CO6670529A2 - Sistema de suministro de buprenorfina de liberación sostenida - Google Patents

Sistema de suministro de buprenorfina de liberación sostenida

Info

Publication number
CO6670529A2
CO6670529A2 CO13001795A CO13001795A CO6670529A2 CO 6670529 A2 CO6670529 A2 CO 6670529A2 CO 13001795 A CO13001795 A CO 13001795A CO 13001795 A CO13001795 A CO 13001795A CO 6670529 A2 CO6670529 A2 CO 6670529A2
Authority
CO
Colombia
Prior art keywords
sustained release
buprenorphine
delivery system
release system
metabolite
Prior art date
Application number
CO13001795A
Other languages
English (en)
Inventor
Richard L Norton
Andrew Watkins
Mingxing Zhou
Original Assignee
Rb Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42471306&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6670529(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rb Pharmaceuticals Ltd filed Critical Rb Pharmaceuticals Ltd
Publication of CO6670529A2 publication Critical patent/CO6670529A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La presente invención se refiere a un sistema de suministro de buprenorfina de liberación sostenida capaz de proporcionar buprenorfina, un metabolito o un profármaco de la misma por una duración de aproximadamente 14 días hasta aproximadamente 3 meses. El sistema de suministro de buprenorfina de liberación sostenida incluye un compuesto capaz de fluir y un implante sólido para la liberación sostenida de buprenorfina, un metabolito o un profármaco de la misma. El implante es producido de un compuesto capaz de fluir. El sistema de suministro de buprenorfina de liberación sostenida proporciona perfiles de liberación de 1 mes y 3 meses in situ caracterizados una biodisponibilidad excepcionalmente alta y un riesgo mínimo de daño permanente del tejido y por lo general, no hay riesgo de necrosis muscular.
CO13001795A 2010-06-08 2013-01-04 Sistema de suministro de buprenorfina de liberación sostenida CO6670529A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1009549.5A GB2481018B (en) 2010-06-08 2010-06-08 Injectable flowable composition comprising buprenorphine

Publications (1)

Publication Number Publication Date
CO6670529A2 true CO6670529A2 (es) 2013-05-15

Family

ID=42471306

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13001795A CO6670529A2 (es) 2010-06-08 2013-01-04 Sistema de suministro de buprenorfina de liberación sostenida

Country Status (31)

Country Link
US (1) US8921387B2 (es)
EP (3) EP3360538B1 (es)
JP (2) JP5986072B2 (es)
KR (1) KR101865689B1 (es)
CN (1) CN103079544B (es)
AU (1) AU2011263478B2 (es)
BR (1) BR112012031290A2 (es)
CA (1) CA2801676C (es)
CL (1) CL2012003462A1 (es)
CO (1) CO6670529A2 (es)
CY (1) CY1120761T1 (es)
DK (2) DK2579874T3 (es)
ES (2) ES2939612T3 (es)
FI (1) FI3360538T3 (es)
GB (2) GB2481018B (es)
HR (1) HRP20180118T1 (es)
HU (1) HUE038275T2 (es)
IL (2) IL223488A (es)
LT (1) LT2579874T (es)
MX (1) MX339209B (es)
MY (1) MY171625A (es)
NO (1) NO2579874T3 (es)
NZ (1) NZ604026A (es)
PL (1) PL2579874T3 (es)
PT (1) PT2579874T (es)
RS (1) RS56820B1 (es)
RU (1) RU2607498C2 (es)
SG (1) SG186200A1 (es)
SI (1) SI2579874T1 (es)
WO (1) WO2011154724A2 (es)
ZA (1) ZA201209233B (es)

