US6576636B2
(en)
*
|
1996-05-22 |
2003-06-10 |
Protarga, Inc. |
Method of treating a liver disorder with fatty acid-antiviral agent conjugates
|
US6326507B1
(en)
|
1998-06-19 |
2001-12-04 |
Trustees Of Dartmouth College |
Therapeutic compounds and methods of use
|
US7435755B2
(en)
|
2000-11-28 |
2008-10-14 |
The Trustees Of Dartmouth College |
CDDO-compounds and combination therapies thereof
|
WO2002076402A2
(en)
*
|
2001-03-23 |
2002-10-03 |
Protarga, Inc. |
Fatty amine drug conjugates
|
ES2312568T3
(es)
*
|
2001-04-06 |
2009-03-01 |
Wyeth |
Combinaciones antineoplasicas que comprenden cci-779 (derivado de rapamicina) junto con gemcitabina o fluoruracilo.
|
US7176237B2
(en)
|
2002-01-15 |
2007-02-13 |
The Trustees Of Dartmouth College |
Tricyclic-bis-enone derivatives and methods of use thereof
|
EP1567169A4
(en)
|
2002-11-04 |
2009-10-21 |
Xenoport Inc |
GEMCITABINE PROMOTERS, THEIR PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
|
US20050234009A1
(en)
*
|
2004-03-29 |
2005-10-20 |
Johnson Candace S |
Method of treating solid tumors and leukemias using combination therapy of vitamin D and anti-metabolic nucleoside analogs
|
FR2874016B1
(fr)
*
|
2004-06-30 |
2006-11-24 |
Centre Nat Rech Scient Cnrse |
Nanoparticules de derives de la gemcitabine
|
KR100699099B1
(ko)
*
|
2004-07-29 |
2007-03-22 |
한미약품 주식회사 |
1-α-할로-2,2-다이플루오로-2-데옥시-D-라이보퓨라노스유도체 및 이의 제조방법
|
WO2006029081A2
(en)
*
|
2004-09-02 |
2006-03-16 |
Neopharm, Inc. |
Nucleoside-lipid conjugates, their method of preparation and uses thereof
|
GB0420722D0
(en)
|
2004-09-17 |
2004-10-20 |
Addex Pharmaceuticals Sa |
Novel allosteric modulators
|
BRPI0519117A2
(pt)
*
|
2004-12-17 |
2008-12-23 |
Lilly Co Eli |
composto, composiÇço farmacÊutica, mÉtodo para tratar neoplasmas suscetÍveis em um mamÍfero, e, uso de um composto
|
NO322682B1
(no)
*
|
2005-03-18 |
2006-11-27 |
Clavis Pharma Asa |
Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer
|
KR100680765B1
(ko)
*
|
2005-04-28 |
2007-02-09 |
주식회사 삼천리제약 |
3'-아미노-2',3'-디데옥시구아노신의 제조 방법
|
NO324263B1
(no)
*
|
2005-12-08 |
2007-09-17 |
Clavis Pharma Asa |
Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
|
US8497292B2
(en)
|
2005-12-28 |
2013-07-30 |
Translational Therapeutics, Inc. |
Translational dysfunction based therapeutics
|
EP1994042A4
(en)
*
|
2006-02-06 |
2009-03-18 |
Reddys Lab Ltd Dr |
PREPARATION OF GEMCITABINE
|
AR059898A1
(es)
|
2006-03-15 |
2008-05-07 |
Janssen Pharmaceutica Nv |
Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
|
CN101448504B
(zh)
*
|
2006-06-21 |
2012-04-11 |
伊莱利利公司 |
吉西他滨酰胺前体药物的结晶形式、其组合物以及用途
|
WO2008064132A2
(en)
|
2006-11-17 |
2008-05-29 |
Trustees Of Dartmouth College |
Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
|
US8921340B2
(en)
|
2006-11-17 |
2014-12-30 |
Trustees Of Dartmouth College |
Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
|
US7714012B2
(en)
|
2006-11-17 |
2010-05-11 |
Trustees Of Dartmouth University |
Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
|
TW200845978A
(en)
|
2007-03-07 |
2008-12-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
|
TW200900065A
(en)
|
2007-03-07 |
2009-01-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
|
KR100957756B1
(ko)
*
|
2007-12-12 |
2010-05-12 |
동우신테크 주식회사 |
2'-데옥시-2',2'-다이플루오로사이티딘의 제조 방법
|
KR20100065191A
(ko)
|
2007-09-14 |
2010-06-15 |
오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 |
1,3-이치환된 4-(아릴-x-페닐)-1h-피리딘-2-온
|
CN101801951B
(zh)
|
2007-09-14 |
2013-11-13 |
杨森制药有限公司 |
1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮
|
AU2008304380A1
(en)
*
|
2007-09-26 |
2009-04-02 |
Mount Sinai School Of Medicine |
Azacytidine analogues and uses thereof
|
ES2402138T3
(es)
*
|
2007-12-28 |
2013-04-29 |
Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts |
Terapia contra el cáncer con un parvovirus combinado con quimioterapia
|
MX356760B
(es)
|
2008-01-11 |
2018-06-12 |
Dartmouth College |
Triterpenoides sinteticos y metodos de uso en el tratamiento de enfermedad.
