SK287495B6 - Rádiofarmaceutiká na diagnostikovanie Alzheimerovej choroby - Google Patents
Rádiofarmaceutiká na diagnostikovanie Alzheimerovej choroby Download PDFInfo
- Publication number
- SK287495B6 SK287495B6 SK547-2003A SK5472003A SK287495B6 SK 287495 B6 SK287495 B6 SK 287495B6 SK 5472003 A SK5472003 A SK 5472003A SK 287495 B6 SK287495 B6 SK 287495B6
- Authority
- SK
- Slovakia
- Prior art keywords
- chloro
- benzyl
- fluoro
- phenyl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24629900P | 2000-11-06 | 2000-11-06 | |
PCT/EP2001/012607 WO2002036581A1 (en) | 2000-11-06 | 2001-11-01 | Radiopharmaceuticals for diagnosing alzheimer's disease |
Publications (2)
Publication Number | Publication Date |
---|---|
SK5472003A3 SK5472003A3 (en) | 2003-10-07 |
SK287495B6 true SK287495B6 (sk) | 2010-12-07 |
Family
ID=22930075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK547-2003A SK287495B6 (sk) | 2000-11-06 | 2001-11-01 | Rádiofarmaceutiká na diagnostikovanie Alzheimerovej choroby |
Country Status (29)
Country | Link |
---|---|
US (2) | US6676926B2 (de) |
EP (1) | EP1332138B1 (de) |
JP (1) | JP4234425B2 (de) |
KR (1) | KR20030045167A (de) |
CN (1) | CN1473158A (de) |
AR (1) | AR035366A1 (de) |
AT (1) | ATE314354T1 (de) |
AU (2) | AU1403402A (de) |
BG (1) | BG107762A (de) |
BR (1) | BR0115150A (de) |
CA (1) | CA2424598A1 (de) |
DE (1) | DE60116365T2 (de) |
EA (1) | EA006199B1 (de) |
EE (1) | EE200300216A (de) |
HR (1) | HRP20030459A2 (de) |
HU (1) | HUP0301710A3 (de) |
IL (1) | IL155191A0 (de) |
JO (1) | JO2207B1 (de) |
MX (1) | MXPA03003759A (de) |
NO (1) | NO20032007L (de) |
NZ (1) | NZ525303A (de) |
PE (1) | PE20020531A1 (de) |
PL (1) | PL361631A1 (de) |
SK (1) | SK287495B6 (de) |
TW (1) | TWI238820B (de) |
UY (1) | UY27003A1 (de) |
WO (1) | WO2002036581A1 (de) |
YU (1) | YU33203A (de) |
ZA (1) | ZA200304409B (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY27003A1 (es) * | 2000-11-06 | 2002-07-31 | Schering Ag | Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer |
JP2005507923A (ja) | 2001-10-22 | 2005-03-24 | ファイザー・プロダクツ・インク | Ccr1受容体アンタゴニスト活性を有するピペラジン誘導体 |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
EP1465869B1 (de) | 2001-12-21 | 2013-05-15 | Exelixis Patent Company LLC | Modulatoren von lxr |
EP1620373B1 (de) * | 2003-05-07 | 2008-03-26 | Bayer Schering Pharma Aktiengesellschaft | Vorrichtung und verfahren zum nucleophilen fluorieren |
US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
MXPA06009634A (es) * | 2004-02-24 | 2007-04-23 | Gen Hospital Corp | Radiofrecuencia catalitica. |
US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
GB0409236D0 (en) * | 2004-04-26 | 2004-05-26 | Novartis Ag | Organic compounds |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
KR100778888B1 (ko) * | 2005-11-29 | 2007-11-28 | 재단법인서울대학교산학협력재단 | 베타아밀로이드 펩타이드 플라크의 영상화를 위한벤질리덴아닐린 계열의 유도체 및 그의 방사성 동위원소표지화합물 |
WO2008030595A2 (en) | 2006-09-08 | 2008-03-13 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced liver disease |
WO2008030604A2 (en) | 2006-09-08 | 2008-03-13 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced brain disease |
JP5562036B2 (ja) * | 2006-12-21 | 2014-07-30 | ハマースミス・イメイネット・リミテッド | 放射性標識方法 |
GB0625523D0 (en) | 2006-12-21 | 2007-01-31 | Ge Healthcare Ltd | In vivo imaging agents |
JP2011502966A (ja) * | 2007-10-31 | 2011-01-27 | アルセレス ファーマシューティカルズ, インコーポレイテッド | ドーパミントランスポーターレベルを評価することによるレビー小体型認知症の診断およびレビー小体型認知症の処置のモニタリングのための方法 |
US8450466B2 (en) | 2008-03-21 | 2013-05-28 | The General Hosptial Corporation | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders |
EP2161256A1 (de) * | 2008-09-08 | 2010-03-10 | Atomic Energy Council - Institute of Nuclear Energy Research | Verbindung mit Carboxylat-Ester und bifunktionalen N2S2-Liganden-Gruppen und Herstellungsverfahren davon |
EP2163541A1 (de) * | 2008-09-12 | 2010-03-17 | Bayer Schering Pharma Aktiengesellschaft | Piperazin-Derivate zur Bindung und Abbildung von Amyloidplaques und deren Verwendung |
WO2011041470A2 (en) * | 2009-09-30 | 2011-04-07 | Mallinckrodt Inc. | Sustained-release opiate and opiate derivative compositions |
TW201201846A (en) * | 2010-02-08 | 2012-01-16 | Bayer Schering Pharma Ag | Iodo precursor for a PET imaging agent of amyloid plaques |
