SMT201800038T1 - Composizione fluida iniettabile comprendente buprenorfina - Google Patents
Composizione fluida iniettabile comprendente buprenorfinaInfo
- Publication number
- SMT201800038T1 SMT201800038T1 SM20180038T SMT201800038T SMT201800038T1 SM T201800038 T1 SMT201800038 T1 SM T201800038T1 SM 20180038 T SM20180038 T SM 20180038T SM T201800038 T SMT201800038 T SM T201800038T SM T201800038 T1 SMT201800038 T1 SM T201800038T1
- Authority
- SM
- San Marino
- Prior art keywords
- buprenorphine
- flowable composition
- injectable flowable
- injectable
- composition
- Prior art date
Links
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 title 1
- 229960001736 buprenorphine Drugs 0.000 title 1
- 230000009969 flowable effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Addiction (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1009549.5A GB2481018B (en) | 2010-06-08 | 2010-06-08 | Injectable flowable composition comprising buprenorphine |
| EP11728037.0A EP2579874B1 (en) | 2010-06-08 | 2011-06-06 | Injectable flowable composition comprising buprenorphine |
| PCT/GB2011/051057 WO2011154724A2 (en) | 2010-06-08 | 2011-06-06 | Compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201800038T1 true SMT201800038T1 (it) | 2018-03-08 |
Family
ID=42471306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM20180038T SMT201800038T1 (it) | 2010-06-08 | 2011-06-06 | Composizione fluida iniettabile comprendente buprenorfina |
Country Status (32)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8470359B2 (en) | 2000-11-13 | 2013-06-25 | Qlt Usa, Inc. | Sustained release polymer |
| GB2513267B (en) | 2010-06-08 | 2015-03-18 | Rb Pharmaceuticals Ltd | Injectable flowable composition comprising buprenorphine |
| GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
| WO2013126552A1 (en) | 2012-02-21 | 2013-08-29 | Auburn University | Buprenorphine nanoparticle composition and methods thereof |
| CH708257B1 (de) | 2012-04-17 | 2019-05-15 | Purdue Pharma Lp | Zusammensetzung zur Behandlung einer Opioid-induzierten unerwünschten pharmakodynamischen Reaktion. |
| ES2837803T3 (es) | 2012-07-26 | 2021-07-01 | Camurus Ab | Formulaciones de opioides |
| EP2877155B1 (en) * | 2012-07-26 | 2020-10-28 | Camurus AB | Opioid formulations |
| US20150320866A1 (en) * | 2012-12-13 | 2015-11-12 | Heron Therapeutics, Inc. | Pharmaceutical composition comprising antiemetic compounds and polyorthoester |
| KR102370470B1 (ko) * | 2013-03-15 | 2022-03-04 | 헤론 테라퓨틱스 인코포레이티드 | 폴리오르토에스테르 및 비프로톤성 용매의 조성물 |
| US9636308B2 (en) | 2013-03-15 | 2017-05-02 | Oakwood Laboratories LLC | High drug load buprenorphine microspheres and method of producing same |
| US9393211B2 (en) | 2013-03-15 | 2016-07-19 | Oakwood Laboratories LLC | High drug load buprenorphine microspheres and method of producing same |
| GB201404139D0 (en) * | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| HUE055973T2 (hu) | 2014-04-21 | 2022-01-28 | Heron Therapeutics Inc | Hosszanható polimerikus célba juttató rendszerek |
| US11083730B2 (en) | 2014-04-21 | 2021-08-10 | Heron Therapeutics, Inc. | Long-acting polymeric delivery systems |
