SK287632B6 - Použitie (R)-ibuprofénmetánsulfonamidu alebo jeho solí - Google Patents
Použitie (R)-ibuprofénmetánsulfonamidu alebo jeho solí Download PDFInfo
- Publication number
- SK287632B6 SK287632B6 SK973-2003A SK9732003A SK287632B6 SK 287632 B6 SK287632 B6 SK 287632B6 SK 9732003 A SK9732003 A SK 9732003A SK 287632 B6 SK287632 B6 SK 287632B6
- Authority
- SK
- Slovakia
- Prior art keywords
- kidney
- transplant
- renal
- ischemia
- transplantation
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims abstract description 10
- URZONQSEPBBTSB-HNCPQSOCSA-N methanesulfonamide;(2r)-2-[4-(2-methylpropyl)phenyl]propanoic acid Chemical compound CS(N)(=O)=O.CC(C)CC1=CC=C([C@@H](C)C(O)=O)C=C1 URZONQSEPBBTSB-HNCPQSOCSA-N 0.000 title abstract 2
- 210000000056 organ Anatomy 0.000 claims abstract description 12
- 206010063837 Reperfusion injury Diseases 0.000 claims abstract description 11
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 7
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims abstract description 6
- 230000002265 prevention Effects 0.000 claims abstract description 6
- 238000006243 chemical reaction Methods 0.000 claims abstract 2
- 210000003734 kidney Anatomy 0.000 claims description 34
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 14
- 230000000302 ischemic effect Effects 0.000 claims description 12
- 208000037906 ischaemic injury Diseases 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- KDXKERNSBIXSRK-UHFFFAOYSA-N lysine Chemical class NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 5
- 235000019766 L-Lysine Nutrition 0.000 claims description 3
- 239000004472 Lysine Substances 0.000 claims description 3
- 230000009760 functional impairment Effects 0.000 claims description 2
- 125000001176 L-lysyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])C(N([H])[H])([H])[H] 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 abstract description 25
- 230000006378 damage Effects 0.000 abstract description 6
- 208000027418 Wounds and injury Diseases 0.000 abstract description 2
- 208000014674 injury Diseases 0.000 abstract description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 26
- 241001465754 Metazoa Species 0.000 description 21
- 238000002054 transplantation Methods 0.000 description 21
- 241000700159 Rattus Species 0.000 description 15
- 229940109239 creatinine Drugs 0.000 description 13
- 102000004890 Interleukin-8 Human genes 0.000 description 12
- 108090001007 Interleukin-8 Proteins 0.000 description 12
- 229940096397 interleukin-8 Drugs 0.000 description 12
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 12
- 208000021709 Delayed Graft Function Diseases 0.000 description 11
- 230000000694 effects Effects 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 239000003112 inhibitor Substances 0.000 description 6
- 238000011694 lewis rat Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000010410 reperfusion Effects 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 6
- 206010062237 Renal impairment Diseases 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 238000011685 brown norway rat Methods 0.000 description 4
- 210000003714 granulocyte Anatomy 0.000 description 4
- 230000008595 infiltration Effects 0.000 description 4
- 238000001764 infiltration Methods 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- KQDRVXQXKZXMHP-UHFFFAOYSA-N 2-[4-(2-methylpropyl)phenyl]-n-methylsulfonylpropanamide Chemical compound CC(C)CC1=CC=C(C(C)C(=O)NS(C)(=O)=O)C=C1 KQDRVXQXKZXMHP-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 230000003872 anastomosis Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 210000004969 inflammatory cell Anatomy 0.000 description 3
