SU1375113A3 - Способ получени эмульсии 9-(2-оксиэтоксиметил)гуанина "Ацикловир - Google Patents
Способ получени эмульсии 9-(2-оксиэтоксиметил)гуанина "Ацикловир Download PDFInfo
- Publication number
- SU1375113A3 SU1375113A3 SU813310056A SU3310056A SU1375113A3 SU 1375113 A3 SU1375113 A3 SU 1375113A3 SU 813310056 A SU813310056 A SU 813310056A SU 3310056 A SU3310056 A SU 3310056A SU 1375113 A3 SU1375113 A3 SU 1375113A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- guanine
- oxyethoxymethyl
- producing emulsion
- weight
- emulsion
- Prior art date
Links
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 title claims abstract description 7
- 239000000839 emulsion Substances 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 4
- 229960004150 aciclovir Drugs 0.000 title abstract description 4
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 title description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 229940057995 liquid paraffin Drugs 0.000 claims description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 3
- 239000012188 paraffin wax Substances 0.000 claims description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 3
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 3
- 239000000203 mixture Substances 0.000 abstract description 2
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 210000004877 mucosa Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000005846 sugar alcohols Polymers 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000012544 Viral Skin disease Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LV920331A LV5174A3 (lv) | 1980-07-18 | 1992-12-18 | Panemiens "aciklovira" 9-(2-oksietoksimetil)guanina emulsijas iegusanai |
| LTRP426A LT2117B (lt) | 1980-07-18 | 1993-03-15 | Ro") gavimo budas 9-(2-oksietoksimetil) guanino emulsijos ("aciklovi |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8023645 | 1980-07-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1375113A3 true SU1375113A3 (ru) | 1988-02-15 |
Family
ID=10514892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU813310056A SU1375113A3 (ru) | 1980-07-18 | 1981-07-17 | Способ получени эмульсии 9-(2-оксиэтоксиметил)гуанина "Ацикловир |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4963555A (enExample) |
| JP (1) | JPH0148885B2 (enExample) |
| KR (1) | KR830005852A (enExample) |
| GE (1) | GEP19981256B (enExample) |
| SU (1) | SU1375113A3 (enExample) |
| ZA (1) | ZA814925B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005067941A1 (es) * | 2004-01-08 | 2005-07-28 | Universidad De Concepcion | Formulacion topica de aciclovir |
| RU2457843C1 (ru) * | 2011-05-11 | 2012-08-10 | Общество с ограниченной ответственностью фирма "Вита" | Стабилизированный фармацевтический состав с противовирусным действием |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9001886D0 (en) * | 1990-01-26 | 1990-03-28 | Beecham Group Plc | Pharmaceutical formulation |
| GB9315755D0 (en) * | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized formulation |
| GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
| US6653318B1 (en) | 1999-07-21 | 2003-11-25 | Yale University | 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use |
| US20050058673A1 (en) | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| AU2004270258A1 (en) * | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| US20060051384A1 (en) * | 2004-09-07 | 2006-03-09 | 3M Innovative Properties Company | Antiseptic compositions and methods of use |
| US8198326B2 (en) * | 2004-09-07 | 2012-06-12 | 3M Innovative Properties Company | Phenolic antiseptic compositions and methods of use |
| US9028852B2 (en) | 2004-09-07 | 2015-05-12 | 3M Innovative Properties Company | Cationic antiseptic compositions and methods of use |
| CN101137359B (zh) | 2005-03-10 | 2011-01-12 | 3M创新有限公司 | 治疗耳感染的方法 |
| CA2599667C (en) | 2005-03-10 | 2014-12-16 | 3M Innovative Properties Company | Antimicrobial compositions comprising esters of hydroxy carboxylic acids |
| TW200716200A (en) | 2005-03-10 | 2007-05-01 | 3M Innovative Properties Co | Methods of reducing microbial contamination |
| US8771712B2 (en) * | 2006-05-09 | 2014-07-08 | Emisphere Technologies, Inc. | Topical administration of acyclovir |
| JP4972062B2 (ja) * | 2008-03-17 | 2012-07-11 | メディヴィル・アクチエボラーグ | 抗ウイルス製剤 |
| US8236768B2 (en) | 2008-10-03 | 2012-08-07 | 3B Pharmaceuticals, Inc. | Topical antiviral formulations |