| US9801945B2 (en) | 2014-04-21 | 2017-10-31 | Heron Therapeutics, Inc. | Long-acting polymeric delivery systems |
| HRP20202010T1 (hr) * | 2014-04-21 | 2021-03-05 | Heron Therapeutics, Inc. | Pripravci poliortoestera i organska kiselina kao pomoćna tvar |
| CA2945181C (en) | 2014-04-28 | 2022-10-18 | Orphomed, Inc. | Pharmaceutically active dimers linked through phenolic hydroxyl groups |
| GB201419091D0 (en) | 2014-10-27 | 2014-12-10 | Camurus Ab | Formulations |
| WO2016071767A1 (en) * | 2014-11-07 | 2016-05-12 | Indivior Uk Limited | Buprenorphine dosing regimens |
| BR112018002414B1 (pt) | 2015-08-03 | 2023-11-21 | Tolmar International Limited | Composição farmacêutica de polímero líquido para administração no corpo de um animal, seu uso para tratar, prover uma terapia para curar ou prevenir uma doença, distúrbio ou outra enfermidade e sistema de distribuição para administração da dita composição |
| KR102766991B1 (ko) | 2015-11-16 | 2025-02-13 | 메딘셀 에스.에이. | 활액 조직에 약제학적으로 활성인 유효성분을 모셀라이징 및/또는 표적화하는 방법 |
| CA3033046C (en) | 2016-09-13 | 2021-09-07 | Alar Pharmaceuticals Inc. | Sustained-release buprenorphine formulations |
| US10646484B2 (en) | 2017-06-16 | 2020-05-12 | Indivior Uk Limited | Methods to treat opioid use disorder |
| EP3638240A2 (en) | 2017-06-16 | 2020-04-22 | Indivior UK Limited | Methods to treat opioid use disorder |
| AU2019209416A1 (en) | 2018-01-22 | 2020-07-30 | Foresee Pharmaceuticals Co., Ltd. | Pharmaceutical composition for sustained release delivery of buprenorphine |
| BR112020016576A2 (pt) | 2018-05-11 | 2020-12-15 | Alar Pharmaceuticals Inc. | Formulações injetáveis de ação prolongada e formas cristalinas de derivados de buprenorfina |
| AU2019357036B2 (en) | 2018-10-11 | 2024-11-14 | Indivior Uk Limited | Buprenorphine to treat respiratory depression |
| US12403291B2 (en) * | 2019-08-30 | 2025-09-02 | Intersect Ent, Inc. | Submucosal bioresorbable drug eluting platform |
| CN118831057A (zh) * | 2023-04-25 | 2024-10-25 | 深圳善康医药科技股份有限公司 | 丁丙诺啡植入剂及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| CA2187353C (en) | 1994-04-08 | 2007-05-22 | Gerald L. Yewey | Liquid delivery compositions |
| US20030211157A1 (en) * | 1996-05-06 | 2003-11-13 | Simon David Lew | Semi-sol delivery blend for water soluble molecules |
| US6143314A (en) * | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
| US6565874B1 (en) | 1998-10-28 | 2003-05-20 | Atrix Laboratories | Polymeric delivery formulations of leuprolide with improved efficacy |
| US6461631B1 (en) | 1999-11-16 | 2002-10-08 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| AU2003240493B2 (en) * | 2002-05-31 | 2008-06-12 | L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. | Implantable polymeric device for sustained release of buprenorphine |
| KR20050088288A (ko) * | 2002-11-06 | 2005-09-05 | 알자 코포레이션 | 제어식 방출 데포 제형 |
| WO2004081196A2 (en) * | 2003-03-11 | 2004-09-23 | Qlt Usa Inc. | Formulations for cell- schedule dependent anticancer agents |
| EP1804751A2 (en) * | 2004-10-04 | 2007-07-11 | QLT USA, Inc. | Ocular delivery of polymeric delivery formulations |
