SMT201300104B - Sali di addizione di ammine contenenti gruppi idrossilici e/o carbossilici con deriviati dell'acido amminonicotinico come inibitori di dhodh - Google Patents

Sali di addizione di ammine contenenti gruppi idrossilici e/o carbossilici con deriviati dell'acido amminonicotinico come inibitori di dhodh

Info

Publication number
SMT201300104B
SMT201300104B SM201300104T SM201300104T SMT201300104B SM T201300104 B SMT201300104 B SM T201300104B SM 201300104 T SM201300104 T SM 201300104T SM 201300104 T SM201300104 T SM 201300104T SM T201300104 B SMT201300104 B SM T201300104B
Authority
SM
San Marino
Prior art keywords
groups
addition salts
acid derivatives
carboxylic groups
containing hydroxyl
Prior art date
Application number
SM201300104T
Other languages
English (en)
Italian (it)
Inventor
Carrera Francesc Carrera
Garcia Juan Baustista Perez
Martin Digna Jose Gracia
Bernardini Maria Carmen Boix
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of SMT201300104B publication Critical patent/SMT201300104B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SM201300104T 2009-03-13 2013-09-23 Sali di addizione di ammine contenenti gruppi idrossilici e/o carbossilici con deriviati dell'acido amminonicotinico come inibitori di dhodh SMT201300104B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09382031A EP2228367A1 (fr) 2009-03-13 2009-03-13 Sels adjuvants d'amines contenant des groupes hydroxyle et/ou carbonyle avec des dérivés d'acides aminonicotiques en tant qu'inhibiteurs de la DHODH
PCT/EP2010/001550 WO2010102826A1 (fr) 2009-03-13 2010-03-11 Sels d'addition d'amines contenant des groupes hydroxyle et/ou carboxyle avec des dérivés d'acide amino-nicotinique, comme inhibiteurs de la dhodh

Publications (1)

Publication Number Publication Date
SMT201300104B true SMT201300104B (it) 2013-11-08

Family

ID=40677683

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201300104T SMT201300104B (it) 2009-03-13 2013-09-23 Sali di addizione di ammine contenenti gruppi idrossilici e/o carbossilici con deriviati dell'acido amminonicotinico come inibitori di dhodh

Country Status (35)

Country Link
US (1) US20120014918A1 (fr)
EP (2) EP2228367A1 (fr)
JP (1) JP5674685B2 (fr)
KR (1) KR101674699B1 (fr)
CN (1) CN102348689B (fr)
AR (1) AR075738A1 (fr)
AU (1) AU2010223528B2 (fr)
BR (1) BRPI1006766B8 (fr)
CA (1) CA2754804C (fr)
CL (1) CL2011002216A1 (fr)
CO (1) CO6420337A2 (fr)
CY (1) CY1114418T1 (fr)
DK (1) DK2406225T3 (fr)
EA (1) EA022350B1 (fr)
EC (1) ECSP11011365A (fr)
ES (1) ES2428746T3 (fr)
HK (1) HK1162487A1 (fr)
HR (1) HRP20130851T1 (fr)
IL (1) IL214519A (fr)
ME (1) ME01564B (fr)
MX (1) MX2011009146A (fr)
MY (1) MY155140A (fr)
NZ (1) NZ594493A (fr)
PE (1) PE20120171A1 (fr)
PL (1) PL2406225T3 (fr)
PT (1) PT2406225E (fr)
RS (1) RS52949B (fr)
SG (1) SG173823A1 (fr)
SI (1) SI2406225T1 (fr)
SM (1) SMT201300104B (fr)
TW (1) TWI428127B (fr)
UA (1) UA105786C2 (fr)
UY (1) UY32467A (fr)
WO (1) WO2010102826A1 (fr)
ZA (1) ZA201105744B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2319596B1 (es) 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
UY31272A1 (es) 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
EP2135610A1 (fr) 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combinaison comportant des inhibiteurs DHODH et de la méthotrexate
EP2239256A1 (fr) 2009-03-13 2010-10-13 Almirall, S.A. Sel de sodium de l'acide 5-cyclopropyl-2-{[2-(2,6-difluorophényl)pyrimidin-5-yl]amino}benzoïque en tant qu'inhibiteurs de la DHOD
EP2314577A1 (fr) 2009-10-16 2011-04-27 Almirall, S.A. Procédé de fabrication de l'acide 2-[(3,5-difluoro-3'-méthoxy-1,1'-biphényl-4-yl)amino]nicotinique
EP2444088A1 (fr) * 2010-10-22 2012-04-25 Almirall, S.A. Dérivés amino pour le traitement de troubles prolifératifs de la peau
EP2594271A1 (fr) * 2011-11-21 2013-05-22 Almirall, S.A. Acide 2-[(3,5-difluoro-3'-méthoxy-1,1'-biphényl-4-YL)aminonicotinique pour le traitement du psoriasis
KR101251851B1 (ko) 2011-11-30 2013-04-10 현대자동차주식회사 Ｉｓｇ 시스템 및 이의 제어방법
TW201350467A (zh) * 2012-05-08 2013-12-16 Teva Pharma Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh) * 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
EP3308770A1 (fr) * 2013-04-12 2018-04-18 Actavis Group PTC EHF Formulation de pemetrexed
WO2018136009A1 (fr) 2017-01-20 2018-07-26 Aslan Pharmaceuticals Pte Ltd Polythérapie
WO2018136010A1 (fr) 2017-01-20 2018-07-26 Aslan Pharmaceuticals Pte Ltd Polythérapie
CN108524482B (zh) * 2017-03-02 2022-11-25 中国科学院上海药物研究所 2-(取代苯氨基)苯甲酸类fto抑制剂治疗白血病的用途
KR20210090625A (ko) 2018-10-09 2021-07-20 아슬란 파마슈티컬스 피티이 엘티디 바를리티닙의 말론산 염
JOP20210147A1 (ar) * 2018-12-21 2023-01-30 Les Laboratoires Servier Sas صور بلورية وملح من مركب عضوي وتركيبات صيدلانية منه
EP4228640A1 (fr) * 2020-10-15 2023-08-23 ASLAN Pharmaceuticals Pte Ltd Traitement de maladies auto-immunes au moyen d'un inhibiteur de dihydroorotate déhydrogénase (dhodh)
CN114907267A (zh) * 2021-02-08 2022-08-16 中国科学院上海药物研究所 用于抗肿瘤的药物组合