- 230000003907 kidney function Effects 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 229960003646 lysine Drugs 0.000 description 3
- 210000000440 neutrophil Anatomy 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 3
- 210000000626 ureter Anatomy 0.000 description 3
- QXVRLFIKHYCFJS-SNVBAGLBSA-N (2r)-2-[4-(2-methylpropyl)phenyl]propanoyl chloride Chemical compound CC(C)CC1=CC=C([C@@H](C)C(Cl)=O)C=C1 QXVRLFIKHYCFJS-SNVBAGLBSA-N 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 108010002386 Interleukin-3 Proteins 0.000 description 2
- 102000043131 MHC class II family Human genes 0.000 description 2
- 108091054438 MHC class II family Proteins 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000035605 chemotaxis Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000002254 renal artery Anatomy 0.000 description 2
- 210000002796 renal vein Anatomy 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- KZMAWJRXKGLWGS-UHFFFAOYSA-N 2-chloro-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-n-(3-methoxypropyl)acetamide Chemical compound S1C(N(C(=O)CCl)CCCOC)=NC(C=2C=CC(OC)=CC=2)=C1 KZMAWJRXKGLWGS-UHFFFAOYSA-N 0.000 description 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 description 1
- 102000001326 Chemokine CCL4 Human genes 0.000 description 1
- 108010055165 Chemokine CCL4 Proteins 0.000 description 1
- 206010058060 Graft complication Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 102000003814 Interleukin-10 Human genes 0.000 description 1
- 108090000174 Interleukin-10 Proteins 0.000 description 1
- 102000013691 Interleukin-17 Human genes 0.000 description 1
- 108050003558 Interleukin-17 Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 150000008545 L-lysines Chemical class 0.000 description 1
- 206010063897 Renal ischaemia Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 229960004676 antithrombotic agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000003399 chemotactic effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000005786 degenerative changes Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000001434 glomerular Effects 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000001744 histochemical effect Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000002570 interstitial cell Anatomy 0.000 description 1
- HEFNNWSXXWATRW-SNVBAGLBSA-N levibuprofen Chemical compound CC(C)CC1=CC=C([C@@H](C)C(O)=O)C=C1 HEFNNWSXXWATRW-SNVBAGLBSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000011242 neutrophil chemotaxis Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000000082 organ preservation Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 210000000512 proximal kidney tubule Anatomy 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000009966 trimming Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 210000004926 tubular epithelial cell Anatomy 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI000206A ITMI20010206A1 (it) | 2001-02-02 | 2001-02-02 | Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz |
| PCT/EP2002/000946 WO2002062330A2 (en) | 2001-02-02 | 2002-01-30 | Use of (r)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK9732003A3 SK9732003A3 (en) | 2003-11-04 |
| SK287632B6 true SK287632B6 (sk) | 2011-04-05 |
Family
ID=11446717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK973-2003A SK287632B6 (sk) | 2001-02-02 | 2002-01-30 | Použitie (R)-ibuprofénmetánsulfonamidu alebo jeho solí |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7560487B2 (https=) |
| EP (1) | EP1355641B1 (https=) |
| JP (1) | JP2004517948A (https=) |
| KR (1) | KR100857898B1 (https=) |
| CN (1) | CN1561205A (https=) |
| AT (1) | ATE304846T1 (https=) |
| AU (1) | AU2002250869B2 (https=) |
| BR (2) | BR0206804A (https=) |
| CA (1) | CA2432432C (https=) |
