SK282063B6 - Použitie derivátov pyrolidínu na prípravu liečiva na liečenie alkoholizmu - Google Patents
Použitie derivátov pyrolidínu na prípravu liečiva na liečenie alkoholizmu Download PDFInfo
- Publication number
- SK282063B6 SK282063B6 SK1611-97A SK161197A SK282063B6 SK 282063 B6 SK282063 B6 SK 282063B6 SK 161197 A SK161197 A SK 161197A SK 282063 B6 SK282063 B6 SK 282063B6
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- phenyl
- alkyl
- alk
- optionally substituted
- Prior art date
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- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000008393 encapsulating agent Substances 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229960003646 lysine Drugs 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 150000002895 organic esters Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- VQULDYIEWYJFOP-UHFFFAOYSA-N tert-butyl 1-[2-[[3-(1-hydroxyethyl)phenyl]carbamoylamino]acetyl]-5-phenylpyrrolidine-2-carboxylate Chemical compound CC(O)C1=CC=CC(NC(=O)NCC(=O)N2C(CCC2C(=O)OC(C)(C)C)C=2C=CC=CC=2)=C1 VQULDYIEWYJFOP-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical group C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9506530A FR2734724B1 (fr) | 1995-06-01 | 1995-06-01 | Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'alcoolisme |
| PCT/FR1996/000801 WO1996038139A1 (fr) | 1995-06-01 | 1996-05-29 | Utilisation de derives de pyrrolidine au traitement de l'alcoolisme |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK161197A3 SK161197A3 (en) | 1998-05-06 |
| SK282063B6 true SK282063B6 (sk) | 2001-10-08 |
Family
ID=9479586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1611-97A SK282063B6 (sk) | 1995-06-01 | 1996-05-29 | Použitie derivátov pyrolidínu na prípravu liečiva na liečenie alkoholizmu |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5935980A (cs) |
| EP (1) | EP0828486B1 (cs) |
| JP (1) | JPH11511747A (cs) |
| KR (1) | KR100424997B1 (cs) |
| CN (1) | CN1186432A (cs) |
| AT (1) | ATE224190T1 (cs) |
| AU (1) | AU711625B2 (cs) |
| BG (1) | BG63189B1 (cs) |
| BR (1) | BR9608633A (cs) |
| CA (1) | CA2219455C (cs) |
| CZ (1) | CZ289344B6 (cs) |
| DE (1) | DE69623767T2 (cs) |
| DK (1) | DK0828486T3 (cs) |
| EA (1) | EA000722B1 (cs) |
| ES (1) | ES2182987T3 (cs) |
| FR (1) | FR2734724B1 (cs) |
| GE (1) | GEP19991780B (cs) |
| HU (1) | HUP9900748A3 (cs) |
| IL (1) | IL118491A (cs) |
| NO (1) | NO975488L (cs) |
| NZ (1) | NZ310488A (cs) |
| PT (1) | PT828486E (cs) |
| RO (1) | RO117297B1 (cs) |
| SK (1) | SK282063B6 (cs) |
| UA (1) | UA58492C2 (cs) |
| WO (1) | WO1996038139A1 (cs) |
| ZA (1) | ZA964270B (cs) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2744361B1 (fr) * | 1996-02-07 | 1998-02-27 | Rhone Poulenc Rorer Sa | Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif |
| FR2744363B1 (fr) * | 1996-02-07 | 1998-02-27 | Rhone Poulenc Rorer Sa | Application de derives de thiazolidine a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif |
| FR2744362B1 (fr) * | 1996-02-07 | 1998-02-27 | Rhone Poulenc Rorer Sa | Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif |
| TW442449B (en) | 1996-07-04 | 2001-06-23 | Hoechst Ag | Process for preparing 1,2-dichloroethane by direct chlorination |
| US6512120B1 (en) | 2001-03-12 | 2003-01-28 | Ortho Mcneil Pharmaceutical, Inc. | Methods for the synthesis of densely functionalized pyrrolidine intermediates |
| US6869335B2 (en) | 2002-07-08 | 2005-03-22 | Micron Technology, Inc. | Retaining rings, planarizing apparatuses including retaining rings, and methods for planarizing micro-device workpieces |
| US8247438B2 (en) | 2008-02-27 | 2012-08-21 | Neuropill, Inc. | Methods for treating schizophrenia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2678938B1 (fr) * | 1991-07-10 | 1993-10-08 | Rhone Poulenc Rorer Sa | Derives de pyrrolidine, leur preparation et les medicaments les contenant. |
| GB9203790D0 (en) * | 1992-02-21 | 1992-04-08 | Merck Sharp & Dohme | Therapeutic agents |
| FR2700166B1 (fr) * | 1993-01-07 | 1995-02-17 | Rhone Poulenc Rorer Sa | Dérivés de pyrrolidine, leur préparation et les médicaments les contenant. |
-
1995
- 1995-06-01 FR FR9506530A patent/FR2734724B1/fr not_active Expired - Fee Related
-
1996
- 1996-05-27 ZA ZA964270A patent/ZA964270B/xx unknown
- 1996-05-29 JP JP8536251A patent/JPH11511747A/ja active Pending
- 1996-05-29 SK SK1611-97A patent/SK282063B6/sk not_active IP Right Cessation
- 1996-05-29 GE GEAP19964043A patent/GEP19991780B/en unknown
- 1996-05-29 PT PT96918727T patent/PT828486E/pt unknown
- 1996-05-29 HU HU9900748A patent/HUP9900748A3/hu unknown
- 1996-05-29 CZ CZ19973785A patent/CZ289344B6/cs not_active IP Right Cessation
- 1996-05-29 NZ NZ310488A patent/NZ310488A/en not_active IP Right Cessation
- 1996-05-29 CA CA002219455A patent/CA2219455C/fr not_active Expired - Fee Related
- 1996-05-29 ES ES96918727T patent/ES2182987T3/es not_active Expired - Lifetime
- 1996-05-29 KR KR1019970708333A patent/KR100424997B1/ko not_active Expired - Fee Related
- 1996-05-29 EP EP96918727A patent/EP0828486B1/fr not_active Expired - Lifetime
- 1996-05-29 CN CN96194338A patent/CN1186432A/zh active Pending
- 1996-05-29 DK DK96918727T patent/DK0828486T3/da active
- 1996-05-29 RO RO97-02202A patent/RO117297B1/ro unknown
- 1996-05-29 BR BR9608633A patent/BR9608633A/pt not_active Application Discontinuation
- 1996-05-29 UA UA97115678A patent/UA58492C2/uk unknown
- 1996-05-29 WO PCT/FR1996/000801 patent/WO1996038139A1/fr active IP Right Grant
- 1996-05-29 US US08/952,937 patent/US5935980A/en not_active Expired - Lifetime
- 1996-05-29 DE DE69623767T patent/DE69623767T2/de not_active Expired - Lifetime
- 1996-05-29 AT AT96918727T patent/ATE224190T1/de active
- 1996-05-29 EA EA199700439A patent/EA000722B1/ru not_active IP Right Cessation
- 1996-05-29 AU AU61290/96A patent/AU711625B2/en not_active Ceased
- 1996-05-30 IL IL11849196A patent/IL118491A/en not_active IP Right Cessation
-
1997
- 1997-11-28 NO NO975488A patent/NO975488L/no unknown
- 1997-12-01 BG BG102087A patent/BG63189B1/bg unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20120529 |