TNSN90051A1 - Procede de preparation de derives di-substitues des n,n'- ditrimethoxybenzoyle piperazines - Google Patents

Procede de preparation de derives di-substitues des n,n'- ditrimethoxybenzoyle piperazines

Info

Publication number
TNSN90051A1
TNSN90051A1 TNTNSN90051A TNSN90051A TNSN90051A1 TN SN90051 A1 TNSN90051 A1 TN SN90051A1 TN TNSN90051 A TNTNSN90051 A TN TNSN90051A TN SN90051 A TNSN90051 A TN SN90051A TN SN90051 A1 TNSN90051 A1 TN SN90051A1
Authority
TN
Tunisia
Prior art keywords
preparation
ditrimethoxybenzoyle
piperazines
substituted derivatives
piperazine
Prior art date
Application number
TNTNSN90051A
Other languages
English (en)
Inventor
Braquet Pierre
Pirotzky Eduardo
Godfroid Jean-Jacques
Heymans Francoise
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of TNSN90051A1 publication Critical patent/TNSN90051A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENTION CONCERNE UN PROCEDE DE PREPARATION DES DERIVES DE LA PIPERAZINE REPONDANT A LA FORMULE GENERALE I DANS LAQUELLE -(CH2)n - REPRESENTE UN GROUPEMENT ALCOYLE EN CHAINE DROITE OU RAMIFIEE, n PRENANT LES VALEURS DE 1 A 20, ET R REPRESENTE DIVERS SUBSTITUANTS, CONSISTANT A FAIRE REAGIR R-(CH2)n-1 -X AVEC DU PYRAZYLMETHYLE SODIUM PUIS A REDUIRE LE COMPOSE PYRAZINE OBTENU POUR DONNER LE DERIVE CORRESPONDANT DE LA PIPERAZINE ET FINALEMENT A DI-N- ACYLER CELUI-CI PAR DU CHLORUE DE TRIMETHOXY-3,4,5 BENZOYLE
TNTNSN90051A 1989-04-15 1990-04-12 Procede de preparation de derives di-substitues des n,n'- ditrimethoxybenzoyle piperazines TNSN90051A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898908587A GB8908587D0 (en) 1989-04-15 1989-04-15 New 2-substituted n,n'-ditrimethoxybenzoyl piperazines

Publications (1)

Publication Number Publication Date
TNSN90051A1 true TNSN90051A1 (fr) 1991-03-05

Family

ID=10655129

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN90051A TNSN90051A1 (fr) 1989-04-15 1990-04-12 Procede de preparation de derives di-substitues des n,n'- ditrimethoxybenzoyle piperazines

Country Status (32)

