TNSN08445A1 - Derives de triazolopyrazine utiles comme agent anticancereux - Google Patents
Derives de triazolopyrazine utiles comme agent anticancereuxInfo
- Publication number
- TNSN08445A1 TNSN08445A1 TNP2008000445A TNSN08445A TNSN08445A1 TN SN08445 A1 TNSN08445 A1 TN SN08445A1 TN P2008000445 A TNP2008000445 A TN P2008000445A TN SN08445 A TNSN08445 A TN SN08445A TN SN08445 A1 TNSN08445 A1 TN SN08445A1
- Authority
- TN
- Tunisia
- Prior art keywords
- anticancer agent
- derivatives useful
- formula
- compounds
- triazolopyrazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79996606P | 2006-05-11 | 2006-05-11 | |
US89323107P | 2007-03-06 | 2007-03-06 | |
PCT/IB2007/001142 WO2007132308A1 (en) | 2006-05-11 | 2007-04-30 | Triazolopyrazine derivatives useful as anti-cancer agents |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN08445A1 true TNSN08445A1 (fr) | 2010-04-14 |
Family
ID=38441445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2008000445A TNSN08445A1 (fr) | 2006-05-11 | 2008-11-06 | Derives de triazolopyrazine utiles comme agent anticancereux |
Country Status (32)
Country | Link |
---|---|
US (2) | US7732604B2 (xx) |
EP (1) | EP2018383B1 (xx) |
JP (1) | JP4377962B2 (xx) |
KR (1) | KR101099161B1 (xx) |
CN (1) | CN101443331A (xx) |
AP (1) | AP2008004674A0 (xx) |
AR (1) | AR060994A1 (xx) |
AT (1) | ATE532785T1 (xx) |
AU (1) | AU2007251283A1 (xx) |
BR (1) | BRPI0711809A2 (xx) |
CA (1) | CA2651363C (xx) |
CR (1) | CR10383A (xx) |
EA (1) | EA016204B1 (xx) |
EC (1) | ECSP088871A (xx) |
ES (1) | ES2376913T3 (xx) |
GE (1) | GEP20115174B (xx) |
GT (1) | GT200700039A (xx) |
HN (1) | HN2007015177A (xx) |
IL (1) | IL194813A0 (xx) |
MA (1) | MA30411B1 (xx) |
ME (1) | MEP36508A (xx) |
MX (1) | MX2008014399A (xx) |
NL (1) | NL2000613C2 (xx) |
NO (1) | NO20085060L (xx) |
NZ (1) | NZ572361A (xx) |
PE (1) | PE20080067A1 (xx) |
RS (1) | RS20080533A (xx) |
TN (1) | TNSN08445A1 (xx) |
TW (1) | TWI346115B (xx) |
UY (1) | UY30334A1 (xx) |
WO (1) | WO2007132308A1 (xx) |
ZA (1) | ZA200809020B (xx) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8198448B2 (en) * | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
PE20121506A1 (es) | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
US20110039856A1 (en) * | 2007-11-29 | 2011-02-17 | Pfizer Inc. | Polymorphs of a c-met/hgfr inhibitor |
DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
US20110009421A1 (en) * | 2008-02-27 | 2011-01-13 | Takeda Pharmaceutical Company Limited | Compound having 6-membered aromatic ring |
AR070487A1 (es) * | 2008-02-28 | 2010-04-07 | Novartis Ag | Derivados de 3- metil- imidazo -( 1,2-b)- piridazina |
KR20100126467A (ko) * | 2008-03-03 | 2010-12-01 | 타이거 파마테크 | 티로신 키나아제 억제제 |
DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
US20110130384A1 (en) * | 2008-06-25 | 2011-06-02 | Takeda Pharmaceutical Company Limited | Amide compound |
DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
US8592448B2 (en) | 2008-11-20 | 2013-11-26 | OSI Pharmaceuticals, LLC | Substituted pyrrolo[2,3-b]-pyridines and -pyrazines |
EP2381777A4 (en) | 2008-12-12 | 2012-08-08 | Ariad Pharma Inc | AZAINDOL DERIVATIVES AS KINASEHEMMER |
NZ594172A (en) | 2008-12-22 | 2013-04-26 | Merck Patent Gmbh | Novel polymorphic forms of 6-(1-methyl-1h-pyrazol-4-yl)-2-{ 3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl} -2h-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof |
JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
RS53011B (en) * | 2009-05-28 | 2014-04-30 | Vertex Pharmaceuticals Incorporated | AMINOPIRAZOL TRIAZOLOTIADIAZOL INHIBITORI C-MET PROTEIN KINAZE |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
BR112012003262A8 (pt) | 2009-08-12 | 2016-05-17 | Novartis Ag | compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação |