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US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
GB2481018B (en) 2010-06-08 2015-03-18 Rb Pharmaceuticals Ltd Injectable flowable composition comprising buprenorphine
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
WO2013126552A1 (en) * 2012-02-21 2013-08-29 Auburn University Buprenorphine nanoparticle composition and methods thereof
CN104302280A (zh) 2012-04-17 2015-01-21 普渡制药公司 用于治疗阿片样物质所致不良药效学响应的系统和方法
DK2877155T3 (da) * 2012-07-26 2021-01-18 Camurus Ab Opioidformuleringer
EP2877155B1 (en) 2012-07-26 2020-10-28 Camurus AB Opioid formulations
WO2014093907A1 (en) * 2012-12-13 2014-06-19 A.P. Pharma, Inc. Pharmaceutical composition comprising antiemetic compounds and polyorthoester
US9636308B2 (en) 2013-03-15 2017-05-02 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
WO2014143635A1 (en) * 2013-03-15 2014-09-18 Heron Therapeutics, Inc. Compositions of a polyorthoester and an aprotic solvent
US9393211B2 (en) 2013-03-15 2016-07-19 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
GB201404139D0 (en) * 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
HUE052224T2 (hu) * 2014-04-21 2021-04-28 Heron Therapeutics Inc Poliortoészterbõl és szerves sav segédanyagból álló készítmények
CN106535886A (zh) 2014-04-21 2017-03-22 赫伦治疗有限公司 长效聚合物输送系统
EP3509601A1 (en) 2014-04-21 2019-07-17 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam
US9801945B2 (en) 2014-04-21 2017-10-31 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
US9309256B2 (en) 2014-04-28 2016-04-12 Orphomed, Inc. Pharmaceutically active dimers linked through phenolic hydroxyl groups
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AU2018283724B2 (en) 2017-06-16 2021-08-19 Indivior Uk Limited Methods to treat opioid use disorder
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
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Also Published As

Publication number Publication date
SI2579874T1 (en) 2018-03-30
KR101865689B1 (ko) 2018-06-08
MX2012014335A (es) 2013-03-05
BR112012031290A2 (pt) 2016-11-01
JP2013533230A (ja) 2013-08-22
AU2011263478A1 (en) 2013-01-10
PL2579874T3 (pl) 2018-05-30
PT2579874T (pt) 2018-01-29
US20130210853A1 (en) 2013-08-15
MX339209B (es) 2016-04-15
EP2579874A2 (en) 2013-04-17
IL223488A (en) 2017-10-31
JP2016155865A (ja) 2016-09-01
JP6251774B2 (ja) 2017-12-20
CL2012003462A1 (es) 2013-04-01
WO2011154724A9 (en) 2012-08-16
HUE038275T2 (hu) 2018-10-29
NZ604026A (en) 2015-01-30
EP3360538B1 (en) 2023-02-15
EP3360538A1 (en) 2018-08-15
CN103079544B (zh) 2017-06-09
NO2579874T3 (es) 2018-06-09
FI3360538T3 (fi) 2023-03-22
WO2011154724A2 (en) 2011-12-15
RU2012157244A (ru) 2014-07-20
WO2011154724A3 (en) 2012-07-12
DK2579874T3 (da) 2018-01-29
GB201413064D0 (en) 2014-09-03
ES2939612T3 (es) 2023-04-25
HRP20180118T1 (hr) 2018-03-09
GB2513267A (en) 2014-10-22
MY171625A (en) 2019-10-21
CY1120761T1 (el) 2019-12-11
CN103079544A (zh) 2013-05-01
SG186200A1 (en) 2013-01-30
AU2011263478B2 (en) 2015-01-22
GB2481018A (en) 2011-12-14
US8921387B2 (en) 2014-12-30
RU2607498C2 (ru) 2017-01-10
ES2656938T3 (es) 2018-03-01
CA2801676C (en) 2018-08-07
EP2579874B1 (en) 2018-01-10
LT2579874T (lt) 2018-02-12
KR20130135026A (ko) 2013-12-10
DK3360538T3 (da) 2023-03-06
ZA201209233B (en) 2014-04-30
CA2801676A1 (en) 2011-12-15
GB201009549D0 (en) 2010-07-21
GB2513267B (en) 2015-03-18
JP5986072B2 (ja) 2016-09-06
GB2481018B (en) 2015-03-18
IL254417A0 (en) 2017-11-30
EP4218720A1 (en) 2023-08-02
RS56820B1 (sr) 2018-04-30

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