CA3125756A1 - Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same - Google Patents

Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same Download PDF

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Publication number
CA3125756A1
CA3125756A1 CA3125756A CA3125756A CA3125756A1 CA 3125756 A1 CA3125756 A1 CA 3125756A1 CA 3125756 A CA3125756 A CA 3125756A CA 3125756 A CA3125756 A CA 3125756A CA 3125756 A1 CA3125756 A1 CA 3125756A1
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Canada
Prior art keywords
xrpd pattern
solid form
approximately
compound
peaks
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Pending
Application number
CA3125756A
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English (en)
French (fr)
Inventor
Gerald D. Artman, Iii
Antonio C. Ferretti
Lianfeng Huang
Udaykumar JAIN
Hon-Wah Man
Paula A. Tavares-Greco
Wenju Wu
Nancy Nienhua Tsou
Zhiwei Yin
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Celgene Corp
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Celgene Corp
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Publication of CA3125756A1 publication Critical patent/CA3125756A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3125756A 2019-01-09 2020-01-08 Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same Pending CA3125756A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962790342P 2019-01-09 2019-01-09
US62/790,342 2019-01-09
PCT/US2020/012687 WO2020146463A1 (en) 2019-01-09 2020-01-08 Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same

Publications (1)

Publication Number Publication Date
CA3125756A1 true CA3125756A1 (en) 2020-07-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA3125756A Pending CA3125756A1 (en) 2019-01-09 2020-01-08 Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same

Country Status (23)

Country Link
US (3) US11370777B2 (https=)
EP (2) EP3908582B1 (https=)
JP (1) JP7483722B2 (https=)
KR (1) KR102875111B1 (https=)
CN (3) CN113597425A (https=)
AU (1) AU2020206694B2 (https=)
BR (1) BR112021013435A2 (https=)
CA (1) CA3125756A1 (https=)
DK (1) DK3908582T3 (https=)
EA (1) EA202191620A1 (https=)
ES (1) ES3059967T3 (https=)
FI (1) FI3908582T3 (https=)
HR (1) HRP20260065T1 (https=)
IL (1) IL284680A (https=)
LT (1) LT3908582T (https=)
MX (1) MX2021008295A (https=)
PL (1) PL3908582T3 (https=)
PT (1) PT3908582T (https=)
RS (1) RS67646B1 (https=)
SG (1) SG11202107439XA (https=)
SI (1) SI3908582T1 (https=)
SM (1) SMT202600018T1 (https=)
WO (1) WO2020146463A1 (https=)

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WO2020146441A1 (en) * 2019-01-09 2020-07-16 Celgene Corporation Pharmaceutical compositions comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and methods of using the same
KR20220124228A (ko) * 2020-01-20 2022-09-13 강푸 바이오파마슈티칼즈 리미티드 이소인돌린 유도체, 및 이의 제약 조성물 및 용도
BR112023000817A2 (pt) * 2020-07-20 2023-02-07 Jiangsu Hengrui Pharmaceuticals Co Ltd Derivado de isoindolina contendo enxofre, e método de preparação do mesmo e uso médico do mesmo
KR20240013793A (ko) 2021-05-27 2024-01-30 셀진 코포레이션 조합 요법을 사용하는 다발성 골수종의 치료 방법
US20250368620A1 (en) * 2024-05-30 2025-12-04 Celgene Corporation ARNT Degrading Compounds and Uses Thereof

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PL3796912T3 (pl) * 2018-05-23 2023-09-11 Celgene Corporation Związki przeciwproliferacyjne i przeciwciało bispecyficzne przeciwko bcma i cd3 do zastosowania kombinowanego

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US20200216418A1 (en) 2020-07-09
AU2020206694A1 (en) 2021-07-29
LT3908582T (lt) 2026-02-10
MX2021008295A (es) 2021-10-13
SG11202107439XA (en) 2021-08-30
AU2020206694B2 (en) 2025-05-22
RS67646B1 (sr) 2026-02-27
CN118324742A (zh) 2024-07-12
DK3908582T3 (da) 2026-01-19
EA202191620A1 (ru) 2021-11-01
CN113597425A (zh) 2021-11-02
KR102875111B1 (ko) 2025-10-23
IL284680A (en) 2021-08-31
US20250340536A1 (en) 2025-11-06
EP3908582B1 (en) 2025-11-12
CN114394954B (zh) 2024-04-02
BR112021013435A2 (pt) 2021-10-19
PL3908582T3 (pl) 2026-03-30
HRP20260065T1 (hr) 2026-02-27
US20220289713A1 (en) 2022-09-15
US11370777B2 (en) 2022-06-28
CN114394954A (zh) 2022-04-26
EP3908582A1 (en) 2021-11-17
JP2022518175A (ja) 2022-03-14
WO2020146463A1 (en) 2020-07-16
PT3908582T (pt) 2026-01-28
ES3059967T3 (en) 2026-03-24
EP4725553A2 (en) 2026-04-15
SMT202600018T1 (it) 2026-03-09
JP7483722B2 (ja) 2024-05-15
FI3908582T3 (fi) 2026-01-27
KR20210125491A (ko) 2021-10-18
US12391672B2 (en) 2025-08-19
SI3908582T1 (sl) 2026-03-31

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