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US3839344A (en) * 1973-03-28 1974-10-01 Schering Corp N-methyl d-glucamine salt of 2(2'-methyl-3'-trifluoromethylanilino)nicotinic acid
GB9804343D0 (en) 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
DZ3252A1 (fr) * 1999-06-10 2000-12-21 Warner Lambert Co
PT1381356E (pt) 2001-04-05 2008-07-24 Aventis Pharma Inc Utilização de (4' -trifluorometilfenil) - amida do ácido (z) -2- ciano-3-hidroxi-but-2-enóico para tratamento da esclerose múltipla
MXPA04000224A (es) 2001-07-10 2005-07-25 4Sc Ag Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos.
JP2004099586A (ja) * 2002-05-21 2004-04-02 Sumitomo Pharmaceut Co Ltd ジヒドロオロテートデヒドロゲナーゼ阻害剤
AU2003300530A1 (en) 2002-12-23 2004-07-14 4Sc Ag Dhodh-inhibitors and method for their identification
WO2004056746A1 (fr) 2002-12-23 2004-07-08 4Sc Ag Composes d'acide dicarboxylique de cycloalcene servant d'agents anti-inflammatoires, d'immunomodulation et anti-proliferation
WO2006001961A2 (fr) 2004-05-21 2006-01-05 The Uab Research Foundation Compositions et methodes se rapportant aux inhibiteurs de la synthese de la pyrimidine
WO2006022442A1 (fr) 2004-08-24 2006-03-02 Santen Pharmaceutical Co., Ltd. Nouveaux derives d’amides heterocycliques ayant une activite d’inhibition de la dihydroorotate deshydrogenase
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JP2007015952A (ja) * 2005-07-06 2007-01-25 Shionogi & Co Ltd ナフタレン誘導体
ES2303758B1 (es) 2006-02-20 2009-08-13 Laboratorios Almirall S.A. Nuevos derivados de piridin-3-amina.
ES2301380B1 (es) 2006-08-09 2009-06-08 Laboratorios Almirall S.A. Nuevos derivados de 1,7-naftiridina.
ES2319596B1 (es) 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
UY31272A1 (es) * 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico

Also Published As

Publication number Publication date
AU2010223528A1 (en) 2011-08-25
ES2428746T3 (es) 2013-11-11
PL2406225T3 (pl) 2013-12-31
BRPI1006766B8 (pt) 2021-05-25
CO6420337A2 (es) 2012-04-16
TWI428127B (zh) 2014-03-01
ME01564B (me) 2014-09-20
ZA201105744B (en) 2012-04-25
JP2012520252A (ja) 2012-09-06
RS52949B (en) 2014-02-28
TW201034669A (en) 2010-10-01
MY155140A (en) 2015-09-15
CL2011002216A1 (es) 2012-03-09
SI2406225T1 (sl) 2013-10-30
UY32467A (es) 2010-05-31
IL214519A0 (en) 2011-09-27
SG173823A1 (en) 2011-09-29
UA105786C2 (uk) 2014-06-25
AR075738A1 (es) 2011-04-20
CA2754804A1 (fr) 2010-09-16
KR20110126694A (ko) 2011-11-23
EP2228367A1 (fr) 2010-09-15
CN102348689B (zh) 2014-05-14
WO2010102826A1 (fr) 2010-09-16
CN102348689A (zh) 2012-02-08
DK2406225T3 (da) 2013-09-30
BRPI1006766B1 (pt) 2021-03-23
HRP20130851T1 (hr) 2013-10-25
KR101674699B1 (ko) 2016-11-09
IL214519A (en) 2015-03-31
CY1114418T1 (el) 2016-08-31
ECSP11011365A (es) 2011-10-31
MX2011009146A (es) 2011-09-15
NZ594493A (en) 2013-11-29
US20120014918A1 (en) 2012-01-19
JP5674685B2 (ja) 2015-02-25
HK1162487A1 (en) 2012-08-31
PT2406225E (pt) 2013-09-19
EP2406225A1 (fr) 2012-01-18
AU2010223528B2 (en) 2017-02-16
EP2406225B1 (fr) 2013-06-26
PE20120171A1 (es) 2012-03-01
CA2754804C (fr) 2018-07-24
EA022350B1 (ru) 2015-12-30
EA201101297A1 (ru) 2012-04-30

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