A1 (en, 2012) |
| AT (1) | ATE219067T1 (en, 2012) |
| AU (1) | AU710835B2 (en, 2012) |
| BE (1) | BE1010094A3 (en, 2012) |
| BR (1) | BR9708763A (en, 2012) |
| CZ (1) | CZ295068B6 (en, 2012) |
| DE (1) | DE69713352T2 (en, 2012) |
| DK (1) | DK0927173T3 (en, 2012) |
| EA (1) | EA000831B1 (en, 2012) |
| ES (1) | ES2177965T3 (en, 2012) |
| HU (1) | HU225478B1 (en, 2012) |
| IN (1) | IN186873B (en, 2012) |
| MY (1) | MY118237A (en, 2012) |
| NO (1) | NO311615B1 (en, 2012) |
| NZ (1) | NZ332057A (en, 2012) |
| PL (1) | PL188819B1 (en, 2012) |
| PT (1) | PT927173E (en, 2012) |
| RS (1) | RS49574B (en, 2012) |
| TR (1) | TR199802025T2 (en, 2012) |
| WO (1) | WO1997037982A1 (en, 2012) |
| ZA (1) | ZA972973B (en, 2012) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0919550A1 (en) | 1997-11-26 | 1999-06-02 | Ucb, S.A. | Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride |
| IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
| CZ304892B6 (cs) * | 1999-11-30 | 2015-01-07 | EGIS Gyógyszergyár Rt. | Způsob přípravy {2-[4-(α-fenyl-p-chlorbenzyl)piperazin-1-yl]ethoxy}octové kyseliny a nové meziprodukty |
| US7199241B1 (en) | 2001-05-29 | 2007-04-03 | Ucb, S.A. | Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
| US6977301B1 (en) | 2001-05-29 | 2005-12-20 | Ucb, S.A. | Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
| US6838052B2 (en) | 2001-06-29 | 2005-01-04 | Symyx Technologies, Inc. | In-situ injection and materials screening device |
| WO2003009849A1 (en) * | 2001-07-26 | 2003-02-06 | Ucb, S.A. | Process for the preparation of 2-(2-(4-(bis(4-fluorophenyl)methyl)-piperazin-1-yl)ethoxy)acetic acid derivatives or corresponding salt forms thereof and intermediates therefor |
| US7160513B2 (en) | 2002-12-20 | 2007-01-09 | Symyx Technologies, Inc. | Batch reactor with injection system |
| US20040266787A1 (en) * | 2003-03-25 | 2004-12-30 | Dr. Reddy's Laboratories Limited | Novel amorphous form of [2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]ethoxy]acetic acid and process for the preparation thereof |
| US20050020608A1 (en) * | 2003-03-25 | 2005-01-27 | Dr. Reddy's Laboratories Limited | Crystalline cetirizine monohydrochloride |
| EP1628964A1 (en) * | 2003-05-21 | 2006-03-01 | Wockhardt Limited | 2-[2-[4-[(4-chlorophenyl) phenylmethyl] -1-piperazinyl] ethoxy] acetic acid monohydrochloride as anti-allergenic compound and process for its production |
| KR100503443B1 (ko) * | 2004-02-02 | 2005-07-22 | 한림제약(주) | 광학적으로 활성인 세티리진 또는 그의 염의 제조방법 |
| WO2006050909A1 (en) * | 2004-11-10 | 2006-05-18 | Ucb Farchim Sa | Novel forms of efletirizine dihydrochloride, processes for making them and pharmaceutical compositions including them |
| EP1845088B1 (en) * | 2006-04-10 | 2009-07-22 | Ranbaxy Laboratories Limited | An improved process for the preparation of aripipirazole |
| US20110172425A1 (en) * | 2008-09-17 | 2011-07-14 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Novel water based process for the preparation of substituted diphenylmethyl piperazines |
| KR101418404B1 (ko) | 2012-01-06 | 2014-07-10 | 한미약품 주식회사 | 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제 |
| KR102226833B1 (ko) | 2013-06-28 | 2021-03-12 | 한미약품 주식회사 | 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH505116A (it) * | 1966-11-21 | 1971-03-31 | Crc Ricerca Chim | Metodo per l'ottenimento di derivati della piperazina |
| GB1184395A (en) * | 1967-03-08 | 1970-03-18 | Egyt Gyogyszervegyeszeti Gyar | Substituted Piperazine Derivatives |
| DK154078C (da) * | 1981-02-06 | 1989-05-22 | Ucb Sa | Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf |
| GB8827390D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
| GB8827391D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
-
1996
- 1996-04-10 BE BE9600310A patent/BE1010094A3/fr active
-
1997
- 1997-03-28 EP EP97915205A patent/EP0927173B1/fr not_active Expired - Lifetime
- 1997-03-28 ES ES97915205T patent/ES2177965T3/es not_active Expired - Lifetime
- 1997-03-28 CN CN97193721A patent/CN1072661C/zh not_active Expired - Fee Related
- 1997-03-28 PL PL97329307A patent/PL188819B1/pl not_active IP Right Cessation
- 1997-03-28 AU AU22818/97A patent/AU710835B2/en not_active Ceased
- 1997-03-28 TR TR1998/02025T patent/TR199802025T2/xx unknown
- 1997-03-28 EA EA199800879A patent/EA000831B1/ru not_active IP Right Cessation
- 1997-03-28 CZ CZ19983151A patent/CZ295068B6/cs not_active IP Right Cessation
- 1997-03-28 DK DK97915205T patent/DK0927173T3/da active
- 1997-03-28 US US09/155,977 patent/US6140501A/en not_active Expired - Lifetime
- 1997-03-28 DE DE69713352T patent/DE69713352T2/de not_active Expired - Fee Related
- 1997-03-28 HU HU9901804A patent/HU225478B1/hu not_active IP Right Cessation
- 1997-03-28 BR BR9708763A patent/BR9708763A/pt active Search and Examination
- 1997-03-28 JP JP9535681A patent/JP2000508634A/ja not_active Ceased
- 1997-03-28 WO PCT/BE1997/000038 patent/WO1997037982A1/fr active IP Right Grant
- 1997-03-28 AT AT97915205T patent/ATE219067T1/de not_active IP Right Cessation
- 1997-03-28 NZ NZ332057A patent/NZ332057A/xx unknown
- 1997-03-28 PT PT97915205T patent/PT927173E/pt unknown
- 1997-04-08 ZA ZA9702973A patent/ZA972973B/xx unknown
- 1997-04-08 AR ARP970101379A patent/AR006761A1/es active IP Right Grant
- 1997-04-08 MY MYPI97001510A patent/MY118237A/en unknown
- 1997-04-09 IN IN919DE1997 patent/IN186873B/en unknown
-
1998
- 1998-03-28 RS YUP-441/98A patent/RS49574B/sr unknown
- 1998-10-09 NO NO19984738A patent/NO311615B1/no unknown
-
2000
- 2000-03-21 US US09/532,159 patent/US6255487B1/en not_active Expired - Lifetime
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