SI20019A - Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola - Google Patents

Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola Download PDF

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Publication number
SI20019A
SI20019A SI9800196A SI9800196A SI20019A SI 20019 A SI20019 A SI 20019A SI 9800196 A SI9800196 A SI 9800196A SI 9800196 A SI9800196 A SI 9800196A SI 20019 A SI20019 A SI 20019A
Authority
SI
Slovenia
Prior art keywords
methoxy
omeprazole
dimethyl
methyl
pyridyl
Prior art date
Application number
SI9800196A
Other languages
English (en)
Slovenian (sl)
Inventor
MILA� Nata�a HAFNER
Darja Jereb
Original Assignee
LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20432301&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI20019(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. filed Critical LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.
Priority to SI9800196A priority Critical patent/SI20019A/sl
Priority to EP99930107A priority patent/EP1095037B2/fr
Priority to HU0102523A priority patent/HUP0102523A2/hu
Priority to CZ2001123A priority patent/CZ293653B6/cs
Priority to NZ509000A priority patent/NZ509000A/en
Priority to SK25-2001A priority patent/SK286432B6/sk
Priority to PCT/SI1999/000020 priority patent/WO2000002876A1/fr
Priority to AU46714/99A priority patent/AU4671499A/en
Priority to RU2001103900/04A priority patent/RU2197486C2/ru
Priority to US09/463,651 priority patent/US6268502B1/en
Priority to AT99930107T priority patent/ATE216382T1/de
Priority to DE69901307T priority patent/DE69901307D1/de
Priority to PL345543A priority patent/PL202167B1/pl
Priority to SI9930057T priority patent/SI1095037T2/sl
Publication of SI20019A publication Critical patent/SI20019A/sl
Priority to US09/919,068 priority patent/US20020007069A1/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00Formation or introduction of functional groups containing oxygen
    • C07B41/06Formation or introduction of functional groups containing oxygen of carbonyl groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI9800196A 1998-07-13 1998-07-13 Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola SI20019A (sl)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SI9800196A SI20019A (sl) 1998-07-13 1998-07-13 Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
SI9930057T SI1095037T2 (sl) 1998-07-13 1999-07-12 Postopek za pripravo 5-metoksi-2-((4-metoksi-3,5-dimetil-2-piridil)metil)sulfinil-1H- benzimidazola
PCT/SI1999/000020 WO2000002876A1 (fr) 1998-07-13 1999-07-12 Procede ameliore de synthese de 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl-1h-benzimidazole
RU2001103900/04A RU2197486C2 (ru) 1998-07-13 1999-07-12 Усовершенствованный способ синтеза 5-метокси-2-[(4-метокси-3,5-диметил-2-пиридил)метил]сульфинил-1н-бензимидазола
CZ2001123A CZ293653B6 (cs) 1998-07-13 1999-07-12 Zlepšený způsob syntézy 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl-1H-benzimidazolu
NZ509000A NZ509000A (en) 1998-07-13 1999-07-12 A process of synthesis of 5-methoxy-2-[(4-methoxy- 3,5-dimethyl- 2-pyridyl)methyl]sulfinyl-1H-benzimidazole using ethyl acetate as a solvent
SK25-2001A SK286432B6 (sk) 1998-07-13 1999-07-12 Spôsob syntézy 5-metoxy-2-[(4-metoxy-3,5-dimetyl-2- pyridyl)metyl]sulfinyl-1H-benzimidazolu
EP99930107A EP1095037B2 (fr) 1998-07-13 1999-07-12 Procede de synthese de 5-methoxy-2- (4-methoxy-3,5-dimethyl-2-pyridyl)methyl|sulfinyl-1h-benzimidazole
AU46714/99A AU4671499A (en) 1998-07-13 1999-07-12 Improved process of synthesis of 5-methoxy- 2-((4-methoxy- 3,5-dimethyl- 2-pyridyl)methyl)sulfinyl-1h-benzimidazole
HU0102523A HUP0102523A2 (hu) 1998-07-13 1999-07-12 Javított eljárás 5-metoxi-2-[(4-metoxi-3,5-dimetil-2-piridil)-metil]-szulfinil-1H-benzimidazol előállítására
US09/463,651 US6268502B1 (en) 1998-07-13 1999-07-12 Process of synthesis of 5-methoxy- 2-[(4-methoxy-3,5-dimethy-2-pyridyl)methyl]sulfiny-1h-benzimidazole
AT99930107T ATE216382T1 (de) 1998-07-13 1999-07-12 Verfahren zur herstellung von 5-methoxy-2-((4- methoxy-3,5-dimethyl-2-pyrydyl)methyl)sulfinyl- h-benzimidazol
DE69901307T DE69901307D1 (de) 1998-07-13 1999-07-12 Verfahren zur herstellung von 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyrydyl)methyl]sulfinyl-1h-benzimidazol
PL345543A PL202167B1 (pl) 1998-07-13 1999-07-12 Ulepszony sposób wytwarzania 5-metoksy-2-[(4-metoksy-3,5-dimetylo-2-pirydylo)metylo]sulfinylo-1H-benzimidazolu
US09/919,068 US20020007069A1 (en) 1998-07-13 2001-07-30 Process of synthesis of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl] sulfinyl-1 H-benzimidazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9800196A SI20019A (sl) 1998-07-13 1998-07-13 Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola

