SMT202600018T1 - Forme solide comprendenti (s)-4-(4-(4-(((2-(2,6-diossopiperidin-3-il)-1-ossoisoindolin-4- il)ossi)metil)benzil)piperazin-1-il)-3-fluorobenzonitrile e suoi sali, e composizioni che comprendono le, e metodi d'uso delle stesse - Google Patents

Forme solide comprendenti (s)-4-(4-(4-(((2-(2,6-diossopiperidin-3-il)-1-ossoisoindolin-4- il)ossi)metil)benzil)piperazin-1-il)-3-fluorobenzonitrile e suoi sali, e composizioni che comprendono le, e metodi d'uso delle stesse

Info

Publication number
SMT202600018T1
SMT202600018T1 SM20260018T SMT202600018T SMT202600018T1 SM T202600018 T1 SMT202600018 T1 SM T202600018T1 SM 20260018 T SM20260018 T SM 20260018T SM T202600018 T SMT202600018 T SM T202600018T SM T202600018 T1 SMT202600018 T1 SM T202600018T1
Authority
SM
San Marino
Prior art keywords
dioxopiperidin
oxoisoindolin
fluorobenzonitrile
piperazin
oxy
Prior art date
Application number
SM20260018T
Other languages
English (en)
Italian (it)
Inventor
Hon-Wah Man
Lianfeng Huang
Wenju Wu
Iii Gerald D Artman
Antonio C Ferretti
Udaykumar Jain
Paula A Tavares-Greco
Nancy Nienhua Tsou
Zhiwei Yin
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of SMT202600018T1 publication Critical patent/SMT202600018T1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SM20260018T 2019-01-09 2020-01-08 Forme solide comprendenti (s)-4-(4-(4-(((2-(2,6-diossopiperidin-3-il)-1-ossoisoindolin-4- il)ossi)metil)benzil)piperazin-1-il)-3-fluorobenzonitrile e suoi sali, e composizioni che comprendono le, e metodi d'uso delle stesse SMT202600018T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962790342P 2019-01-09 2019-01-09
EP20703618.7A EP3908582B1 (en) 2019-01-09 2020-01-08 Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same
PCT/US2020/012687 WO2020146463A1 (en) 2019-01-09 2020-01-08 Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same

Publications (1)

Publication Number Publication Date
SMT202600018T1 true SMT202600018T1 (it) 2026-03-09

Family

ID=69467745

Family Applications (1)

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SM20260018T SMT202600018T1 (it) 2019-01-09 2020-01-08 Forme solide comprendenti (s)-4-(4-(4-(((2-(2,6-diossopiperidin-3-il)-1-ossoisoindolin-4- il)ossi)metil)benzil)piperazin-1-il)-3-fluorobenzonitrile e suoi sali, e composizioni che comprendono le, e metodi d'uso delle stesse

Country Status (23)

Country Link
US (3) US11370777B2 (https=)
EP (2) EP3908582B1 (https=)
JP (1) JP7483722B2 (https=)
KR (1) KR102875111B1 (https=)
CN (3) CN113597425A (https=)
AU (1) AU2020206694B2 (https=)
BR (1) BR112021013435A2 (https=)
CA (1) CA3125756A1 (https=)
DK (1) DK3908582T3 (https=)
EA (1) EA202191620A1 (https=)
ES (1) ES3059967T3 (https=)
FI (1) FI3908582T3 (https=)
HR (1) HRP20260065T1 (https=)
IL (1) IL284680A (https=)
LT (1) LT3908582T (https=)
MX (1) MX2021008295A (https=)
PL (1) PL3908582T3 (https=)
PT (1) PT3908582T (https=)
RS (1) RS67646B1 (https=)
SG (1) SG11202107439XA (https=)
SI (1) SI3908582T1 (https=)
SM (1) SMT202600018T1 (https=)
WO (1) WO2020146463A1 (https=)

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WO2020146441A1 (en) * 2019-01-09 2020-07-16 Celgene Corporation Pharmaceutical compositions comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and methods of using the same
KR20220124228A (ko) * 2020-01-20 2022-09-13 강푸 바이오파마슈티칼즈 리미티드 이소인돌린 유도체, 및 이의 제약 조성물 및 용도
BR112023000817A2 (pt) * 2020-07-20 2023-02-07 Jiangsu Hengrui Pharmaceuticals Co Ltd Derivado de isoindolina contendo enxofre, e método de preparação do mesmo e uso médico do mesmo
KR20240013793A (ko) 2021-05-27 2024-01-30 셀진 코포레이션 조합 요법을 사용하는 다발성 골수종의 치료 방법
US20250368620A1 (en) * 2024-05-30 2025-12-04 Celgene Corporation ARNT Degrading Compounds and Uses Thereof

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KR102718800B1 (ko) 2018-05-23 2024-10-18 셀진 코포레이션 다발성 골수종의 치료 및 4-(4-(4-(((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-4-일)옥시)메틸)벤질)피페라진-1-일)-3-플루오로벤조니트릴에 대한 바이오마커의 용도
PL3796912T3 (pl) * 2018-05-23 2023-09-11 Celgene Corporation Związki przeciwproliferacyjne i przeciwciało bispecyficzne przeciwko bcma i cd3 do zastosowania kombinowanego

Also Published As

Publication number Publication date
US20200216418A1 (en) 2020-07-09
AU2020206694A1 (en) 2021-07-29
LT3908582T (lt) 2026-02-10
MX2021008295A (es) 2021-10-13
SG11202107439XA (en) 2021-08-30
AU2020206694B2 (en) 2025-05-22
RS67646B1 (sr) 2026-02-27
CN118324742A (zh) 2024-07-12
DK3908582T3 (da) 2026-01-19
CA3125756A1 (en) 2020-07-16
EA202191620A1 (ru) 2021-11-01
CN113597425A (zh) 2021-11-02
KR102875111B1 (ko) 2025-10-23
IL284680A (en) 2021-08-31
US20250340536A1 (en) 2025-11-06
EP3908582B1 (en) 2025-11-12
CN114394954B (zh) 2024-04-02
BR112021013435A2 (pt) 2021-10-19
PL3908582T3 (pl) 2026-03-30
HRP20260065T1 (hr) 2026-02-27
US20220289713A1 (en) 2022-09-15
US11370777B2 (en) 2022-06-28
CN114394954A (zh) 2022-04-26
EP3908582A1 (en) 2021-11-17
JP2022518175A (ja) 2022-03-14
WO2020146463A1 (en) 2020-07-16
PT3908582T (pt) 2026-01-28
ES3059967T3 (en) 2026-03-24
EP4725553A2 (en) 2026-04-15
JP7483722B2 (ja) 2024-05-15
FI3908582T3 (fi) 2026-01-27
KR20210125491A (ko) 2021-10-18
US12391672B2 (en) 2025-08-19
SI3908582T1 (sl) 2026-03-31

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