HUE034487T2 - Novel macrocycles as factor xia inhibitors - Google Patents

Novel macrocycles as factor xia inhibitors Download PDF

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Publication number
HUE034487T2
HUE034487T2 HUE12762427A HUE12762427A HUE034487T2 HU E034487 T2 HUE034487 T2 HU E034487T2 HU E12762427 A HUE12762427 A HU E12762427A HU E12762427 A HUE12762427 A HU E12762427A HU E034487 T2 HUE034487 T2 HU E034487T2
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HU
Hungary
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mmol
közül
added
compounds
concentrated
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HUE12762427A
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English (en)
Hungarian (hu)
Inventor
Donald J Pinto
James R Corte
Paul J Gilligan
Tianan Fang
Ii Leon M Smith
Yufeng Wang
Wu Yang
William R Ewing
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HUE034487T2 publication Critical patent/HUE034487T2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HUE12762427A 2011-08-05 2012-08-06 Novel macrocycles as factor xia inhibitors HUE034487T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161515401P 2011-08-05 2011-08-05

Publications (1)

Publication Number Publication Date
HUE034487T2 true HUE034487T2 (en) 2018-02-28

Family

ID=46889416

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12762427A HUE034487T2 (en) 2011-08-05 2012-08-06 Novel macrocycles as factor xia inhibitors

Country Status (22)

Country Link
US (4) US9221818B2 (enExample)
EP (1) EP2739628B1 (enExample)
JP (1) JP6158181B2 (enExample)
CN (1) CN103857681B (enExample)
AR (1) AR088748A1 (enExample)
BR (1) BR112014002202A2 (enExample)
CA (1) CA2844254A1 (enExample)
CY (1) CY1119281T1 (enExample)
DK (1) DK2739628T3 (enExample)
EA (1) EA024791B1 (enExample)
ES (1) ES2635088T3 (enExample)
HR (1) HRP20171122T1 (enExample)
HU (1) HUE034487T2 (enExample)
LT (1) LT2739628T (enExample)
MX (1) MX345763B (enExample)
PL (1) PL2739628T3 (enExample)
PT (1) PT2739628T (enExample)
RS (1) RS56244B1 (enExample)
SI (1) SI2739628T1 (enExample)
SM (1) SMT201700413T1 (enExample)
TW (1) TW201311689A (enExample)
WO (1) WO2013022818A1 (enExample)

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Publication number Publication date
AR088748A1 (es) 2014-07-02
RS56244B1 (sr) 2017-11-30
JP2014521701A (ja) 2014-08-28
EP2739628B1 (en) 2017-06-07
CY1119281T1 (el) 2018-02-14
US20180148461A1 (en) 2018-05-31
TW201311689A (zh) 2013-03-16
US9902742B2 (en) 2018-02-27
LT2739628T (lt) 2017-08-25
MX2014000831A (es) 2014-02-27
HRP20171122T1 (hr) 2017-10-06
SMT201700413T1 (it) 2017-11-15
US9611274B2 (en) 2017-04-04
US20170158712A1 (en) 2017-06-08
WO2013022818A1 (en) 2013-02-14
US10208068B2 (en) 2019-02-19
MX345763B (es) 2017-02-15
JP6158181B2 (ja) 2017-07-05
US20160068544A1 (en) 2016-03-10
BR112014002202A2 (pt) 2017-03-07
CN103857681B (zh) 2017-07-14
PL2739628T3 (pl) 2017-11-30
SI2739628T1 (sl) 2017-08-31
US9221818B2 (en) 2015-12-29
CA2844254A1 (en) 2013-02-14
ES2635088T3 (es) 2017-10-02
EA201490418A1 (ru) 2014-05-30
CN103857681A (zh) 2014-06-11
PT2739628T (pt) 2017-08-02
EA024791B1 (ru) 2016-10-31
DK2739628T3 (en) 2017-09-11
EP2739628A1 (en) 2014-06-11
US20140221338A1 (en) 2014-08-07

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