SK284810B6 - Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu - Google Patents

Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu Download PDF

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Publication number
SK284810B6
SK284810B6 SK589-98A SK58998A SK284810B6 SK 284810 B6 SK284810 B6 SK 284810B6 SK 58998 A SK58998 A SK 58998A SK 284810 B6 SK284810 B6 SK 284810B6
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SK
Slovakia
Prior art keywords
amino
cyclopentene
carried out
process according
formula
Prior art date
Application number
SK589-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK58998A3 (en
Inventor
Christine Bernegger
Eva Maria Urban
Olwen Mary Birch
Kurt Burgdorf
Frank Brux
Kay-Sara Etter
Pierre Bossard
Walter Brieden
Laurent Duc
John Gordon
Murchu Colm O'
Yves Guggisberg
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of SK58998A3 publication Critical patent/SK58998A3/sk
Publication of SK284810B6 publication Critical patent/SK284810B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK589-98A 1997-05-13 1998-05-04 Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu SK284810B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH111697 1997-05-13
CH274097 1997-11-27

Publications (2)

Publication Number Publication Date
SK58998A3 SK58998A3 (en) 1998-12-02
SK284810B6 true SK284810B6 (sk) 2005-12-01

Family

ID=25686703

Family Applications (3)

Application Number Title Priority Date Filing Date
SK53-2005A SK285228B6 (sk) 1997-05-13 1998-05-04 Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén
SK54-2005A SK285229B6 (sk) 1997-05-13 1998-05-04 Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu
SK589-98A SK284810B6 (sk) 1997-05-13 1998-05-04 Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SK53-2005A SK285228B6 (sk) 1997-05-13 1998-05-04 Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén
SK54-2005A SK285229B6 (sk) 1997-05-13 1998-05-04 Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu

Country Status (17)

Country Link
US (4) US6156893A (zh)
EP (2) EP1502914A1 (zh)
JP (3) JP4540136B2 (zh)
KR (2) KR100577886B1 (zh)
CN (2) CN1302116C (zh)
AT (1) ATE275206T1 (zh)
CA (1) CA2237297C (zh)
CZ (3) CZ297894B6 (zh)
DE (1) DE59811884D1 (zh)
DK (1) DK0878548T3 (zh)
ES (1) ES2223095T3 (zh)
HK (1) HK1092782A1 (zh)
HU (1) HU226327B1 (zh)
NO (1) NO324679B1 (zh)
PL (1) PL197848B1 (zh)
PT (1) PT878548E (zh)
SK (3) SK285228B6 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0705263T3 (da) * 1993-06-21 1997-05-05 Merrell Pharma Inc Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner
GB9717928D0 (en) * 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams
GB9721780D0 (en) * 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
SK284596B6 (sk) * 1997-11-27 2005-07-01 Lonza Ag Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purin-9-yl)-2-cyklopentén-1-metanolu alebo jeho solí
PL196857B1 (pl) * 1998-12-23 2008-02-29 Lonza Ag Sposób wytwarzania enancjomerycznie wzbogaconych pochodnych 1-amino-4- (hydroksymetylo)-cyklopent-2-enu oraz 1-amino-4-(hydroksymetylo)-cyklopent-2-enów
KR101120813B1 (ko) * 2003-07-25 2012-03-23 프로메틱 바이오사이언시즈 인코포레이티드 중-쇄 지방산 금속염의 제조 방법
DE102005061756B4 (de) * 2005-12-21 2008-01-03 Sanofi-Aventis Deutschland Gmbh Verbessertes Verfahren zur Herstellung von Ramipril
US8236853B1 (en) 2007-12-03 2012-08-07 University Of South Florida Formation of cyclopentene nitro-ester and derivatives
WO2012099904A1 (en) 2011-01-18 2012-07-26 General Atomics Hydrolase enzyme substrates and uses thereof
CN102557990B (zh) * 2011-04-25 2014-06-25 开原亨泰制药股份有限公司 (1s，4r)n-叔丁氧羰基-4-氨基-2-环戊烯-1-羧酸甲酯的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931559A (en) * 1988-01-20 1990-06-05 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US4950758A (en) * 1988-01-20 1990-08-21 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
CA2055086A1 (en) * 1991-02-12 1992-08-13 Chikara Kaneko Cyclopentene derivatives and their use
US5200527A (en) * 1991-04-08 1993-04-06 Lonza Ltd. Process for the production of 2-azabicyclo [2.2.1] hept-5-en-3-one
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
GB9217823D0 (en) * 1992-08-21 1992-10-07 Glaxo Group Ltd Chemical process
JPH06116217A (ja) * 1992-10-02 1994-04-26 Kuraray Co Ltd （±）−シス−４−アミノシクロペント−２−エンカルボン酸誘導体の光学分割法
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
ATE283348T1 (de) * 1996-05-30 2004-12-15 Lonza Ag Verfahren zur herstellung von aminoalkoholen und derivaten davon
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers

Also Published As

Publication number Publication date
SK285229B6 (sk) 2006-09-07
JP4540136B2 (ja) 2010-09-08
NO982149L (no) 1998-11-16
HUP9801083A3 (en) 2001-09-28
DE59811884D1 (de) 2004-10-07
EP1502914A1 (de) 2005-02-02
EP0878548A2 (de) 1998-11-18
EP0878548A3 (de) 1999-10-13
CZ297894B6 (cs) 2007-04-25
HK1092782A1 (en) 2007-02-16
US6252112B1 (en) 2001-06-26
CZ145898A3 (cs) 1998-12-16
EP0878548B1 (de) 2004-09-01
ES2223095T3 (es) 2005-02-16
KR19980086933A (ko) 1998-12-05
CN1515673A (zh) 2004-07-28
DK0878548T3 (da) 2004-12-06
CA2237297A1 (en) 1998-11-13
JPH115793A (ja) 1999-01-12
ATE275206T1 (de) 2004-09-15
PL326267A1 (en) 1998-11-23
CN1115343C (zh) 2003-07-23
KR100601764B1 (ko) 2006-07-19
SK58998A3 (en) 1998-12-02
KR100577886B1 (ko) 2006-08-30
NO982149D0 (no) 1998-05-12
US6137007A (en) 2000-10-24
US6262295B1 (en) 2001-07-17
HUP9801083A2 (hu) 1999-11-29
PT878548E (pt) 2005-01-31
CN1201794A (zh) 1998-12-16
CZ297888B6 (cs) 2007-04-18
PL197848B1 (pl) 2008-05-30
JP2010116397A (ja) 2010-05-27
US6156893A (en) 2000-12-05
NO324679B1 (no) 2007-12-03
CN1302116C (zh) 2007-02-28
CA2237297C (en) 2008-03-11
HU9801083D0 (en) 1998-07-28
HU226327B1 (en) 2008-08-28
JP2010106025A (ja) 2010-05-13
CZ297887B6 (cs) 2007-04-18
SK285228B6 (sk) 2006-09-07

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20120504