SMT201300108B - Nuove composizioni di 1-Ä2-(2,4-dimetilfenil solfanil)-fenilÜ piperazina - Google Patents
Nuove composizioni di 1-Ä2-(2,4-dimetilfenil solfanil)-fenilÜ piperazinaInfo
- Publication number
- SMT201300108B SMT201300108B SM201300108T SM201300108T SMT201300108B SM T201300108 B SMT201300108 B SM T201300108B SM 201300108 T SM201300108 T SM 201300108T SM 201300108 T SM201300108 T SM 201300108T SM T201300108 B SMT201300108 B SM T201300108B
- Authority
- SM
- San Marino
- Prior art keywords
- piperazine
- phenylü
- sulfanil
- dimethylphenyl
- new compositions
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- -1 2,4-dimethylphenyl sulfanil Chemical compound 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- YQNWZWMKLDQSAC-UHFFFAOYSA-N vortioxetine Chemical group CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 YQNWZWMKLDQSAC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23622309P | 2009-08-24 | 2009-08-24 | |
DKPA200900950 | 2009-08-24 | ||
PCT/DK2010/050216 WO2011023194A2 (en) | 2009-08-24 | 2010-08-23 | New compositions of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine |
Publications (1)
Publication Number | Publication Date |
---|---|
SMT201300108B true SMT201300108B (it) | 2013-11-08 |
Family
ID=43628463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SM201300108T SMT201300108B (it) | 2009-08-24 | 2013-09-30 | Nuove composizioni di 1-Ä2-(2,4-dimetilfenil solfanil)-fenilÜ piperazina |
Country Status (32)
Country | Link |
---|---|
US (3) | US20120189697A1 (es) |
EP (1) | EP2470166B1 (es) |
JP (1) | JP2013502446A (es) |
KR (1) | KR20120065328A (es) |
CN (1) | CN102639117A (es) |
AU (1) | AU2010289022B2 (es) |
BR (1) | BR112012003280A2 (es) |
CA (1) | CA2769872A1 (es) |
CL (1) | CL2012000457A1 (es) |
CO (1) | CO6612204A2 (es) |
CR (1) | CR20120058A (es) |
DK (1) | DK2470166T3 (es) |
DO (1) | DOP2012000050A (es) |
EA (1) | EA021321B1 (es) |
ES (1) | ES2427628T3 (es) |
GE (1) | GEP20135950B (es) |
HR (1) | HRP20130819T1 (es) |
IL (1) | IL217914A0 (es) |
MA (1) | MA33598B1 (es) |
ME (1) | ME01602B (es) |
MX (1) | MX2012002199A (es) |
NZ (1) | NZ598083A (es) |
PL (1) | PL2470166T3 (es) |
PT (1) | PT2470166E (es) |
RS (1) | RS52959B (es) |
SG (1) | SG178325A1 (es) |
SI (1) | SI2470166T1 (es) |
SM (1) | SMT201300108B (es) |
TN (1) | TN2012000038A1 (es) |
UA (1) | UA105057C2 (es) |
WO (1) | WO2011023194A2 (es) |
ZA (1) | ZA201201360B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200932233A (en) | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
MY162392A (en) * | 2010-04-30 | 2017-06-15 | Takeda Pharmaceuticals Co | Enteric tablet |
EP2564837B1 (en) | 2010-04-30 | 2019-01-30 | Takeda Pharmaceutical Company Limited | Enteric tablet |
CN104146953A (zh) * | 2014-07-24 | 2014-11-19 | 李雪梅 | 一种氢溴酸沃替西汀注射液 |
CN104610195B (zh) * | 2015-01-30 | 2017-06-27 | 上虞京新药业有限公司 | 沃替西汀的天冬氨酸盐或其水合物及其制备方法和用途 |
JO3456B1 (ar) | 2015-05-13 | 2020-07-05 | H Lundbeck As | فيروتيوكسيتين بيروجلوتامات |
EP3184102A1 (en) | 2015-12-23 | 2017-06-28 | Hexal AG | Pharmaceutical composition of vortioxetine hydrobromide comprising an inert core formed of an acidic reacting compound |
EP3184104B1 (en) * | 2015-12-23 | 2018-09-12 | Hexal AG | Pharmaceutical composition of vortioxetine hydrobromide comprising vortioxetine hydrobromide in a polyethylene oxide matrix |
CA3026728A1 (en) | 2016-07-01 | 2018-01-04 | H. Lundbeck A/S | Vortioxetine dosing regimes for fast onset of antidepressant effect |
WO2018065348A1 (en) | 2016-10-05 | 2018-04-12 | Hexal Ag | Novel enteric-coated tablet comprising vortioxetine |
CN112006995A (zh) * | 2020-08-14 | 2020-12-01 | 石药集团中奇制药技术(石家庄)有限公司 | 一种氢溴酸伏硫西汀片的制备方法 |
