HUE034487T2 - Novel macrocycles as factor xia inhibitors - Google Patents

Novel macrocycles as factor xia inhibitors Download PDF

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Publication number
HUE034487T2
HUE034487T2 HUE12762427A HUE12762427A HUE034487T2 HU E034487 T2 HUE034487 T2 HU E034487T2 HU E12762427 A HUE12762427 A HU E12762427A HU E12762427 A HUE12762427 A HU E12762427A HU E034487 T2 HUE034487 T2 HU E034487T2
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Hungary
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mmol
közül
added
compounds
concentrated
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HUE12762427A
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English (en)
Hungarian (hu)
Inventor
Donald J Pinto
James R Corte
Paul J Gilligan
Tianan Fang
Ii Leon M Smith
Yufeng Wang
Wu Yang
William R Ewing
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HUE034487T2 publication Critical patent/HUE034487T2/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HUE12762427A 2011-08-05 2012-08-06 Novel macrocycles as factor xia inhibitors HUE034487T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161515401P 2011-08-05 2011-08-05

Publications (1)

Publication Number Publication Date
HUE034487T2 true HUE034487T2 (en) 2018-02-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12762427A HUE034487T2 (en) 2011-08-05 2012-08-06 Novel macrocycles as factor xia inhibitors

Country Status (22)

Country Link
US (4) US9221818B2 (enExample)
EP (1) EP2739628B1 (enExample)
JP (1) JP6158181B2 (enExample)
CN (1) CN103857681B (enExample)
AR (1) AR088748A1 (enExample)
BR (1) BR112014002202A2 (enExample)
CA (1) CA2844254A1 (enExample)
CY (1) CY1119281T1 (enExample)
DK (1) DK2739628T3 (enExample)
EA (1) EA024791B1 (enExample)
ES (1) ES2635088T3 (enExample)
HR (1) HRP20171122T1 (enExample)
HU (1) HUE034487T2 (enExample)
LT (1) LT2739628T (enExample)
MX (1) MX345763B (enExample)
PL (1) PL2739628T3 (enExample)
PT (1) PT2739628T (enExample)
RS (1) RS56244B1 (enExample)
SI (1) SI2739628T1 (enExample)
SM (1) SMT201700413T1 (enExample)
TW (1) TW201311689A (enExample)
WO (1) WO2013022818A1 (enExample)

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Publication number Publication date
TW201311689A (zh) 2013-03-16
US10208068B2 (en) 2019-02-19
EP2739628A1 (en) 2014-06-11
CA2844254A1 (en) 2013-02-14
EA024791B1 (ru) 2016-10-31
US20160068544A1 (en) 2016-03-10
CY1119281T1 (el) 2018-02-14
US20170158712A1 (en) 2017-06-08
LT2739628T (lt) 2017-08-25
US9902742B2 (en) 2018-02-27
US20180148461A1 (en) 2018-05-31
BR112014002202A2 (pt) 2017-03-07
MX2014000831A (es) 2014-02-27
SMT201700413T1 (it) 2017-11-15
EA201490418A1 (ru) 2014-05-30
CN103857681B (zh) 2017-07-14
JP2014521701A (ja) 2014-08-28
JP6158181B2 (ja) 2017-07-05
ES2635088T3 (es) 2017-10-02
MX345763B (es) 2017-02-15
PT2739628T (pt) 2017-08-02
RS56244B1 (sr) 2017-11-30
SI2739628T1 (sl) 2017-08-31
WO2013022818A1 (en) 2013-02-14
AR088748A1 (es) 2014-07-02
US20140221338A1 (en) 2014-08-07
DK2739628T3 (en) 2017-09-11
HRP20171122T1 (hr) 2017-10-06
US9611274B2 (en) 2017-04-04
CN103857681A (zh) 2014-06-11
US9221818B2 (en) 2015-12-29
EP2739628B1 (en) 2017-06-07
PL2739628T3 (pl) 2017-11-30

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