SK286155B6 - Spôsob prípravy vnútornej soli L-karnitínu, medziprodukty na jej prípravu a ich použitie - Google Patents

Spôsob prípravy vnútornej soli L-karnitínu, medziprodukty na jej prípravu a ich použitie Download PDF

Info

Publication number
SK286155B6
SK286155B6 SK1601-2001A SK16012001A SK286155B6 SK 286155 B6 SK286155 B6 SK 286155B6 SK 16012001 A SK16012001 A SK 16012001A SK 286155 B6 SK286155 B6 SK 286155B6
Authority
SK
Slovakia
Prior art keywords
reduction
carnitine
compound
inner salt
acid
Prior art date
Application number
SK1601-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK16012001A3 (sk
Inventor
Piero Melloni
Alberto Cerri
Marco Santagostino
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT1999RM000310 external-priority patent/IT1306142B1/it
Priority claimed from IT1999RM000670 external-priority patent/IT1306737B1/it
Priority claimed from IT2000RM000061 external-priority patent/IT1316989B1/it
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of SK16012001A3 publication Critical patent/SK16012001A3/sk
Publication of SK286155B6 publication Critical patent/SK286155B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
SK1601-2001A 1999-05-18 2000-05-12 Spôsob prípravy vnútornej soli L-karnitínu, medziprodukty na jej prípravu a ich použitie SK286155B6 (sk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT1999RM000310 IT1306142B1 (it) 1999-05-18 1999-05-18 Procedimento per la preparazione di r-(-)-carnitina a partiredall'acido s-(-)-clorosuccinico.
IT1999RM000670 IT1306737B1 (it) 1999-10-29 1999-10-29 Procedimento per la preparazione di acidi carbossilici chirali.
IT2000RM000061 IT1316989B1 (it) 2000-02-10 2000-02-10 Procedimento per la preparazione di r-(-)- carnitina a partire daacido s-(-)- clorosuccinico o da un suo derivato.
PCT/IT2000/000187 WO2000069808A1 (en) 1999-05-18 2000-05-12 Process for preparing r-(-)-carnitine from s-(-)-chlorosuccinic acid or from a derivative thereof

Publications (2)

Publication Number Publication Date
SK16012001A3 SK16012001A3 (sk) 2002-04-04
SK286155B6 true SK286155B6 (sk) 2008-04-07

Family

ID=27274166

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1601-2001A SK286155B6 (sk) 1999-05-18 2000-05-12 Spôsob prípravy vnútornej soli L-karnitínu, medziprodukty na jej prípravu a ich použitie

Country Status (19)

Country Link
US (3) US6677476B1 (enExample)
EP (2) EP1468979A1 (enExample)
JP (2) JP4584464B2 (enExample)
KR (2) KR100684379B1 (enExample)
CN (1) CN1158244C (enExample)
AT (1) ATE346838T1 (enExample)
AU (1) AU4612100A (enExample)
CA (1) CA2372424A1 (enExample)
CY (1) CY1107566T1 (enExample)
CZ (1) CZ20013816A3 (enExample)
DE (1) DE60032139T2 (enExample)
DK (1) DK1187805T3 (enExample)
ES (1) ES2277838T3 (enExample)
HU (1) HUP0201418A3 (enExample)
MX (1) MXPA01011758A (enExample)
PL (1) PL203993B1 (enExample)
PT (1) PT1187805E (enExample)
SK (1) SK286155B6 (enExample)
WO (1) WO2000069808A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI367882B (en) 2003-03-26 2012-07-11 Du Pont Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates
WO2007139238A1 (en) * 2006-05-26 2007-12-06 Enzytech, Ltd. Process for l-carnitine and acetyl l-carnitine hydrochloride
EP2096103A4 (en) 2006-11-09 2012-11-21 Mitsubishi Rayon Co PROCESS FOR PREPARING A BETAIN
EP2325164A1 (en) * 2009-11-18 2011-05-25 Lonza Ltd. Methods for the production of l-carnitine
US8310256B2 (en) 2009-12-22 2012-11-13 Teradyne, Inc. Capacitive opens testing in low signal environments
CN103003257B (zh) * 2010-07-21 2016-03-16 隆萨有限公司 用于由β-内酯生产肉碱的方法
KR101110206B1 (ko) * 2011-05-02 2012-02-15 송명호 개폐가 용이하도록 완충기가 구비된 진동선별장치
CN118638020B (zh) * 2024-08-08 2024-11-19 杭州海尔希畜牧科技有限公司 L-天门冬氨酸l(-)肉碱(1:1)的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45594A (en) * 1973-11-12 1977-12-30 Stauffer Chemical Co Bis-substituted succinamides and their use as herbicides
GB1513257A (en) * 1975-02-03 1978-06-07 Stauffer Chemical Co Bis-substituted succinamides and the use thereof as herbicides
US4265247A (en) * 1979-11-07 1981-05-05 Research Corporation Malic acid polymers
ZA826022B (en) * 1981-08-21 1983-08-31 Univ Miami Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
DE3144698A1 (de) * 1981-11-11 1983-05-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von hydantoinen
DE3144697A1 (de) * 1981-11-11 1983-05-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von hydantoinen
US5473104A (en) 1994-09-13 1995-12-05 Neurocrine Biosciences, Inc. Process for the preparation of L-carnitine
KR100255039B1 (ko) * 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법

