TR199800084A2 - Bifenilsülfonil ikameli bes üyeli heterosiklenler, bunlarin üretimi. - Google Patents

Bifenilsülfonil ikameli bes üyeli heterosiklenler, bunlarin üretimi.

Info

Publication number
TR199800084A2
TR199800084A2 TR1998/00084A TR9800084A TR199800084A2 TR 199800084 A2 TR199800084 A2 TR 199800084A2 TR 1998/00084 A TR1998/00084 A TR 1998/00084A TR 9800084 A TR9800084 A TR 9800084A TR 199800084 A2 TR199800084 A2 TR 199800084A2
Authority
TR
Turkey
Prior art keywords
compounds
biphenylsulfonyl
substituted
production
membered heterocycles
Prior art date
Application number
TR1998/00084A
Other languages
English (en)
Other versions
TR199800084A3 (tr
Inventor
Heinz-Werner Kleemann Dr.
Jochen Lang Dr.Hans
Jan-Robert Schwark Dr.
Andreas Weichert Dr.
Sabine Faser Ap
Hans-Willi Jansen Dr.
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19702045A external-priority patent/DE19702045A1/de
Priority claimed from DE19731328A external-priority patent/DE19731328A1/de
Priority claimed from DE1997141636 external-priority patent/DE19741636A1/de
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of TR199800084A2 publication Critical patent/TR199800084A2/tr
Publication of TR199800084A3 publication Critical patent/TR199800084A3/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Formül I'e göre olan bilesikler, ki bu formüldeki semboller istemlerde belirtilen anlamlari tasimaktadir, mükemmel antiaritmik özelliklere sahiptirler, kardiyoprotektif bir komponent ihtiva etmektedirler. Bilesikler patofizyolojik olaylari isemik kaynakli hasarlarin olusumunda, özellikle de kansizligin neden oldugu kalp ritm bozukluklarinda koruyucu sekilde engellemekte veya kuvvetli derecede önleyebilmektedir. Sözkonusu bilesikler hücrelerin profilasyonu üzerinde engelleyici bir etkiye de sahiptirler.
TR1998/00084A 1997-01-22 1998-01-20 Bifenilsülfonil ikameli bes üyeli heterosiklenler, bunlarin üretimi. TR199800084A3 (tr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19702045A DE19702045A1 (de) 1997-01-22 1997-01-22 Imidazol-Derivae mit Biphenylsulfonylcyanamid-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19731328A DE19731328A1 (de) 1997-07-22 1997-07-22 Imidazol-Derivate mit Biphenylsulfonylcyanamid-Seitenkette, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE1997141636 DE19741636A1 (de) 1997-09-22 1997-09-22 Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (2)

Publication Number Publication Date
TR199800084A2 true TR199800084A2 (tr) 1998-08-21
TR199800084A3 TR199800084A3 (tr) 1998-08-21

Family

ID=27217050

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/00084A TR199800084A3 (tr) 1997-01-22 1998-01-20 Bifenilsülfonil ikameli bes üyeli heterosiklenler, bunlarin üretimi.

Country Status (22)

Country Link
US (2) US6335451B1 (tr)
EP (1) EP0855392A3 (tr)
JP (1) JPH10204064A (tr)
KR (1) KR100529479B1 (tr)
CN (1) CN1176911C (tr)
AR (1) AR011082A1 (tr)
AU (1) AU738676B2 (tr)
BR (1) BR9800436A (tr)
CA (1) CA2227112A1 (tr)
CZ (1) CZ18598A3 (tr)
HK (1) HK1009814A1 (tr)
HR (1) HRP980025A2 (tr)
HU (1) HUP9800112A3 (tr)
ID (1) ID19574A (tr)
IL (1) IL123013A (tr)
MY (1) MY121708A (tr)
NO (1) NO311570B1 (tr)
NZ (1) NZ329606A (tr)
PL (1) PL191575B1 (tr)
SK (1) SK284126B6 (tr)
TR (1) TR199800084A3 (tr)
TW (1) TW593283B (tr)