| WO2011035120A2 (en) * | 2009-09-17 | 2011-03-24 | Gk Ventures, L.L.C. | Therapeutic composition to treat lesions caused by herpes simplex virus |
| US8853223B2 (en) * | 2010-09-17 | 2014-10-07 | G2L Touch, Inc. | Therapeutic composition to treat lesions caused by herpes simplex virus |
| EP2782585B1 (en) * | 2011-11-23 | 2018-12-26 | 3B Pharmaceuticals, Inc. | Antiviral formulations |
| US10456435B2 (en) | 2015-07-15 | 2019-10-29 | Christopher A. MCELVANY | Topical antiviral formulations and methods of using the same |
| FI3638251T3 (fi) * | 2017-06-12 | 2024-04-29 | Lakewood Amedex Inc | Bisfosfosiinin geeliformulaatioita ja niiden käyttötapoja |
| JP2022538782A (ja) | 2019-06-14 | 2022-09-06 | プロペラ セラピューティクス インコーポレイテッド | 局所用アシクロビル製剤およびその使用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536816A (en) * | 1964-09-30 | 1970-10-27 | Atlas Chem Ind | Water-in-oil emulsion |
| US3592930A (en) * | 1968-07-19 | 1971-07-13 | Syntex Corp | Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle |
| CH558659A (fr) * | 1969-11-26 | 1975-02-14 | Orsymonde | Procede pour la preparation d'une composition lyophilisee a usage hygienique. |
| US3924004A (en) * | 1971-11-24 | 1975-12-02 | Syntex Corp | Fatty alcohol-propylene carbonate-glycol solvent cream vehicle |
| ZA72698B (en) * | 1972-02-03 | 1973-09-26 | Liebenberg R W | Method of preparing medicinal compositions |
| US3892857A (en) * | 1972-11-24 | 1975-07-01 | Squibb & Sons Inc | Steroid formulation |
| ZA738657B (en) * | 1973-01-05 | 1974-10-30 | Hoffmann La Roche | Emulsions |
| GB1478009A (en) * | 1973-04-02 | 1977-06-29 | Glaxo Lab Ltd | Pharmaceutical compositions |
| US3867528A (en) * | 1973-10-11 | 1975-02-18 | American Cyanamid Co | Steroidal topical cream base |
| GB1523865A (en) * | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
| GB1543907A (en) * | 1975-02-19 | 1979-04-11 | Dermal Labor Ltd | Steroid compositions |
| US3934013A (en) * | 1975-02-21 | 1976-01-20 | Syntex (U.S.A.) Inc. | Pharmaceutical composition |
| US4049802A (en) * | 1975-03-19 | 1977-09-20 | Research Corporation | Zinc sulfadiazine and its use in the treatment of burns |
| GB1554720A (en) * | 1975-07-10 | 1979-10-24 | Nyegaard & Co As | Pyridthione derivatives |
| US4144332A (en) * | 1976-01-05 | 1979-03-13 | The Regents Of The University Of Michigan | Process for alleviating proliferative skin diseases |
| JPS52105195A (en) * | 1976-03-01 | 1977-09-03 | Wellcome Found | Substituted purine |
| SE7702990L (sv) * | 1976-03-19 | 1977-09-20 | Minnesota Mining & Mfg | Tropiskt administreringssystem for lekemedel med forsterkt peutreringsformaga |
| DE2646435B2 (de) * | 1976-10-14 | 1979-05-31 | Shiseido Co., Ltd., Tokio | Verfahren zur Herstellung einer stabilen Öl-in-Wasser-Emulsion |
| GB1556632A (en) * | 1977-01-14 | 1979-11-28 | Sterling Drug Inc | Antimicrobial skin cleasing composition |
| US4145440A (en) * | 1977-08-18 | 1979-03-20 | The Upjohn Company | Liquid suspension of an aluminum salt of ibuprofen |
| CA1113005A (en) * | 1977-12-06 | 1981-11-24 | Pierluigi Vanoni | Excipient composition for creams |
| DE2847975A1 (de) * | 1978-11-04 | 1980-05-14 | Merck Patent Gmbh | Verfahren zur bindung von freiem formaldehyd in pharmazeutischen und kosmetischen zubereitungen |
-
1981
- 1981-07-16 KR KR1019810002601A patent/KR830005852A/ko not_active Ceased
- 1981-07-17 SU SU813310056A patent/SU1375113A3/ru active
- 1981-07-17 ZA ZA814925A patent/ZA814925B/xx unknown
- 1981-07-17 JP JP56110980A patent/JPH0148885B2/ja not_active Expired
-
1989
- 1989-03-01 US US07/317,129 patent/US4963555A/en not_active Expired - Lifetime
-
1994
- 1994-09-07 GE GEAP19942163A patent/GEP19981256B/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005067941A1 (es) * | 2004-01-08 | 2005-07-28 | Universidad De Concepcion | Formulacion topica de aciclovir |
| RU2457843C1 (ru) * | 2011-05-11 | 2012-08-10 | Общество с ограниченной ответственностью фирма "Вита" | Стабилизированный фармацевтический состав с противовирусным действием |
Also Published As
| Publication number | Publication date |
|---|---|
| US4963555A (en) | 1990-10-16 |
| ZA814925B (en) | 1983-02-23 |
| GEP19981256B (en) | 1998-04-01 |
| JPH0148885B2 (enExample) | 1989-10-20 |
| JPS5742615A (enExample) | 1982-03-10 |
| KR830005852A (ko) | 1983-09-14 |
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