SU1256698A3 - Способ получени цис-дихлор-транс-диокси-бис/изопропиламин/платины /1у/ - Google Patents
Способ получени цис-дихлор-транс-диокси-бис/изопропиламин/платины /1у/ Download PDFInfo
- Publication number
- SU1256698A3 SU1256698A3 SU823434800A SU3434800A SU1256698A3 SU 1256698 A3 SU1256698 A3 SU 1256698A3 SU 823434800 A SU823434800 A SU 823434800A SU 3434800 A SU3434800 A SU 3434800A SU 1256698 A3 SU1256698 A3 SU 1256698A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- dimethylacetamide
- product
- cis
- trans
- analysis
- Prior art date
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title claims abstract description 7
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 title claims abstract 3
- 229910052697 platinum Inorganic materials 0.000 title abstract 2
- 238000000034 method Methods 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 21
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims abstract description 16
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000000047 product Substances 0.000 claims description 16
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 9
- 239000013078 crystal Substances 0.000 claims description 5
- 238000002411 thermogravimetry Methods 0.000 claims description 5
- 238000004458 analytical method Methods 0.000 claims description 4
- 238000000921 elemental analysis Methods 0.000 claims description 3
- 238000001030 gas--liquid chromatography Methods 0.000 claims description 3
- AJWDBMRAQLRSCK-UHFFFAOYSA-N platinum;propan-2-amine Chemical compound [Pt].CC(C)N AJWDBMRAQLRSCK-UHFFFAOYSA-N 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims description 2
- 239000012043 crude product Substances 0.000 claims description 2
- 238000002474 experimental method Methods 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 238000007605 air drying Methods 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 abstract 1
- 229940113088 dimethylacetamide Drugs 0.000 description 8
- 238000002329 infrared spectrum Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000004580 weight loss Effects 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 238000000634 powder X-ray diffraction Methods 0.000 description 2
- 101100310633 Xenopus laevis sojo gene Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000012866 crystallographic experiment Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- NDBYXKQCPYUOMI-UHFFFAOYSA-N platinum(4+) Chemical compound [Pt+4] NDBYXKQCPYUOMI-UHFFFAOYSA-N 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8028484 | 1980-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1256698A3 true SU1256698A3 (ru) | 1986-09-07 |
Family
ID=10515824
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU823434800A SU1256698A3 (ru) | 1980-09-03 | 1982-05-03 | Способ получени цис-дихлор-транс-диокси-бис/изопропиламин/платины /1у/ |
| SU3495252A SU1188179A1 (ru) | 1980-09-03 | 1982-09-20 | Цис-дихлор-транс-дигидроксибис(изопропиламин)платина(1V),про вл юща противоопухолевую активность |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU3495252A SU1188179A1 (ru) | 1980-09-03 | 1982-09-20 | Цис-дихлор-транс-дигидроксибис(изопропиламин)платина(1V),про вл юща противоопухолевую активность |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5777694A (enrdf_load_stackoverflow) |
| KR (1) | KR890000640B1 (enrdf_load_stackoverflow) |
| BE (1) | BE890209A (enrdf_load_stackoverflow) |
| SU (2) | SU1256698A3 (enrdf_load_stackoverflow) |
| ZA (1) | ZA815852B (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984004524A1 (en) * | 1983-05-10 | 1984-11-22 | Andrulis Res Corp | Bis-platinum complexes as antitumor agents |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1578323A (en) * | 1976-02-26 | 1980-11-05 | Rustenburg Platinum Mines Ltd | Compositions containing platinum |
-
1981
- 1981-08-25 ZA ZA815852A patent/ZA815852B/xx unknown
- 1981-09-02 KR KR1019810003274A patent/KR890000640B1/ko not_active Expired
- 1981-09-03 JP JP56137856A patent/JPS5777694A/ja active Granted
- 1981-09-03 BE BE0/205862A patent/BE890209A/fr not_active IP Right Cessation
-
1982
- 1982-05-03 SU SU823434800A patent/SU1256698A3/ru active
- 1982-09-20 SU SU3495252A patent/SU1188179A1/ru active
Non-Patent Citations (1)
| Title |
|---|
| За вка FR 2342299, кл, С 07 F Г5/00, 1977, * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR890000640B1 (ko) | 1989-03-22 |
| KR830008543A (ko) | 1983-12-10 |
| ZA815852B (en) | 1982-08-25 |
| BE890209A (fr) | 1982-01-04 |
| SU1188179A1 (ru) | 1985-10-30 |
| JPS5777694A (en) | 1982-05-15 |
| JPH0349916B2 (enrdf_load_stackoverflow) | 1991-07-31 |
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