WO2011110511A1 (en) * | 2010-03-11 | 2011-09-15 | Bayer Pharma Aktiengesellschaft | Spect imaging agents of amyloid plaques |
WO2012159107A1 (en) | 2011-05-19 | 2012-11-22 | Rhode Island Hospital | Inhibition of renal fibrosis |
EP3088898B1 (de) | 2013-12-27 | 2024-02-07 | National University Corporation Tokyo Medical and Dental University | Verfahren zur diagnose von morbus alzheimer und frontotemporaler lobärer degeneration, diagnosemittel, therapeutisches mittel und screening-verfahren für die besagten mittel |
EP3340796B1 (de) | 2015-08-28 | 2021-04-21 | CHDI Foundation, Inc. | Sonden zur bildgebung von huntingtin-protein |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06510021A (ja) | 1991-03-13 | 1994-11-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | アルツハイマー病検出用の放射性薬剤 |
EP0524146A1 (de) | 1991-07-19 | 1993-01-20 | Ciba-Geigy Ag | Aminosubstituierte Piperazinderivate |
GB9413772D0 (en) | 1994-07-08 | 1994-08-24 | Wyeth John & Brother Ltd | 5-HT1A ligands |
WO1997040010A1 (en) * | 1996-04-24 | 1997-10-30 | Emory University | Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites |
JP2000516210A (ja) | 1996-07-12 | 2000-12-05 | ロイコサイト,インコーポレーテッド | ケモカインレセプターアンタゴニストとその使用方法 |
FR2758328B1 (fr) | 1997-01-15 | 1999-04-02 | Pf Medicament | Nouvelles amines aromatiques derivees d'amines cycliques utiles comme medicaments |
US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
AUPP278498A0 (en) * | 1998-04-03 | 1998-04-30 | Australian Nuclear Science & Technology Organisation | Peripheral benzodiazepine receptor binding agents |
US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
AUPP818099A0 (en) | 1999-01-14 | 1999-02-11 | Fujisawa Pharmaceutical Co., Ltd. | New n-containing heterocyclic compounds |
CA2361366A1 (en) | 1999-03-26 | 2000-10-05 | Nicholas Kindon | Novel compounds |
UY27003A1 (es) * | 2000-11-06 | 2002-07-31 | Schering Ag | Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer |
-
2001
- 2001-10-31 UY UY27003A patent/UY27003A1/es not_active Application Discontinuation
- 2001-11-01 EA EA200300507A patent/EA006199B1/ru not_active IP Right Cessation
- 2001-11-01 AU AU1403402A patent/AU1403402A/xx active Pending
- 2001-11-01 EP EP01982450A patent/EP1332138B1/de not_active Expired - Lifetime
- 2001-11-01 YU YU33203A patent/YU33203A/sh unknown
- 2001-11-01 NZ NZ525303A patent/NZ525303A/en unknown
- 2001-11-01 AU AU2002214034A patent/AU2002214034B2/en not_active Ceased
- 2001-11-01 HU HU0301710A patent/HUP0301710A3/hu unknown
- 2001-11-01 KR KR10-2003-7006187A patent/KR20030045167A/ko not_active Application Discontinuation
- 2001-11-01 WO PCT/EP2001/012607 patent/WO2002036581A1/en not_active Application Discontinuation
- 2001-11-01 IL IL15519101A patent/IL155191A0/xx unknown
- 2001-11-01 CA CA002424598A patent/CA2424598A1/en not_active Abandoned
- 2001-11-01 MX MXPA03003759A patent/MXPA03003759A/es unknown
- 2001-11-01 AT AT01982450T patent/ATE314354T1/de not_active IP Right Cessation
- 2001-11-01 PL PL01361631A patent/PL361631A1/xx not_active Application Discontinuation
- 2001-11-01 JP JP2002539340A patent/JP4234425B2/ja not_active Expired - Fee Related
- 2001-11-01 EE EEP200300216A patent/EE200300216A/xx unknown
- 2001-11-01 CN CNA01818409XA patent/CN1473158A/zh active Pending
- 2001-11-01 DE DE60116365T patent/DE60116365T2/de not_active Expired - Lifetime
- 2001-11-01 BR BR0115150-9A patent/BR0115150A/pt not_active IP Right Cessation
- 2001-11-01 SK SK547-2003A patent/SK287495B6/sk not_active IP Right Cessation
- 2001-11-02 AR ARP010105127A patent/AR035366A1/es unknown
- 2001-11-05 PE PE2001001092A patent/PE20020531A1/es not_active Application Discontinuation
- 2001-11-05 JO JO2001178A patent/JO2207B1/en active
- 2001-11-06 TW TW090127552A patent/TWI238820B/zh not_active IP Right Cessation
- 2001-11-06 US US09/985,938 patent/US6676926B2/en not_active Expired - Fee Related
-
2003
- 2003-04-25 BG BG107762A patent/BG107762A/xx unknown
- 2003-05-05 NO NO20032007A patent/NO20032007L/no unknown
- 2003-06-05 ZA ZA200304409A patent/ZA200304409B/en unknown
- 2003-06-06 HR HR20030459A patent/HRP20030459A2/hr not_active Application Discontinuation
- 2003-07-25 US US10/626,725 patent/US6872381B1/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20111101 |