SMT201600072B - Sale sodico di 6-fluoro-3-idrossi-2-pirazina carbossammide - Google Patents
Sale sodico di 6-fluoro-3-idrossi-2-pirazina carbossammideInfo
- Publication number
- SMT201600072B SMT201600072B SM201600072T SM201600072T SMT201600072B SM T201600072 B SMT201600072 B SM T201600072B SM 201600072 T SM201600072 T SM 201600072T SM 201600072 T SM201600072 T SM 201600072T SM T201600072 B SMT201600072 B SM T201600072B
- Authority
- SM
- San Marino
- Prior art keywords
- carbossamide
- pirazine
- fluoro
- hydroxy
- sodium salt
- Prior art date
Links
- NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010221682 | 2010-09-30 | ||
| PCT/JP2011/072333 WO2012043700A1 (ja) | 2010-09-30 | 2011-09-29 | ６－フルオロ－３－ヒドロキシ－２－ピラジンカルボキサミドのナトリウム塩 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600072B true SMT201600072B (it) | 2016-04-29 |
Family
ID=45893139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600072T SMT201600072B (it) | 2010-09-30 | 2016-03-14 | Sale sodico di 6-fluoro-3-idrossi-2-pirazina carbossammide |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20130274472A1 (pl) |
| EP (1) | EP2623498B1 (pl) |
| JP (1) | JPWO2012043700A1 (pl) |
| CN (1) | CN103209966B (pl) |
| CY (1) | CY1117041T1 (pl) |
| DK (1) | DK2623498T3 (pl) |
| ES (1) | ES2554630T3 (pl) |
| HR (1) | HRP20151263T1 (pl) |
| HU (1) | HUE026872T2 (pl) |
| MY (1) | MY161429A (pl) |
| PH (2) | PH12013500604A1 (pl) |
| PL (1) | PL2623498T3 (pl) |
| PT (1) | PT2623498E (pl) |
| RS (1) | RS54408B1 (pl) |
| SG (1) | SG189161A1 (pl) |
| SI (1) | SI2623498T1 (pl) |
| SM (1) | SMT201600072B (pl) |
| TW (1) | TWI552998B (pl) |
| WO (1) | WO2012043700A1 (pl) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| MX391660B (es) | 2010-03-24 | 2025-03-21 | Jazz Pharmaceuticals Inc | Formas de dosis de liberacion controlada para substancias de farmaco de alta dosis, solubles en agua e higroscopicas |
| US20130217708A1 (en) * | 2010-09-30 | 2013-08-22 | Toyama Chemical Co., Ltd. | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
| EP2937348B1 (en) * | 2012-12-22 | 2021-09-08 | Kbp Biosciences Pte. Ltd. | Process for the preparation of a compound used as mineralocorticoid receptor antagonist |
| WO2016108534A1 (ko) * | 2014-12-30 | 2016-07-07 | 주식회사 삼양바이오팜 | 고분자 나노입자 동결건조물 및 그 제조방법 |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| TW201808291A (zh) * | 2016-06-30 | 2018-03-16 | 富山化學工業股份有限公司 | 冷凍乾燥製劑之製造方法 |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| US11679083B2 (en) * | 2017-12-28 | 2023-06-20 | Fujifilm Toyama Chemical Co., Ltd. | Method for producing freeze-dried formulation |
| WO2020106735A1 (en) | 2018-11-19 | 2020-05-28 | Jazz Pharmaceuticals Ireland Limited | Alcohol-resistant drug formulations |
| JP7553453B2 (ja) | 2019-03-01 | 2024-09-18 | フラメル アイルランド リミテッド | 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物 |
| TW202139986A (zh) | 2020-02-21 | 2021-11-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 治療原發性嗜睡症之方法 |
| CN111249229B (zh) * | 2020-03-10 | 2023-05-02 | 北京阜康仁生物制药科技有限公司 | 一种稳定的法匹拉韦注射液及其制备方法 |
| CN114075145A (zh) * | 2020-08-14 | 2022-02-22 | 广东东阳光药业有限公司 | 一种法匹拉韦盐及其晶型和制备方法 |
| WO2022076824A1 (en) | 2020-10-08 | 2022-04-14 | Jazz Pharmaceuticals Ireland Limited | Sodium oxybate to treat idiopathic hypersomnia |
| TR202017792A2 (tr) * | 2020-11-06 | 2021-01-21 | Aroma Ilac Sanayi Ltd Sti | 6-floro-3-hidroksi-2-pirazinkarboksamid etken maddesi veya sodyum tuzunu içeren liyofilizasyon tekniğiyle üretilen yeni bir farmasötik kompozisyon |
| CN113750105A (zh) * | 2020-12-11 | 2021-12-07 | 山东大学 | 一种法匹拉韦药用结合物及在制备抗病毒药物制剂中的应用 |
| CN112574130B (zh) * | 2020-12-11 | 2021-10-15 | 山东大学 | 一种法匹拉韦药物共晶及其制备方法和应用 |
| JPWO2022131112A1 (pl) * | 2020-12-18 | 2022-06-23 | ||
| CN116761591A (zh) * | 2020-12-18 | 2023-09-15 | 富士胶片富山化学株式会社 | 药物组合物 |
