GB2481018B - Injectable flowable composition comprising buprenorphine - Google Patents
Injectable flowable composition comprising buprenorphineInfo
- Publication number
- GB2481018B GB2481018B GB1009549.5A GB201009549A GB2481018B GB 2481018 B GB2481018 B GB 2481018B GB 201009549 A GB201009549 A GB 201009549A GB 2481018 B GB2481018 B GB 2481018B
- Authority
- GB
- United Kingdom
- Prior art keywords
- buprenorphine
- flowable composition
- injectable flowable
- injectable
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 title 1
- 229960001736 buprenorphine Drugs 0.000 title 1
- 230000009969 flowable effect Effects 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (47)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1009549.5A GB2481018B (en) | 2010-06-08 | 2010-06-08 | Injectable flowable composition comprising buprenorphine |
| GB1413064.5A GB2513267B (en) | 2010-06-08 | 2010-06-08 | Injectable flowable composition comprising buprenorphine |
| FIEP17205986.7T FI3360538T3 (fi) | 2010-06-08 | 2011-06-06 | Injektoitava, juokseva koostumus käsittäen buprenorfiinia |
| BR112012031290A BR112012031290A2 (pt) | 2010-06-08 | 2011-06-06 | composição fluidificável injetável compreendendo buprenorfina |
| EP23150636.1A EP4218720A1 (en) | 2010-06-08 | 2011-06-06 | Injectable flowable composition comprising buprenorphine |
| LTEP11728037.0T LT2579874T (lt) | 2010-06-08 | 2011-06-06 | Injekuojama skysta kompozicija, apimanti buprenorfiną |
| PCT/GB2011/051057 WO2011154724A2 (en) | 2010-06-08 | 2011-06-06 | Compositions |
| PL11728037T PL2579874T3 (pl) | 2010-06-08 | 2011-06-06 | Płynna kompozycja do wstrzykiwania zawierająca buprenorfinę |
| MYPI2012005274A MY171625A (en) | 2010-06-08 | 2011-06-06 | Injectable flowable composition comprising buprenorphine |
| AU2011263478A AU2011263478B2 (en) | 2010-06-08 | 2011-06-06 | Injectable flowable composition comprising buprenorphine |
| SM20180038T SMT201800038T1 (it) | 2010-06-08 | 2011-06-06 | Composizione fluida iniettabile comprendente buprenorfina |
| EP17205986.7A EP3360538B1 (en) | 2010-06-08 | 2011-06-06 | Injectable flowable composition comprising buprenorphine |
| HRP20180118TT HRP20180118T1 (hr) | 2010-06-08 | 2011-06-06 | Injekcijski tekući pripravak koji sadrži buprenorfin |
| DK17205986.7T DK3360538T3 (da) | 2010-06-08 | 2011-06-06 | Injicerbar, flydende sammensætning omfattende buprenorphin |
| SI201131401T SI2579874T1 (en) | 2010-06-08 | 2011-06-06 | INJECTION LIQUID COMPONENTS, EXPLOSIVE BUPRENORPHIN |
| CA2801676A CA2801676C (en) | 2010-06-08 | 2011-06-06 | Compositions |
| JP2013513755A JP5986072B2 (ja) | 2010-06-08 | 2011-06-06 | 組成物 |
| EP11728037.0A EP2579874B1 (en) | 2010-06-08 | 2011-06-06 | Injectable flowable composition comprising buprenorphine |
| SG2012089652A SG186200A1 (en) | 2010-06-08 | 2011-06-06 | Injectable flowable composition comprising buprenorphine |
| RU2012157244A RU2607498C2 (ru) | 2010-06-08 | 2011-06-06 | Жидкотекучие композиции для инъекций, включающие бупренорфин |
| KR1020127032282A KR101865689B1 (ko) | 2010-06-08 | 2011-06-06 | 부프레노르핀을 포함하는 주입가능한 유동성 조성물 |
| NZ604026A NZ604026A (en) | 2010-06-08 | 2011-06-06 | Injectable flowable composition comprising buprenorphine |
| CN201180039223.3A CN103079544B (zh) | 2010-06-08 | 2011-06-06 | 包含丁丙诺啡的可注射的可流动组合物 |
| PT117280370T PT2579874T (pt) | 2010-06-08 | 2011-06-06 | Composição fluidificável injetável que compreende buprenorfina |
| ES11728037.0T ES2656938T3 (es) | 2010-06-08 | 2011-06-06 | Composición que fluye inyectable que comprende buprenorfina |
| HUE11728037A HUE038275T2 (hu) | 2010-06-08 | 2011-06-06 | Buprenorfin tartalmú injektálható, folyékony készítmény |
| DK11728037.0T DK2579874T3 (da) | 2010-06-08 | 2011-06-06 | Injicerbar, flydende sammensætning omfattende buprenorphin |
