SK287085B6 - Izolovaný polypeptid, ktorý sa viaže na TRAF2 a modeluje aktivitu NF-kB, DNA sekvencia, ktorá ho kóduje, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

Izolovaný polypeptid, ktorý sa viaže na TRAF2 a modeluje aktivitu NF-kB, DNA sekvencia, ktorá ho kóduje, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

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Publication number
SK287085B6
SK287085B6 SK1361-98A SK136198A SK287085B6 SK 287085 B6 SK287085 B6 SK 287085B6 SK 136198 A SK136198 A SK 136198A SK 287085 B6 SK287085 B6 SK 287085B6
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SK
Slovakia
Prior art keywords
traf2
protein
binding
nik
sequence
Prior art date
Application number
SK1361-98A
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English (en)
Slovak (sk)
Other versions
SK136198A3 (en
Inventor
David Wallach
Nikolai Malinin
Mark Boldin
Andrei Kovalenko
Igor Mett
Original Assignee
Yeda Research And Development Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11780096A external-priority patent/IL117800A0/xx
Priority claimed from IL11913396A external-priority patent/IL119133A0/xx
Application filed by Yeda Research And Development Co., Ltd. filed Critical Yeda Research And Development Co., Ltd.
Publication of SK136198A3 publication Critical patent/SK136198A3/sk
Publication of SK287085B6 publication Critical patent/SK287085B6/sk

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SK1361-98A 1996-04-02 1997-04-01 Izolovaný polypeptid, ktorý sa viaže na TRAF2 a modeluje aktivitu NF-kB, DNA sekvencia, ktorá ho kóduje, farmaceutický prostriedok s ich obsahom a ich použitie SK287085B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11780096A IL117800A0 (en) 1996-04-02 1996-04-02 Modulators of TNF receptor associated factor (TRAF) their preparation and use
IL11913396A IL119133A0 (en) 1996-08-26 1996-08-26 Modulators of TNF receptor associated factor (TRAF) their preparation and use
PCT/IL1997/000117 WO1997037016A1 (en) 1996-04-02 1997-04-01 Modulators of tnf receptor associated factor (traf), their preparation and use

Publications (2)

Publication Number Publication Date
SK136198A3 SK136198A3 (en) 1999-05-07
SK287085B6 true SK287085B6 (sk) 2009-11-05

Family

ID=26323248

Family Applications (3)

Application Number Title Priority Date Filing Date
SK50017-2007A SK287890B6 (sk) 1996-04-02 1997-04-01 Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use
SK50016-2007A SK287889B6 (sk) 1996-04-02 1997-04-01 Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use
SK1361-98A SK287085B6 (sk) 1996-04-02 1997-04-01 Izolovaný polypeptid, ktorý sa viaže na TRAF2 a modeluje aktivitu NF-kB, DNA sekvencia, ktorá ho kóduje, farmaceutický prostriedok s ich obsahom a ich použitie

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SK50017-2007A SK287890B6 (sk) 1996-04-02 1997-04-01 Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use
SK50016-2007A SK287889B6 (sk) 1996-04-02 1997-04-01 Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use

Country Status (23)

