JP6158181B2 - 第ｘｉａ因子阻害剤としての新規大環状分子 - Google Patents
第ｘｉａ因子阻害剤としての新規大環状分子 Download PDFInfo
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- JP6158181B2 JP6158181B2 JP2014524152A JP2014524152A JP6158181B2 JP 6158181 B2 JP6158181 B2 JP 6158181B2 JP 2014524152 A JP2014524152 A JP 2014524152A JP 2014524152 A JP2014524152 A JP 2014524152A JP 6158181 B2 JP6158181 B2 JP 6158181B2
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- methyl
- chloro
- fluorophenyl
- oxo
- nonadeca
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- 0 *C(CCCC(c([n]1)nc(-c(ccc(*)c2)c2N2)c1O*)N(C(C(*=C=*1)=C(*)N1c1c(*)c(*)ccc1)=O)[Rh])(C2=O)[Rn] Chemical compound *C(CCCC(c([n]1)nc(-c(ccc(*)c2)c2N2)c1O*)N(C(C(*=C=*1)=C(*)N1c1c(*)c(*)ccc1)=O)[Rh])(C2=O)[Rn] 0.000 description 11
- KMQNBCIFCMBYAX-MDZDMXLPSA-N C/C(/C(C)=O)=C(/C)\N(c1cc(Cl)ccc1)N=C Chemical compound C/C(/C(C)=O)=C(/C)\N(c1cc(Cl)ccc1)N=C KMQNBCIFCMBYAX-MDZDMXLPSA-N 0.000 description 1
- IAJSHJBGCZQHJC-UHFFFAOYSA-O CC(CCCC(c1nc(-c(ccc(NC(OC)=O)c2)c2N2)c[nH]1)NC(C(C=N)=C(C)[NH2+]c(cccc1Cl)c1F)=O)CC2=O Chemical compound CC(CCCC(c1nc(-c(ccc(NC(OC)=O)c2)c2N2)c[nH]1)NC(C(C=N)=C(C)[NH2+]c(cccc1Cl)c1F)=O)CC2=O IAJSHJBGCZQHJC-UHFFFAOYSA-O 0.000 description 1
- DKHFTUMOZBQIRX-UHFFFAOYSA-N CC(CCCC(c1nccc(-c(ccc(-c2nc(C)n[o]2)c2)c2N2)c1)NC(c1c(C)[n](-c(cccc3Cl)c3F)nc1)=O)C2=O Chemical compound CC(CCCC(c1nccc(-c(ccc(-c2nc(C)n[o]2)c2)c2N2)c1)NC(c1c(C)[n](-c(cccc3Cl)c3F)nc1)=O)C2=O DKHFTUMOZBQIRX-UHFFFAOYSA-N 0.000 description 1
- CZKOJVZAFKIPOV-JXFKEZNVSA-N CC[C@@H](CCC[C@@H](c1nc(-c(ccc(NC(OC)=O)c2)c2N2)c[nH]1)NC(c1c[n](-c(cccc3[Cl]=C)c3F)nn1)=O)C2=O Chemical compound CC[C@@H](CCC[C@@H](c1nc(-c(ccc(NC(OC)=O)c2)c2N2)c[nH]1)NC(c1c[n](-c(cccc3[Cl]=C)c3F)nn1)=O)C2=O CZKOJVZAFKIPOV-JXFKEZNVSA-N 0.000 description 1
- PHSKILVNSFCZAT-MWTRTKDXSA-N C[C@H](CCC[C@@H](c1cc(-c(ccc(C(O)=O)c2)c2N2)ccn1)NC(c1c(C)[n](-c3cccc(Cl)c3F)nc1)=O)C2=O Chemical compound C[C@H](CCC[C@@H](c1cc(-c(ccc(C(O)=O)c2)c2N2)ccn1)NC(c1c(C)[n](-c3cccc(Cl)c3F)nc1)=O)C2=O PHSKILVNSFCZAT-MWTRTKDXSA-N 0.000 description 1
- MWTDOFBSGRAAKC-NQIIRXRSSA-N C[C@H](CCC[C@@H](c1nc(-c(c(N2)c3)ccc3NC(OCCOC)=O)c[nH]1)NC(c1c[n](-c(cccc3C)c3F)nn1)=O)C2=O Chemical compound C[C@H](CCC[C@@H](c1nc(-c(c(N2)c3)ccc3NC(OCCOC)=O)c[nH]1)NC(c1c[n](-c(cccc3C)c3F)nn1)=O)C2=O MWTDOFBSGRAAKC-NQIIRXRSSA-N 0.000 description 1
- SUPLGQSSUCWMJT-IBGZPJMESA-N Cc([n](-c(cccc1Cl)c1F)nc1)c1C(N[C@@H](CCCC(C(Nc1c-2ccc(NC(OC)=O)c1)=O)(F)F)c1nc-2c[nH]1)=O Chemical compound Cc([n](-c(cccc1Cl)c1F)nc1)c1C(N[C@@H](CCCC(C(Nc1c-2ccc(NC(OC)=O)c1)=O)(F)F)c1nc-2c[nH]1)=O SUPLGQSSUCWMJT-IBGZPJMESA-N 0.000 description 1
- MXMIAKADRFOSIT-UHFFFAOYSA-N Cc([n](-c(cccc1Cl)c1F)nc1)c1C(O)=O Chemical compound Cc([n](-c(cccc1Cl)c1F)nc1)c1C(O)=O MXMIAKADRFOSIT-UHFFFAOYSA-N 0.000 description 1
- BDEUBOJWIKLFSM-UHFFFAOYSA-N Cc(ccc(OC)n1)c1OC Chemical compound Cc(ccc(OC)n1)c1OC BDEUBOJWIKLFSM-UHFFFAOYSA-N 0.000 description 1