| PT1824460E (pt) * | 2004-11-10 | 2015-01-14 | Tolmar Therapeutics Inc | Um sistema de administração polimérico estabilizado |
| PT2115029E (pt) | 2007-02-15 | 2015-10-26 | Tolmar Therapeutics Inc | Poli-(lactido/glicolido) de efeito de libertação imediata reduzido e métodos de produção de polímeros |
| US20090181068A1 (en) * | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
| GB2513267B (en) | 2010-06-08 | 2015-03-18 | Rb Pharmaceuticals Ltd | Injectable flowable composition comprising buprenorphine |
-
2010
- 2010-06-08 GB GB1413064.5A patent/GB2513267B/en active Active
- 2010-06-08 GB GB1009549.5A patent/GB2481018B/en active Active
-
2011
- 2011-06-06 SG SG2012089652A patent/SG186200A1/en unknown
- 2011-06-06 AU AU2011263478A patent/AU2011263478B2/en active Active
- 2011-06-06 SM SM20180038T patent/SMT201800038T1/it unknown
- 2011-06-06 HR HRP20180118TT patent/HRP20180118T1/hr unknown
- 2011-06-06 PL PL11728037T patent/PL2579874T3/pl unknown
- 2011-06-06 SI SI201131401T patent/SI2579874T1/en unknown
- 2011-06-06 FI FIEP17205986.7T patent/FI3360538T3/fi active
- 2011-06-06 MY MYPI2012005274A patent/MY171625A/en unknown
- 2011-06-06 EP EP11728037.0A patent/EP2579874B1/en active Active
- 2011-06-06 DK DK17205986.7T patent/DK3360538T3/da active
- 2011-06-06 WO PCT/GB2011/051057 patent/WO2011154724A2/en not_active Ceased
- 2011-06-06 EP EP23150636.1A patent/EP4218720A1/en active Pending
- 2011-06-06 DK DK11728037.0T patent/DK2579874T3/da active
- 2011-06-06 ES ES17205986T patent/ES2939612T3/es active Active
- 2011-06-06 CN CN201180039223.3A patent/CN103079544B/zh not_active Expired - Fee Related
- 2011-06-06 HU HUE11728037A patent/HUE038275T2/hu unknown
- 2011-06-06 NZ NZ604026A patent/NZ604026A/en unknown
- 2011-06-06 KR KR1020127032282A patent/KR101865689B1/ko not_active Expired - Fee Related
- 2011-06-06 MX MX2012014335A patent/MX339209B/es active IP Right Grant
- 2011-06-06 BR BR112012031290A patent/BR112012031290A2/pt not_active Application Discontinuation
- 2011-06-06 US US13/703,013 patent/US8921387B2/en active Active
- 2011-06-06 LT LTEP11728037.0T patent/LT2579874T/lt unknown
- 2011-06-06 ES ES11728037.0T patent/ES2656938T3/es active Active
- 2011-06-06 CA CA2801676A patent/CA2801676C/en active Active
- 2011-06-06 PT PT117280370T patent/PT2579874T/pt unknown
- 2011-06-06 RU RU2012157244A patent/RU2607498C2/ru not_active IP Right Cessation
- 2011-06-06 RS RS20180068A patent/RS56820B1/sr unknown
- 2011-06-06 EP EP17205986.7A patent/EP3360538B1/en active Active
- 2011-06-06 JP JP2013513755A patent/JP5986072B2/ja not_active Expired - Fee Related
- 2011-06-06 NO NO11728037A patent/NO2579874T3/no unknown
-
2012
- 2012-12-06 IL IL223488A patent/IL223488A/en active IP Right Grant
- 2012-12-06 ZA ZA2012/09233A patent/ZA201209233B/en unknown
- 2012-12-07 CL CL2012003462A patent/CL2012003462A1/es unknown
-
2013
- 2013-01-04 CO CO13001795A patent/CO6670529A2/es unknown
-
2016
- 2016-06-01 JP JP2016110259A patent/JP6251774B2/ja active Active
-
2017
- 2017-09-11 IL IL254417A patent/IL254417A0/en unknown
-
2018
- 2018-01-24 CY CY181100098T patent/CY1120761T1/el unknown
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