SK8182003A3 - Urea and urethane derivative as integrin inhibitor, process for the preparation thereof, its use and pharmaceutical composition comprising same - Google Patents
Urea and urethane derivative as integrin inhibitor, process for the preparation thereof, its use and pharmaceutical composition comprising same Download PDFInfo
- Publication number
- SK8182003A3 SK8182003A3 SK818-2003A SK8182003A SK8182003A3 SK 8182003 A3 SK8182003 A3 SK 8182003A3 SK 8182003 A SK8182003 A SK 8182003A SK 8182003 A3 SK8182003 A3 SK 8182003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- ylamino
- group
- pyridin
- formula
- ethanoylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Surgery (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10063173A DE10063173A1 (de) | 2000-12-18 | 2000-12-18 | Harnstoff- und Urethanderivate |
PCT/EP2001/014039 WO2002050039A1 (en) | 2000-12-18 | 2001-11-30 | Urea and urethane derivatives as integrin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SK8182003A3 true SK8182003A3 (en) | 2003-10-07 |
Family
ID=7667710
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK818-2003A SK8182003A3 (en) | 2000-12-18 | 2001-11-30 | Urea and urethane derivative as integrin inhibitor, process for the preparation thereof, its use and pharmaceutical composition comprising same |
Country Status (23)
Country | Link |
---|---|
US (1) | US7135587B2 (da) |
EP (1) | EP1343764B1 (da) |
JP (1) | JP4216071B2 (da) |
KR (1) | KR20030063432A (da) |
CN (1) | CN1481364A (da) |
AR (1) | AR035608A1 (da) |
AT (1) | ATE274497T1 (da) |
AU (1) | AU2002217078A1 (da) |
BR (1) | BR0116202A (da) |
CA (1) | CA2431974C (da) |
CZ (1) | CZ20031775A3 (da) |
DE (2) | DE10063173A1 (da) |
DK (1) | DK1343764T3 (da) |
ES (1) | ES2227063T3 (da) |
HU (1) | HUP0302753A3 (da) |
MX (1) | MXPA03005431A (da) |
NO (1) | NO20032754D0 (da) |
PL (1) | PL361745A1 (da) |
PT (1) | PT1343764E (da) |
RU (1) | RU2003121015A (da) |
SK (1) | SK8182003A3 (da) |
WO (1) | WO2002050039A1 (da) |
ZA (1) | ZA200305550B (da) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10204789A1 (de) | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Inhibitoren des Integrins alpha¶v¶beta6 |
NZ535425A (en) | 2002-03-13 | 2008-05-30 | Biogen Idec Inc | Anti-alphavbeta6 antibodies |
DE602004014795D1 (de) * | 2003-10-01 | 2008-08-14 | Merck Patent Gmbh | Alfavbeta3 und alfavbeta6 integrin antagonisten als antifibrotische mittel |
CN102875681A (zh) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
EP2046374A4 (en) | 2006-07-10 | 2010-05-05 | Biogen Idec Inc | COMPOSITIONS AND METHODS FOR GROWTH INHIBITION OF SMAD4-DEFICIENT TUMORS |
AU2007354317A1 (en) * | 2006-10-19 | 2008-12-04 | Biogen Idec Ma Inc. | Treatment and prevention of chronic asthma using antagonists of integrin alphaVbeta6 |
AT509266B1 (de) * | 2009-12-28 | 2014-07-15 | Tech Universität Wien | Substituierte pyridine und pyrimidine |
CN102353728B (zh) * | 2011-06-29 | 2013-03-27 | 中国食品发酵工业研究院 | 一种黄酒生产过程质量控制快速检测方法 |
US10035859B2 (en) | 2013-03-15 | 2018-07-31 | Biogen Ma Inc. | Anti-alpha V beta 6 antibodies and uses thereof |
US10035860B2 (en) | 2013-03-15 | 2018-07-31 | Biogen Ma Inc. | Anti-alpha V beta 6 antibodies and uses thereof |
NZ740675A (en) | 2015-10-23 | 2024-02-23 | Vifor Int Ag | Novel ferroportin inhibitors |
JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
KR20010042704A (ko) * | 1998-04-16 | 2001-05-25 | 데이비드 비. 맥윌리암스 | 인테그린이 인테그린 수용체에 결합하는 것을 억제하는n,n-이치환된 아미드 |
GB9909409D0 (en) | 1999-04-24 | 1999-06-23 | Zeneca Ltd | Chemical compounds |
DE19939980A1 (de) * | 1999-08-24 | 2001-03-01 | Merck Patent Gmbh | Inhibitoren des Integrins alphavbeta¶3¶ |
-
2000
- 2000-12-18 DE DE10063173A patent/DE10063173A1/de not_active Withdrawn
-
2001
- 2001-11-30 JP JP2002551536A patent/JP4216071B2/ja not_active Expired - Fee Related