- RIKMMFOAQPJVMX-UHFFFAOYSA-N Cc1c[nH]nc1 Chemical compound Cc1c[nH]nc1 RIKMMFOAQPJVMX-UHFFFAOYSA-N 0.000 description 1
- DVGNYVVFWIWKON-UHFFFAOYSA-N Cc1cccnc1OC Chemical compound Cc1cccnc1OC DVGNYVVFWIWKON-UHFFFAOYSA-N 0.000 description 1
- BAEACXLWSZGCAZ-UHFFFAOYSA-N Cc1n[s]c(C)c1 Chemical compound Cc1n[s]c(C)c1 BAEACXLWSZGCAZ-UHFFFAOYSA-N 0.000 description 1
- LNJMHEJAYSYZKK-UHFFFAOYSA-N Cc1ncccn1 Chemical compound Cc1ncccn1 LNJMHEJAYSYZKK-UHFFFAOYSA-N 0.000 description 1
- LVILGAOSPDLNRM-UHFFFAOYSA-N Cc1ncncc1 Chemical compound Cc1ncncc1 LVILGAOSPDLNRM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161515401P | 2011-08-05 | 2011-08-05 | |
| US61/515,401 | 2011-08-05 | ||
| PCT/US2012/049706 WO2013022818A1 (en) | 2011-08-05 | 2012-08-06 | Novel macrocycles as factor xia inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014521701A JP2014521701A (ja) | 2014-08-28 |
| JP2014521701A5 JP2014521701A5 (enExample) | 2015-09-24 |
| JP6158181B2 true JP6158181B2 (ja) | 2017-07-05 |
Family
ID=46889416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014524152A Active JP6158181B2 (ja) | 2011-08-05 | 2012-08-06 | 第ｘｉａ因子阻害剤としての新規大環状分子 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US9221818B2 (enExample) |
| EP (1) | EP2739628B1 (enExample) |
| JP (1) | JP6158181B2 (enExample) |
| CN (1) | CN103857681B (enExample) |
| AR (1) | AR088748A1 (enExample) |
| BR (1) | BR112014002202A2 (enExample) |
| CA (1) | CA2844254A1 (enExample) |
| CY (1) | CY1119281T1 (enExample) |
| DK (1) | DK2739628T3 (enExample) |
| EA (1) | EA024791B1 (enExample) |
| ES (1) | ES2635088T3 (enExample) |
| HR (1) | HRP20171122T1 (enExample) |
| HU (1) | HUE034487T2 (enExample) |
| LT (1) | LT2739628T (enExample) |
| MX (1) | MX345763B (enExample) |
| PL (1) | PL2739628T3 (enExample) |
| PT (1) | PT2739628T (enExample) |
| RS (1) | RS56244B1 (enExample) |
| SI (1) | SI2739628T1 (enExample) |
| SM (1) | SMT201700413T1 (enExample) |
| TW (1) | TW201311689A (enExample) |
| WO (1) | WO2013022818A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2822130T3 (es) | 2010-02-11 | 2021-04-29 | Bristol Myers Squibb Co | Macrociclos como inhibidores del factor XIa |
| TW201319068A (zh) | 2011-08-05 | 2013-05-16 | 必治妥美雅史谷比公司 | 作為ｘｉａ因子抑制劑之環狀ｐ１接合劑 |
| TW201311689A (zh) | 2011-08-05 | 2013-03-16 | 必治妥美雅史谷比公司 | 作為因子ｘｉａ抑制劑之新穎巨環化合物 |
| IN2014CN02806A (enExample) | 2011-10-14 | 2015-07-03 | Bristol Myers Squibb Co | |
| ES2579832T3 (es) | 2011-10-14 | 2016-08-17 | Bristol-Myers Squibb Company | Compuestos de tetrahidroisoquinolina sustituida como inhibidores del factor XIa |
| EA023649B1 (ru) | 2011-10-14 | 2016-06-30 | Бристол-Майерс Сквибб Кампани | ЗАМЕЩЕННЫЕ СОЕДИНЕНИЯ ТЕТРАГИДРОИЗОХИНОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА XIa |
| CA2880898A1 (en) | 2012-08-03 | 2014-02-06 | Bristol-Myers Squibb Company | Dihydropyridone p1 as factor xia inhibitors |
| HUE032622T2 (en) | 2012-08-03 | 2017-10-30 | Bristol Myers Squibb Co | Dihydropyridone p1 as factor xia inhibitors |
