BRPI0408924A - preparação de cloridrato de quinapril - Google Patents

preparação de cloridrato de quinapril

Info

Publication number
BRPI0408924A
BRPI0408924A BRPI0408924-3A BRPI0408924A BRPI0408924A BR PI0408924 A BRPI0408924 A BR PI0408924A BR PI0408924 A BRPI0408924 A BR PI0408924A BR PI0408924 A BRPI0408924 A BR PI0408924A
Authority
BR
Brazil
Prior art keywords
quinapril
acid
preparation
tert
give
Prior art date
Application number
BRPI0408924-3A
Other languages
English (en)
Inventor
Sandra Marie Jennings
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BRPI0408924A publication Critical patent/BRPI0408924A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

"PREPARAçãO DE CLORIDRATO DE QUINAPRIL". A presente invenção refere-se a materiais e métodos de preparação de quinapril, seus sais farmaceuticamente aceitáveis, incluindo cloridrato de quinapril. O método inclui a reação do éster etílico do ácido (2S,4S)-2-(4-metil-2,5-dioxo-oxazolidin-3-il)-4-fenil-butírico com o éster terc-butlíco do ácido (3S)-1,2,3,4-tetrahidro-isoquinolina-3-carboxílico para originar o éster terc-butílico de quinapril, que é subseqüentemente reagido com um ácido para originar quinapril ou um sal de adição de ácido de quinapril.
BRPI0408924-3A 2003-03-31 2004-03-19 preparação de cloridrato de quinapril BRPI0408924A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45901603P 2003-03-31 2003-03-31
PCT/IB2004/000942 WO2004087671A1 (en) 2003-03-31 2004-03-19 Preparation of quinapril hydrochloride

Publications (1)

Publication Number Publication Date
BRPI0408924A true BRPI0408924A (pt) 2006-04-04

Family

ID=33131855

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408924-3A BRPI0408924A (pt) 2003-03-31 2004-03-19 preparação de cloridrato de quinapril

Country Status (22)

Country Link
US (1) US6858735B2 (pt)
EP (1) EP1611106B1 (pt)
JP (1) JP2006522092A (pt)
KR (1) KR20050115323A (pt)
CN (1) CN1747935A (pt)
AR (1) AR043949A1 (pt)
AT (1) ATE340161T1 (pt)
AU (1) AU2004226154B2 (pt)
BR (1) BRPI0408924A (pt)
CA (1) CA2517451C (pt)
CL (1) CL2004000541A1 (pt)
DE (1) DE602004002473T2 (pt)
DK (1) DK1611106T3 (pt)
ES (1) ES2271868T3 (pt)
MX (1) MXPA05010498A (pt)
PL (1) PL1611106T3 (pt)
PT (1) PT1611106E (pt)
RS (1) RS20050597A (pt)
RU (1) RU2298004C2 (pt)
TW (1) TWI284637B (pt)
WO (1) WO2004087671A1 (pt)
ZA (1) ZA200505214B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009053994A1 (en) * 2007-10-26 2009-04-30 Matrix Laboratories Limited Process for preparing pure amorphous quinapril hydrochloride
WO2014074853A1 (en) 2012-11-12 2014-05-15 DePuy Synthes Products, LLC Interbody interference implant and instrumentation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4686295A (en) * 1982-03-10 1987-08-11 Usv Pharmaceutical Corporation N-carboxy anhydride intermediates
US4761479A (en) * 1987-03-30 1988-08-02 Warner-Lambert Company Crystalline quinapril and a process for producing the same
WO2002018321A2 (en) * 2000-08-29 2002-03-07 Abbott Laboratories Amino(oxo)acetic acid protein tyrosine phosphatase inhibitors
US6541635B1 (en) * 2002-03-29 2003-04-01 Everlight Usa, Inc. Method for producing angiotensin converting enzyme inhibitor
SI1572661T1 (sl) * 2002-12-16 2007-10-31 Lupin Ltd Kristalna oblika kvinapril hidroklorida in postopek njene priprave

Also Published As

Publication number Publication date
CL2004000541A1 (es) 2005-02-04
JP2006522092A (ja) 2006-09-28
DE602004002473D1 (de) 2006-11-02
DK1611106T3 (da) 2006-12-27
CA2517451C (en) 2009-04-21
US20040192613A1 (en) 2004-09-30
EP1611106B1 (en) 2006-09-20
AU2004226154A1 (en) 2004-10-14
EP1611106A1 (en) 2006-01-04
CA2517451A1 (en) 2004-10-14
TW200424177A (en) 2004-11-16
AU2004226154B2 (en) 2007-03-08
CN1747935A (zh) 2006-03-15
WO2004087671A1 (en) 2004-10-14
US6858735B2 (en) 2005-02-22
PT1611106E (pt) 2006-11-30
RU2298004C2 (ru) 2007-04-27
KR20050115323A (ko) 2005-12-07
MXPA05010498A (es) 2005-11-16
ES2271868T3 (es) 2007-04-16
RS20050597A (en) 2007-09-21
DE602004002473T2 (de) 2007-06-14
AR043949A1 (es) 2005-08-17
RU2005130402A (ru) 2006-02-10
PL1611106T3 (pl) 2007-01-31
ATE340161T1 (de) 2006-10-15
TWI284637B (en) 2007-08-01
ZA200505214B (en) 2008-08-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES.