SI3908582T1 - Trdne oblike, ki vsebujejo (S)-4-(4-(4-(((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-4-il)oksi)metil) benzil)piperazin-1-il)-3-fluorobenzonitril in njegove soli, sestavki, ki jih vsebujejo in postopki njihove uporabe - Google Patents

Trdne oblike, ki vsebujejo (S)-4-(4-(4-(((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-4-il)oksi)metil) benzil)piperazin-1-il)-3-fluorobenzonitril in njegove soli, sestavki, ki jih vsebujejo in postopki njihove uporabe

Info

Publication number
SI3908582T1
SI3908582T1 SI202030713T SI202030713T SI3908582T1 SI 3908582 T1 SI3908582 T1 SI 3908582T1 SI 202030713 T SI202030713 T SI 202030713T SI 202030713 T SI202030713 T SI 202030713T SI 3908582 T1 SI3908582 T1 SI 3908582T1
Authority
SI
Slovenia
Prior art keywords
dioxopiperidin
oxoisoindolin
fluorobenzonitrile
piperazin
oxy
Prior art date
Application number
SI202030713T
Other languages
English (en)
Slovenian (sl)
Inventor
Iii Gerald D. Artman
Antonio C. Ferretti
Lianfeng Huang
Udaykumar Jain
Hon-Wah Man
Paula A. Tavares-Greco
Wenju Wu
Nancy Nienhua Tsou
Zhiwei Yin
Original Assignee
Celgene Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corporation filed Critical Celgene Corporation
Publication of SI3908582T1 publication Critical patent/SI3908582T1/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI202030713T 2019-01-09 2020-01-08 Trdne oblike, ki vsebujejo (S)-4-(4-(4-(((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-4-il)oksi)metil) benzil)piperazin-1-il)-3-fluorobenzonitril in njegove soli, sestavki, ki jih vsebujejo in postopki njihove uporabe SI3908582T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962790342P 2019-01-09 2019-01-09
EP20703618.7A EP3908582B1 (en) 2019-01-09 2020-01-08 Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same
PCT/US2020/012687 WO2020146463A1 (en) 2019-01-09 2020-01-08 Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same

Publications (1)

Publication Number Publication Date
SI3908582T1 true SI3908582T1 (sl) 2026-03-31

Family

ID=69467745

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SI202030713T SI3908582T1 (sl) 2019-01-09 2020-01-08 Trdne oblike, ki vsebujejo (S)-4-(4-(4-(((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-4-il)oksi)metil) benzil)piperazin-1-il)-3-fluorobenzonitril in njegove soli, sestavki, ki jih vsebujejo in postopki njihove uporabe

Country Status (23)

Country Link
US (3) US11370777B2 (https=)
EP (2) EP3908582B1 (https=)
JP (1) JP7483722B2 (https=)
KR (1) KR102875111B1 (https=)
CN (3) CN113597425A (https=)
AU (1) AU2020206694B2 (https=)
BR (1) BR112021013435A2 (https=)
CA (1) CA3125756A1 (https=)
DK (1) DK3908582T3 (https=)
EA (1) EA202191620A1 (https=)
ES (1) ES3059967T3 (https=)
FI (1) FI3908582T3 (https=)
HR (1) HRP20260065T1 (https=)
IL (1) IL284680A (https=)
LT (1) LT3908582T (https=)
MX (1) MX2021008295A (https=)
PL (1) PL3908582T3 (https=)
PT (1) PT3908582T (https=)
RS (1) RS67646B1 (https=)
SG (1) SG11202107439XA (https=)
SI (1) SI3908582T1 (https=)
SM (1) SMT202600018T1 (https=)
WO (1) WO2020146463A1 (https=)

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WO2020146441A1 (en) * 2019-01-09 2020-07-16 Celgene Corporation Pharmaceutical compositions comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and methods of using the same
KR20220124228A (ko) * 2020-01-20 2022-09-13 강푸 바이오파마슈티칼즈 리미티드 이소인돌린 유도체, 및 이의 제약 조성물 및 용도
BR112023000817A2 (pt) * 2020-07-20 2023-02-07 Jiangsu Hengrui Pharmaceuticals Co Ltd Derivado de isoindolina contendo enxofre, e método de preparação do mesmo e uso médico do mesmo
KR20240013793A (ko) 2021-05-27 2024-01-30 셀진 코포레이션 조합 요법을 사용하는 다발성 골수종의 치료 방법
US20250368620A1 (en) * 2024-05-30 2025-12-04 Celgene Corporation ARNT Degrading Compounds and Uses Thereof

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Also Published As

Publication number Publication date
US20200216418A1 (en) 2020-07-09
AU2020206694A1 (en) 2021-07-29
LT3908582T (lt) 2026-02-10
MX2021008295A (es) 2021-10-13
SG11202107439XA (en) 2021-08-30
AU2020206694B2 (en) 2025-05-22
RS67646B1 (sr) 2026-02-27
CN118324742A (zh) 2024-07-12
DK3908582T3 (da) 2026-01-19
CA3125756A1 (en) 2020-07-16
EA202191620A1 (ru) 2021-11-01
CN113597425A (zh) 2021-11-02
KR102875111B1 (ko) 2025-10-23
IL284680A (en) 2021-08-31
US20250340536A1 (en) 2025-11-06
EP3908582B1 (en) 2025-11-12
CN114394954B (zh) 2024-04-02
BR112021013435A2 (pt) 2021-10-19
PL3908582T3 (pl) 2026-03-30
HRP20260065T1 (hr) 2026-02-27
US20220289713A1 (en) 2022-09-15
US11370777B2 (en) 2022-06-28
CN114394954A (zh) 2022-04-26
EP3908582A1 (en) 2021-11-17
JP2022518175A (ja) 2022-03-14
WO2020146463A1 (en) 2020-07-16
PT3908582T (pt) 2026-01-28
ES3059967T3 (en) 2026-03-24
EP4725553A2 (en) 2026-04-15
SMT202600018T1 (it) 2026-03-09
JP7483722B2 (ja) 2024-05-15
FI3908582T3 (fi) 2026-01-27
KR20210125491A (ko) 2021-10-18
US12391672B2 (en) 2025-08-19

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