JP5986072B2 - 組成物 - Google Patents

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Publication number
JP5986072B2
JP5986072B2 JP2013513755A JP2013513755A JP5986072B2 JP 5986072 B2 JP5986072 B2 JP 5986072B2 JP 2013513755 A JP2013513755 A JP 2013513755A JP 2013513755 A JP2013513755 A JP 2013513755A JP 5986072 B2 JP5986072 B2 JP 5986072B2
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JP
Japan
Prior art keywords
buprenorphine
implant
pharmaceutical composition
polymer
lactide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013513755A
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English (en)
Japanese (ja)
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JP2013533230A5 (cg-RX-API-DMAC7.html
JP2013533230A (ja
Inventor
リチャード エル ノートン
リチャード エル ノートン
アンドリュー ワトキンス
アンドリュー ワトキンス
ミンシン チョウ
ミンシン チョウ
Original Assignee
インディヴィオ ユーケー リミテッド
インディヴィオ ユーケー リミテッド
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42471306&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5986072(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by インディヴィオ ユーケー リミテッド, インディヴィオ ユーケー リミテッド filed Critical インディヴィオ ユーケー リミテッド
Publication of JP2013533230A publication Critical patent/JP2013533230A/ja
Publication of JP2013533230A5 publication Critical patent/JP2013533230A5/ja
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2013513755A 2010-06-08 2011-06-06 組成物 Expired - Fee Related JP5986072B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1009549.5A GB2481018B (en) 2010-06-08 2010-06-08 Injectable flowable composition comprising buprenorphine
GB1009549.5 2010-06-08
PCT/GB2011/051057 WO2011154724A2 (en) 2010-06-08 2011-06-06 Compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016110259A Division JP6251774B2 (ja) 2010-06-08 2016-06-01 組成物

Publications (3)

Publication Number Publication Date
JP2013533230A JP2013533230A (ja) 2013-08-22
JP2013533230A5 JP2013533230A5 (cg-RX-API-DMAC7.html) 2014-07-24
JP5986072B2 true JP5986072B2 (ja) 2016-09-06

Family

ID=42471306

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013513755A Expired - Fee Related JP5986072B2 (ja) 2010-06-08 2011-06-06 組成物
JP2016110259A Active JP6251774B2 (ja) 2010-06-08 2016-06-01 組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016110259A Active JP6251774B2 (ja) 2010-06-08 2016-06-01 組成物

Country Status (32)

Country Link
US (1) US8921387B2 (cg-RX-API-DMAC7.html)
EP (3) EP2579874B1 (cg-RX-API-DMAC7.html)
JP (2) JP5986072B2 (cg-RX-API-DMAC7.html)
KR (1) KR101865689B1 (cg-RX-API-DMAC7.html)
CN (1) CN103079544B (cg-RX-API-DMAC7.html)
AU (1) AU2011263478B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012031290A2 (cg-RX-API-DMAC7.html)
CA (1) CA2801676C (cg-RX-API-DMAC7.html)
CL (1) CL2012003462A1 (cg-RX-API-DMAC7.html)
CO (1) CO6670529A2 (cg-RX-API-DMAC7.html)
CY (1) CY1120761T1 (cg-RX-API-DMAC7.html)
DK (2) DK2579874T3 (cg-RX-API-DMAC7.html)
ES (2) ES2656938T3 (cg-RX-API-DMAC7.html)
FI (1) FI3360538T3 (cg-RX-API-DMAC7.html)
GB (2) GB2481018B (cg-RX-API-DMAC7.html)
HR (1) HRP20180118T1 (cg-RX-API-DMAC7.html)
HU (1) HUE038275T2 (cg-RX-API-DMAC7.html)
IL (2) IL223488A (cg-RX-API-DMAC7.html)
LT (1) LT2579874T (cg-RX-API-DMAC7.html)
MX (1) MX339209B (cg-RX-API-DMAC7.html)
MY (1) MY171625A (cg-RX-API-DMAC7.html)
NO (1) NO2579874T3 (cg-RX-API-DMAC7.html)
NZ (1) NZ604026A (cg-RX-API-DMAC7.html)
PL (1) PL2579874T3 (cg-RX-API-DMAC7.html)
PT (1) PT2579874T (cg-RX-API-DMAC7.html)
RS (1) RS56820B1 (cg-RX-API-DMAC7.html)
RU (1) RU2607498C2 (cg-RX-API-DMAC7.html)
SG (1) SG186200A1 (cg-RX-API-DMAC7.html)
SI (1) SI2579874T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201800038T1 (cg-RX-API-DMAC7.html)
WO (1) WO2011154724A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201209233B (cg-RX-API-DMAC7.html)

