SK282706B6 - Indolínové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukt - Google Patents

Indolínové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukt Download PDF

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Publication number
SK282706B6
SK282706B6 SK1752-98A SK175298A SK282706B6 SK 282706 B6 SK282706 B6 SK 282706B6 SK 175298 A SK175298 A SK 175298A SK 282706 B6 SK282706 B6 SK 282706B6
Authority
SK
Slovakia
Prior art keywords
mmol
solution
formula
indoline
compounds
Prior art date
Application number
SK1752-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK175298A3 (en
Inventor
Steven Mark Bromidge
Ian Thomson Forbes
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of SK175298A3 publication Critical patent/SK175298A3/sk
Publication of SK282706B6 publication Critical patent/SK282706B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK1752-98A 1996-06-20 1997-06-16 Indolínové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukt SK282706B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9612883.0A GB9612883D0 (en) 1996-06-20 1996-06-20 Novel compounds
PCT/EP1997/003156 WO1997048699A1 (en) 1996-06-20 1997-06-16 Indoline derivatives useful as 5-ht-2c receptor antagonists

Publications (2)

Publication Number Publication Date
SK175298A3 SK175298A3 (en) 1999-05-07
SK282706B6 true SK282706B6 (sk) 2002-11-06

Family

ID=10795575

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1752-98A SK282706B6 (sk) 1996-06-20 1997-06-16 Indolínové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukt

Country Status (33)

Country Link
US (1) US6369060B1 (enFirst)
EP (1) EP0912554B1 (enFirst)
JP (1) JP2000512306A (enFirst)
KR (1) KR20000022045A (enFirst)
CN (1) CN1229408A (enFirst)
AP (2) AP9801410A0 (enFirst)
AR (1) AR008243A1 (enFirst)
AT (1) ATE228514T1 (enFirst)
AU (1) AU718597B2 (enFirst)
BG (1) BG103089A (enFirst)
BR (1) BR9709911A (enFirst)
CA (1) CA2258240A1 (enFirst)
CO (1) CO4890847A1 (enFirst)
CZ (1) CZ420598A3 (enFirst)
DE (1) DE69717449T2 (enFirst)
DZ (1) DZ2250A1 (enFirst)
EA (1) EA001780B1 (enFirst)
ES (1) ES2187783T3 (enFirst)
GB (1) GB9612883D0 (enFirst)
HU (1) HUP9903439A3 (enFirst)
ID (1) ID19433A (enFirst)
IL (1) IL127417A0 (enFirst)
MA (1) MA24214A1 (enFirst)
NO (1) NO985972L (enFirst)
NZ (1) NZ333229A (enFirst)
OA (1) OA10944A (enFirst)
PE (1) PE86698A1 (enFirst)
PL (1) PL330796A1 (enFirst)
SK (1) SK282706B6 (enFirst)
TR (1) TR199802661T2 (enFirst)
TW (1) TW382015B (enFirst)
WO (1) WO1997048699A1 (enFirst)
ZA (1) ZA975415B (enFirst)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043650A2 (en) * 1998-02-25 1999-09-02 Smithkline Beecham Plc Process(es) for the preparation of 6-trifluoromethyl-indoline derivatives
GB0019950D0 (en) * 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds
JP2005535560A (ja) * 2001-11-28 2005-11-24 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 治療用の化合物
MXPA04008517A (es) * 2002-03-04 2005-08-19 Pharmacia & Upjohn Co Llc Compuestos terapeuticos.
KR101062376B1 (ko) * 2008-04-10 2011-09-06 한국화학연구원 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물
CN102348798A (zh) 2009-01-16 2012-02-08 麻省理工学院 孤独症谱系障碍的诊断和治疗
EP2651403B1 (en) 2010-12-17 2020-12-02 Glaxo Group Limited Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases
WO2014046544A1 (en) 2012-09-21 2014-03-27 Aapa B.V. Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
CA2142721A1 (en) * 1992-08-20 1994-03-03 Ian T. Forbes Condensed indole derivatives as 5ht and 5ht antagonists
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
NZ301265A (en) 1995-02-02 1998-12-23 Smithkline Beecham Plc Indole derivatives as 5ht receptor antagonists, preparation and pharmaceutical compositions thereof
GB9607219D0 (en) * 1996-04-04 1996-06-12 Smithkline Beecham Plc Novel compounds
GB9615767D0 (en) * 1996-07-26 1996-09-04 Smithkline Beecham Plc Novel treatment

Also Published As

Publication number Publication date
AP745A (en) 1999-04-28
KR20000022045A (ko) 2000-04-25
CN1229408A (zh) 1999-09-22
MA24214A1 (fr) 1997-12-31
CA2258240A1 (en) 1997-12-24
AP9801410A0 (en) 1998-12-31
CZ420598A3 (cs) 1999-06-16
EP0912554A1 (en) 1999-05-06
NZ333229A (enFirst) 2000-01-28
AP9701037A0 (en) 1997-07-31
BR9709911A (pt) 1999-08-10
HUP9903439A3 (en) 2002-12-28
DE69717449T2 (de) 2003-10-02
ID19433A (id) 1998-07-09
TW382015B (en) 2000-02-11
ZA975415B (en) 1998-12-21
OA10944A (en) 2003-02-27
ES2187783T3 (es) 2003-06-16
GB9612883D0 (en) 1996-08-21
AR008243A1 (es) 1999-12-29
PE86698A1 (es) 1999-01-28
BG103089A (en) 1999-09-30
DE69717449D1 (de) 2003-01-09
PL330796A1 (en) 1999-06-07
SK175298A3 (en) 1999-05-07
JP2000512306A (ja) 2000-09-19
EP0912554B1 (en) 2002-11-27
EA001780B1 (ru) 2001-08-27
EA199900043A1 (ru) 1999-06-24
AU718597B2 (en) 2000-04-20
DZ2250A1 (fr) 2002-12-18
HUP9903439A2 (en) 2000-07-28
TR199802661T2 (xx) 1999-03-22
IL127417A0 (en) 1999-10-28
WO1997048699A1 (en) 1997-12-24
CO4890847A1 (es) 2000-02-28
ATE228514T1 (de) 2002-12-15
AU3260297A (en) 1998-01-07
US6369060B1 (en) 2002-04-09
NO985972D0 (no) 1998-12-18
NO985972L (no) 1998-12-18

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