SK287546B6 - Benzazolové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

Benzazolové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

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Publication number
SK287546B6
SK287546B6 SK898-2002A SK8982002A SK287546B6 SK 287546 B6 SK287546 B6 SK 287546B6 SK 8982002 A SK8982002 A SK 8982002A SK 287546 B6 SK287546 B6 SK 287546B6
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SK
Slovakia
Prior art keywords
substituted
unsubstituted
benzothiazol
acetonitrile
alkyl
Prior art date
Application number
SK898-2002A
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English (en)
Slovak (sk)
Other versions
SK8982002A3 (en
Inventor
Serge Halazy
Dennis Church
Montserrat Camps
Pascale Gaillard
Jean Pierre Gotteland
Original Assignee
Laboratoires Serono Sa
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Filing date
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Application filed by Laboratoires Serono Sa filed Critical Laboratoires Serono Sa
Publication of SK8982002A3 publication Critical patent/SK8982002A3/sk
Publication of SK287546B6 publication Critical patent/SK287546B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK898-2002A 1999-12-24 2000-12-20 Benzazolové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie SK287546B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99811207A EP1110957A1 (en) 1999-12-24 1999-12-24 Benzazole derivatives and their use as JNK modulators
PCT/EP2000/013006 WO2001047920A1 (en) 1999-12-24 2000-12-20 Benzazole derivatives and their use as jnk modulators

Publications (2)

Publication Number Publication Date
SK8982002A3 SK8982002A3 (en) 2002-10-08
SK287546B6 true SK287546B6 (sk) 2011-01-04

Family

ID=8243214

Family Applications (1)

Application Number Title Priority Date Filing Date
SK898-2002A SK287546B6 (sk) 1999-12-24 2000-12-20 Benzazolové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (33)

Country Link
US (2) US7259162B2 (ko)
EP (2) EP1110957A1 (ko)
JP (1) JP4782344B2 (ko)
KR (2) KR20070047853A (ko)
CN (1) CN1252067C (ko)
AR (1) AR029215A1 (ko)
AT (1) ATE254123T1 (ko)
AU (1) AU780241B2 (ko)
BG (1) BG65986B1 (ko)
BR (1) BR0016911A (ko)
CA (1) CA2394809C (ko)
CZ (1) CZ300984B6 (ko)
DE (1) DE60006580T2 (ko)
DK (1) DK1240164T3 (ko)
EA (1) EA007152B1 (ko)
EE (1) EE05456B1 (ko)
ES (1) ES2206351T3 (ko)
HK (1) HK1055730A1 (ko)
HR (1) HRP20020496B1 (ko)
HU (1) HU229625B1 (ko)
IL (2) IL150346A0 (ko)
MX (1) MXPA02006242A (ko)
NO (1) NO323146B1 (ko)
NZ (1) NZ519423A (ko)
PL (1) PL356634A1 (ko)
PT (1) PT1240164E (ko)
RS (1) RS51008B (ko)
SI (1) SI1240164T1 (ko)
SK (1) SK287546B6 (ko)
TR (2) TR200201509T2 (ko)
UA (1) UA73151C2 (ko)
WO (1) WO2001047920A1 (ko)
ZA (1) ZA200204427B (ko)