Publications (1)

Publication Number Publication Date
SI20019A true SI20019A (sl) 2000-02-29

Family

ID=20432301

Family Applications (2)

Application Number Title Priority Date Filing Date
SI9800196A SI20019A (sl) 1998-07-13 1998-07-13 Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
SI9930057T SI1095037T2 (sl) 1998-07-13 1999-07-12 Postopek za pripravo 5-metoksi-2-((4-metoksi-3,5-dimetil-2-piridil)metil)sulfinil-1H- benzimidazola

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI9930057T SI1095037T2 (sl) 1998-07-13 1999-07-12 Postopek za pripravo 5-metoksi-2-((4-metoksi-3,5-dimetil-2-piridil)metil)sulfinil-1H- benzimidazola

Country Status (13)

Country Link
US (2) US6268502B1 (fr)
EP (1) EP1095037B2 (fr)
AT (1) ATE216382T1 (fr)
AU (1) AU4671499A (fr)
CZ (1) CZ293653B6 (fr)
DE (1) DE69901307D1 (fr)
HU (1) HUP0102523A2 (fr)
NZ (1) NZ509000A (fr)
PL (1) PL202167B1 (fr)
RU (1) RU2197486C2 (fr)
SI (2) SI20019A (fr)
SK (1) SK286432B6 (fr)
WO (1) WO2000002876A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
MXPA03006904A (es) 2001-02-02 2004-12-06 Teva Pharma Procesos para la produccion de 2-(2-piridilmetil) sulfinil - 1h - bencimidazoles sustituidos.
SI20875A (sl) 2001-04-25 2002-10-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristalna oblika omeprazola
EP1409478B1 (fr) 2001-07-16 2006-03-29 Janssen Pharmaceutica N.V. Procede ameliore de preparation de composes de type benzimidazole
KR100873419B1 (ko) * 2002-06-18 2008-12-11 페어차일드코리아반도체 주식회사 높은 항복 전압, 낮은 온 저항 및 작은 스위칭 손실을갖는 전력용 반도체 소자
EP1764364A1 (fr) * 2002-08-21 2007-03-21 Teva Pharmaceutical Industries Ltd Une méthode pour la purification de lansoprazole
AU2003258335A1 (en) * 2002-08-21 2004-03-11 Teva Pharmaceutical Industries Ltd. A method for the purification of lansoprazole
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
EP1743893A1 (fr) * 2002-11-18 2007-01-17 Teva Pharmaceutical Industries Ltd. Lansoprazole stable contenant plus de 500 parties par million, jusqu'à environ 3000 parties par million d'eau et plus de 200 parties par million, jusqu'à environ 5000 parties par million d'alcool
EP1465890B1 (fr) * 2002-11-18 2007-04-04 Teva Pharmaceutical Industries Ltd. Lansoprazole stable contenant plus de 500 parties par million, jusqu'a environ 3000 parties par million d'eau et plus de 200 parties par million, jusqu'a environ 5000 parties par million d'alcool
US7678816B2 (en) * 2003-02-05 2010-03-16 Teva Pharmaceutical Industries Ltd. Method of stabilizing lansoprazole
PL1802584T3 (pl) * 2004-10-11 2010-03-31 Ranbaxy Laboratories Ltd Sposób wytwarzania podstawionych sulfotlenków
EP1801110A1 (fr) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Sel d'arginine d'ésoméprazole

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
SE9002043D0 (sv) 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
SE510666C2 (sv) 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
UA72748C2 (en) * 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole

Also Published As

Publication number Publication date
EP1095037A1 (fr) 2001-05-02
WO2000002876A1 (fr) 2000-01-20
EP1095037B1 (fr) 2002-04-17
CZ2001123A3 (en) 2001-05-16
US6268502B1 (en) 2001-07-31
PL345543A1 (en) 2001-12-17
SK286432B6 (sk) 2008-10-07
SK252001A3 (en) 2001-07-10
PL202167B1 (pl) 2009-06-30
SI1095037T1 (en) 2002-08-31
DE69901307D1 (de) 2002-05-23
AU4671499A (en) 2000-02-01
CZ293653B6 (cs) 2004-06-16
RU2197486C2 (ru) 2003-01-27
SI1095037T2 (sl) 2007-10-31
US20020007069A1 (en) 2002-01-17
EP1095037B2 (fr) 2007-08-08
HUP0102523A2 (hu) 2001-11-28
ATE216382T1 (de) 2002-05-15
NZ509000A (en) 2001-12-21

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Effective date: 20080814