SK285128B6 - Liečivý prípravok s riadeným uvoľňovaním obsahujúci tramadol hydrochlorid a spôsob jeho prípravy - Google Patents
Liečivý prípravok s riadeným uvoľňovaním obsahujúci tramadol hydrochlorid a spôsob jeho prípravy Download PDFInfo
- Publication number
- SK285128B6 SK285128B6 SK1868-99A SK186899A SK285128B6 SK 285128 B6 SK285128 B6 SK 285128B6 SK 186899 A SK186899 A SK 186899A SK 285128 B6 SK285128 B6 SK 285128B6
- Authority
- SK
- Slovakia
- Prior art keywords
- weight
- amount
- controlled release
- tramadol hydrochloride
- preparation
- Prior art date
Links
- PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 24
- 229960003107 tramadol hydrochloride Drugs 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 238000013270 controlled release Methods 0.000 title claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 35
- 239000004480 active ingredient Substances 0.000 claims abstract description 18
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims abstract description 14
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 12
- 239000000194 fatty acid Substances 0.000 claims abstract description 12
- 229930195729 fatty acid Natural products 0.000 claims abstract description 12
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 11
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 8
- 229910052814 silicon oxide Inorganic materials 0.000 claims abstract description 8
- 229920000642 polymer Polymers 0.000 claims abstract description 7
- LIVNPJMFVYWSIS-UHFFFAOYSA-N silicon monoxide Chemical class [Si-]#[O+] LIVNPJMFVYWSIS-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000000126 substance Substances 0.000 claims abstract description 7
- 150000001447 alkali salts Chemical class 0.000 claims abstract description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 10
- 150000003839 salts Chemical class 0.000 claims abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000002245 particle Substances 0.000 claims description 22
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims description 20
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 16
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 14
- -1 phosphoric acid alkali salts Chemical class 0.000 claims description 13
- 235000021357 Behenic acid Nutrition 0.000 claims description 10
- 229940116226 behenic acid Drugs 0.000 claims description 10
- KFEVDPWXEVUUMW-UHFFFAOYSA-N docosanoic acid Natural products CCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(O)C=C1 KFEVDPWXEVUUMW-UHFFFAOYSA-N 0.000 claims description 10
- POULHZVOKOAJMA-UHFFFAOYSA-N methyl undecanoic acid Natural products CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 10
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 claims description 9
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 9
- 239000013543 active substance Substances 0.000 claims description 8
- 235000019441 ethanol Nutrition 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 229910052783 alkali metal Inorganic materials 0.000 claims description 7
- 229920000831 ionic polymer Polymers 0.000 claims description 7
- 125000005908 glyceryl ester group Chemical group 0.000 claims description 5
- 239000008119 colloidal silica Substances 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 3
- 150000001340 alkali metals Chemical class 0.000 claims 3
- 229940126601 medicinal product Drugs 0.000 claims 2
- 150000003016 phosphoric acids Chemical class 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 21
- 150000002148 esters Chemical class 0.000 abstract description 3
- 229910052751 metal Inorganic materials 0.000 abstract description 2