| RS20180068A RS56820B1 (sr) | 2010-06-08 | 2011-06-06 | Injektabilna tečna kompozicija koja sadrži buprenorfin |
| US13/703,013 US8921387B2 (en) | 2010-06-08 | 2011-06-06 | Injectable flowable composition comprising buprenorphine |
| ES17205986T ES2939612T3 (es) | 2010-06-08 | 2011-06-06 | Composición fluyente inyectable que comprende buprenorfina |
| MX2012014335A MX339209B (es) | 2010-06-08 | 2011-06-06 | Composiciones. |
| NO11728037A NO2579874T3 (cg-RX-API-DMAC7.html) | 2010-06-08 | 2011-06-06 | |
| ZA2012/09233A ZA201209233B (en) | 2010-06-08 | 2012-12-06 | Injectable flowable composition cimprising buprenorphine |
| IL223488A IL223488A (en) | 2010-06-08 | 2012-12-06 | Injectable flow bar preparation containing buprenorphine |
| CL2012003462A CL2012003462A1 (es) | 2010-06-08 | 2012-12-07 | Composicion fluida injectable que comprende al menos un polimero termoplastico biodegradable, un liquido organico aprotico polar biocompatible y buprenorfina, donde la composicion es transformada in situ en un implante solido por contacto con agua u otro medio; método para prepararla; implante y kit. |
| CO13001795A CO6670529A2 (es) | 2010-06-08 | 2013-01-04 | Sistema de suministro de buprenorfina de liberación sostenida |
| US13/836,134 US8975270B2 (en) | 2010-06-08 | 2013-03-15 | Injectable flowable composition comprising buprenorphine |
| US14/610,818 US9272044B2 (en) | 2010-06-08 | 2015-01-30 | Injectable flowable composition buprenorphine |
| US14/995,053 US9498432B2 (en) | 2010-06-08 | 2016-01-13 | Injectable flowable composition comprising buprenorphine |
| JP2016110259A JP6251774B2 (ja) | 2010-06-08 | 2016-06-01 | 組成物 |
| US15/334,000 US9782402B2 (en) | 2010-06-08 | 2016-10-25 | Injectable composition comprising buprenorphine |
| US15/623,191 US9827241B2 (en) | 2010-06-08 | 2017-06-14 | Injectable flowable composition comprising buprenorphine |
| IL254417A IL254417A0 (en) | 2010-06-08 | 2017-09-11 | A flowable, injectable preparation containing buprenorphine |
| US15/820,048 US10558394B2 (en) | 2010-06-08 | 2017-11-21 | Injectable flowable composition comprising buprenorphine |
| US15/857,507 US10198218B2 (en) | 2010-06-08 | 2017-12-28 | Injectable flowable composition comprising buprenorphine |
| CY181100098T CY1120761T1 (el) | 2010-06-08 | 2018-01-24 | Ενεσιμη συνθεση αιωρηματος που αποτελειται απο βουπρενορφινη |
| US16/693,726 US10592168B1 (en) | 2010-06-08 | 2019-11-25 | Injectable flowable composition comprising buprenorphine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1009549.5A GB2481018B (en) | 2010-06-08 | 2010-06-08 | Injectable flowable composition comprising buprenorphine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB201009549D0 GB201009549D0 (en) | 2010-07-21 |
| GB2481018A GB2481018A (en) | 2011-12-14 |
| GB2481018B true GB2481018B (en) | 2015-03-18 |
Family
ID=42471306
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1009549.5A Active GB2481018B (en) | 2010-06-08 | 2010-06-08 | Injectable flowable composition comprising buprenorphine |
| GB1413064.5A Active GB2513267B (en) | 2010-06-08 | 2010-06-08 | Injectable flowable composition comprising buprenorphine |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1413064.5A Active GB2513267B (en) | 2010-06-08 | 2010-06-08 | Injectable flowable composition comprising buprenorphine |
Country Status (32)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8470359B2 (en) * | 2000-11-13 | 2013-06-25 | Qlt Usa, Inc. | Sustained release polymer |
| GB2481018B (en) | 2010-06-08 | 2015-03-18 | Rb Pharmaceuticals Ltd | Injectable flowable composition comprising buprenorphine |
| GB2481017B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
