SK282448B6 - Použitie derivátov cystínu - Google Patents
Použitie derivátov cystínu Download PDFInfo
- Publication number
- SK282448B6 SK282448B6 SK1207-97A SK120797A SK282448B6 SK 282448 B6 SK282448 B6 SK 282448B6 SK 120797 A SK120797 A SK 120797A SK 282448 B6 SK282448 B6 SK 282448B6
- Authority
- SK
- Slovakia
- Prior art keywords
- butyl
- methylpropyl
- restenosis
- methylbutyl
- propyl
- Prior art date
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- LEVWYRKDKASIDU-IMJSIDKUSA-N cystine group Chemical class C([C@@H](C(=O)O)N)SSC[C@@H](C(=O)O)N LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 title claims abstract description 7
- 208000037803 restenosis Diseases 0.000 claims abstract description 20
- 150000003839 salts Chemical class 0.000 claims abstract description 15
- 238000011282 treatment Methods 0.000 claims abstract description 12
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 238000011321 prophylaxis Methods 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 6
- -1 n-octyl Chemical group 0.000 claims description 26
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 9
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 9
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 7
- 125000004493 2-methylbut-1-yl group Chemical group CC(C*)CC 0.000 claims description 6
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims description 6
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 5
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229960002969 oleic acid Drugs 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 description 1
- 229960003912 probucol Drugs 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- SNYDMZJXWYXCKT-UHFFFAOYSA-M sodium propane-1,2,3-triol benzoate Chemical compound [Na+].OCC(O)CO.[O-]C(=O)c1ccccc1 SNYDMZJXWYXCKT-UHFFFAOYSA-M 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- JVFFWGJAAQAIBS-UHFFFAOYSA-K trisodium 2,2-dioctyl-3-sulfonatobutanedioate Chemical compound [Na+].C(CCCCCCC)C(C(C(=O)[O-])S(=O)(=O)[O-])(C(=O)[O-])CCCCCCCC.[Na+].[Na+] JVFFWGJAAQAIBS-UHFFFAOYSA-K 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9500897A SE9500897D0 (sv) | 1995-03-14 | 1995-03-14 | The pharmacological use of certain cystine derivatives |
PCT/SE1996/000320 WO1996028149A1 (en) | 1995-03-14 | 1996-03-12 | The pharmacological use of certain cystine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
SK120797A3 SK120797A3 (en) | 1998-02-04 |
SK282448B6 true SK282448B6 (sk) | 2002-02-05 |
Family
ID=20397536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1207-97A SK282448B6 (sk) | 1995-03-14 | 1996-03-12 | Použitie derivátov cystínu |
Country Status (24)
Country | Link |
---|---|
US (1) | US5883126A (pt) |
EP (1) | EP0814798A1 (pt) |
JP (1) | JPH11501916A (pt) |
KR (1) | KR19980703055A (pt) |
CN (1) | CN1183718A (pt) |
AR (1) | AR002716A1 (pt) |
AU (1) | AU701287B2 (pt) |
BR (1) | BR9607225A (pt) |
CA (1) | CA2214831A1 (pt) |
CZ (1) | CZ288219B6 (pt) |
EE (1) | EE03382B1 (pt) |
HU (1) | HUP9801985A3 (pt) |
IL (1) | IL117465A (pt) |
IS (1) | IS4554A (pt) |
NO (1) | NO974143D0 (pt) |
NZ (1) | NZ303781A (pt) |
PL (1) | PL183234B1 (pt) |
SE (1) | SE9500897D0 (pt) |
SK (1) | SK282448B6 (pt) |
TR (1) | TR199700945T1 (pt) |
TW (1) | TW385249B (pt) |
UA (1) | UA42830C2 (pt) |
WO (1) | WO1996028149A1 (pt) |
ZA (1) | ZA961749B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU718140B2 (en) * | 1995-10-17 | 2000-04-06 | Dovetail Technologies, Inc. | Low molecular weight cell, bone marrow and immune stimulants |
DE19821625C1 (de) * | 1998-05-15 | 2000-01-05 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
SE9900438D0 (sv) * | 1999-02-10 | 1999-02-10 | Astra Ab | The pharmacological use of certian cystine derivatives |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR8205M (pt) * | 1968-12-20 | 1970-09-14 | ||
US3878305A (en) * | 1972-05-25 | 1975-04-15 | Procter & Gamble | Fortification of foodstuffs with n-acyl derivatives of sulphur-containing l-amino acids |
FR2289179A1 (fr) * | 1974-10-28 | 1976-05-28 | Morelle Jean | Sels metalliques de lipoaminoacides |
US3952115A (en) * | 1975-04-02 | 1976-04-20 | The Procter & Gamble Company | Fortification of foodstuffs with N-acyl derivatives of sulfur-containing L-amino acid esters |
