SK5612000A3 - Process of the separation and purification of n-[n-(3,3- -dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine methyl ester, process for the preparation thereof, n-[n-(3,3-dimethylbutyl)-l- -alpha-aspartyl]-l-phenylalanine methyl ester prepared by this method and sweetener containing the same - Google Patents

Process of the separation and purification of n-[n-(3,3- -dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine methyl ester, process for the preparation thereof, n-[n-(3,3-dimethylbutyl)-l- -alpha-aspartyl]-l-phenylalanine methyl ester prepared by this method and sweetener containing the same Download PDF

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Publication number
SK5612000A3
SK5612000A3 SK561-2000A SK5612000A SK5612000A3 SK 5612000 A3 SK5612000 A3 SK 5612000A3 SK 5612000 A SK5612000 A SK 5612000A SK 5612000 A3 SK5612000 A3 SK 5612000A3
Authority
SK
Slovakia
Prior art keywords
apm
dimethylbutyl
aspartyl
methyl ester
separation
Prior art date
Application number
SK561-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Yusuke Amino
Tadashi Takemoto
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of SK5612000A3 publication Critical patent/SK5612000A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
    • A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK561-2000A 1997-10-23 1998-10-21 Process of the separation and purification of n-[n-(3,3- -dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine methyl ester, process for the preparation thereof, n-[n-(3,3-dimethylbutyl)-l- -alpha-aspartyl]-l-phenylalanine methyl ester prepared by this method and sweetener containing the same SK5612000A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9290216A JPH11130794A (ja) 1997-10-23 1997-10-23 アスパルテーム誘導体の精製方法
PCT/JP1998/004783 WO1999020648A1 (fr) 1997-10-23 1998-10-21 Procede de purification d'un derive d'aspartame

Publications (1)

Publication Number Publication Date
SK5612000A3 true SK5612000A3 (en) 2000-10-09

Family

ID=17753266

Family Applications (1)

Application Number Title Priority Date Filing Date
SK561-2000A SK5612000A3 (en) 1997-10-23 1998-10-21 Process of the separation and purification of n-[n-(3,3- -dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine methyl ester, process for the preparation thereof, n-[n-(3,3-dimethylbutyl)-l- -alpha-aspartyl]-l-phenylalanine methyl ester prepared by this method and sweetener containing the same

Country Status (10)

Country Link
US (1) US6335461B1 (zh)
EP (1) EP1081158A1 (zh)
JP (1) JPH11130794A (zh)
KR (1) KR20010024551A (zh)
CN (1) CN1276795A (zh)
BR (1) BR9814091A (zh)
CA (1) CA2301688A1 (zh)
HU (1) HUP0004030A3 (zh)
SK (1) SK5612000A3 (zh)
WO (1) WO1999020648A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1010063C2 (nl) * 1998-09-10 2000-03-13 Holland Sweetener Co Werkwijze voor de bereiding van neotaam.
WO2000026234A1 (fr) 1998-10-30 2000-05-11 Ajinomoto Co., Inc. Procede de cristallisation pour la formation de cristaux stables de derive d'aspartame
AU2158700A (en) * 1998-11-25 2000-06-19 Nutrasweet Company, The Process for purification of N- (N-(3,3-dimethylbutyl) -l-alpha-aspartyl) -l-phenylalanine 1-methyl ester
WO2000052019A2 (en) * 1999-03-03 2000-09-08 The Nutrasweet Company Crystallization products of neotame and methods for producing same
JP2001097998A (ja) 1999-10-01 2001-04-10 Ajinomoto Co Inc アスパルチルジペプチドエステル誘導体及び甘味剤
WO2001085761A1 (fr) * 2000-05-10 2001-11-15 Ajinomoto Co., Inc. Procede permettant de produire des derives d'aspartyle dipeptide ester
US6281380B1 (en) * 2000-05-18 2001-08-28 The Nutra Sweet Company Synthesis of N-(N-(3,3-dimethylbutyl)-L-α-aspartyl)L-phenylalanine1-methyl ester by reductive alkylation and crystallization/ isolation in aqueous methanol
CN108464425B (zh) 2011-01-28 2021-10-01 泰特&莱尔组分美国公司 甜叶菊提取物和甜味组合物
US8962698B2 (en) * 2011-01-28 2015-02-24 Tate & Lyle Ingredients Americas Llc Rebaudioside-mogroside V blends
GB201217700D0 (en) 2012-08-01 2012-11-14 Tate & Lyle Ingredients Sweetener compositions containing rebaudioside B

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017472A (en) * 1973-03-05 1977-04-12 G. D. Searle & Co. Process for isolation of aspartyl dipeptide esters
US3901871A (en) * 1973-09-21 1975-08-26 American Cyanamid Co Process of preparing ' -l-aspartyl-l-phenylalanine methyl ester
US4440667A (en) * 1982-07-02 1984-04-03 Exxon Research And Engineering Co. Catalyst regeneration in a catalytic reforming process
US5055588A (en) * 1988-07-06 1991-10-08 Daicel Chemical Industries Ltd. Process for preparing N-substituted amino acid esters
FR2697844B1 (fr) 1992-11-12 1995-01-27 Claude Nofre Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
US5286415A (en) 1992-12-28 1994-02-15 Advanced Products, Inc. Water-based polymer thick film conductive ink
FR2719590B1 (fr) * 1994-05-09 1996-07-26 Claude Nofre Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.
US5728862A (en) 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
JP3651161B2 (ja) * 1997-03-10 2005-05-25 味の素株式会社 改善された呈味を有する甘味料組成物
JP3651162B2 (ja) 1997-03-10 2005-05-25 味の素株式会社 甘味料組成物
JPH10259194A (ja) 1997-03-18 1998-09-29 Ajinomoto Co Inc 新規ジペプチド誘導体及び甘味剤

Also Published As

Publication number Publication date
EP1081158A1 (en) 2001-03-07
KR20010024551A (ko) 2001-03-26
CA2301688A1 (en) 1999-04-29
WO1999020648A1 (fr) 1999-04-29
US6335461B1 (en) 2002-01-01
HUP0004030A2 (en) 2001-03-28
BR9814091A (pt) 2000-10-03
CN1276795A (zh) 2000-12-13
HUP0004030A3 (en) 2001-04-28
JPH11130794A (ja) 1999-05-18

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