Country Link
US (2) US7485456B1 (da)
EP (1) EP0894130B1 (da)
JP (1) JP4180114B2 (da)
CN (1) CN1197966C (da)
AT (1) ATE380866T1 (da)
AU (1) AU732793B2 (da)
BG (1) BG64755B1 (da)
BR (1) BR9708518A (da)
CA (1) CA2250085C (da)
CZ (3) CZ299682B6 (da)
DE (1) DE69738370T2 (da)
DK (1) DK0894130T3 (da)
EA (1) EA004309B1 (da)
EE (1) EE04783B1 (da)
ES (1) ES2294796T3 (da)
HK (1) HK1018910A1 (da)
HU (1) HU226328B1 (da)
NO (1) NO327054B1 (da)
NZ (1) NZ331902A (da)
PT (1) PT894130E (da)
SK (3) SK287890B6 (da)
UA (1) UA71889C2 (da)
WO (1) WO1997037016A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA71889C2 (uk) * 1996-04-02 2005-01-17 Йєда Рісерч Енд Дівелопмент Ко. Лтд. Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
US5843721A (en) * 1997-07-03 1998-12-01 Tularik Inc. Nucleic acids encoding human NIK protein
CA2309007A1 (en) * 1997-11-07 1999-05-20 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
AU2877899A (en) * 1998-02-27 1999-09-15 Regents Of The University Of California, The A novel inhibitor of the inflammatory response induced by tnfalpha and il-1
EP1075519B1 (en) * 1998-05-06 2005-11-09 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Inhibitors of nf-kb activation
HUP0103797A2 (hu) * 1998-08-18 2003-10-28 Abbott Gmbh & Co. Kg TPL-2/COT kináz és alkalmazásai
IL131719A0 (en) * 1999-09-02 2001-03-19 Yeda Res & Dev Iren protein its preparation and use
GB9930616D0 (en) 1999-12-24 2000-02-16 Mathilda & Terence Kennedy Ins Activation and inhibition of the immune system
US20040109854A1 (en) * 2001-02-21 2004-06-10 Zang-Hee Lee Novel traf6 inhibiting protein
DE60213596T2 (de) 2001-06-22 2007-09-13 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Abin zum schutz gegen hepatitis
CA2482387C (en) 2002-04-18 2015-03-03 Yeda Research And Development Co. Ltd Derivatives of the nf-kappab inducing enzyme, their preparation and use
IL158287A0 (en) 2003-10-07 2004-05-12 Yeda Res & Dev Antibodies to nik, their preparation and use
JP4943848B2 (ja) * 2003-10-07 2012-05-30 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド Nikに対する抗体、その調製および使用
EP1689786B1 (en) * 2003-11-30 2014-05-14 Yeda Research And Development Co., Ltd. Methods and agents for immune modulation and methods for identifying immune modulators
IL173104A0 (en) * 2006-01-12 2006-06-11 Yeda Res & Dev Siva and ubiquintination
ES2752025T3 (es) 2008-07-25 2020-04-02 Wagner Richard W Métodos de cribado de proteínas
GB201012420D0 (en) 2010-07-23 2010-09-08 Univ Erasmus Medical Ct Foetal heamoglobin inhibitor
EP2608801B1 (en) 2010-08-25 2019-08-21 aTyr Pharma, Inc. INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES
CN105177032B (zh) * 2010-09-01 2019-05-10 山东新时代药业有限公司 新型人肿瘤坏死因子受体-Fc融合基因及其产物蛋白
BR112013023681A2 (pt) 2011-03-16 2016-12-13 Hoffmann La Roche compostos de álcool propargílico 6,5-heterocíclico e uso dos mesmos
EP3357511B1 (en) 2011-06-30 2020-05-13 Genzyme Corporation Inhibitors of t-cell activation
US9549981B2 (en) 2011-07-19 2017-01-24 Philogen S.P.A. Sequential antibody therapy
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
CN105986001B (zh) * 2015-02-12 2019-12-03 上海交通大学 一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法
AU2020253455A1 (en) 2019-04-03 2021-11-04 Genzyme Corporation Anti-alpha beta TCR binding polypeptides with reduced fragmentation
WO2024062074A1 (en) 2022-09-21 2024-03-28 Sanofi Biotechnology Humanized anti-il-1r3 antibody and methods of use

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Publication number Priority date Publication date Assignee Title
US5641876A (en) * 1990-01-05 1997-06-24 Cornell Research Foundation, Inc. Rice actin gene and promoter
CA2228039A1 (en) * 1995-08-02 1997-02-13 Teresa J. Ingram Composition for administration to patients with chronic fatigue syndrome and acquired immune deficiency syndrome
AU6692996A (en) * 1995-08-08 1997-03-05 Tularik Inc. Inhibitors of apoptosis
US5804412A (en) * 1996-04-01 1998-09-08 The Regents Of The University Of California Nucleic acids encoding sorting nexins and methods of using same
UA71889C2 (uk) * 1996-04-02 2005-01-17 Йєда Рісерч Енд Дівелопмент Ко. Лтд. Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
CA2251376A1 (en) 1996-05-08 1997-11-13 Norman Milstein Alkyl polyglycoside ether carboxylates
US5843721A (en) * 1997-07-03 1998-12-01 Tularik Inc. Nucleic acids encoding human NIK protein

Also Published As

Publication number Publication date
ATE380866T1 (de) 2007-12-15
CZ299682B6 (cs) 2008-10-15
HU226328B1 (en) 2008-09-29
NO984551D0 (no) 1998-09-29
CZ298866B6 (cs) 2008-02-27
JP2000507826A (ja) 2000-06-27
BG64755B1 (bg) 2006-02-28
US8236507B2 (en) 2012-08-07
DK0894130T3 (da) 2008-01-07
BG102817A (en) 1999-05-31
DE69738370D1 (de) 2008-01-24
CZ318398A3 (cs) 1999-05-12
CN1221449A (zh) 1999-06-30
NO327054B1 (no) 2009-04-14
CA2250085C (en) 2009-10-20
PT894130E (pt) 2008-01-14
EA004309B1 (ru) 2004-02-26
SK287889B6 (sk) 2012-03-02
CA2250085A1 (en) 1997-10-09
SK287890B6 (sk) 2012-03-02
ES2294796T3 (es) 2008-04-01
HK1018910A1 (en) 2000-01-07
HUP9902429A2 (hu) 1999-10-28
UA71889C2 (uk) 2005-01-17
CN1197966C (zh) 2005-04-20
BR9708518A (pt) 1999-08-03
EE9800322A (et) 1999-04-15
DE69738370T2 (de) 2008-12-04
US20090291888A1 (en) 2009-11-26
AU732793B2 (en) 2001-05-03
JP4180114B2 (ja) 2008-11-12
HUP9902429A3 (en) 2001-11-28
SK136198A3 (en) 1999-05-07
EP0894130A1 (en) 1999-02-03
US7485456B1 (en) 2009-02-03
NZ331902A (en) 2000-02-28
EP0894130B1 (en) 2007-12-12
EA199800885A1 (ru) 1999-04-29
CZ299094B6 (cs) 2008-04-23
WO1997037016A1 (en) 1997-10-09
NO984551L (no) 1998-11-24
EE04783B1 (et) 2007-02-15
AU2175597A (en) 1997-10-22

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Expiry date: 20170401