| CZ (1) | CZ303665B6 (https=) |
| DE (1) | DE60206245T2 (https=) |
| DK (1) | DK1355641T3 (https=) |
| EE (1) | EE05233B1 (https=) |
| ES (1) | ES2248541T3 (https=) |
| HU (1) | HU229070B1 (https=) |
| IL (1) | IL157180A (https=) |
| IT (1) | ITMI20010206A1 (https=) |
| MX (1) | MXPA03006686A (https=) |
| NO (1) | NO334285B1 (https=) |
| NZ (1) | NZ526655A (https=) |
| PL (1) | PL215109B1 (https=) |
| PT (1) | PT1355641E (https=) |
| RU (1) | RU2257895C2 (https=) |
| SK (1) | SK287632B6 (https=) |
| WO (1) | WO2002062330A2 (https=) |
| ZA (1) | ZA200304861B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1579859T3 (da) * | 2004-03-25 | 2007-04-10 | Dompe Pha R Ma Spa Res & Mfg | Anvendelse af N-(2-arylpropionyl)-sulfonamider til behandling af rygmarvsskader |
| CA2607953A1 (en) | 2005-05-09 | 2006-11-16 | Tap Pharmaceutical Products, Inc. | Methods for treating nephrolithiasis |
| EP2101761A4 (en) * | 2006-11-13 | 2010-01-27 | Takeda Pharmaceuticals North A | METHODS FOR PRESERVING RENAL FUNCTION USING XANTHINE OXYDOREDUCTASE INHIBITORS |
| EP2308484A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| EP2308485A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
| AU2011299153B2 (en) | 2010-09-10 | 2014-10-30 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for concomitant treatment of theophylline and febuxostat |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| US10561676B2 (en) * | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| CA3055004C (en) * | 2017-03-15 | 2023-10-03 | Numares Ag | Use of a marker set for determining the risk of kidney rejection |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879283A (en) * | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
| RU2008901C1 (ru) * | 1991-03-29 | 1994-03-15 | Донецкий государственный медицинский институт им.М.Горького | Способ фармакологической защиты децентрализованной почки |
| ATE257389T1 (de) * | 1992-09-17 | 2004-01-15 | Amgen Inc | Pharmazeutische zusammensetzungen mit interleukin-1 inhibitoren |
| IL110296A (en) * | 1993-07-16 | 1999-12-31 | Smithkline Beecham Corp | Imidazole compounds process for their preparation and pharmaceutical compositions containing them |
| JPH08231413A (ja) * | 1994-12-29 | 1996-09-10 | Mochida Pharmaceut Co Ltd | 臓器障害に基づく疾患の予防・治療剤 |
| IT1303249B1 (it) * | 1998-10-23 | 2000-11-06 | Dompe Spa | Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono. |
| US6355682B1 (en) * | 2001-05-11 | 2002-03-12 | Assa Weinberg | Treatment of acute renal failure by administration of N-acetylcysteine |
-
2001
- 2001-02-02 IT IT2001MI000206A patent/ITMI20010206A1/it unknown
-
2002
- 2002-01-30 BR BR0206804-4A patent/BR0206804A/pt not_active IP Right Cessation
- 2002-01-30 PT PT02719742T patent/PT1355641E/pt unknown
- 2002-01-30 EP EP02719742A patent/EP1355641B1/en not_active Expired - Lifetime
- 2002-01-30 HU HU0303024A patent/HU229070B1/hu not_active IP Right Cessation
- 2002-01-30 KR KR1020037009714A patent/KR100857898B1/ko not_active Expired - Fee Related
- 2002-01-30 EE EEP200300340A patent/EE05233B1/xx not_active IP Right Cessation
- 2002-01-30 SK SK973-2003A patent/SK287632B6/sk not_active IP Right Cessation
- 2002-01-30 DK DK02719742T patent/DK1355641T3/da active
- 2002-01-30 AU AU2002250869A patent/AU2002250869B2/en not_active Ceased
- 2002-01-30 JP JP2002562337A patent/JP2004517948A/ja active Pending
- 2002-01-30 NZ NZ526655A patent/NZ526655A/en not_active IP Right Cessation
- 2002-01-30 RU RU2003126600/15A patent/RU2257895C2/ru not_active IP Right Cessation
- 2002-01-30 CA CA002432432A patent/CA2432432C/en not_active Expired - Fee Related
- 2002-01-30 AT AT02719742T patent/ATE304846T1/de active
- 2002-01-30 CN CNA028042263A patent/CN1561205A/zh active Pending