|
CN102066397B
(zh)
|
2008-04-18 |
2013-09-11 |
里亚塔医药公司 |
包含抗炎症药效团的化合物以及使用方法
|
US7915402B2
(en)
|
2008-04-18 |
2011-03-29 |
Reata Pharmaceuticals, Inc. |
Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
|
AU2009237579C1
(en)
|
2008-04-18 |
2016-05-12 |
Reata Pharmaceuticals Holdings, LLC |
Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
|
US8071632B2
(en)
|
2008-04-18 |
2011-12-06 |
Reata Pharmaceuticals, Inc. |
Antioxidant inflammation modulators: novel derivatives of oleanolic acid
|
WO2009129548A1
(en)
|
2008-04-18 |
2009-10-22 |
Reata Pharmaceuticals, Inc. |
Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives
|
FR2931152B1
(fr)
*
|
2008-05-16 |
2010-07-30 |
Centre Nat Rech Scient |
Nouveau systeme de transfert d'acide nucleique
|
EP2309860B1
(en)
|
2008-07-22 |
2014-01-08 |
Trustees of Dartmouth College |
Monocyclic cyanoenones and methods of use thereof
|
RU2510396C2
(ru)
|
2008-09-02 |
2014-03-27 |
Янссен Фармасьютикалз, Инк. |
3-азабицикло[3.1.0]гексильные производные в качестве модуляторов метаботропных глутаматных рецепторов
|
WO2010039039A1
(en)
*
|
2008-10-03 |
2010-04-08 |
Clavis Pharma Asa |
Oral formulations of gemcitabine derivatives
|
AU2009319387B2
(en)
|
2008-11-28 |
2012-05-10 |
Addex Pharma S.A. |
Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
|
CN101525361B
(zh)
|
2009-04-21 |
2010-11-17 |
济南圣鲁金药物技术开发有限公司 |
基于吉西他滨结构的前药及其合成方法及应用
|
GB0907551D0
(en)
|
2009-05-01 |
2009-06-10 |
Univ Dundee |
Treatment or prophylaxis of proliferative conditions
|
RS53075B
(en)
|
2009-05-12 |
2014-04-30 |
Janssen Pharmaceuticals Inc. |
1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
|
JP5707390B2
(ja)
|
2009-05-12 |
2015-04-30 |
ジャンセン ファーマシューティカルズ, インコーポレイテッド |
1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体の正のアロステリック調節因子としてのその使用
|
MY153913A
(en)
|
2009-05-12 |
2015-04-15 |
Janssen Pharmaceuticals Inc |
7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
WO2011062503A1
(en)
*
|
2009-11-20 |
2011-05-26 |
Clavis Pharma As |
Parenteral formulations of gemcitabine derivatives
|
GB201006181D0
(en)
|
2010-04-14 |
2010-06-02 |
Ayanda As |
Composition
|
EP2643320B1
(en)
|
2010-11-08 |
2015-03-04 |
Janssen Pharmaceuticals, Inc. |
1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
EP2661435B1
(en)
|
2010-11-08 |
2015-08-19 |
Janssen Pharmaceuticals, Inc. |
1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
EP2649069B1
(en)
|
2010-11-08 |
2015-08-26 |
Janssen Pharmaceuticals, Inc. |
1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
WO2013009701A2
(en)
|
2011-07-08 |
2013-01-17 |
The University Of North Carolina At Chapel Hill |
Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders
|
WO2013019945A2
(en)
*
|
2011-08-02 |
2013-02-07 |
Clovis Oncology, Inc.. |
Method for selection of chemotherapeutic agents for adenocarcinoma cancer
|
CN102432654A