- 239000002184 metal Substances 0.000 abstract description 2
- 150000002739 metals Chemical class 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 37
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 description 7
- 229960004380 tramadol Drugs 0.000 description 7
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 7
- 238000004090 dissolution Methods 0.000 description 5
- 239000012738 dissolution medium Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000825 pharmaceutical preparation Substances 0.000 description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 239000002552 dosage form Substances 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 235000014443 Pyrus communis Nutrition 0.000 description 2
- 239000012052 hydrophilic carrier Substances 0.000 description 2
- 239000012051 hydrophobic carrier Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229940057305 dihydrate calcium phosphate Drugs 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 208000023589 ischemic disease Diseases 0.000 description 1
- 201000002818 limb ischemia Diseases 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000007912 modified release tablet Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SK1868-99A SK285128B6 (sk) | 1999-12-28 | 1999-12-28 | Liečivý prípravok s riadeným uvoľňovaním obsahujúci tramadol hydrochlorid a spôsob jeho prípravy |
| TW089125229A TWI221419B (en) | 1999-12-28 | 2000-11-28 | Controlled release-pharmaceutical composition containing tramadol hydrochloride and method for its preparation |
| AT00987947T ATE324103T1 (de) | 1999-12-28 | 2000-12-20 | Arzneizubereitung mit kontrollierter freisetzung enthaltend tramadol hydrochlorid |
| HU0203842A HUP0203842A3 (en) | 1999-12-28 | 2000-12-20 | Controlled release pharmaceutical composition containing tramadol hydrochloride and method for its preparation |
| AU24216/01A AU2421601A (en) | 1999-12-28 | 2000-12-20 | Controlled release pharmaceutical composition containing tramadol hydrochloride and method for its preparation |
| PT00987947T PT1255535E (pt) | 1999-12-28 | 2000-12-20 | Composicao farmaceutica de libertacao controlada contendo cloridrato de tramadol |
| US10/168,967 US20030175343A1 (en) | 1999-12-28 | 2000-12-20 | Controlled release pharmaceutical composition containing tramadol hydrochloride |
| GE4852A GEP20053532B (en) | 1999-12-28 | 2000-12-20 | Controlled Release Pharmaceutical Composition Containing Tramadol Hydrochloride |
| EEP200200368A EE05231B1 (et) | 1999-12-28 | 2000-12-20 | Tramadoolvesinikkloriidi sisaldav toimeainet reguleeritult vabastav ravimkoostis ja meetod selle valmistamiseks |
| EP00987947A EP1255535B1 (en) | 1999-12-28 | 2000-12-20 | Controlled release pharmaceutical composition containing tramadol hydrochloride |
| UA2002076286A UA76411C2 (en) | 1999-12-28 | 2000-12-20 | Controlled release pharmaceutical composition containing tramadol hydrochloride and method for its preparation |
| JP2001548092A JP2003518486A (ja) | 1999-12-28 | 2000-12-20 | トラマドール・ハイドロクロライドを含む放出の調整された医薬組成物およびその調製方法 |
| CZ20022371A CZ297394B6 (cs) | 1999-12-28 | 2000-12-20 | Lécivý prípravek s rízeným uvolnováním obsahujícítramadol hydrochlorid a zpusob jeho prípravy |
| EA200200720A EA006438B1 (ru) | 1999-12-28 | 2000-12-20 | Фармацевтическая композиция с контролируемым высвобождением, содержащая гидрохлорид трамадола, и способ ее получения |
| DK00987947T DK1255535T3 (da) | 1999-12-28 | 2000-12-20 | Lægemiddelsammensætning med kontrolleret frisætning indeholdende tramadol-hydrochlorid |