| WO2023033683A1 (ru) * | 2021-09-06 | 2023-03-09 | Общество С Ограниченной Ответственностью "Промомед Рус" | Противовирусная фармацевтическая композиция, содержащая фавипиравир и аминокислоту |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| CN121038779A (zh) | 2023-02-03 | 2025-11-28 | 特瑞斯制药公司 | 每晚一次的低钠羟丁酸盐组合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU736555B2 (en) | 1998-01-07 | 2001-08-02 | Meiji Seika Pharma Co., Ltd. | A composition comprising a crystallographically stable, amphorous cephalosporin and processes for the preparation thereof |
| ID28806A (id) | 1998-08-20 | 2001-07-05 | Toyama Chemical Co Ltd | Turunan-turunan karboksamida heterosiklik yang mengandung nitrogen atau garam-garam daripadanya dan zat-zat antivirus yang terdiri dari senyawa ini |
| KR100604955B1 (ko) | 2000-02-16 | 2006-07-26 | 토야마 케미칼 컴퍼니 리미티드 | 신규한 피라진 유도체 또는 그 염, 이를 함유하는 의약조성물, 및 그 제조 중간물 |
| BRPI0807597B8 (pt) * | 2007-02-16 | 2021-05-25 | Fujifilm Toyama Chemical Co Ltd | composição farmacêutica, e, uso de um derivado de pirazina ou um sal do mesmo e um ou mais inibidor(es) de neuraminidase em combinação |
| JP2008231064A (ja) | 2007-03-23 | 2008-10-02 | Nippon Shokubai Co Ltd | カルバゾイルアルキル（メタ）アクリレートの製造方法 |
| JP5174365B2 (ja) * | 2007-03-23 | 2013-04-03 | 第一三共株式会社 | キノロン含有凍結乾燥製剤の製造方法 |
| EP2192117B1 (en) * | 2007-09-27 | 2014-06-04 | Toyama Chemical Co., Ltd. | Organic amine salt of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile and method for producing the same |
| TWI463999B (zh) | 2009-03-13 | 2014-12-11 | Toyama Chemical Co Ltd | 含有６-氟-３-羥基-２-吡羧醯胺之錠劑及粒狀粉末 |
| US20130217708A1 (en) | 2010-09-30 | 2013-08-22 | Toyama Chemical Co., Ltd. | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
-
2011
- 2011-09-29 HR HRP20151263TT patent/HRP20151263T1/hr unknown
- 2011-09-29 SG SG2013023437A patent/SG189161A1/en unknown
- 2011-09-29 SI SI201130722T patent/SI2623498T1/sl unknown
- 2011-09-29 JP JP2012536536A patent/JPWO2012043700A1/ja active Pending
- 2011-09-29 CN CN201180055060.8A patent/CN103209966B/zh active Active
- 2011-09-29 DK DK11829253.1T patent/DK2623498T3/en active
- 2011-09-29 HU HUE11829253A patent/HUE026872T2/en unknown
- 2011-09-29 EP EP11829253.1A patent/EP2623498B1/en active Active
- 2011-09-29 PH PH1/2013/500604A patent/PH12013500604A1/en unknown
- 2011-09-29 PT PT118292531T patent/PT2623498E/pt unknown
- 2011-09-29 RS RS20150767A patent/RS54408B1/sr unknown
- 2011-09-29 WO PCT/JP2011/072333 patent/WO2012043700A1/ja not_active Ceased
- 2011-09-29 ES ES11829253.1T patent/ES2554630T3/es active Active
- 2011-09-29 US US13/876,998 patent/US20130274472A1/en not_active Abandoned
- 2011-09-29 TW TW100135298A patent/TWI552998B/zh active
- 2011-09-29 MY MYPI2013001093A patent/MY161429A/en unknown
- 2011-09-29 PL PL11829253T patent/PL2623498T3/pl unknown
-
2014
- 2014-10-16 US US14/515,673 patent/US9096547B2/en active Active
-
2015
- 2015-06-08 US US14/733,199 patent/US20150266831A1/en not_active Abandoned
- 2015-07-24 PH PH12015501649A patent/PH12015501649B1/en unknown
- 2015-12-09 CY CY20151101124T patent/CY1117041T1/el unknown
-
2016
- 2016-03-14 SM SM201600072T patent/SMT201600072B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2623498A4 (en) | 2014-03-26 |
| CY1117041T1 (el) | 2017-04-05 |
| PL2623498T3 (pl) | 2016-05-31 |
| US20130274472A1 (en) | 2013-10-17 |
| JPWO2012043700A1 (ja) | 2014-02-24 |
| PT2623498E (pt) | 2016-02-02 |
| WO2012043700A1 (ja) | 2012-04-05 |
| HK1183015A1 (en) | 2013-12-13 |
| US20150038713A1 (en) | 2015-02-05 |
| CN103209966A (zh) | 2013-07-17 |
| HUE026872T2 (en) | 2016-07-28 |
| ES2554630T3 (es) | 2015-12-22 |
| US9096547B2 (en) | 2015-08-04 |
| HRP20151263T1 (hr) | 2015-12-18 |
| PH12013500604A1 (en) | 2013-05-06 |
| SG189161A1 (en) | 2013-05-31 |
| DK2623498T3 (en) | 2016-02-22 |
| CN103209966B (zh) | 2015-06-10 |
| TWI552998B (zh) | 2016-10-11 |
| SI2623498T1 (sl) | 2016-03-31 |
| TW201219375A (en) | 2012-05-16 |
| PH12015501649A1 (en) | 2015-10-05 |
| PH12015501649B1 (en) | 2015-10-05 |
| RS54408B1 (sr) | 2016-04-28 |
| MY161429A (en) | 2017-04-14 |
| EP2623498B1 (en) | 2015-11-18 |
| US20150266831A1 (en) | 2015-09-24 |
| EP2623498A1 (en) | 2013-08-07 |
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