Country Link
US (1) US5019576A (fr)
JP (1) JP2633709B2 (fr)
KR (1) KR900016178A (fr)
AR (1) AR247736A1 (fr)
AT (1) AT399337B (fr)
AU (1) AU631334B2 (fr)
BE (1) BE1007245A3 (fr)
CA (1) CA2014521C (fr)
CH (1) CH681301A5 (fr)
DE (1) DE4011925A1 (fr)
DK (1) DK91890A (fr)
DZ (1) DZ1407A1 (fr)
ES (1) ES2019554A6 (fr)
FI (1) FI92058C (fr)
FR (2) FR2645743B1 (fr)
GB (2) GB8908587D0 (fr)
GR (1) GR1000355B (fr)
HK (1) HK95092A (fr)
IE (1) IE65058B1 (fr)
IN (1) IN175799B (fr)
IT (1) IT1241631B (fr)
LU (1) LU87719A1 (fr)
MA (1) MA21805A1 (fr)
NL (1) NL9000798A (fr)
NO (1) NO176098C (fr)
NZ (1) NZ233250A (fr)
OA (1) OA09446A (fr)
PT (1) PT93736B (fr)
SE (1) SE505186C2 (fr)
SG (1) SG92092G (fr)
TN (1) TNSN90051A1 (fr)
ZA (1) ZA902566B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5344830A (en) * 1992-12-10 1994-09-06 Merck & Co., Inc. N,N-diacylpiperazine tachykinin antagonists
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
US5883098A (en) * 1993-11-29 1999-03-16 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
US5610165A (en) * 1994-02-17 1997-03-11 Merck & Co., Inc. N-acylpiperidine tachykinin antagonists
WO1996034864A1 (fr) * 1995-05-02 1996-11-07 Schering Corporation Derives piperazino en tant qu'antagonistes des neurokinines
US5795894A (en) * 1995-05-02 1998-08-18 Schering Corporation Piperazino derivatives as neurokinn antagonists
US5892039A (en) * 1995-08-31 1999-04-06 Schering Corporation Piperazino derivatives as neurokinin antagonists
BR9610277A (pt) * 1995-08-31 1999-07-06 Schering Corp Derivados de piperazino como antagonistas de neurowuinina
US5869488A (en) * 1996-05-01 1999-02-09 Schering Corporation Piperazino derivatives as neurokinin antagonists
FR2780649B1 (fr) * 1998-07-06 2001-03-09 Univ Paris Vii Denis Diderot Derives de la piperazine pour l'inhibition de la replication du virus de l'immunodeficience humaine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1243991A (en) * 1968-06-10 1971-08-25 Ici Ltd Piperidine, morpholine and piperazine derivatives
FR2209560A1 (en) * 1972-12-07 1974-07-05 Degussa N-(Trialkoxyaroyl)-ethylenediamine derivs - useful as cardioactive medicaments, exhibit anti-ischaemic activity comparable to nitroglycerin
IL85700A0 (en) * 1987-03-24 1988-08-31 Takeda Chemical Industries Ltd 1,4-disubstituted piperazine compounds,their production and use
EP0318235A3 (fr) * 1987-11-25 1991-05-02 Takeda Chemical Industries, Ltd. Composés de pipérazine PAF-antagoniste 1,4-disubstitués et leur production
PT90619B (pt) * 1988-05-23 1994-10-31 Glaxo Group Ltd Processo para a preparacao de compostos de piperazina
GB8823776D0 (en) * 1988-10-11 1988-11-16 Scras New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
GB8823775D0 (en) * 1988-10-11 1988-11-16 Scras New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use

Also Published As

Publication number Publication date
FR2645859A1 (fr) 1990-10-19
AT399337B (de) 1995-04-25
OA09446A (fr) 1992-10-15
GB2230262B (en) 1992-02-26
IT1241631B (it) 1994-01-25
JPH02292266A (ja) 1990-12-03
SG92092G (en) 1992-12-04
AU5326190A (en) 1990-11-01
NL9000798A (nl) 1990-11-01
FR2645859B1 (fr) 1992-06-05
DZ1407A1 (fr) 2004-09-13
GR1000355B (el) 1992-06-25
FR2645743B1 (fr) 1992-06-05
GR900100270A (en) 1991-09-27
DE4011925A1 (de) 1990-10-18
ATA86690A (de) 1994-09-15
NO176098C (no) 1995-02-01
AU631334B2 (en) 1992-11-19
ES2019554A6 (es) 1991-06-16
IE65058B1 (en) 1995-10-04
NZ233250A (en) 1991-03-26
DK91890A (da) 1990-10-16
NO176098B (no) 1994-10-24
FI92058B (fi) 1994-06-15
IE901314L (en) 1990-10-15
GB2230262A (en) 1990-10-17
GB8908587D0 (en) 1989-06-01
IT9020020A1 (it) 1991-10-12
LU87719A1 (fr) 1990-07-24
IT9020020A0 (it) 1990-04-12
SE9001269L (sv) 1990-10-16
KR900016178A (ko) 1990-11-12
ZA902566B (en) 1991-01-30
PT93736B (pt) 1996-09-30
CA2014521C (fr) 1997-09-09
DK91890D0 (da) 1990-04-11
CH681301A5 (fr) 1993-02-26
SE9001269D0 (sv) 1990-04-06
NO901631D0 (no) 1990-04-10
IN175799B (fr) 1995-08-26
MA21805A1 (fr) 1990-12-31
FI901883A0 (fi) 1990-04-12
BE1007245A3 (fr) 1995-05-02
US5019576A (en) 1991-05-28
CA2014521A1 (fr) 1990-10-15
SE505186C2 (sv) 1997-07-14
HK95092A (en) 1992-12-04
GB9007612D0 (en) 1990-05-30
PT93736A (pt) 1990-11-20
JP2633709B2 (ja) 1997-07-23
FI92058C (fi) 1994-09-26
NO901631L (no) 1990-10-16
AR247736A1 (es) 1995-03-31
FR2645743A1 (fr) 1990-10-19

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