| EP2906552B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| EP2906541B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| NZ707990A (en) | 2012-10-12 | 2018-07-27 | Bristol Myers Squibb Co | Crystalline forms of a factor xia inhibitor |
| US9738655B2 (en) | 2013-03-25 | 2017-08-22 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors |
| WO2014160592A2 (en) | 2013-03-27 | 2014-10-02 | Merck Sharp & Dohme Corp. | FACTOR XIa INHIBITORS |
| FR3010076B1 (fr) * | 2013-09-02 | 2016-12-23 | Centre Nat De La Rech Scient - Cnrs - | Inhibiteurs de metalloproteases, leurs procedes de preparation et leurs utilisations therapeutiques |
| TWI859674B (zh) * | 2014-01-31 | 2024-10-21 | 美商必治妥美雅史谷比公司 | 作為凝血因子xia抑制劑之具有雜環p2'基團之巨環化合物 |
| NO2760821T3 (enExample) | 2014-01-31 | 2018-03-10 | ||
| WO2015123091A1 (en) | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Factor xia inhibitors |
| EP3104703B1 (en) * | 2014-02-11 | 2020-11-18 | Merck Sharp & Dohme Corp. | Factor xia inhibitors |
| US10093683B2 (en) | 2014-04-22 | 2018-10-09 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| US9868727B2 (en) | 2014-07-28 | 2018-01-16 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| US10081623B2 (en) | 2014-09-04 | 2018-09-25 | Bristol-Myers Squibb Company | Diamide macrocycles that are FXIa inhibitors |
| NO2721243T3 (enExample) * | 2014-10-01 | 2018-10-20 | ||
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| ES2762987T3 (es) | 2015-06-19 | 2020-05-26 | Bristol Myers Squibb Co | Macrociclos de diamida como inhibidores del factor XIA |
| EP3868753B1 (en) | 2015-07-29 | 2022-12-21 | Bristol-Myers Squibb Company | Factor xia macrocyclic inhibitors bearing a non-aromatic p2' group |
| CN107849026B (zh) | 2015-07-29 | 2021-01-01 | 百时美施贵宝公司 | 携带烷基或环烷基p2′部分的因子xia大环抑制剂 |
| RS65443B1 (sr) | 2015-10-01 | 2024-05-31 | Biocryst Pharm Inc | Inhibitori kalikreina humane plazme |
| US10344039B2 (en) | 2015-10-29 | 2019-07-09 | Merck Sharp & Dohme Corp. | Macrocyclic spirocarbamate derivatives as factor XIa inhibitors, pharmaceutically acceptable compositions and their use |
| CN108430471B (zh) | 2015-10-29 | 2021-07-09 | 默沙东公司 | 因子XIa抑制剂 |
| WO2017151746A1 (en) | 2016-03-02 | 2017-09-08 | Bristol-Myers Squibb Company | Diamide macrocycles having factor xia inhibiting activity |
| WO2017194517A1 (en) * | 2016-05-10 | 2017-11-16 | Solvay Sa | Composition comprising 3-(haloalkyl or formyl)-1h-pyrazole-4-carboxylic acids or esters, its manufacture and its use for the preparation of carboxamides |
| TW201808908A (zh) | 2016-08-22 | 2018-03-16 | 美商默沙東藥廠 | 因子XIa抑制劑 |
| EP3309143A1 (en) * | 2016-10-17 | 2018-04-18 | Solvay SA | Method for producing fluoroformate compounds |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| CN107011275A (zh) * | 2017-03-31 | 2017-08-04 | 深圳市众康动保科技有限公司 | 一种1,4,5‑三取代‑1,2,3‑三氮唑类化合物的合成方法 |
| WO2019011166A1 (zh) * | 2017-07-14 | 2019-01-17 | 四川科伦博泰生物医药股份有限公司 | 大环酰胺化合物及其药物组合物和用途 |
