HUP0302753A2 - Integrin inhibitor hatású karbamid- és uretánszármazékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Integrin inhibitor hatású karbamid- és uretánszármazékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0302753A2 HUP0302753A2 HU0302753A HUP0302753A HUP0302753A2 HU P0302753 A2 HUP0302753 A2 HU P0302753A2 HU 0302753 A HU0302753 A HU 0302753A HU P0302753 A HUP0302753 A HU P0302753A HU P0302753 A2 HUP0302753 A2 HU P0302753A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- nhr7
- hal
- cycloalkyl
- singly
- Prior art date
Links
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003673 urethanes Chemical class 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000029078 coronary artery disease Diseases 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 206010003211 Arteriosclerosis coronary artery Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- -1 biphenylyl group Chemical group 0.000 abstract 1
- 208000026758 coronary atherosclerosis Diseases 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Surgery (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
(I) általános képletű vegyületek, fiziológiailag elfogadható sóik ésszolvátjaik, amelyekben X jelentése -O- vagy NR5, Y jelentése -N(R5)R4, -C(=NR7)-NHR7 vagy -C(=NR9)-NHR7, B jelentése H vagy (a)általános képletű csoport R jelentése H, A, cikloalkil-csoport, Ar,arilalkil vagy Pol, R1 jelentése -OR vagy -N(R)2, R2 és R3 jelentéseegymástól függetlenül H, A, Hal, -NO2, -OR, -N(R)2, CN, -COR, -SO3R, -SO2R, -NHC(O)A vagy -SR, R4 jelentése H, R7, -C(=NR7)-NHR7, -C(=NR9)-NHR7, -C(=CH-NO2)-NHR7 vagy Het, R5 és R5' jelentése egymástólfüggetlenül H vagy A, R6 jelentése Hal vagy -NO2, R7 jelentése H, -C(O)R8, -C(O)Ar, R8, -COOR8, -COO(CH2)o-Ar; -SO2-Ar, -SO2R8 vagy -SO2Het, R8 jelentése A vagy cikloalkilcsoport, R9 jelentése -CN vagy -NO2, A jelentése 1-8 szénatomos alkilcsoport, ahol az alkilcsoportadott esetben egyszeresen vagy többszörösen R6 csoporttalhelyettesitett lehet és/vagy a szénlánc -O- atommal megszakítottlehet, Ar jelentése fenil-, naftil-, antril- vagy bifenilil-csoport,amelyek mindegyike helyettesítetlen vagy egyszeresen, kétszeresen vagyháromszorosan A, -OH, -OA, -CN, -NO2 vagy Hal szubsztituensselhelyettesített, cikloalkil jelentése 3-15 szénatomoscikloalkilcsoport, Hal jelentése F, Cl, Br vagy I, Het jelentésetelített, részben telítetlen vagy teljesen telítetlen monociklusosvagy biciklusos, 5-10 tagú heterociklusos csoport, amelybengyűrűtagként 1 vagy 2 N és/vagy 1 vagy 2 S vagy O atom lehet jelen, ésa heterociklusos csoport adott esetben egyszeresen vagy kétszeresenhelyettesített lehet egy =O, A, -NO2, -NHCOA- vagy -NHA-csoporttal,Pol jelentése szilárd fázis a funkciós végcsoportok nélkül, n és mjelentése egymástól függetlenül 1, 2, 3, 4, 5 vagy 6, o jelentése 1,2, 3 vagy 4, p jelentése 1, 2, 3, 4 vagy 5. A találmány kiterjed avegyületek előállítására, ezeket tartalmazó gyógyszerkészítményekre ésalkalmazásukra trombózis, szívinfarktus, szívkoronária-betegség,érelmeszesedés kezelésére alkalmas gyógyszerkészítmények előállításárais. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10063173A DE10063173A1 (de) | 2000-12-18 | 2000-12-18 | Harnstoff- und Urethanderivate |