CN112245432B (zh) * | 2020-11-05 | 2021-12-21 | 东南大学 | 一种1-二苯甲基-4-甲基哌嗪类化合物在制备抗抑郁症药物中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9514842D0 (en) * | 1995-07-20 | 1995-09-20 | Smithkline Beecham Plc | Novel formulation |
UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
US6866146B2 (en) | 2001-10-09 | 2005-03-15 | Christian M. Heesch | Protective case for string instruments |
US8512751B2 (en) * | 2004-12-20 | 2013-08-20 | Collegium Pharmaceutical, Inc. | Pharmaceutical compositions for sleep disorders |
NZ561609A (en) * | 2005-05-12 | 2010-03-26 | Abbott Lab | 3-((trifluoromethyl)sulfonyl)benzenesulfonamide and 3-((chloro(difluoro)methyl)sulfonyl)benzenesulfonamide apoptosis promoters |
JP5153629B2 (ja) * | 2005-08-02 | 2013-02-27 | ルピン・リミテッド | 選択的セロトニン再取り込み阻害剤の新規の制御放出組成物 |
MX2008016141A (es) * | 2006-06-16 | 2009-02-04 | Lundbeck & Co As H | 1-[2-(2,4-dimetilfenilsulfanil)-fenil] piperazina como un compuesto con actividad combinada de recaptación de serotonina, 5-ht3 y 5-ht1a.para el tratamiento de daño cognitivo. |
TW200848411A (en) | 2007-03-20 | 2008-12-16 | Lundbeck & Co As H | Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine |
TW200932233A (en) * | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
-
2010
- 2010-08-23 DK DK10805414.9T patent/DK2470166T3/da active
- 2010-08-23 US US13/388,750 patent/US20120189697A1/en not_active Abandoned
- 2010-08-23 EA EA201290116A patent/EA021321B1/ru not_active IP Right Cessation
- 2010-08-23 BR BR112012003280A patent/BR112012003280A2/pt not_active IP Right Cessation
- 2010-08-23 PL PL10805414T patent/PL2470166T3/pl unknown
- 2010-08-23 JP JP2012525884A patent/JP2013502446A/ja active Pending
- 2010-08-23 CA CA2769872A patent/CA2769872A1/en not_active Abandoned
- 2010-08-23 PT PT108054149T patent/PT2470166E/pt unknown
- 2010-08-23 EP EP10805414.9A patent/EP2470166B1/en not_active Revoked
- 2010-08-23 NZ NZ598083A patent/NZ598083A/xx not_active IP Right Cessation
- 2010-08-23 ME MEP-2013-99A patent/ME01602B/me unknown
- 2010-08-23 SI SI201030343T patent/SI2470166T1/sl unknown
- 2010-08-23 SG SG2012008868A patent/SG178325A1/en unknown
- 2010-08-23 KR KR1020127004405A patent/KR20120065328A/ko not_active Application Discontinuation
- 2010-08-23 GE GEAP201012633A patent/GEP20135950B/en unknown
- 2010-08-23 MX MX2012002199A patent/MX2012002199A/es active IP Right Grant
- 2010-08-23 CN CN2010800376999A patent/CN102639117A/zh active Pending
- 2010-08-23 ES ES10805414T patent/ES2427628T3/es active Active
- 2010-08-23 UA UAA201203101A patent/UA105057C2/uk unknown
- 2010-08-23 WO PCT/DK2010/050216 patent/WO2011023194A2/en active Application Filing
- 2010-08-23 AU AU2010289022A patent/AU2010289022B2/en not_active Ceased
- 2010-08-23 RS RS20130404A patent/RS52959B/en unknown
-
2012
- 2012-01-25 TN TNP2012000038A patent/TN2012000038A1/en unknown
- 2012-02-02 IL IL217914A patent/IL217914A0/en unknown
- 2012-02-07 CR CR20120058A patent/CR20120058A/es unknown
- 2012-02-17 CO CO12028578A patent/CO6612204A2/es not_active Application Discontinuation
- 2012-02-22 CL CL2012000457A patent/CL2012000457A1/es unknown
- 2012-02-23 DO DO2012000050A patent/DOP2012000050A/es unknown
- 2012-02-23 ZA ZA2012/01360A patent/ZA201201360B/en unknown
- 2012-03-21 MA MA34709A patent/MA33598B1/fr unknown
-
2013
- 2013-09-02 HR HRP20130819AT patent/HRP20130819T1/hr unknown
- 2013-09-30 SM SM201300108T patent/SMT201300108B/xx unknown
-
2015
- 2015-02-04 US US14/613,693 patent/US20150150867A1/en not_active Abandoned
- 2015-10-19 US US14/886,333 patent/US20160256398A1/en not_active Abandoned
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