| PL357680A PL208096B1 (pl) | 1999-12-28 | 2000-12-20 | Kompozycja farmaceutyczna o kontrolowanym uwalnianiu zawierająca chlorowodorek tramadolu i sposób jej wytwarzania |
| CA002397942A CA2397942C (en) | 1999-12-28 | 2000-12-20 | Controlled release pharmaceutical composition containing tramadol hydrochloride and method for its preparation |
| PCT/SK2000/000027 WO2001047497A2 (en) | 1999-12-28 | 2000-12-20 | Controlled release pharmaceutical composition containing tramadol hydrochloride |
| SI200030873T SI1255535T1 (sl) | 1999-12-28 | 2000-12-20 | Farmacevtski sestavek s kontroliranim sproscanjem, ki vsebuje tramadol hidroklorid |
| ES00987947T ES2266018T3 (es) | 1999-12-28 | 2000-12-20 | Composicion farmaceutica de liberacion controlada, que contiene hidrocloruro de tramadol. |
| DE60027601T DE60027601T2 (de) | 1999-12-28 | 2000-12-20 | Arzneizubereitung mit kontrollierter freisetzung enthaltend tramadol hydrochlorid |
| LT2002078A LT5033B (lt) | 1999-12-28 | 2002-07-02 | Kontroliuojamo išsiskyrimo farmacinė kompozicija, turinti tramadolo hidrochlorido, ir jos paruošimo būdas |
| BG106952A BG65713B1 (bg) | 1999-12-28 | 2002-07-25 | Фармацевтичен състав с контролирано освобождаване, съдържащ трамадол хидрохлорид, и метод за неговото получаване |
| LVP-02-137A LV12917B (en) | 1999-12-28 | 2002-07-26 | Controlled release pharmaceutical composition containing tramadol hydrochloride and method for its preparation |
| CY20061101035T CY1106127T1 (el) | 1999-12-28 | 2006-07-26 | Φαρμακευτικη συσταση ελεγχομενης αποδεσμευσης που πepιεχει υδροχλωρικη τραμαδολη |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SK1868-99A SK285128B6 (sk) | 1999-12-28 | 1999-12-28 | Liečivý prípravok s riadeným uvoľňovaním obsahujúci tramadol hydrochlorid a spôsob jeho prípravy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK186899A3 SK186899A3 (en) | 2001-07-10 |
| SK285128B6 true SK285128B6 (sk) | 2006-07-07 |
Family
ID=20434830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1868-99A SK285128B6 (sk) | 1999-12-28 | 1999-12-28 | Liečivý prípravok s riadeným uvoľňovaním obsahujúci tramadol hydrochlorid a spôsob jeho prípravy |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20030175343A1 (cs) |
| EP (1) | EP1255535B1 (cs) |
| JP (1) | JP2003518486A (cs) |
| AT (1) | ATE324103T1 (cs) |
| AU (1) | AU2421601A (cs) |
| BG (1) | BG65713B1 (cs) |
| CA (1) | CA2397942C (cs) |
| CY (1) | CY1106127T1 (cs) |
| CZ (1) | CZ297394B6 (cs) |
| DE (1) | DE60027601T2 (cs) |
| DK (1) | DK1255535T3 (cs) |
| EA (1) | EA006438B1 (cs) |
| EE (1) | EE05231B1 (cs) |
| ES (1) | ES2266018T3 (cs) |
| GE (1) | GEP20053532B (cs) |
| HU (1) | HUP0203842A3 (cs) |
| LT (1) | LT5033B (cs) |
| LV (1) | LV12917B (cs) |
| PL (1) | PL208096B1 (cs) |
| PT (1) | PT1255535E (cs) |
| SI (1) | SI1255535T1 (cs) |
| SK (1) | SK285128B6 (cs) |
| TW (1) | TWI221419B (cs) |
| UA (1) | UA76411C2 (cs) |
| WO (1) | WO2001047497A2 (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050182056A9 (en) * | 2002-02-21 | 2005-08-18 | Seth Pawan | Modified release formulations of at least one form of tramadol |
| US8128957B1 (en) | 2002-02-21 | 2012-03-06 | Valeant International (Barbados) Srl | Modified release compositions of at least one form of tramadol |
| SK286107B6 (sk) * | 2002-04-12 | 2008-03-05 | Zentiva, A. S. | Analgeticky účinný perorálny liečivý prípravok s kontrolovaným uvoľňovaním opioidnej účinnej látky a spôsob jeho prípravy |
| DE10245623A1 (de) * | 2002-09-30 | 2004-04-08 | Clariant Gmbh | Ester und Partialester aus mehrwertigen Alkoholen |
| ATE442158T1 (de) * | 2003-07-11 | 2009-09-15 | Novartis Pharma Gmbh | Oral verabreichte pharmazeutische zusammensetzungen mit einem abgabemittel in mikronisierter form |
