BR0206804A - Utilização de (r)-ibuprofeno metanossulfonamida e sais do mesmo no tratamento e prevenção de reações de rejeição a órgãos transplantados - Google Patents
Utilização de (r)-ibuprofeno metanossulfonamida e sais do mesmo no tratamento e prevenção de reações de rejeição a órgãos transplantadosInfo
- Publication number
- BR0206804A BR0206804A BR0206804-4A BR0206804A BR0206804A BR 0206804 A BR0206804 A BR 0206804A BR 0206804 A BR0206804 A BR 0206804A BR 0206804 A BR0206804 A BR 0206804A
- Authority
- BR
- Brazil
- Prior art keywords
- prevention
- treatment
- salts
- transplant rejection
- organ transplant
- Prior art date
Links
- 230000002265 prevention Effects 0.000 title abstract 4
- URZONQSEPBBTSB-HNCPQSOCSA-N methanesulfonamide;(2r)-2-[4-(2-methylpropyl)phenyl]propanoic acid Chemical compound CS(N)(=O)=O.CC(C)CC1=CC=C([C@@H](C)C(O)=O)C=C1 URZONQSEPBBTSB-HNCPQSOCSA-N 0.000 title abstract 3
- 210000000056 organ Anatomy 0.000 title abstract 3
- 206010052779 Transplant rejections Diseases 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 125000001176 L-lysyl group Chemical class [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])C(N([H])[H])([H])[H] 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
"UTILIZAçãO DE (R)-IBUPROFENO METANOSSULFONAMIDA E SAIS DO MESMO NO TRATAMENTO E PREVENçãO DE REAçõES DE REJEIçãO A óRGãOS TRANSPLANTADOS". A presente invenção refere-se à utilização de (R)-ibuprofeno metanossulfonamida para a preparação de medicamentos para o tratamento e prevenção de lesão funcional resultante de reações de rejeição de órgãos transplantados. Em particular, é descrita a utilização de sais não-tóxicos de (R)-ibuprofeno metanossulfonamida, tal como o sal de L-lisina, para a prevenção e o tratamento de reações de rejeição de rins transplantados.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI000206A ITMI20010206A1 (it) | 2001-02-02 | 2001-02-02 | Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz |
| PCT/EP2002/000946 WO2002062330A2 (en) | 2001-02-02 | 2002-01-30 | Use of (r)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0206804A true BR0206804A (pt) | 2004-02-03 |
Family
ID=11446717
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0206804-4A BR0206804A (pt) | 2001-02-02 | 2002-01-30 | Utilização de (r)-ibuprofeno metanossulfonamida e sais do mesmo no tratamento e prevenção de reações de rejeição a órgãos transplantados |
| BRPI0206804A BRPI0206804B1 (pt) | 2001-02-02 | 2002-01-30 | utilização de (r)-ibuprofeno metanossulfonamida e sais do mesmo no tratamento e prevenção de lesão funcional resultante de reações de rejeição de orgãos transplantados |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0206804A BRPI0206804B1 (pt) | 2001-02-02 | 2002-01-30 | utilização de (r)-ibuprofeno metanossulfonamida e sais do mesmo no tratamento e prevenção de lesão funcional resultante de reações de rejeição de orgãos transplantados |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7560487B2 (pt) |
| EP (1) | EP1355641B1 (pt) |
| JP (1) | JP2004517948A (pt) |
| KR (1) | KR100857898B1 (pt) |
| CN (1) | CN1561205A (pt) |
| AT (1) | ATE304846T1 (pt) |
| AU (1) | AU2002250869B2 (pt) |
| BR (2) | BR0206804A (pt) |
| CA (1) | CA2432432C (pt) |
| CZ (1) | CZ303665B6 (pt) |
| DE (1) | DE60206245T2 (pt) |
| DK (1) | DK1355641T3 (pt) |
| EE (1) | EE05233B1 (pt) |
| ES (1) | ES2248541T3 (pt) |
| HU (1) | HU229070B1 (pt) |
| IL (1) | IL157180A (pt) |
| IT (1) | ITMI20010206A1 (pt) |
| MX (1) | MXPA03006686A (pt) |
| NO (1) | NO334285B1 (pt) |
| NZ (1) | NZ526655A (pt) |
| PL (1) | PL215109B1 (pt) |
| PT (1) | PT1355641E (pt) |
| RU (1) | RU2257895C2 (pt) |
| SK (1) | SK287632B6 (pt) |
| WO (1) | WO2002062330A2 (pt) |
| ZA (1) | ZA200304861B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1579859T1 (sl) * | 2004-03-25 | 2007-04-30 | Dompe Pha R Ma Spa Res & Mfg | Uporaba n-(2-aril-propionil)-sulfonamidov za zdravljenje poskodbe hrbtnega mozga |
