SU584774A3 - Способ получени производных изоксазола - Google Patents
Способ получени производных изоксазолаInfo
- Publication number
- SU584774A3 SU584774A3 SU7602373645A SU2373645A SU584774A3 SU 584774 A3 SU584774 A3 SU 584774A3 SU 7602373645 A SU7602373645 A SU 7602373645A SU 2373645 A SU2373645 A SU 2373645A SU 584774 A3 SU584774 A3 SU 584774A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- derivatives
- azoxazole
- preparing
- reaction
- methylisoxazolo
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 5
- JKFAIQOWCVVSKC-UHFFFAOYSA-N furazan Chemical class C=1C=NON=1 JKFAIQOWCVVSKC-UHFFFAOYSA-N 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 150000002545 isoxazoles Chemical class 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- VUBCNGCMOPTDED-UHFFFAOYSA-N 3-methyl-1,2-oxazole-5-carbonyl chloride Chemical compound CC=1C=C(C(Cl)=O)ON=1 VUBCNGCMOPTDED-UHFFFAOYSA-N 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims description 2
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 239000011541 reaction mixture Substances 0.000 claims description 2
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 238000002474 experimental method Methods 0.000 claims 1
- -1 p-carboxyphenyl Chemical group 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QIKYZXDTTPVVAC-UHFFFAOYSA-N 4-Aminobenzamide Chemical compound NC(=O)C1=CC=C(N)C=C1 QIKYZXDTTPVVAC-UHFFFAOYSA-N 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- SOWBFZRMHSNYGE-UHFFFAOYSA-N Monoamide-Oxalic acid Natural products NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229960004050 aminobenzoic acid Drugs 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 229940125708 antidiabetic agent Drugs 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP50076176A JPS52264A (en) | 1975-06-21 | 1975-06-21 | Process for preparing novel isoxazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU584774A3 true SU584774A3 (ru) | 1977-12-15 |
Family
ID=13597782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU7602373645A SU584774A3 (ru) | 1975-06-21 | 1976-06-18 | Способ получени производных изоксазола |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4026902A (enExample) |
| JP (1) | JPS52264A (enExample) |
| AR (1) | AR209492A1 (enExample) |
| AU (1) | AU497558B2 (enExample) |
| BE (1) | BE843195A (enExample) |
| CA (1) | CA1050996A (enExample) |
| DE (1) | DE2627696A1 (enExample) |
| ES (1) | ES449068A1 (enExample) |
| FR (1) | FR2315923A1 (enExample) |
| GB (1) | GB1529403A (enExample) |
| SE (1) | SE428688B (enExample) |
| SU (1) | SU584774A3 (enExample) |
| ZA (1) | ZA763356B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196046A (en) * | 1984-07-26 | 1993-03-23 | Rohm And Haas Company | N-acetonyl-substituted-amides |
| US4863940A (en) * | 1984-07-26 | 1989-09-05 | Rohm And Haas | N-acetonyl-substituted amides and phytopathogenic fungicidal use thereof |
| US4717064A (en) * | 1986-08-15 | 1988-01-05 | Unisys Corporation | Wave solder finger shield apparatus |
| US5258397A (en) * | 1988-11-30 | 1993-11-02 | Novapharme | 3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions |
| FR2662692B1 (fr) * | 1990-05-30 | 1995-04-28 | Novapharme | Derives heterocycliques doues d'activite anticonvulsivante, procede de preparation et composition pharmaceutique. |
| FR2639636B1 (fr) * | 1988-11-30 | 1994-03-04 | Novapharme | Nouveaux composes heterocycliques a activite anticonvulsivante, procede de preparation et compositions therapeutiques les contenant |
| US4930204A (en) * | 1989-02-01 | 1990-06-05 | A. O. Smith Corporation | Method of forming composite tubular structure |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2073284B1 (enExample) * | 1969-12-23 | 1973-07-13 | Ferlux |
-
1975
- 1975-06-21 JP JP50076176A patent/JPS52264A/ja active Granted
-
1976
- 1976-06-03 AU AU14593/76A patent/AU497558B2/en not_active Expired
- 1976-06-04 ZA ZA763356A patent/ZA763356B/xx unknown
- 1976-06-04 US US05/692,908 patent/US4026902A/en not_active Expired - Lifetime
- 1976-06-09 GB GB23841/76A patent/GB1529403A/en not_active Expired
- 1976-06-17 CA CA255,153A patent/CA1050996A/en not_active Expired
- 1976-06-18 SE SE7607038A patent/SE428688B/xx not_active IP Right Cessation
- 1976-06-18 AR AR263666A patent/AR209492A1/es active
- 1976-06-18 SU SU7602373645A patent/SU584774A3/ru active
- 1976-06-21 FR FR7618776A patent/FR2315923A1/fr active Granted
- 1976-06-21 ES ES449068A patent/ES449068A1/es not_active Expired
- 1976-06-21 DE DE19762627696 patent/DE2627696A1/de not_active Ceased
- 1976-06-21 BE BE168133A patent/BE843195A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2315923A1 (fr) | 1977-01-28 |
| DE2627696A1 (de) | 1977-01-13 |
| BE843195A (fr) | 1976-10-18 |
| GB1529403A (en) | 1978-10-18 |
| JPS5314067B2 (enExample) | 1978-05-15 |
| FR2315923B1 (enExample) | 1979-09-21 |
| AU1459376A (en) | 1977-12-08 |
| AU497558B2 (en) | 1978-12-14 |
| ZA763356B (en) | 1977-05-25 |
| AR209492A1 (es) | 1977-04-29 |
| SE428688B (sv) | 1983-07-18 |
| JPS52264A (en) | 1977-01-05 |
| US4026902A (en) | 1977-05-31 |
| SE7607038L (sv) | 1976-12-22 |
| CA1050996A (en) | 1979-03-20 |
| ES449068A1 (es) | 1977-07-16 |
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