| WO2013126552A1 (en) | 2012-02-21 | 2013-08-29 | Auburn University | Buprenorphine nanoparticle composition and methods thereof |
| NZ631539A (en) | 2012-04-17 | 2016-10-28 | Purdue Pharma Lp | Systems and methods for treating an opioid-induced adverse pharmacodynamic response |
| MX387722B (es) | 2012-07-26 | 2025-03-18 | Camurus Ab | Formulaciones de opioides. |
| SI2877155T1 (sl) | 2012-07-26 | 2021-04-30 | Camurus Ab | Opioidne formulacije |
| EP2931253A1 (en) * | 2012-12-13 | 2015-10-21 | Heron Therapeutics, Inc. | Pharmaceutical composition comprising antiemetic compounds and polyorthoester |
| US9393211B2 (en) * | 2013-03-15 | 2016-07-19 | Oakwood Laboratories LLC | High drug load buprenorphine microspheres and method of producing same |
| KR102505642B1 (ko) * | 2013-03-15 | 2023-03-06 | 헤론 테라퓨틱스 인코포레이티드 | 폴리오르토에스테르 및 비프로톤성 용매의 조성물 |
| US9636308B2 (en) | 2013-03-15 | 2017-05-02 | Oakwood Laboratories LLC | High drug load buprenorphine microspheres and method of producing same |
| GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| EP3509601A1 (en) | 2014-04-21 | 2019-07-17 | Heron Therapeutics, Inc. | A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam |
| EP3785700A1 (en) * | 2014-04-21 | 2021-03-03 | Heron Therapeutics, Inc. | Compositions of a polyorthoester and an organic acid excipient |
| KR20220138419A (ko) | 2014-04-21 | 2022-10-12 | 헤론 테라퓨틱스 인코포레이티드 | 장기간 작용하는 중합체 전달 시스템 |
| US9801945B2 (en) | 2014-04-21 | 2017-10-31 | Heron Therapeutics, Inc. | Long-acting polymeric delivery systems |
| JP6568102B2 (ja) | 2014-04-28 | 2019-08-28 | オーフォームド,インコーポレイティド | ブプレノルフィン二量体及び消化管疾患の治療におけるその使用 |
| GB201419091D0 (en) | 2014-10-27 | 2014-12-10 | Camurus Ab | Formulations |
| ES2808150T3 (es) * | 2014-11-07 | 2021-02-25 | Indivior Uk Ltd | Regímenes de dosificación de buprenorfina |
| KR102696721B1 (ko) * | 2015-08-03 | 2024-08-19 | 톨마 인터내셔날 리미티드 | 약물의 장기간 지속적인 투여를 위한 액체 폴리머 전달 시스템 |
| AU2016355236C1 (en) | 2015-11-16 | 2022-09-22 | Medincell | A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
| FI3512518T3 (fi) * | 2016-09-13 | 2023-01-31 | Hitaasti vapautuvia buprenorfiiniformulaatioita | |
| US10646484B2 (en) | 2017-06-16 | 2020-05-12 | Indivior Uk Limited | Methods to treat opioid use disorder |
| AU2018283724B2 (en) | 2017-06-16 | 2021-08-19 | Indivior Uk Limited | Methods to treat opioid use disorder |
| CN112236142A (zh) | 2018-01-22 | 2021-01-15 | 逸达生物科技股份有限公司 | 用于缓释递送丁丙诺啡的药物组合物 |
| NZ766474A (en) * | 2018-05-11 | 2023-03-31 | Alar Pharmaceuticals Inc | Long-acting injectable formulations and crystalline forms of buprenorphine derivatives |
| AU2019357036B2 (en) | 2018-10-11 | 2024-11-14 | Indivior Uk Limited | Buprenorphine to treat respiratory depression |
| US12403291B2 (en) | 2019-08-30 | 2025-09-02 | Intersect Ent, Inc. | Submucosal bioresorbable drug eluting platform |
| CN118831057A (zh) * | 2023-04-25 | 2024-10-25 | 深圳善康医药科技股份有限公司 | 丁丙诺啡植入剂及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030211157A1 (en) * | 1996-05-06 | 2003-11-13 | Simon David Lew | Semi-sol delivery blend for water soluble molecules |
| US20040033250A1 (en) * | 2002-05-31 | 2004-02-19 | Patel Rajesh A. | Implantable polymeric device for sustained release of buprenorphine |
| US20060210604A1 (en) * | 2004-10-04 | 2006-09-21 | Eric Dadey | Ocular delivery of polymeric delivery formulations |
| WO2009091737A2 (en) * | 2008-01-14 | 2009-07-23 | Dunn Research & Consulting, Llc | Low viscosity liquid polymeric delivery system |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| CA2582666C (en) | 1994-04-08 | 2010-05-25 | Qlt Usa, Inc. | Controlled release implant |
| US6143314A (en) * | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
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