| PCT/EP2001/014039 WO2002050039A1 (en) | 2000-12-18 | 2001-11-30 | Urea and urethane derivatives as integrin inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0302753A2 true HUP0302753A2 (hu) | 2003-12-29 |
| HUP0302753A3 HUP0302753A3 (en) | 2005-03-29 |
Family
ID=7667710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302753A HUP0302753A3 (en) | 2000-12-18 | 2001-11-30 | Urea and urethane derivatives as integrin inhibitors, process for their preparation, their use and pharmaceutical compositions containing them |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7135587B2 (hu) |
| EP (1) | EP1343764B1 (hu) |
| JP (1) | JP4216071B2 (hu) |
| KR (1) | KR20030063432A (hu) |
| CN (1) | CN1481364A (hu) |
| AR (1) | AR035608A1 (hu) |
| AT (1) | ATE274497T1 (hu) |
| AU (1) | AU2002217078A1 (hu) |
| BR (1) | BR0116202A (hu) |
| CA (1) | CA2431974C (hu) |
| CZ (1) | CZ20031775A3 (hu) |
| DE (2) | DE10063173A1 (hu) |
| DK (1) | DK1343764T3 (hu) |
| ES (1) | ES2227063T3 (hu) |
| HU (1) | HUP0302753A3 (hu) |
| MX (1) | MXPA03005431A (hu) |
| NO (1) | NO20032754L (hu) |
| PL (1) | PL361745A1 (hu) |
| PT (1) | PT1343764E (hu) |
| RU (1) | RU2003121015A (hu) |
| SK (1) | SK8182003A3 (hu) |
| WO (1) | WO2002050039A1 (hu) |
| ZA (1) | ZA200305550B (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10204789A1 (de) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Inhibitoren des Integrins alpha¶v¶beta6 |
| EP2287199B1 (en) | 2002-03-13 | 2017-08-02 | Biogen MA Inc. | Anti-alpha V beta 6 antibodies |
| PL1667668T3 (pl) * | 2003-10-01 | 2008-10-31 | Merck Patent Gmbh | Antagoniści integryny alfavbeta3 oraz alfavbeta6 jako czynniki przeciwzwłóknieniowe |
| CN104072614B (zh) | 2005-07-08 | 2017-04-26 | 生物基因Ma公司 | 抗-αvβ6 抗体及其用途 |
| SG173364A1 (en) | 2006-07-10 | 2011-08-29 | Biogen Idec Inc | Compositions and methods for inhibiting growth of smad4-deficient cancers |
| AU2007354317A1 (en) * | 2006-10-19 | 2008-12-04 | Biogen Idec Ma Inc. | Treatment and prevention of chronic asthma using antagonists of integrin alphaVbeta6 |
| AT509266B1 (de) * | 2009-12-28 | 2014-07-15 | Tech Universität Wien | Substituierte pyridine und pyrimidine |
| CN102353728B (zh) * | 2011-06-29 | 2013-03-27 | 中国食品发酵工业研究院 | 一种黄酒生产过程质量控制快速检测方法 |
| WO2014144466A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
| US10035860B2 (en) | 2013-03-15 | 2018-07-31 | Biogen Ma Inc. | Anti-alpha V beta 6 antibodies and uses thereof |
| WO2017068090A1 (en) | 2015-10-23 | 2017-04-27 | Vifor (International) Ag | Novel ferroportin inhibitors |
| JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| KR20010087125A (ko) * | 1998-04-16 | 2001-09-15 | 데이비드 비. 맥윌리암스 | 인테그린 수용체에 대한 인테그린의 결합을 억제하는 화합물 |
| GB9909409D0 (en) * | 1999-04-24 | 1999-06-23 | Zeneca Ltd | Chemical compounds |
