SU519135A3 - Способ получени производных имидазо (1,2-а) симм-триазина - Google Patents
Способ получени производных имидазо (1,2-а) симм-триазинаInfo
- Publication number
- SU519135A3 SU519135A3 SU2007687A SU2007687A SU519135A3 SU 519135 A3 SU519135 A3 SU 519135A3 SU 2007687 A SU2007687 A SU 2007687A SU 2007687 A SU2007687 A SU 2007687A SU 519135 A3 SU519135 A3 SU 519135A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- sim
- triazine derivatives
- imidazo
- triazine
- preparing imidazo
- Prior art date
Links
- 239000002904 solvent Substances 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- -1 2,6-Dichlorophenyl Chemical group 0.000 description 9
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 7
- 238000000605 extraction Methods 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- KVNYFPKFSJIPBJ-UHFFFAOYSA-N 1,2-diethylbenzene Chemical compound CCC1=CC=CC=C1CC KVNYFPKFSJIPBJ-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- UTCSSFWDNNEEBH-UHFFFAOYSA-N imidazo[1,2-a]pyridine Chemical compound C1=CC=CC2=NC=CN21 UTCSSFWDNNEEBH-UHFFFAOYSA-N 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- AUHZEENZYGFFBQ-UHFFFAOYSA-N mesitylene Substances CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 description 2
- 125000001827 mesitylenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 150000002905 orthoesters Chemical class 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 description 1
- JZCUPRBTPVMOJI-UHFFFAOYSA-N 4,5-dihydroimidazole-1-carboxamide Chemical compound NC(=O)N1CCN=C1 JZCUPRBTPVMOJI-UHFFFAOYSA-N 0.000 description 1
- XRHGYUZYPHTUJZ-UHFFFAOYSA-N 4-chlorobenzoic acid Chemical compound OC(=O)C1=CC=C(Cl)C=C1 XRHGYUZYPHTUJZ-UHFFFAOYSA-N 0.000 description 1
- XZLIYCQRASOFQM-UHFFFAOYSA-N 5h-imidazo[4,5-d]triazine Chemical compound N1=NC=C2NC=NC2=N1 XZLIYCQRASOFQM-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2314488A DE2314488C3 (de) | 1973-03-23 | 1973-03-23 | 8-(2,6-Dichlorphenyl)-7-(4-chlorphenyl)-5-oxo-233,8-tetrahydro-imidazo [1,2-a] -s-triazin, Verfahren zu dessen Herstellung und dieses enthaltene Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU519135A3 true SU519135A3 (ru) | 1976-06-25 |
Family
ID=5875651
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU2007687A SU519135A3 (ru) | 1973-03-23 | 1974-03-21 | Способ получени производных имидазо (1,2-а) симм-триазина |
| SU2007686A SU496734A3 (ru) | 1973-03-23 | 1974-03-21 | Способ получени производных имидазо (1,2-а) симм-триазина |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU2007686A SU496734A3 (ru) | 1973-03-23 | 1974-03-21 | Способ получени производных имидазо (1,2-а) симм-триазина |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US3887552A (enExample) |
| JP (1) | JPS5821634B2 (enExample) |
| AT (1) | AT331256B (enExample) |
| BE (1) | BE812736A (enExample) |
| BG (2) | BG23750A3 (enExample) |
| CA (1) | CA1017339A (enExample) |
| CH (2) | CH588492A5 (enExample) |
| CS (1) | CS191229B2 (enExample) |
| DD (1) | DD112266A5 (enExample) |
| DE (1) | DE2314488C3 (enExample) |
| DK (1) | DK139519C (enExample) |
| ES (2) | ES424345A1 (enExample) |
| FI (1) | FI55664C (enExample) |
| FR (1) | FR2222100B1 (enExample) |