- 2002-01-30 BR BRPI0206804A patent/BRPI0206804B1/pt unknown
- 2002-01-30 PL PL363576A patent/PL215109B1/pl unknown
- 2002-01-30 CZ CZ20032095A patent/CZ303665B6/cs not_active IP Right Cessation
- 2002-01-30 ES ES02719742T patent/ES2248541T3/es not_active Expired - Lifetime
- 2002-01-30 DE DE60206245T patent/DE60206245T2/de not_active Expired - Lifetime
- 2002-01-30 WO PCT/EP2002/000946 patent/WO2002062330A2/en not_active Ceased
- 2002-01-30 MX MXPA03006686A patent/MXPA03006686A/es active IP Right Grant
-
2003
- 2003-01-30 US US10/250,465 patent/US7560487B2/en not_active Expired - Fee Related
- 2003-06-23 ZA ZA200304861A patent/ZA200304861B/en unknown
- 2003-07-18 NO NO20033273A patent/NO334285B1/no not_active IP Right Cessation
- 2003-07-31 IL IL157180A patent/IL157180A/en not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Andoh et al. | Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506 | |
| Schaper et al. | Reperfusion of ischemic myocardium: ultrastructural and histochemical aspects | |
| CA2189336A1 (en) | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases | |
| FR2685916A1 (fr) | Inhibiteurs mixtes de la no synthase et de la cyclooxygenase, ainsi qu'un procede pour leur preparation. | |
| SK287632B6 (sk) | Použitie (R)-ibuprofénmetánsulfonamidu alebo jeho solí | |
| JP2829440B2 (ja) | Ｏ▲上６▼―アルキルグアニン―ｄｎａアルキルトランスフェラーゼ減少化活性を有するｏ▲上６▼―ベンジル化グアニン、グアノシンおよび２′―デオキシグアノシン化合物 | |
| Faure et al. | Polyethylene glycol reduces early and long-term cold ischemia-reperfusion and renal medulla injury | |
| HU228937B1 (en) | Compositions for treating inflammatory response | |
| AU2002250869A1 (en) | Use of (R)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs | |
| CN118001283A (zh) | 用于预防及治疗糖尿病性肾病的包含腺苷衍生物的药学组合物 | |
| FR2822464A1 (fr) | Derives biguanides et leurs applications en therapeutique | |
| CZ300455B6 (cs) | Stabilní diester, farmaceutický prostredek jej obsahující a jeho použití | |
| Hertle et al. | Calcium channel blocker nisoldipine limits ischemic damage in rat kidney | |
| SK103497A3 (en) | Substituted indanylidine acetylguanidines, method for preparing, their use as a drug or diagnostic agent and drugs containing the same | |
| PL226999B1 (pl) | Azotan (III) 3 -karbamoilo -1-metylopirydyniowy, sposób jego otrzymywania izastosowanie | |
| KR900006124B1 (ko) | Gem-디할로 및 테트라할로-1,12-디아미노-4,9-디아자-도데칸 및 이들의 제조방법 | |
| JP2011153139A (ja) | ビタミンｅ誘導体を有効成分とする抗サイトカイン介在疾患剤 | |
| EP0215319A2 (en) | Gem-dihalo-1,8-diamino-4-aza-octanes | |
| JP2000511916A (ja) | ポリオールスクシネートおよびその医薬製剤 | |
| HRP20020362A2 (en) | Use of 2-imidazolyl substituted carbinols for production of a medicament for treatment or prohylaxis of disease states as a result of ischaemic conditions | |
| Vicente et al. | Cerebrocrast as a neuroprotective, anti-diabetic and mitochondrial bioenergetic effector: A putative mechanism of action | |
| HK1071853A (en) | Use of (r)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs | |
| SK282350B6 (sk) | Orto-substituované benzoylguanidíny, spôsob ich prípravy, liečivo, ktoré ich obsahuje a ich použitie | |
| MXPA96005675A (en) | Diguanididas of bencenodicarboxilicos substitute acids, procedure for its preparation, its employment as a diagnostic medicine or agent, as well as a medication that the |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Assignment and transfer of rights |
Owner name: DOMPE FARMACEUTICI S.P.A., MILANO, IT Free format text: FORMER OWNER: DOMPE S.P.A., L'AQUILA, IT Effective date: 20160309 Owner name: DOMPE S.P.A., L'AQUILA, IT Free format text: FORMER OWNER: DOMPE PHA.R.MA S.P.A., L'AQUILA, IT Effective date: 20160309 |
|
| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20200130 |