Also Published As

Publication number Publication date
HUP0201418A2 (en) 2002-08-28
US7247747B2 (en) 2007-07-24
KR100684379B1 (ko) 2007-02-20
PL351646A1 (en) 2003-05-19
EP1187805A1 (en) 2002-03-20
CN1158244C (zh) 2004-07-21
ATE346838T1 (de) 2006-12-15
WO2000069808A1 (en) 2000-11-23
EP1468979A1 (en) 2004-10-20
ES2277838T3 (es) 2007-08-01
CY1107566T1 (el) 2013-03-13
DE60032139T2 (de) 2007-09-27
MXPA01011758A (es) 2002-05-14
KR20020009609A (ko) 2002-02-01
EP1187805B1 (en) 2006-11-29
PT1187805E (pt) 2007-01-31
CZ20013816A3 (cs) 2002-02-13
HUP0201418A3 (en) 2002-11-28
SK16012001A3 (sk) 2002-04-04
JP2002544252A (ja) 2002-12-24
US20040102645A1 (en) 2004-05-27
JP4584464B2 (ja) 2010-11-24
DK1187805T3 (da) 2007-04-16
US20050245762A1 (en) 2005-11-03
AU4612100A (en) 2000-12-05
KR20060114044A (ko) 2006-11-03
CN1352630A (zh) 2002-06-05
CA2372424A1 (en) 2000-11-23
DE60032139D1 (de) 2007-01-11
US6677476B1 (en) 2004-01-13
JP2010229157A (ja) 2010-10-14
KR100789468B1 (ko) 2008-01-02
US6984739B2 (en) 2006-01-10
PL203993B1 (pl) 2009-11-30

Similar Documents

Publication Publication Date Title
JP2010229157A (ja) Ｓ−（−）−クロロコハク酸またはその誘導体からｒ−（−）−カルニチンを調製するための方法
AU1808401A (en) Method for the stereoselective synthesis of cyclic amino acids
DK152752B (da) Fremgangsmaade til fremstilling af l-sulpirid
JP4568398B2 (ja) ヘキサヒドロイソインドリン・酸付加塩およびその使用方法
TW201711992A (zh) 製備拉科醯胺的方法
AU2016336891A1 (en) Industrial process for the preparation of (5S,10S)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (E)-3-carboxyacrylate salt
US4664852A (en) Process for the preparation of L-carnitine
EP1940387B1 (en) Process for the stereoselective preparation of (-)-halofenate and intermediates thereof
EP1554235B1 (en) Process for synthesizing l-y-methylene glutamic acid and analogs
JP5704763B2 (ja) トランス−４−アミノシクロペンタ−２−エン−１−カルボン酸誘導体の製造
CN115433133B (zh) 一种l-肌肽的合成方法
ITRM20000061A1 (it) Procedimento per la preparazione di r-(-)- carnitina a partire da acido s-(-)- clorosuccinico o da un suo derivato.
JP2014031372A (ja) 高純度ミチグリニドを調製するための効率的な方法
ITRM990310A1 (it) Procedimento per la preparazione di r-(-)-carnitina a partire dall'acido s-(-)-clorosuccinico.
HK1259577A1 (en) Industrial process for the preparation of (5s,10s)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (e)-3-carboxyacrylate salt
HK1259577B (en) Industrial process for the preparation of (5s,10s)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (e)-3-carboxyacrylate salt
HK1119953B (en) Process for the stereoselective preparation of (-)-halofenate and intermediates thereof
JP2003342267A (ja) エポキシブタン酸エステル類の製造方法

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20110512