| GB (1) | GB1455356A (enExample) |
| HU (1) | HU171082B (enExample) |
| IE (1) | IE39965B1 (enExample) |
| IL (1) | IL44470A (enExample) |
| NL (1) | NL179479C (enExample) |
| NO (1) | NO139049C (enExample) |
| PL (2) | PL88663B1 (enExample) |
| RO (2) | RO68650A (enExample) |
| SE (1) | SE419087B (enExample) |
| SU (2) | SU519135A3 (enExample) |
| YU (2) | YU36959B (enExample) |
| ZA (1) | ZA741864B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1428269A (en) * | 1973-11-07 | 1976-03-17 | Ici Ltd | Pyrimidino-triazine compounds and their use as pesticides |
| US4195092A (en) * | 1977-12-27 | 1980-03-25 | Eli Lilly And Company | 2-(Substituted amino)-N-(3-substituted phenyl)-2-imidazoline-1-carbothioamides |
| JPS6050207U (ja) * | 1983-09-09 | 1985-04-09 | ビ−・エス・コンクリ−ト株式会社 | 桁下の吊り足場 |
| JPS61246273A (ja) * | 1985-04-25 | 1986-11-01 | Dainippon Ink & Chem Inc | 顔料ベ−スト |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791025A (fr) * | 1971-11-19 | 1973-05-07 | Allen & Hanburys Ltd | Composes heterocycliques |
-
1973
- 1973-03-23 DE DE2314488A patent/DE2314488C3/de not_active Expired
-
1974
- 1974-03-08 AT AT193674A patent/AT331256B/de not_active IP Right Cessation
- 1974-03-12 US US450289A patent/US3887552A/en not_active Expired - Lifetime
- 1974-03-16 ES ES424345A patent/ES424345A1/es not_active Expired
- 1974-03-16 ES ES424346A patent/ES424346A1/es not_active Expired
- 1974-03-18 CS CS741939A patent/CS191229B2/cs unknown
- 1974-03-19 FI FI822/74A patent/FI55664C/fi active
- 1974-03-20 CH CH382974A patent/CH588492A5/xx not_active IP Right Cessation
- 1974-03-20 RO RO7484657A patent/RO68650A/ro unknown
- 1974-03-20 CH CH382874A patent/CH584714A5/xx not_active IP Right Cessation
- 1974-03-20 RO RO7400078112A patent/RO63042A/ro unknown
- 1974-03-21 SU SU2007687A patent/SU519135A3/ru active
- 1974-03-21 BG BG030628A patent/BG23750A3/xx unknown
- 1974-03-21 HU HU74BO00001492A patent/HU171082B/hu unknown
- 1974-03-21 SU SU2007686A patent/SU496734A3/ru active
- 1974-03-21 YU YU0790/74A patent/YU36959B/xx unknown
- 1974-03-21 BG BG026154A patent/BG23006A3/xx unknown
- 1974-03-22 NL NLAANVRAGE7403893,A patent/NL179479C/xx not_active IP Right Cessation
- 1974-03-22 CA CA195,706A patent/CA1017339A/en not_active Expired
- 1974-03-22 ZA ZA00741864A patent/ZA741864B/xx unknown
- 1974-03-22 JP JP49032462A patent/JPS5821634B2/ja not_active Expired
- 1974-03-22 DK DK159774A patent/DK139519C/da not_active IP Right Cessation
- 1974-03-22 NO NO741044A patent/NO139049C/no unknown
- 1974-03-22 BE BE142376A patent/BE812736A/xx not_active IP Right Cessation
- 1974-03-22 PL PL1974169752A patent/PL88663B1/pl unknown
- 1974-03-22 FR FR7410019A patent/FR2222100B1/fr not_active Expired
- 1974-03-22 DD DD177384A patent/DD112266A5/xx unknown
- 1974-03-22 SE SE7403942A patent/SE419087B/xx unknown
- 1974-03-22 IE IE635/74A patent/IE39965B1/xx unknown
- 1974-03-22 PL PL1974183800A patent/PL92111B1/zh unknown
- 1974-03-22 GB GB1290574A patent/GB1455356A/en not_active Expired
- 1974-03-22 IL IL44470A patent/IL44470A/en unknown
-
1980
- 1980-07-08 YU YU1763/80A patent/YU36961B/xx unknown
Also Published As
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