KR20120089463A (ko) | 2009-08-20 | 2012-08-10 | 노파르티스 아게 | 헤테로시클릭 옥심 화합물 |
DE102009056886A1 (de) * | 2009-12-03 | 2011-06-09 | Bayer Schering Pharma Aktiengesellschaft | cMet-Inhibitoren zur Behandlung der Endometriose |
PL2719699T3 (pl) * | 2009-12-31 | 2016-01-29 | Hutchison Medipharma Ltd | Pewne triazolopirazyny, ich kompozycje i sposoby ich stosowania |
TWI423974B (zh) * | 2010-02-11 | 2014-01-21 | Hutchison Medipharma Ltd | 三氮唑並吡啶和三氮唑並吡嗪化合物及其組合物和應用 |
AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
WO2011143646A1 (en) | 2010-05-14 | 2011-11-17 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
JP5960688B2 (ja) * | 2010-05-17 | 2016-08-02 | インコゼン セラピューティクス プライベート リミテッド | プロテインキナーゼ調節物質としての新規3,5−二置換−3h−[1,2,3]トリアゾロ[4,5−b]ピリジン化合物 |
US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
CN102532141A (zh) | 2010-12-08 | 2012-07-04 | 中国科学院上海药物研究所 | [1,2,4]三唑并[4,3-b][1,2,4]三嗪类化合物、其制备方法和用途 |
EP2710003A1 (en) | 2011-05-16 | 2014-03-26 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
AU2012310168B2 (en) | 2011-09-15 | 2015-07-16 | Novartis Ag | 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase |
CN102516263B (zh) * | 2011-10-25 | 2015-04-08 | 南方医科大学 | 一种螺三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用 |
CN102503959B (zh) * | 2011-10-25 | 2015-04-08 | 南方医科大学 | 一种稠三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用 |
CN103204844A (zh) * | 2012-01-17 | 2013-07-17 | 上海艾力斯医药科技有限公司 | 氨基杂芳基化合物及其制备方法与应用 |
AP3908A (en) | 2012-03-30 | 2016-11-24 | Rhizen Pharmaceuticals Sa | Novel 3,5-disubstituted-3H-imidazo[4,5-B]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo [4,5-B] pyridine compounds as modulators of C-met protein kinases |
JP2015512425A (ja) | 2012-04-03 | 2015-04-27 | ノバルティス アーゲー | チロシンキナーゼ阻害剤との組合せ製品及びそれらの使用 |
JP2015512447A (ja) | 2012-04-03 | 2015-04-27 | ノバルティス アーゲー | チロシンキナーゼ阻害薬の組合せおよびその使用 |
CN105968115B (zh) * | 2013-04-17 | 2018-11-09 | 上海医药集团股份有限公司 | 喹啉类化合物、其制备方法、中间体、药物组合物和应用 |
WO2014174478A1 (en) | 2013-04-26 | 2014-10-30 | Novartis Ag | Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor |
RU2643361C2 (ru) * | 2013-09-30 | 2018-02-01 | Кореа Рисёч Инститьют Оф Кемикал Текнолоджи | Новые производные триазолопиразина и их применение |
WO2016091891A1 (en) | 2014-12-09 | 2016-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Human monoclonal antibodies against axl |
WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
JP2018123059A (ja) * | 2015-06-10 | 2018-08-09 | 石原産業株式会社 | 1−シクロプロピルエチルアミン又はその塩の製造方法 |
IL276292B2 (en) * | 2015-07-20 | 2024-02-01 | Genzyme Corp | CSF–1R receptor antagonists |
US10301325B2 (en) | 2015-09-24 | 2019-05-28 | Shanghai Haiju Biological Technology Co., Ltd. | Quinoline derivative, and pharmaceutical composition, preparation method and use thereof |
ES2877799T3 (es) * | 2015-12-31 | 2021-11-17 | Shanghai Pharmaceuticals Holding Co Ltd | Sal de derivado de quinolina, formas polimórficas de la misma, métodos de preparación de la misma, composición y aplicaciones |
KR20230042756A (ko) | 2016-03-15 | 2023-03-29 | 오리존 지노믹스 에스.에이. | 고형 종양의 치료에 사용하기 위한 lsd1 억제제의 조합물 |
CN109563100B (zh) | 2016-06-20 | 2021-08-27 | 诺华股份有限公司 | 三唑并嘧啶化合物的晶体形式 |
KR20180092096A (ko) * | 2017-02-08 | 2018-08-17 | 에이비온 주식회사 | 트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법 |
CN108570053A (zh) * | 2017-03-13 | 2018-09-25 | 中国科学院上海药物研究所 | 五元并六元杂环化合物、制备方法、中间体、组合和应用 |
CN108276418A (zh) * | 2018-03-20 | 2018-07-13 | 北京凯恩梅格医药科技有限公司 | 化合物、含有该化合物的药用组合物及其用途 |
WO2020124060A1 (en) * | 2018-12-14 | 2020-06-18 | Beta Pharma, Inc. | Organophosphorus-substituted compounds as c-met inhibitors and therapeutic uses thereof |
