SMT201700413T1 - Nuovi macrocicli come inibitori del fattore xia - Google Patents

Nuovi macrocicli come inibitori del fattore xia

Info

Publication number
SMT201700413T1
SMT201700413T1 SM20170413T SMT201700413T SMT201700413T1 SM T201700413 T1 SMT201700413 T1 SM T201700413T1 SM 20170413 T SM20170413 T SM 20170413T SM T201700413 T SMT201700413 T SM T201700413T SM T201700413 T1 SMT201700413 T1 SM T201700413T1
Authority
SM
San Marino
Prior art keywords
factor xia
xia inhibitors
novel macrocycles
macrocycles
novel
Prior art date
Application number
SM20170413T
Other languages
English (en)
Italian (it)
Inventor
William R Ewing
Wu Yang
James R Corte
Paul J Gilligan
Yufeng Wang
Tianan Fang
Ii Leon M Smith
Donald J Pinto
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SMT201700413T1 publication Critical patent/SMT201700413T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SM20170413T 2011-08-05 2012-08-06 Nuovi macrocicli come inibitori del fattore xia SMT201700413T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161515401P 2011-08-05 2011-08-05
PCT/US2012/049706 WO2013022818A1 (en) 2011-08-05 2012-08-06 Novel macrocycles as factor xia inhibitors
EP12762427.8A EP2739628B1 (en) 2011-08-05 2012-08-06 Novel macrocycles as factor xia inhibitors

Publications (1)

Publication Number Publication Date
SMT201700413T1 true SMT201700413T1 (it) 2017-11-15

Family

ID=46889416

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20170413T SMT201700413T1 (it) 2011-08-05 2012-08-06 Nuovi macrocicli come inibitori del fattore xia

Country Status (22)

Country Link
US (4) US9221818B2 (enExample)
EP (1) EP2739628B1 (enExample)
JP (1) JP6158181B2 (enExample)
CN (1) CN103857681B (enExample)
AR (1) AR088748A1 (enExample)
BR (1) BR112014002202A2 (enExample)
CA (1) CA2844254A1 (enExample)
CY (1) CY1119281T1 (enExample)
DK (1) DK2739628T3 (enExample)
EA (1) EA024791B1 (enExample)
ES (1) ES2635088T3 (enExample)
HR (1) HRP20171122T1 (enExample)
HU (1) HUE034487T2 (enExample)
LT (1) LT2739628T (enExample)
MX (1) MX345763B (enExample)
PL (1) PL2739628T3 (enExample)
PT (1) PT2739628T (enExample)
RS (1) RS56244B1 (enExample)
SI (1) SI2739628T1 (enExample)
SM (1) SMT201700413T1 (enExample)
TW (1) TW201311689A (enExample)
WO (1) WO2013022818A1 (enExample)

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Also Published As

Publication number Publication date
US20140221338A1 (en) 2014-08-07
SI2739628T1 (sl) 2017-08-31
DK2739628T3 (en) 2017-09-11
TW201311689A (zh) 2013-03-16
RS56244B1 (sr) 2017-11-30
US9902742B2 (en) 2018-02-27
MX2014000831A (es) 2014-02-27
BR112014002202A2 (pt) 2017-03-07
PT2739628T (pt) 2017-08-02
US20160068544A1 (en) 2016-03-10
CN103857681A (zh) 2014-06-11
EP2739628B1 (en) 2017-06-07
CA2844254A1 (en) 2013-02-14
CY1119281T1 (el) 2018-02-14
EA024791B1 (ru) 2016-10-31
LT2739628T (lt) 2017-08-25
HUE034487T2 (en) 2018-02-28
JP2014521701A (ja) 2014-08-28
JP6158181B2 (ja) 2017-07-05
US20170158712A1 (en) 2017-06-08
EA201490418A1 (ru) 2014-05-30
HRP20171122T1 (hr) 2017-10-06
PL2739628T3 (pl) 2017-11-30
US10208068B2 (en) 2019-02-19
MX345763B (es) 2017-02-15
US20180148461A1 (en) 2018-05-31
US9221818B2 (en) 2015-12-29
AR088748A1 (es) 2014-07-02
WO2013022818A1 (en) 2013-02-14
ES2635088T3 (es) 2017-10-02
EP2739628A1 (en) 2014-06-11
CN103857681B (zh) 2017-07-14
US9611274B2 (en) 2017-04-04

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