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Publication number Priority date Publication date Assignee Title
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19741635A1 (de) * 1997-09-22 1999-03-25 Hoechst Marion Roussel De Gmbh Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
HUP0003982A3 (en) * 1997-10-17 2002-01-28 Eurogene Ltd The use of inhibitors of the renin-angiotensin system for producing pharmaceutical compositions using for the treatment of hypoxia or impaired metabolic function
DE19802969A1 (de) 1998-01-27 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten
DE19804251A1 (de) 1998-02-04 1999-08-05 Hoechst Marion Roussel De Gmbh Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832429A1 (de) 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
WO2000066161A1 (fr) * 1999-04-28 2000-11-09 Takeda Chemical Industries, Ltd. Preventifs / remedes / inhibiteurs de progression pour retinopathie simplex ou retinopathie preproliferante
WO2002034263A1 (fr) * 2000-10-25 2002-05-02 Takeda Chemical Industries, Ltd. Agents preventifs/remedes destines a l'hypertension portale
US6423705B1 (en) 2001-01-25 2002-07-23 Pfizer Inc. Combination therapy
IL147696A0 (en) * 2001-01-25 2002-08-14 Pfizer Prod Inc Combination therapy
AU2002257970B2 (en) * 2001-05-31 2007-08-02 Vicore Pharma Ab Tricyclic compounds useful as angiotensin II agonists
NZ534479A (en) * 2002-02-04 2006-03-31 Sanofi Aventis Deutschland Combination preparation of the sodium-hydrogen exchange inhibitor cariporide with ACE inhibitors for preventing heart failure and other age-related dysfunctions of organs, age-related diseases and for prolonging lifespan
US6844361B2 (en) 2002-02-04 2005-01-18 Aventis Pharma Deutschland Gmbh Pharmaceutical composition comprising a sodium hydrogen exchange inhibitor and an angiotensin converting enzyme inhibitor
US20030220383A1 (en) * 2002-02-14 2003-11-27 Aventis Pharma Deutschland Gmbh Use of inhibitors of the sodium-dependent chloride/bicarbonate exchanger for the treatment of thrombotic and inflammatory disorders
CA2568640C (en) 2004-06-04 2011-08-09 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
DE602006018122D1 (de) * 2005-04-12 2010-12-23 Vicore Pharma Ab Neue tricyclische angiotensin-ii-agonisten
JP5179349B2 (ja) * 2005-04-12 2013-04-10 ヴィコール・ファルマ・アーベー 新規な二環式アンジオテンシンｉｉアゴニスト
AU2006235698B2 (en) * 2005-04-12 2012-03-29 Vicore Pharma Ab New tricyclic angiotensin II agonists
US10517839B2 (en) 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
US8236843B2 (en) 2008-09-02 2012-08-07 Elder Pharmaceuticals Ltd. Anti inflammatory compounds
CN103992276B (zh) * 2014-06-03 2016-08-24 吉林省药物研究院 4’-{[(2,4,5-三取代苯基)-1h-咪唑-1-基]甲基}联苯-2-甲酸衍生物
CA2953064C (en) * 2014-07-17 2023-06-20 University Of Southern California Methods, compounds, and compositions for the treatment of musculoskeletal diseases
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

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JPH0819110B2 (ja) * 1986-06-04 1996-02-28 富山化学工業株式会社 新規なイミダゾール誘導体もしくはその塩およびそれらを含有する抗炎症剤、解熱鎮痛剤または抗関節炎剤
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JP2000501736A (ja) * 1995-12-12 2000-02-15 メルク エンド カンパニー インコーポレーテッド ロサルタンの新用途
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
JPH10204064A (ja) 1998-08-04
MX9800611A (es) 1998-10-31
HK1009814A1 (en) 1999-06-11
PL191575B1 (pl) 2006-06-30
BR9800436A (pt) 1999-09-08
NO311570B1 (no) 2001-12-10
US6335451B1 (en) 2002-01-01
MY121708A (en) 2006-02-28
AU738676B2 (en) 2001-09-20
HUP9800112A3 (en) 2001-07-30
SK284126B6 (sk) 2004-09-08
CZ18598A3 (cs) 1998-08-12
KR19980070682A (ko) 1998-10-26
CN1176911C (zh) 2004-11-24
IL123013A (en) 2003-02-12
NO980273D0 (no) 1998-01-21
KR100529479B1 (ko) 2006-10-19
PL324418A1 (en) 1998-08-03
AR011082A1 (es) 2000-08-02
CA2227112A1 (en) 1998-07-22
HRP980025A2 (en) 1998-10-31
CN1188760A (zh) 1998-07-29
EP0855392A2 (de) 1998-07-29
TR199800084A3 (tr) 1998-08-21
AU5215998A (en) 1998-07-30
IL123013A0 (en) 1998-09-24
ID19574A (id) 1998-07-23
US20020045761A1 (en) 2002-04-18
NO980273L (no) 1998-07-23
HU9800112D0 (en) 1998-03-30
TW593283B (en) 2004-06-21
EP0855392A3 (de) 2000-01-05
HUP9800112A2 (hu) 1998-08-28
US6486189B2 (en) 2002-11-26
SK7798A3 (en) 1998-08-05
NZ329606A (en) 1999-10-28

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