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US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
WO2013126552A1 (en) 2012-02-21 2013-08-29 Auburn University Buprenorphine nanoparticle composition and methods thereof
NZ631539A (en) 2012-04-17 2016-10-28 Purdue Pharma Lp Systems and methods for treating an opioid-induced adverse pharmacodynamic response
MX387722B (es) 2012-07-26 2025-03-18 Camurus Ab Formulaciones de opioides.
SI2877155T1 (sl) 2012-07-26 2021-04-30 Camurus Ab Opioidne formulacije
EP2931253A1 (en) * 2012-12-13 2015-10-21 Heron Therapeutics, Inc. Pharmaceutical composition comprising antiemetic compounds and polyorthoester
US9393211B2 (en) * 2013-03-15 2016-07-19 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
KR102505642B1 (ko) * 2013-03-15 2023-03-06 헤론 테라퓨틱스 인코포레이티드 폴리오르토에스테르 및 비프로톤성 용매의 조성물
US9636308B2 (en) 2013-03-15 2017-05-02 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
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KR102696721B1 (ko) * 2015-08-03 2024-08-19 톨마 인터내셔날 리미티드 약물의 장기간 지속적인 투여를 위한 액체 폴리머 전달 시스템
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FI3512518T3 (fi) * 2016-09-13 2023-01-31 Hitaasti vapautuvia buprenorfiiniformulaatioita
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
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Also Published As

Publication number Publication date
JP2016155865A (ja) 2016-09-01
PT2579874T (pt) 2018-01-29
FI3360538T3 (fi) 2023-03-22
MX2012014335A (es) 2013-03-05
ES2939612T3 (es) 2023-04-25
WO2011154724A3 (en) 2012-07-12
CO6670529A2 (es) 2013-05-15
ZA201209233B (en) 2014-04-30
SMT201800038T1 (it) 2018-03-08
CL2012003462A1 (es) 2013-04-01
GB2481018A (en) 2011-12-14
GB201009549D0 (en) 2010-07-21
GB201413064D0 (en) 2014-09-03
EP3360538B1 (en) 2023-02-15
PL2579874T3 (pl) 2018-05-30
GB2481018B (en) 2015-03-18
CA2801676A1 (en) 2011-12-15
IL223488A (en) 2017-10-31
EP4218720A1 (en) 2023-08-02
MX339209B (es) 2016-04-15
RU2012157244A (ru) 2014-07-20
HUE038275T2 (hu) 2018-10-29
EP2579874A2 (en) 2013-04-17
BR112012031290A2 (pt) 2016-11-01
SG186200A1 (en) 2013-01-30
MY171625A (en) 2019-10-21
EP3360538A1 (en) 2018-08-15
RU2607498C2 (ru) 2017-01-10
ES2656938T3 (es) 2018-03-01
KR101865689B1 (ko) 2018-06-08
DK2579874T3 (da) 2018-01-29
CY1120761T1 (el) 2019-12-11
EP2579874B1 (en) 2018-01-10
AU2011263478B2 (en) 2015-01-22
CA2801676C (en) 2018-08-07
AU2011263478A1 (en) 2013-01-10
WO2011154724A2 (en) 2011-12-15
SI2579874T1 (en) 2018-03-30
KR20130135026A (ko) 2013-12-10
DK3360538T3 (da) 2023-03-06
US20130210853A1 (en) 2013-08-15
CN103079544A (zh) 2013-05-01
JP6251774B2 (ja) 2017-12-20
WO2011154724A9 (en) 2012-08-16
CN103079544B (zh) 2017-06-09
HRP20180118T1 (hr) 2018-03-09
RS56820B1 (sr) 2018-04-30
NZ604026A (en) 2015-01-30
JP2013533230A (ja) 2013-08-22
LT2579874T (lt) 2018-02-12
GB2513267B (en) 2015-03-18
GB2513267A (en) 2014-10-22
US8921387B2 (en) 2014-12-30
NO2579874T3 (cg-RX-API-DMAC7.html) 2018-06-09
IL254417A0 (en) 2017-11-30

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