| JP2008545627A (ja) | 2005-05-09 | 2008-12-18 | タツプ・フアーマシユーテイカル・プロダクツ・インコーポレイテツド | 腎結石症を治療する方法 |
| CN101677999A (zh) * | 2006-11-13 | 2010-03-24 | 塔普医药产品公司 | 使用黄嘌呤氧化还原酶抑制剂保护肾功能的方法 |
| EP2308485A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
| EP2308484A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| WO2012033941A1 (en) | 2010-09-10 | 2012-03-15 | Takeda Pharmaceuticals North America, Inc. | Methods for concomitant treatment of theophylline and febuxostat |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| US10561676B2 (en) * | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| CA3055004C (en) * | 2017-03-15 | 2023-10-03 | Numares Ag | Use of a marker set for determining the risk of kidney rejection |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879283A (en) * | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
| JPH08231413A (ja) * | 1994-12-29 | 1996-09-10 | Mochida Pharmaceut Co Ltd | 臓器障害に基づく疾患の予防・治療剤 |
| IT1303249B1 (it) * | 1998-10-23 | 2000-11-06 | Dompe Spa | Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono. |
| US6355682B1 (en) * | 2001-05-11 | 2002-03-12 | Assa Weinberg | Treatment of acute renal failure by administration of N-acetylcysteine |
-
2001
- 2001-02-02 IT IT2001MI000206A patent/ITMI20010206A1/it unknown
-
2002
- 2002-01-30 NZ NZ526655A patent/NZ526655A/en not_active IP Right Cessation
- 2002-01-30 BR BR0206804-4A patent/BR0206804A/pt not_active IP Right Cessation
- 2002-01-30 PL PL363576A patent/PL215109B1/pl unknown
- 2002-01-30 SK SK973-2003A patent/SK287632B6/sk not_active IP Right Cessation
- 2002-01-30 CN CNA028042263A patent/CN1561205A/zh active Pending
- 2002-01-30 DK DK02719742T patent/DK1355641T3/da active
- 2002-01-30 CZ CZ20032095A patent/CZ303665B6/cs not_active IP Right Cessation
- 2002-01-30 JP JP2002562337A patent/JP2004517948A/ja active Pending
- 2002-01-30 KR KR1020037009714A patent/KR100857898B1/ko active IP Right Grant
- 2002-01-30 AT AT02719742T patent/ATE304846T1/de active
- 2002-01-30 MX MXPA03006686A patent/MXPA03006686A/es active IP Right Grant
- 2002-01-30 EP EP02719742A patent/EP1355641B1/en not_active Expired - Lifetime
- 2002-01-30 HU HU0303024A patent/HU229070B1/hu not_active IP Right Cessation
- 2002-01-30 EE EEP200300340A patent/EE05233B1/xx not_active IP Right Cessation
- 2002-01-30 BR BRPI0206804A patent/BRPI0206804B1/pt unknown
- 2002-01-30 WO PCT/EP2002/000946 patent/WO2002062330A2/en active IP Right Grant
- 2002-01-30 ES ES02719742T patent/ES2248541T3/es not_active Expired - Lifetime
- 2002-01-30 CA CA002432432A patent/CA2432432C/en not_active Expired - Fee Related
- 2002-01-30 PT PT02719742T patent/PT1355641E/pt unknown
- 2002-01-30 AU AU2002250869A patent/AU2002250869B2/en not_active Ceased
- 2002-01-30 RU RU2003126600/15A patent/RU2257895C2/ru not_active IP Right Cessation
- 2002-01-30 DE DE60206245T patent/DE60206245T2/de not_active Expired - Lifetime
-
2003
- 2003-01-30 US US10/250,465 patent/US7560487B2/en not_active Expired - Fee Related
- 2003-06-23 ZA ZA200304861A patent/ZA200304861B/en unknown
- 2003-07-18 NO NO20033273A patent/NO334285B1/no not_active IP Right Cessation
- 2003-07-31 IL IL157180A patent/IL157180A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: DOMPE PHA.R.MA S.P.A. (IT) Free format text: TRANSFERIDO DE: DOMPE S.P.A. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: DOMPE' S.P.A. (IT) Free format text: TRANSFERIDO POR FUSAO DE: DOMPE PHA.R.MA S.P.A. |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) DA LPI |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: DOMPE FARMACEUTICI S.P.A (IT) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 25/09/2018, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 19A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2616 DE 23-02-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |