SU1706390A3 - Способ получени гидрохлорида N- @ (4-[(индоло-(3,2-в)хинолин-10-ил)амино]-3-метоксифенил @ )-метансульфонамида - Google Patents

Способ получени гидрохлорида N- @ (4-[(индоло-(3,2-в)хинолин-10-ил)амино]-3-метоксифенил @ )-метансульфонамида Download PDF

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Publication number
SU1706390A3
SU1706390A3 SU894613720A SU4613720A SU1706390A3 SU 1706390 A3 SU1706390 A3 SU 1706390A3 SU 894613720 A SU894613720 A SU 894613720A SU 4613720 A SU4613720 A SU 4613720A SU 1706390 A3 SU1706390 A3 SU 1706390A3
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USSR - Soviet Union
Prior art keywords
indolo
chinoline
methoxyphenyl
amino
preparation
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SU894613720A
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English (en)
Inventor
Ямато Масатоси
Original Assignee
Мект Корпорейшн (Фирма)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Изобретение касаетс  гетероциклических веществ, в частности получени  гидрохлорида N-{4- (индоло

Description

Определ ют концентрацию соединени , способную вызвать 50% подавление роста (ЭД50) по сравнению с контролем. Соединение считают эффек- тивным при менее Ь мкг/мл.
Результаты испытаний на канцеро- статическое действие дано в табл.1.
1 В табл.3 даны сопоставлени  известных соединений.

Claims (1)

  1. ЫН502СН3
    имеющийся тем, что индоло(3,2-Ь)-Ю-хлорхинолин формулы
    40 подвергают взаимодействию с 2-метокси-4-метилсульфамидопланилин формулы
    εΗ3502ΝΗ-<δ\-ΝΗ2 осн3
    в присутствии концентрированной соляной кислоты.
SU894613720A 1988-03-10 1989-03-09 Способ получени гидрохлорида N- @ (4-[(индоло-(3,2-в)хинолин-10-ил)амино]-3-метоксифенил @ )-метансульфонамида SU1706390A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63056883A JPH01228965A (ja) 1988-03-10 1988-03-10 縮合キノリン系化合物及び縮合アクリジン系化合物、それらの製造法ならびにそれらの化合物を有効成分とする抗癌剤

Publications (1)

Publication Number Publication Date
SU1706390A3 true SU1706390A3 (ru) 1992-01-15

Family

ID=13039818

Family Applications (1)

Application Number Title Priority Date Filing Date
SU894613720A SU1706390A3 (ru) 1988-03-10 1989-03-09 Способ получени гидрохлорида N- @ (4-[(индоло-(3,2-в)хинолин-10-ил)амино]-3-метоксифенил @ )-метансульфонамида

Country Status (15)

Country Link
US (1) US5128345A (ru)
EP (1) EP0332190A3 (ru)
JP (1) JPH01228965A (ru)
KR (1) KR890014536A (ru)
CN (1) CN1036763A (ru)
AU (1) AU618991B2 (ru)
BR (1) BR8901100A (ru)
DK (1) DK116289A (ru)
FI (1) FI891061A (ru)
HU (1) HU203225B (ru)
IL (1) IL89510A (ru)
NO (1) NO167861C (ru)
NZ (1) NZ228275A (ru)
SU (1) SU1706390A3 (ru)
ZA (1) ZA891758B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02256667A (ja) * 1988-12-27 1990-10-17 Masatoshi Yamato 縮合キノリン系化合物およびその製造方法
US7728000B2 (en) * 2003-11-20 2010-06-01 Crystax Pharmaceuticals Substituted quinolines for the treatment of cancer
CN103497211B (zh) * 2013-10-15 2016-07-20 中国海洋大学 吲哚并喹啉衍生物及其制备方法和应用
CN103614134B (zh) * 2013-11-08 2014-11-05 吉林奥来德光电材料股份有限公司 一种有机电致发光材料及其制备方法
CN104860945B (zh) * 2014-02-25 2016-08-24 北京大学 稠合吖啶衍生物及其药物组合物、制备方法及应用
CN103951694A (zh) * 2014-04-14 2014-07-30 上海大学 吖啶或苯并吖啶衍生物及其合成方法
CN105399671B (zh) * 2015-12-02 2018-04-17 广西中医药大学 7‑对甲苯氨基苯并[c]吖啶盐酸盐及其制备方法和用途
CN105418501B (zh) * 2015-12-02 2018-04-17 广西中医药大学 7‑对甲氧苯氨基苯并[c]吖啶盐酸盐及其制备方法和用途
CN105669551B (zh) * 2015-12-02 2018-04-17 广西中医药大学 7‑苯并(c)吖啶对氟苯甲酰胺基硫脲及其制备方法和用途
CN105481769B (zh) * 2015-12-02 2018-07-10 广西中医药大学 一种苯并(c)吖啶衍生物及其制备方法和用途
CN114560859B (zh) * 2022-03-11 2023-08-01 华中师范大学 一种吲哚并喹啉衍生物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63101369A (ja) * 1986-10-17 1988-05-06 Mect Corp インデノキノリン系化合物、その製造法及びその化合物を有効成分とする抗癌剤
JPH02256667A (ja) * 1988-12-27 1990-10-17 Masatoshi Yamato 縮合キノリン系化合物およびその製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Atwell G.I. et al.I. Med Chem., 15, 611, 1972. Bruke F. Gain et al. I. Med. Chem., 17, 922, 1974. Gordon W. Rewcastle et. al I.Med. Chem., 30, 1576, 1987. *

Also Published As

Publication number Publication date
NZ228275A (en) 1990-12-21
FI891061A (fi) 1989-09-11
NO167861B (no) 1991-09-09
NO167861C (no) 1991-12-18
AU3112089A (en) 1989-09-14
US5128345A (en) 1992-07-07
EP0332190A2 (en) 1989-09-13
IL89510A (en) 1992-08-18
DK116289A (da) 1989-09-11
HUT50818A (en) 1990-03-28
JPH01228965A (ja) 1989-09-12
FI891061A0 (fi) 1989-03-06
CN1036763A (zh) 1989-11-01
AU618991B2 (en) 1992-01-16
KR890014536A (ko) 1989-10-24
NO891024L (no) 1989-09-11
EP0332190A3 (en) 1991-04-24
BR8901100A (pt) 1989-10-31
HU203225B (en) 1991-06-28
NO891024D0 (no) 1989-03-09
ZA891758B (en) 1989-11-29
DK116289D0 (da) 1989-03-10
IL89510A0 (en) 1989-09-10

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