SK286432B6 - Spôsob syntézy 5-metoxy-2-[(4-metoxy-3,5-dimetyl-2- pyridyl)metyl]sulfinyl-1H-benzimidazolu - Google Patents

Spôsob syntézy 5-metoxy-2-[(4-metoxy-3,5-dimetyl-2- pyridyl)metyl]sulfinyl-1H-benzimidazolu Download PDF

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Publication number
SK286432B6
SK286432B6 SK25-2001A SK252001A SK286432B6 SK 286432 B6 SK286432 B6 SK 286432B6 SK 252001 A SK252001 A SK 252001A SK 286432 B6 SK286432 B6 SK 286432B6
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SK
Slovakia
Prior art keywords
methoxy
omeprazole
benzimidazole
dimethyl
pyridyl
Prior art date
Application number
SK25-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK252001A3 (en
Inventor
MILA� Nata�a HAFNER
Darja Jereb
Original Assignee
Lek, Tovarna Farmacevtskih In Kemi�Nih Izdelkov, D. D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by Lek, Tovarna Farmacevtskih In Kemi�Nih Izdelkov, D. D. filed Critical Lek, Tovarna Farmacevtskih In Kemi�Nih Izdelkov, D. D.
Publication of SK252001A3 publication Critical patent/SK252001A3/sk
Publication of SK286432B6 publication Critical patent/SK286432B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00—Formation or introduction of functional groups containing oxygen
    • C07B41/06—Formation or introduction of functional groups containing oxygen of carbonyl groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK25-2001A 1998-07-13 1999-07-12 Spôsob syntézy 5-metoxy-2-[(4-metoxy-3,5-dimetyl-2- pyridyl)metyl]sulfinyl-1H-benzimidazolu SK286432B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9800196A SI20019A (sl) 1998-07-13 1998-07-13 Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
PCT/SI1999/000020 WO2000002876A1 (fr) 1998-07-13 1999-07-12 Procede ameliore de synthese de 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl-1h-benzimidazole

Publications (2)

Publication Number Publication Date
SK252001A3 SK252001A3 (en) 2001-07-10
SK286432B6 true SK286432B6 (sk) 2008-10-07

Family

ID=20432301

Family Applications (1)

Application Number Title Priority Date Filing Date
SK25-2001A SK286432B6 (sk) 1998-07-13 1999-07-12 Spôsob syntézy 5-metoxy-2-[(4-metoxy-3,5-dimetyl-2- pyridyl)metyl]sulfinyl-1H-benzimidazolu

Country Status (13)

Country Link
US (2) US6268502B1 (fr)
EP (1) EP1095037B2 (fr)
AT (1) ATE216382T1 (fr)
AU (1) AU4671499A (fr)
CZ (1) CZ293653B6 (fr)
DE (1) DE69901307D1 (fr)
HU (1) HUP0102523A2 (fr)
NZ (1) NZ509000A (fr)
PL (1) PL202167B1 (fr)
RU (1) RU2197486C2 (fr)
SI (2) SI20019A (fr)
SK (1) SK286432B6 (fr)
WO (1) WO2000002876A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
CN1781918A (zh) * 2001-02-02 2006-06-07 特瓦制药工业有限公司 制备硫酯化合物的方法
SI20875A (sl) * 2001-04-25 2002-10-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristalna oblika omeprazola
CA2450433C (fr) * 2001-07-16 2010-05-25 Janssen Pharmaceutica N.V. Procede ameliore de preparation de composes de type benzimidazole
KR100873419B1 (ko) * 2002-06-18 2008-12-11 페어차일드코리아반도체 주식회사 높은 항복 전압, 낮은 온 저항 및 작은 스위칭 손실을갖는 전력용 반도체 소자
EP1764364A1 (fr) * 2002-08-21 2007-03-21 Teva Pharmaceutical Industries Ltd Une méthode pour la purification de lansoprazole
ATE375338T1 (de) * 2002-08-21 2007-10-15 Teva Pharma Verfahren zur aufreinigung von lanzoprazol
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
DE03789888T1 (de) * 2002-11-18 2005-08-18 Teva Pharmaceutical Industries Ltd. Stabiles lansoprazol, enthaltend mehr als 500 ppm bis zu 3000 ppm wasser und mehr als 200 ppm bis zu 5000 ppm alkohol
EP1743893A1 (fr) * 2002-11-18 2007-01-17 Teva Pharmaceutical Industries Ltd. Lansoprazole stable contenant plus de 500 parties par million, jusqu'à environ 3000 parties par million d'eau et plus de 200 parties par million, jusqu'à environ 5000 parties par million d'alcool
US7678816B2 (en) * 2003-02-05 2010-03-16 Teva Pharmaceutical Industries Ltd. Method of stabilizing lansoprazole
US7915422B2 (en) * 2004-10-11 2011-03-29 Ranbaxy Laboratories Limited Processes for the preparation of substituted sulfoxides
EP1801110A1 (fr) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Sel d'arginine d'ésoméprazole

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
SE510666C2 (sv) 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
UA72748C2 (en) * 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole

Also Published As

Publication number Publication date
US6268502B1 (en) 2001-07-31
SK252001A3 (en) 2001-07-10
NZ509000A (en) 2001-12-21
DE69901307D1 (de) 2002-05-23
WO2000002876A1 (fr) 2000-01-20
RU2197486C2 (ru) 2003-01-27
HUP0102523A2 (hu) 2001-11-28
PL202167B1 (pl) 2009-06-30
CZ2001123A3 (en) 2001-05-16
SI1095037T2 (sl) 2007-10-31
PL345543A1 (en) 2001-12-17
US20020007069A1 (en) 2002-01-17
SI20019A (sl) 2000-02-29
EP1095037B2 (fr) 2007-08-08
AU4671499A (en) 2000-02-01
CZ293653B6 (cs) 2004-06-16
EP1095037A1 (fr) 2001-05-02
SI1095037T1 (en) 2002-08-31
ATE216382T1 (de) 2002-05-15
EP1095037B1 (fr) 2002-04-17

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20140712