EP4267573A1 (en) | 2020-12-23 | 2023-11-01 | Genzyme Corporation | Deuterated colony stimulating factor-1 receptor (csf-1r) inhibitors |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
ATE503496T1 (de) | 1992-02-06 | 2011-04-15 | Novartis Vaccines & Diagnostic | Biosynthetisches bindeprotein für tumormarker |
IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
GB9520822D0 (en) | 1995-10-11 | 1995-12-13 | Wellcome Found | Therapeutically active compounds |
PL331154A1 (en) | 1996-07-13 | 1999-06-21 | Glaxo Group Ltd | Bicyclic heteroaromatic compounds as inhibitors of proteinous tyrosine kinase |
WO1998002434A1 (en) | 1996-07-13 | 1998-01-22 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
PL354249A1 (en) * | 1999-09-17 | 2003-12-29 | Abbott Gmbhabbott Gmbh | Pyrazolopyrimidines as therapeutic agents |
EP1643836A4 (en) * | 2003-07-02 | 2006-12-06 | Sugen Inc | ARYLMETHYL TRIAZOLO AND IMIDAZOPYRAZINE C-MET INHIBITORS |
EP1675858A2 (en) | 2003-09-03 | 2006-07-05 | Neurogen Corporation | 5-aryl-pyrazolo [4,3-d] pyrimidines, pyridines, and pyrazines and related compounds |
US10181126B2 (en) | 2012-03-13 | 2019-01-15 | American Express Travel Related Services Company, Inc. | Systems and methods for tailoring marketing |
US10884952B2 (en) | 2016-09-30 | 2021-01-05 | Intel Corporation | Enforcing memory operand types using protection keys |
-
2007
- 2007-04-26 NL NL2000613A patent/NL2000613C2/nl not_active IP Right Cessation
- 2007-04-30 AP AP2008004674A patent/AP2008004674A0/xx unknown
- 2007-04-30 JP JP2009508530A patent/JP4377962B2/ja not_active Expired - Fee Related
- 2007-04-30 KR KR1020087027474A patent/KR101099161B1/ko not_active IP Right Cessation
- 2007-04-30 MX MX2008014399A patent/MX2008014399A/es active IP Right Grant
- 2007-04-30 ES ES07734459T patent/ES2376913T3/es active Active
- 2007-04-30 GE GEAP200710971A patent/GEP20115174B/en unknown
- 2007-04-30 RS RSP-2008/0533A patent/RS20080533A/sr unknown
- 2007-04-30 ME MEP-365/08A patent/MEP36508A/xx unknown
- 2007-04-30 NZ NZ572361A patent/NZ572361A/en not_active IP Right Cessation
- 2007-04-30 WO PCT/IB2007/001142 patent/WO2007132308A1/en active Application Filing
- 2007-04-30 EP EP07734459A patent/EP2018383B1/en active Active
- 2007-04-30 CA CA2651363A patent/CA2651363C/en not_active Expired - Fee Related
- 2007-04-30 EA EA200870423A patent/EA016204B1/ru not_active IP Right Cessation
- 2007-04-30 AT AT07734459T patent/ATE532785T1/de active
- 2007-04-30 AU AU2007251283A patent/AU2007251283A1/en not_active Abandoned
- 2007-04-30 CN CNA2007800170852A patent/CN101443331A/zh active Pending
- 2007-04-30 BR BRPI0711809-0A patent/BRPI0711809A2/pt not_active IP Right Cessation
- 2007-05-08 US US11/745,921 patent/US7732604B2/en not_active Expired - Fee Related
- 2007-05-09 GT GT200700039A patent/GT200700039A/es unknown
- 2007-05-09 HN HN2007015177A patent/HN2007015177A/es unknown
- 2007-05-09 PE PE2007000559A patent/PE20080067A1/es not_active Application Discontinuation
- 2007-05-09 UY UY30334A patent/UY30334A1/es unknown
- 2007-05-09 AR ARP070102012A patent/AR060994A1/es not_active Application Discontinuation
- 2007-05-10 TW TW096116645A patent/TWI346115B/zh not_active IP Right Cessation
-
2008
- 2008-10-21 CR CR10383A patent/CR10383A/es not_active Application Discontinuation
- 2008-10-21 ZA ZA2008/09020A patent/ZA200809020B/en unknown
- 2008-10-22 IL IL194813A patent/IL194813A0/en unknown
- 2008-11-06 TN TNP2008000445A patent/TNSN08445A1/fr unknown
- 2008-11-07 EC EC2008008871A patent/ECSP088871A/es unknown
- 2008-11-11 MA MA31378A patent/MA30411B1/fr unknown
- 2008-12-03 NO NO20085060A patent/NO20085060L/no not_active Application Discontinuation
-
2010
- 2010-01-04 US US12/651,984 patent/US20100105656A1/en not_active Abandoned
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