- 2001-11-30 CA CA2431974A patent/CA2431974C/en not_active Expired - Fee Related
- 2001-11-30 SK SK818-2003A patent/SK8182003A3/sk unknown
- 2001-11-30 HU HU0302753A patent/HUP0302753A3/hu unknown
- 2001-11-30 CZ CZ20031775A patent/CZ20031775A3/cs unknown
- 2001-11-30 MX MXPA03005431A patent/MXPA03005431A/es unknown
- 2001-11-30 WO PCT/EP2001/014039 patent/WO2002050039A1/en not_active Application Discontinuation
- 2001-11-30 US US10/450,855 patent/US7135587B2/en not_active Expired - Fee Related
- 2001-11-30 DE DE60105192T patent/DE60105192T2/de not_active Expired - Lifetime
- 2001-11-30 CN CNA01820791XA patent/CN1481364A/zh active Pending
- 2001-11-30 DK DK01271360T patent/DK1343764T3/da active
- 2001-11-30 KR KR10-2003-7008122A patent/KR20030063432A/ko not_active Application Discontinuation
- 2001-11-30 RU RU2003121015/04A patent/RU2003121015A/ru not_active Application Discontinuation
- 2001-11-30 PL PL01361745A patent/PL361745A1/xx unknown
- 2001-11-30 BR BR0116202-0A patent/BR0116202A/pt not_active Application Discontinuation
- 2001-11-30 AU AU2002217078A patent/AU2002217078A1/en not_active Abandoned
- 2001-11-30 EP EP01271360A patent/EP1343764B1/en not_active Expired - Lifetime
- 2001-11-30 PT PT01271360T patent/PT1343764E/pt unknown
- 2001-11-30 ES ES01271360T patent/ES2227063T3/es not_active Expired - Lifetime
- 2001-11-30 AT AT01271360T patent/ATE274497T1/de not_active IP Right Cessation
- 2001-12-14 AR ARP010105796A patent/AR035608A1/es unknown
-
2003
- 2003-06-17 NO NO20032754A patent/NO20032754D0/no unknown
- 2003-07-17 ZA ZA200305550A patent/ZA200305550B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ATE274497T1 (de) | 2004-09-15 |
CA2431974C (en) | 2010-08-17 |
WO2002050039A1 (en) | 2002-06-27 |
US20040063644A1 (en) | 2004-04-01 |
NO20032754L (no) | 2003-06-17 |
MXPA03005431A (es) | 2003-09-10 |
HUP0302753A2 (hu) | 2003-12-29 |
CN1481364A (zh) | 2004-03-10 |
AR035608A1 (es) | 2004-06-16 |
DE60105192T2 (de) | 2005-09-08 |
DE60105192D1 (de) | 2004-09-30 |
DK1343764T3 (da) | 2004-12-06 |
DE10063173A1 (de) | 2002-06-20 |
JP2004516282A (ja) | 2004-06-03 |
CA2431974A1 (en) | 2002-06-27 |
CZ20031775A3 (cs) | 2003-09-17 |
AU2002217078A1 (en) | 2002-07-01 |
HUP0302753A3 (en) | 2005-03-29 |
PT1343764E (pt) | 2005-01-31 |
ZA200305550B (en) | 2004-10-18 |
JP4216071B2 (ja) | 2009-01-28 |
ES2227063T3 (es) | 2005-04-01 |
RU2003121015A (ru) | 2005-02-10 |
EP1343764B1 (en) | 2004-08-25 |
NO20032754D0 (no) | 2003-06-17 |
US7135587B2 (en) | 2006-11-14 |
KR20030063432A (ko) | 2003-07-28 |
EP1343764A1 (en) | 2003-09-17 |
PL361745A1 (en) | 2004-10-04 |
BR0116202A (pt) | 2003-12-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7632951B2 (en) | Inhibitors of integrin ανβ6 | |
AU2002254900A1 (en) | Inhibitors of integrin AlphavBeta6 | |
SK8182003A3 (en) | Urea and urethane derivative as integrin inhibitor, process for the preparation thereof, its use and pharmaceutical composition comprising same | |
AU2003208325B2 (en) | 3-alkanoylamino-propionic acid derivatives used as inhibitors of integrin AVSS6 | |
SK11732001A3 (sk) | Deriváty beta-alanínu | |
US20030171304A1 (en) | Pyridine-2-yl-aminoalkyl carbonyl glycyl-$g(b)-alanine and derivatives thereof | |
SK2962003A3 (en) | Biphenyl derivatives and the use thereof as integrin inhibitors | |
SK192002A3 (en) | Diacylhydrazine derivatives, process for the preparation and use thereof and pharmaceutical composition comprising same | |
SK13732003A3 (sk) | Inhibítory integrínov 'alfa'v'beta'6 | |
US20030187289A1 (en) | Biphenyl derivatives and the use thereof as integrin inhibitors | |
CZ20013704A3 (cs) | Dibenzoazulenové deriváty pro léčbu trombózy, osteoporózy, arteriosklerózy | |
US20040157902A1 (en) | Integrin antagonists | |
Schadt et al. | Inhibitors of integrin α ν β 6 |