| EP3957638B1 (en) | 2019-04-16 | 2025-01-08 | China Resources Biopharmaceutical Company Limited | Macrocyclic derivatives acting as xia factor inhibitor |
| CN114008047B (zh) | 2019-07-23 | 2023-03-21 | 南京明德新药研发有限公司 | 作为XIa因子抑制剂的大环衍生物 |
| CN114901366A (zh) | 2019-11-04 | 2022-08-12 | 锐新医药公司 | Ras抑制剂 |
| WO2021091982A1 (en) | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Ras inhibitors |
| PE20230608A1 (es) | 2020-05-05 | 2023-04-13 | Nuvalent Inc | Quimioterapicos de eter macrociclico heteroaromatico |
| WO2021226269A1 (en) | 2020-05-05 | 2021-11-11 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
| JP2023541916A (ja) | 2020-09-15 | 2023-10-04 | レボリューション メディシンズ インコーポレイテッド | がんの治療における、ｒａｓ阻害剤としてのインドール誘導体 |
| CN112920005B (zh) * | 2021-01-31 | 2022-06-14 | 上海李氏化学科技有限公司 | 一种(r)-3-(3-氯-2-氟苯)-4,5-二氢异噁唑-5-羧酸的制备方法 |
| AU2022270116A1 (en) * | 2021-05-05 | 2023-12-21 | Revolution Medicines, Inc. | Ras inhibitors |
| CN118852330A (zh) | 2021-05-05 | 2024-10-29 | 锐新医药公司 | 用于治疗癌症的ras抑制剂 |
| CN113336715B (zh) * | 2021-08-04 | 2021-11-23 | 山东海利尔化工有限公司 | 一种含二氧戊环的三唑类化合物及其中间体的制备方法 |
| KR20240087788A (ko) | 2021-10-01 | 2024-06-19 | 뉴베일런트, 아이엔씨. | 헤테로방향족 매크로사이클릭 에테르 화합물의 고체 형태, 약학 조성물 및 제조 |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3065190D1 (en) | 1979-11-05 | 1983-11-10 | Beecham Group Plc | Enzyme derivatives, and their preparation |
| PE121699A1 (es) | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| ZA985247B (en) | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
| AU5546000A (en) | 1999-06-14 | 2001-01-02 | Protherics Molecular Design Limited | Compounds |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
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|---|---|
| US9221818B2 (en) | 2015-12-29 |
| AR088748A1 (es) | 2014-07-02 |
| SI2739628T1 (sl) | 2017-08-31 |
| EA024791B1 (ru) | 2016-10-31 |
| PT2739628T (pt) | 2017-08-02 |
| US9611274B2 (en) | 2017-04-04 |
| RS56244B1 (sr) | 2017-11-30 |
| US20160068544A1 (en) | 2016-03-10 |
| ES2635088T3 (es) | 2017-10-02 |
| JP2014521701A (ja) | 2014-08-28 |
| CA2844254A1 (en) | 2013-02-14 |
| EA201490418A1 (ru) | 2014-05-30 |
| EP2739628B1 (en) | 2017-06-07 |
| BR112014002202A2 (pt) | 2017-03-07 |
| WO2013022818A1 (en) | 2013-02-14 |
| SMT201700413T1 (it) | 2017-11-15 |
| MX345763B (es) | 2017-02-15 |
| HRP20171122T1 (hr) | 2017-10-06 |
| CN103857681B (zh) | 2017-07-14 |
| US20170158712A1 (en) | 2017-06-08 |
| TW201311689A (zh) | 2013-03-16 |
| MX2014000831A (es) | 2014-02-27 |
| US20180148461A1 (en) | 2018-05-31 |
| LT2739628T (lt) | 2017-08-25 |
| HUE034487T2 (en) | 2018-02-28 |
| US10208068B2 (en) | 2019-02-19 |
| EP2739628A1 (en) | 2014-06-11 |
| CY1119281T1 (el) | 2018-02-14 |
| US9902742B2 (en) | 2018-02-27 |
| CN103857681A (zh) | 2014-06-11 |
| DK2739628T3 (en) | 2017-09-11 |
| US20140221338A1 (en) | 2014-08-07 |
| PL2739628T3 (pl) | 2017-11-30 |
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