| CA2653684C (en) * | 2006-06-09 | 2012-05-08 | Innophos, Inc. | Calcium fortification substance for clear beverages |
| US20100143573A1 (en) * | 2006-06-09 | 2010-06-10 | John Godber | Mineral fortification substance for clear beverages |
| DE102006044694A1 (de) * | 2006-09-22 | 2008-03-27 | Krewel Meuselbach Gmbh | Perorale feste Schmerzmittelzubereitung |
| US20100003322A1 (en) * | 2008-07-03 | 2010-01-07 | Lai Felix S | Enteric coated hydrophobic matrix formulation |
| KR102237799B1 (ko) | 2012-11-14 | 2021-04-08 | 더블유.알. 그레이스 앤드 캄파니-콘. | 생물학적 활성 물질 및 비-정렬된 무기 산화물을 함유하는 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL119660A (en) | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
| DE4329794C2 (de) * | 1993-09-03 | 1997-09-18 | Gruenenthal Gmbh | Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung |
| ATE212224T1 (de) | 1993-11-23 | 2002-02-15 | Euro Celtique Sa | Verfahren zur herstellung einer arzneizusammensetzung mit verzögerter wirkstoffabgabe |
| DE4343993A1 (de) * | 1993-12-22 | 1995-06-29 | Stockhausen Chem Fab Gmbh | Pfropf-Copolymerisate von ungesättigten Monomeren und Polyhydroxyverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung |
| FR2753904B1 (fr) * | 1996-10-01 | 1998-10-30 | Gattefosse Ets Sa | Composition pharmaceutique a liberation modifiee de principe actif, comportant une matrice, et procede de fabrication |
| US5980941A (en) * | 1997-08-20 | 1999-11-09 | Fuisz Technologies Ltd. | Self-binding shearform compositions |
| DE19901683B4 (de) * | 1999-01-18 | 2005-07-21 | Grünenthal GmbH | Analgetikum mit kontrollierter Wirkstofffreisetzung |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
-
1999
- 1999-12-28 SK SK1868-99A patent/SK285128B6/sk not_active IP Right Cessation
-
2000
- 2000-11-28 TW TW089125229A patent/TWI221419B/zh not_active IP Right Cessation
- 2000-12-20 ES ES00987947T patent/ES2266018T3/es not_active Expired - Lifetime
- 2000-12-20 DE DE60027601T patent/DE60027601T2/de not_active Expired - Fee Related
- 2000-12-20 DK DK00987947T patent/DK1255535T3/da active
- 2000-12-20 AT AT00987947T patent/ATE324103T1/de not_active IP Right Cessation
- 2000-12-20 HU HU0203842A patent/HUP0203842A3/hu unknown
- 2000-12-20 AU AU24216/01A patent/AU2421601A/en not_active Abandoned
- 2000-12-20 PT PT00987947T patent/PT1255535E/pt unknown
- 2000-12-20 PL PL357680A patent/PL208096B1/pl unknown
- 2000-12-20 CA CA002397942A patent/CA2397942C/en not_active Expired - Lifetime
- 2000-12-20 US US10/168,967 patent/US20030175343A1/en not_active Abandoned
- 2000-12-20 WO PCT/SK2000/000027 patent/WO2001047497A2/en not_active Ceased
- 2000-12-20 UA UA2002076286A patent/UA76411C2/uk unknown
- 2000-12-20 CZ CZ20022371A patent/CZ297394B6/cs not_active IP Right Cessation
- 2000-12-20 SI SI200030873T patent/SI1255535T1/sl unknown
- 2000-12-20 JP JP2001548092A patent/JP2003518486A/ja active Pending
- 2000-12-20 EP EP00987947A patent/EP1255535B1/en not_active Expired - Lifetime
- 2000-12-20 GE GE4852A patent/GEP20053532B/en unknown
- 2000-12-20 EE EEP200200368A patent/EE05231B1/xx unknown
- 2000-12-20 EA EA200200720A patent/EA006438B1/ru not_active IP Right Cessation
-
2002
- 2002-07-02 LT LT2002078A patent/LT5033B/lt not_active IP Right Cessation
- 2002-07-25 BG BG106952A patent/BG65713B1/bg unknown
- 2002-07-26 LV LVP-02-137A patent/LV12917B/en unknown
-
2006
- 2006-07-26 CY CY20061101035T patent/CY1106127T1/el unknown
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| Date | Code | Title | Description |
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| MK4A | Expiry of patent |
Expiry date: 20191228 |