| DE19939980A1 (de) * | 1999-08-24 | 2001-03-01 | Merck Patent Gmbh | Inhibitoren des Integrins alphavbeta¶3¶ |
-
2000
- 2000-12-18 DE DE10063173A patent/DE10063173A1/de not_active Withdrawn
-
2001
- 2001-11-30 DE DE60105192T patent/DE60105192T2/de not_active Expired - Lifetime
- 2001-11-30 CN CNA01820791XA patent/CN1481364A/zh active Pending
- 2001-11-30 AT AT01271360T patent/ATE274497T1/de not_active IP Right Cessation
- 2001-11-30 AU AU2002217078A patent/AU2002217078A1/en not_active Abandoned
- 2001-11-30 BR BR0116202-0A patent/BR0116202A/pt not_active Application Discontinuation
- 2001-11-30 EP EP01271360A patent/EP1343764B1/en not_active Expired - Lifetime
- 2001-11-30 RU RU2003121015/04A patent/RU2003121015A/ru not_active Application Discontinuation
- 2001-11-30 KR KR10-2003-7008122A patent/KR20030063432A/ko not_active Application Discontinuation
- 2001-11-30 ES ES01271360T patent/ES2227063T3/es not_active Expired - Lifetime
- 2001-11-30 PL PL01361745A patent/PL361745A1/xx unknown
- 2001-11-30 SK SK818-2003A patent/SK8182003A3/sk unknown
- 2001-11-30 HU HU0302753A patent/HUP0302753A3/hu unknown
- 2001-11-30 JP JP2002551536A patent/JP4216071B2/ja not_active Expired - Fee Related
- 2001-11-30 CA CA2431974A patent/CA2431974C/en not_active Expired - Fee Related
- 2001-11-30 CZ CZ20031775A patent/CZ20031775A3/cs unknown
- 2001-11-30 MX MXPA03005431A patent/MXPA03005431A/es unknown
- 2001-11-30 PT PT01271360T patent/PT1343764E/pt unknown
- 2001-11-30 WO PCT/EP2001/014039 patent/WO2002050039A1/en not_active Application Discontinuation
- 2001-11-30 DK DK01271360T patent/DK1343764T3/da active
- 2001-11-30 US US10/450,855 patent/US7135587B2/en not_active Expired - Fee Related
- 2001-12-14 AR ARP010105796A patent/AR035608A1/es unknown
-
2003
- 2003-06-17 NO NO20032754A patent/NO20032754L/no unknown
- 2003-07-17 ZA ZA200305550A patent/ZA200305550B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1343764E (pt) | 2005-01-31 |
| CA2431974C (en) | 2010-08-17 |
| ES2227063T3 (es) | 2005-04-01 |
| JP2004516282A (ja) | 2004-06-03 |
| KR20030063432A (ko) | 2003-07-28 |
| RU2003121015A (ru) | 2005-02-10 |
| MXPA03005431A (es) | 2003-09-10 |
| DE60105192T2 (de) | 2005-09-08 |
| EP1343764A1 (en) | 2003-09-17 |
| US20040063644A1 (en) | 2004-04-01 |
| DK1343764T3 (da) | 2004-12-06 |
| DE10063173A1 (de) | 2002-06-20 |
| HUP0302753A3 (en) | 2005-03-29 |
| NO20032754D0 (no) | 2003-06-17 |
| NO20032754L (no) | 2003-06-17 |
| ATE274497T1 (de) | 2004-09-15 |
| AR035608A1 (es) | 2004-06-16 |
| JP4216071B2 (ja) | 2009-01-28 |
| CN1481364A (zh) | 2004-03-10 |
| US7135587B2 (en) | 2006-11-14 |
| EP1343764B1 (en) | 2004-08-25 |
| DE60105192D1 (de) | 2004-09-30 |
| CZ20031775A3 (cs) | 2003-09-17 |
| BR0116202A (pt) | 2003-12-23 |
| PL361745A1 (en) | 2004-10-04 |
| ZA200305550B (en) | 2004-10-18 |
| AU2002217078A1 (en) | 2002-07-01 |
| WO2002050039A1 (en) | 2002-06-27 |
| SK8182003A3 (en) | 2003-10-07 |
| CA2431974A1 (en) | 2002-06-27 |
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