(zh)
*
|
2011-09-26 |
2012-05-02 |
宋云龙 |
吉西他滨酰胺衍生物及其制备方法和用途
|
CN102617679B
(zh)
*
|
2012-03-13 |
2014-11-26 |
北京大学 |
一种共轭亚油酸与吉西他滨连接的前体药物制备方法及其应用
|
CA2869460C
(en)
|
2012-04-04 |
2018-05-15 |
Halozyme, Inc. |
Combination therapy with an anti-hyaluronan agent and a tumor-targeted taxane
|
US8921419B2
(en)
|
2012-05-08 |
2014-12-30 |
Trustees Of Dartmouth College |
Triterpenoids and compositions containing the same
|
US9278912B2
(en)
|
2012-09-10 |
2016-03-08 |
Reata Pharmaceuticals, Inc. |
C13-hydroxy derivatives of oleanolic acid and methods of use thereof
|
JP6420247B2
(ja)
*
|
2012-11-13 |
2018-11-07 |
ボーイエン セラピューティクス,インコーポレイティド |
ゲムシタビンプロドラッグ及びその使用
|
CN103130854A
(zh)
*
|
2013-01-31 |
2013-06-05 |
华东师范大学 |
维生素e琥珀酸酯化吉西他滨前药及应用
|
CN103159814B
(zh)
*
|
2013-03-28 |
2015-12-23 |
东华大学 |
一种藤黄酸酯类衍生物及其制备方法和用途
|
CN103265594B
(zh)
*
|
2013-03-28 |
2016-05-04 |
东华大学 |
一种藤黄酸酰胺类衍生物及其制备方法和用途
|
JO3368B1
(ar)
|
2013-06-04 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
|
JO3367B1
(ar)
|
2013-09-06 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
|
US20160250245A1
(en)
*
|
2013-10-21 |
2016-09-01 |
INSERM (Institut National de la Santé et de la Recherche Médicale |
Methods and Pharmaceutical Composition for the Treatment of Polyomavirus Infections
|
EP3065713B1
(en)
|
2013-11-06 |
2024-03-06 |
The University of Chicago |
Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers
|
DK3431106T3
(da)
|
2014-01-21 |
2021-03-15 |
Janssen Pharmaceutica Nv |
Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse
|
ES2860298T3
(es)
|
2014-01-21 |
2021-10-04 |
Janssen Pharmaceutica Nv |
Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso
|
WO2015116782A1
(en)
|
2014-01-29 |
2015-08-06 |
Board Of Regents, The University Of Texas System |
Nucleobase analogue derivatives and their applications
|
CA2963819A1
(en)
*
|
2014-10-08 |
2016-04-14 |
Epigenetics Pharma Llc |
Vitamin e-nucleoside prodrugs
|
CN109310702A
(zh)
|
2016-05-20 |
2019-02-05 |
芝加哥大学 |
用于化学疗法、靶向疗法、光动力疗法、免疫疗法和它们的任何组合的纳米颗粒
|
JP7364552B2
(ja)
|
2017-08-02 |
2023-10-18 |
ザ ユニバーシティ オブ シカゴ |
X線誘起光線力学療法、放射線療法、放射線力学療法、化学療法、免疫療法、及びそれらの任意の組み合わせのための、ナノスケール金属有機層及び金属有機ナノプレート
|
CA3091027A1
(en)
|
2018-02-02 |
2019-08-08 |
Maverix Oncology, Inc. |
Small molecule drug conjugates of gemcitabine monophosphate
|
WO2019222435A1
(en)
|
2018-05-16 |
2019-11-21 |
Halozyme, Inc. |
Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
|
WO2020001475A1
(en)
|
2018-06-29 |
2020-01-02 |
Shanghai Changchengyiyaokeji Company Limited |
Phosphorus-containing prodrugs of gemcitabine
|
CN110054659B
(zh)
*
|
2019-05-05 |
2020-09-11 |
中国医学科学院医药生物技术研究所 |
提高药物抗肿瘤活性的方法
|
US20220396794A1
(en)
|
2019-06-04 |
2022-12-15 |
Apterna Limited |
APTAMERS AGAINST TRANSFERRIN RECEPTOR (TfR)
|
GB202019692D0
(en)
|
2020-12-14 |
2021-01-27 |
Apterna Ltd |
Aptamer-sirna fusions
|