GB2097256B (en) * | 1981-04-02 | 1985-05-30 | Morelle Jean V | Compositions containing n-butyryl alphaaminoacids |
FR2503151A1 (fr) * | 1981-04-02 | 1982-10-08 | Morelle Jean | Butyryminoacides soufres. mode de preparation. emploi comme element keratogenique chez l'homme et l'animal et comme agent de fertilisation chez les vegetaux |
US4708965A (en) * | 1985-09-16 | 1987-11-24 | Morgan Lee R | Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives |
US4724239A (en) * | 1985-09-16 | 1988-02-09 | Morgan Lee R | Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine |
US4827016A (en) * | 1985-09-16 | 1989-05-02 | Morgan Lee R | Method and compounds for reducing dermal inflammations |
JPS62195356A (ja) * | 1986-02-20 | 1987-08-28 | Seiwa Kasei:Kk | シスチン誘導体及びその塩 |
IL98310A (en) * | 1990-06-08 | 1996-08-04 | Astra Ab | Medicinal preparations containing a history of cystine |
TW221376B (pt) * | 1990-06-28 | 1994-03-01 | Astra Ab | |
IT1249650B (it) * | 1991-05-29 | 1995-03-09 | Poli Ind Chimica Spa | N-(5-tioxo-l-prolil)-l-cisteina e suoi derivati, loro preparazione ed impiego terapeutico |
SE9103572D0 (sv) * | 1991-11-29 | 1991-11-29 | Astra Ab | Organic salts of n,n'-diacetyl cystine |
JPH07503010A (ja) * | 1992-01-06 | 1995-03-30 | ヘルス・メインテナンス・プログラムズ,インコーポレイテッド | 薬学活性酸化防止剤含有組成物並びに該組成物を使用する血管形成後の再狭窄予防および治療方法 |
DE4224670A1 (de) * | 1992-07-25 | 1994-01-27 | Boehringer Mannheim Gmbh | Verwendung von â,w-Dicarbonsäuren als Fibrinogensenker |
-
1995
- 1995-03-14 SE SE9500897A patent/SE9500897D0/xx unknown
-
1996
- 1996-02-16 TW TW085101975A patent/TW385249B/zh not_active IP Right Cessation
- 1996-03-04 ZA ZA961749A patent/ZA961749B/xx unknown
- 1996-03-12 BR BR9607225A patent/BR9607225A/pt not_active Application Discontinuation
- 1996-03-12 TR TR97/00945T patent/TR199700945T1/xx unknown
- 1996-03-12 CZ CZ19972804A patent/CZ288219B6/cs not_active IP Right Cessation
- 1996-03-12 KR KR1019970706464A patent/KR19980703055A/ko not_active Application Discontinuation
- 1996-03-12 AU AU50185/96A patent/AU701287B2/en not_active Ceased
- 1996-03-12 CN CN96193717A patent/CN1183718A/zh active Pending
- 1996-03-12 SK SK1207-97A patent/SK282448B6/sk unknown
- 1996-03-12 UA UA97105046A patent/UA42830C2/uk unknown
- 1996-03-12 HU HU9801985A patent/HUP9801985A3/hu unknown
- 1996-03-12 JP JP8527519A patent/JPH11501916A/ja active Pending
- 1996-03-12 CA CA002214831A patent/CA2214831A1/en not_active Abandoned
- 1996-03-12 EE EE9700229A patent/EE03382B1/xx not_active IP Right Cessation
- 1996-03-12 EP EP96906992A patent/EP0814798A1/en not_active Withdrawn
- 1996-03-12 US US08/619,681 patent/US5883126A/en not_active Expired - Fee Related
- 1996-03-12 WO PCT/SE1996/000320 patent/WO1996028149A1/en not_active Application Discontinuation
- 1996-03-13 IL IL11746596A patent/IL117465A/xx not_active IP Right Cessation
- 1996-03-13 AR ARP960101738A patent/AR002716A1/es unknown
- 1996-03-29 NZ NZ303781A patent/NZ303781A/en unknown
- 1996-03-29 PL PL96322328A patent/PL183234B1/pl unknown
-
1997
- 1997-08-27 IS IS4554A patent/IS4554A/is unknown
- 1997-09-09 NO NO974143A patent/NO974143D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX9706825A (es) | 1997-11-29 |
TR199700945T1 (xx) | 1998-02-21 |
AU701287B2 (en) | 1999-01-21 |
CZ288219B6 (en) | 2001-05-16 |
WO1996028149A1 (en) | 1996-09-19 |
CN1183718A (zh) | 1998-06-03 |
CA2214831A1 (en) | 1996-09-19 |
US5883126A (en) | 1999-03-16 |
AU5018596A (en) | 1996-10-02 |
IS4554A (is) | 1997-08-27 |
EE03382B1 (et) | 2001-04-16 |
NZ303781A (en) | 2001-03-30 |
PL183234B1 (pl) | 2002-06-28 |
SE9500897D0 (sv) | 1995-03-14 |
HUP9801985A2 (hu) | 1998-12-28 |
AR002716A1 (es) | 1998-04-29 |
SK120797A3 (en) | 1998-02-04 |
KR19980703055A (ko) | 1998-09-05 |
EE9700229A (et) | 1998-04-15 |
NO974143L (no) | 1997-09-09 |
IL117465A (en) | 2000-07-26 |
NO974143D0 (no) | 1997-09-09 |
EP0814798A1 (en) | 1998-01-07 |
ZA961749B (en) | 1996-09-16 |
PL322328A1 (en) | 1998-01-19 |
JPH11501916A (ja) | 1999-02-16 |
TW385249B (en) | 2000-03-21 |
CZ280497A3 (cs) | 1998-01-14 |
BR9607225A (pt) | 1998-07-07 |
HUP9801985A3 (en) | 2000-07-28 |
IL117465A0 (en) | 1996-07-23 |
UA42830C2 (uk) | 2001-11-15 |
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