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AU2003251721A1 (en) * 2002-06-14 2003-12-31 Laboratoires Serono Sa Azole methylidene cyanide derivatives and their use as protein kinase modulators
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EP1828160B1 (en) 2004-12-21 2011-12-14 Merck Serono SA Sulfonyl amino cyclic derivatives and use thereof as mmp inhibitors
JP4950070B2 (ja) 2005-01-31 2012-06-13 メルク セローノ ソシエテ アノニム Ｎ−ヒドロキシアミド誘導体及びその使用
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BRPI0613042A2 (pt) * 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) * 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
AU2006286489B2 (en) 2005-09-01 2012-08-09 Ares Trading S.A. Treatment of optic neuritis
US9598669B2 (en) 2005-12-29 2017-03-21 Anthrogenesis Corporation Composition for collecting placental stem cells and methods of using the composition
EP2026802A2 (en) * 2006-06-02 2009-02-25 Laboratoires Serono SA Jnk inhibitors for treatment of skin diseases
US20090194268A1 (en) * 2006-08-28 2009-08-06 Dantherm Air Handling A/S Method for manufacturing a heat exchanger
KR20090109127A (ko) 2007-02-12 2009-10-19 안트로제네시스 코포레이션 부착성 태반 줄기세포에서 유래한 간세포와 연골세포 및 ｃｄ34＋, ｃｄ45－ 태반 줄기세포가 농축된 세포군
WO2010019606A1 (en) * 2008-08-12 2010-02-18 Sirtris Pharmaceuticals, Inc. Benzoxazoles, benzthiazoles and related analogs as sirtuin modulators
AU2009296482A1 (en) 2008-09-29 2010-04-01 Telik, Inc. 2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors
AR093183A1 (es) 2010-12-31 2015-05-27 Anthrogenesis Corp Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras
CN102199147A (zh) * 2011-03-19 2011-09-28 陕西合成药业有限公司 用于治疗的硝基咪唑衍生物
MX357749B (es) 2011-06-01 2018-07-23 Anthrogenesis Corp Tratamiento contra el dolor utilizando células madre placentarias.
CN104903331A (zh) * 2013-01-24 2015-09-09 山东亨利医药科技有限责任公司 Jnk抑制剂
JP2017502016A (ja) * 2013-12-20 2017-01-19 バイオメッド バレー ディスカバリーズ，インコーポレイティド １型ｍｅｋ阻害剤およびｅｒｋ阻害剤の組み合わせを使用するがんの処置
KR101520378B1 (ko) * 2014-10-02 2015-05-26 (주)에프테크 습식 가스 스크러버의 배기유도장치
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ZA200204427B (en) 2004-02-03
MXPA02006242A (es) 2003-01-28
KR20020072282A (ko) 2002-09-14
EP1110957A1 (en) 2001-06-27
HK1055730A1 (en) 2004-01-21
HUP0204557A3 (en) 2009-03-30
US20070259892A1 (en) 2007-11-08
TR200302320T4 (tr) 2004-01-21
HRP20020496A2 (en) 2006-03-31
CZ20022169A3 (cs) 2002-09-11
CN1433414A (zh) 2003-07-30
DK1240164T3 (da) 2004-03-01
WO2001047920A1 (en) 2001-07-05
YU49202A (sh) 2006-01-16
UA73151C2 (en) 2005-06-15
AR029215A1 (es) 2003-06-18
NZ519423A (en) 2004-04-30
ES2206351T3 (es) 2004-05-16
DE60006580D1 (de) 2003-12-18
PL356634A1 (en) 2004-06-28
CZ300984B6 (cs) 2009-09-30
JP4782344B2 (ja) 2011-09-28
CA2394809A1 (en) 2001-07-05
US20030162794A1 (en) 2003-08-28
HRP20020496B1 (en) 2009-03-31
BG106830A (bg) 2003-02-28
SI1240164T1 (en) 2004-04-30
DE60006580T2 (de) 2004-09-16
EA200200708A1 (ru) 2003-02-27
CA2394809C (en) 2011-03-15
NO20022997L (no) 2002-06-21
PT1240164E (pt) 2004-02-27
EA007152B1 (ru) 2006-08-25
RS51008B (sr) 2010-10-31
EP1240164A1 (en) 2002-09-18
CN1252067C (zh) 2006-04-19
SK8982002A3 (en) 2002-10-08
HUP0204557A2 (en) 2003-05-28
AU780241B2 (en) 2005-03-10
KR20070047853A (ko) 2007-05-07
IL150346A0 (en) 2002-12-01
EP1240164B1 (en) 2003-11-12
AU3161601A (en) 2001-07-09
TR200201509T2 (tr) 2002-09-23
NO20022997D0 (no) 2002-06-21
HU229625B1 (hu) 2014-03-28
BG65986B1 (bg) 2010-08-31
IL150346A (en) 2010-12-30
BR0016911A (pt) 2002-10-22
ATE254123T1 (de) 2003-11-15
JP2003519142A (ja) 2003-06-17
NO323146B1 (no) 2007-01-08
US7470686B2 (en) 2008-12-30
EE05456B1 (et) 2011-08-15
EE200200318A (et) 2003-10-15
KR100736012B1 (ko) 2007-07-06
US7259162B2 (en) 2007-08-21

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