SK287682B6 - Pentasacharidový konjugát, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie - Google Patents

Pentasacharidový konjugát, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie Download PDF

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Publication number
SK287682B6
SK287682B6 SK794-2002A SK7942002A SK287682B6 SK 287682 B6 SK287682 B6 SK 287682B6 SK 7942002 A SK7942002 A SK 7942002A SK 287682 B6 SK287682 B6 SK 287682B6
Authority
SK
Slovakia
Prior art keywords
compound
pentasaccharide
formula
mmol
compounds
Prior art date
Application number
SK794-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK7942002A3 (en
Inventor
Boeckel Constant Adriaan Anton Van
Cornelia Maria Tromp
Tamara Theodora Maria Geertsen
Original Assignee
N.V. Organon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by N.V. Organon filed Critical N.V. Organon
Publication of SK7942002A3 publication Critical patent/SK7942002A3/sk
Publication of SK287682B6 publication Critical patent/SK287682B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK794-2002A 1999-12-07 2000-12-01 Pentasacharidový konjugát, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie SK287682B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99204172 1999-12-07
PCT/EP2000/012155 WO2001042262A2 (fr) 1999-12-07 2000-12-01 Compose antithrombotique

Publications (2)

Publication Number Publication Date
SK7942002A3 SK7942002A3 (en) 2002-09-10
SK287682B6 true SK287682B6 (sk) 2011-06-06

Family

ID=8240976

Family Applications (1)

Application Number Title Priority Date Filing Date
SK794-2002A SK287682B6 (sk) 1999-12-07 2000-12-01 Pentasacharidový konjugát, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie

Country Status (23)

Country Link
US (1) US6875755B2 (fr)
EP (1) EP1237897B1 (fr)
JP (1) JP4820517B2 (fr)
KR (1) KR100776607B1 (fr)
CN (1) CN1195767C (fr)
AR (1) AR026726A1 (fr)
AU (1) AU781846B2 (fr)
BR (1) BR0016217A (fr)
CA (1) CA2393042C (fr)
CO (1) CO5251449A1 (fr)
CZ (1) CZ303385B6 (fr)
HK (1) HK1047593A1 (fr)
HU (1) HUP0203471A3 (fr)
IL (2) IL149628A0 (fr)
NO (1) NO323059B1 (fr)
NZ (1) NZ519100A (fr)
PE (1) PE20010935A1 (fr)
PL (1) PL202840B1 (fr)
RU (1) RU2266913C2 (fr)
SK (1) SK287682B6 (fr)
TW (1) TWI289566B (fr)
WO (1) WO2001042262A2 (fr)
ZA (1) ZA200203799B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1558911B (zh) * 2001-09-07 2010-05-12 阿尔开密亚有限公司 合成肝素五糖
DE60330485D1 (de) 2002-07-15 2010-01-21 Merck & Co Inc Zur behandlung von diabetes
CA2499586A1 (fr) 2002-10-07 2004-04-22 Merck & Co., Inc. Inhibiteurs de la dipeptidyl peptidase heterocyclique beta-amino utiles pour le traitement ou la prevention du diabete
BR0315796A (pt) 2002-11-07 2005-09-13 Merck & Co Inc Composto, composição farmacêutica, e, métodos para tratar diabetes, para tratar hiperglicemia, e para tratar obesidade em um mamìfero
JP4564952B2 (ja) 2003-01-17 2010-10-20 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体
CA2513684A1 (fr) 2003-01-31 2004-08-19 Merck & Co., Inc. Derives d'acide 3-amino-4-phenylbutanoique utilises comme inhibiteurs de dipeptidyle peptidase pour le traitement ou la prevention du diabete
US7560455B2 (en) 2003-05-14 2009-07-14 Merck & Co., Inc. 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
CN1798556A (zh) 2003-06-06 2006-07-05 麦克公司 作为治疗或者预防糖尿病的二肽基肽酶抑制剂的稠合吲哚
EP1638950A4 (fr) 2003-06-17 2010-06-30 Merck Sharp & Dohme Derives de cyclohexylglycine servant d'inhibiteurs de la dipeptidyl peptidase pour le traitement ou la prevention du diabete
CA2533893A1 (fr) 2003-07-31 2005-02-10 Merck & Co., Inc. Hexahydrodiazepinones utilises en tant qu'inhibiteurs de la dipeptidyl peptidase iv pour le traitement ou la prevention du diabete
EP1574516A1 (fr) 2004-03-05 2005-09-14 Sanofi-Aventis Composés antithrombotiques
TW200621794A (en) * 2004-10-06 2006-07-01 Akzo Nobel Nv Pulmonary administration of an antithrombotic compound
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
RU2434876C2 (ru) * 2005-10-10 2011-11-27 Н.В. Органон Антитромботические двойные ингибиторы, включающие биотиновую метку
AU2010332797B2 (en) 2009-12-18 2015-05-28 Catalent Pharma Solutions Gmbh Pharmaceutical oral dosage form containing a synthetic oligosaccharide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
NZ264340A (en) * 1993-09-01 1995-04-27 Akzo Nobel Nv Bisconjugate comprising two saccharides and a spacer, use in pharmaceutical compositions
IL126893A (en) * 1997-11-19 2003-05-29 Akzo Nobel Nv Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
US6486129B1 (en) * 1998-06-17 2002-11-26 Akzo Nobel N.V. Antithrombotic compounds

Also Published As

Publication number Publication date
SK7942002A3 (en) 2002-09-10
NO323059B1 (no) 2006-12-27
AU781846B2 (en) 2005-06-16
CZ20021958A3 (cs) 2002-08-14
NO20022689L (no) 2002-06-06
KR20020070988A (ko) 2002-09-11
CN1407989A (zh) 2003-04-02
CZ303385B6 (cs) 2012-08-29
BR0016217A (pt) 2002-09-10
PL202840B1 (pl) 2009-07-31
CA2393042A1 (fr) 2001-06-14
TWI289566B (en) 2007-11-11
KR100776607B1 (ko) 2007-11-16
HUP0203471A3 (en) 2003-03-28
US20030114361A1 (en) 2003-06-19
CA2393042C (fr) 2011-06-28
PL355484A1 (en) 2004-05-04
WO2001042262A2 (fr) 2001-06-14
JP2003520208A (ja) 2003-07-02
JP4820517B2 (ja) 2011-11-24
ZA200203799B (en) 2003-10-29
PE20010935A1 (es) 2001-09-20
HUP0203471A2 (hu) 2003-02-28
EP1237897B1 (fr) 2015-01-14
NZ519100A (en) 2004-09-24
AU2003801A (en) 2001-06-18
IL149628A (en) 2010-04-29
CN1195767C (zh) 2005-04-06
RU2266913C2 (ru) 2005-12-27
NO20022689D0 (no) 2002-06-06
WO2001042262A3 (fr) 2001-12-13
EP1237897A2 (fr) 2002-09-11
IL149628A0 (en) 2002-11-10
US6875755B2 (en) 2005-04-05
HK1047593A1 (zh) 2003-02-28
AR026726A1 (es) 2003-02-26
CO5251449A1 (es) 2003-02-28

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Legal Events

Date Code Title Description
PC4A Assignment and transfer of rights

Owner name: MSD OSS B.V., OSS, NL

Free format text: FORMER OWNER: N.V. ORGANON, OSS, NL

Effective date: 20120326

PC4A Assignment and transfer of rights

Owner name: MERCK SHARP & DOHME B.V., BN HAARLEM, NL

Free format text: FORMER OWNER: ORGANON BIOSCIENCES NEDERLAND B.V., AB OSS, NL

Effective date: 20130729

Owner name: ORGANON BIOSCIENCES NEDERLAND B.V., AB OSS, NL

Free format text: FORMER OWNER: MSD OSS B.V., OSS, NL

Effective date: 20130729

MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20131201