SK281496B6 - Soľ nimesulidu rozpustná vo vode, jej vodný roztok alebo kombinácia, farmaceutický prostriedok a použitie - Google Patents

Soľ nimesulidu rozpustná vo vode, jej vodný roztok alebo kombinácia, farmaceutický prostriedok a použitie Download PDF

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Publication number
SK281496B6
SK281496B6 SK356-96A SK35696A SK281496B6 SK 281496 B6 SK281496 B6 SK 281496B6 SK 35696 A SK35696 A SK 35696A SK 281496 B6 SK281496 B6 SK 281496B6
Authority
SK
Slovakia
Prior art keywords
nimesulide
lysine
salt
cyclodextrin
water
Prior art date
Application number
SK356-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK35696A3 (en
Inventor
Bernard Pirotte
G�Raldine Piel
Philippe Neven
Isabelle Delneuville
Joszef Geczy
Original Assignee
Europharmaceuticals S. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Europharmaceuticals S. A. filed Critical Europharmaceuticals S. A.
Publication of SK35696A3 publication Critical patent/SK35696A3/sk
Publication of SK281496B6 publication Critical patent/SK281496B6/sk

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
SK356-96A 1994-06-16 1995-06-16 Soľ nimesulidu rozpustná vo vode, jej vodný roztok alebo kombinácia, farmaceutický prostriedok a použitie SK281496B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE9400582A BE1008307A3 (fr) 1994-06-16 1994-06-16 Sel de nimesulide hydrosoluble, solution aqueuse le contenant, sa preparation et son utilisation.
PCT/BE1995/000055 WO1995034533A1 (fr) 1994-06-16 1995-06-16 Sel de nimesulide hydrosoluble et leurs utilisations pour le traitement des affections inflammatoires

Publications (2)

Publication Number Publication Date
SK35696A3 SK35696A3 (en) 1996-12-04
SK281496B6 true SK281496B6 (sk) 2001-04-09

Family

ID=3888206

Family Applications (1)

Application Number Title Priority Date Filing Date
SK356-96A SK281496B6 (sk) 1994-06-16 1995-06-16 Soľ nimesulidu rozpustná vo vode, jej vodný roztok alebo kombinácia, farmaceutický prostriedok a použitie

Country Status (19)

Country Link
US (1) US5756546A (cs)
EP (1) EP0714386B1 (cs)
JP (1) JPH09503002A (cs)
AT (1) ATE177421T1 (cs)
AU (1) AU693901B2 (cs)
BE (1) BE1008307A3 (cs)
CA (1) CA2169747A1 (cs)
CZ (1) CZ289746B6 (cs)
DE (1) DE69508192T2 (cs)
DK (1) DK0714386T3 (cs)
ES (1) ES2132678T3 (cs)
GR (1) GR3030437T3 (cs)
HU (1) HUT76475A (cs)
NZ (1) NZ288150A (cs)
PL (1) PL179789B1 (cs)
RU (1) RU2151764C1 (cs)
SK (1) SK281496B6 (cs)
UA (1) UA42734C2 (cs)
WO (1) WO1995034533A1 (cs)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9601442A3 (en) * 1995-07-25 1999-03-29 Panacea Biotec Ltd Nes antinflammatory and analgetic pharmaceutical compositions, containing nimesulid for transdermal use, and process for producing them
EE03419B1 (et) * 1995-10-05 2001-06-15 Helsinn Healthcare S.A. Välispidiselt kasutatav põletikuvastane vahend
NO965193L (no) 1995-12-08 1997-06-09 Seikagaku Kogyo Kk Seikagaku C Aminalkoholderivat og fremgangsmåte for fremstilling derav
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
RU2141845C1 (ru) * 1996-07-24 1999-11-27 Панацея Биотек Лтд. Фармацевтическая композиция болеутоляющего средства и способ ее получения
IN186315B (cs) * 1996-12-12 2001-08-04 Panacea Biotec Ltd
ES2129010B1 (es) * 1997-01-02 2000-01-16 Gold Oscar Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion.
IT1289973B1 (it) * 1997-02-25 1998-10-19 Helsinn Healthcare Sa Sistemi gelificati di nimesulide per uso topico
IT1290448B1 (it) * 1997-04-01 1998-12-03 Schiena Michele Giuseppe Di Nimesulide sale di colina,metodo di preparazione e composizioni farmaceutiche che lo contengono
AU718356B2 (en) * 1998-01-12 2000-04-13 Panacea Biotec Limited A parenteral water-miscible non-intensely coloured injectable composition of non-steroidal anit-inflammatory drugs
WO1999041233A1 (en) * 1998-02-17 1999-08-19 Micio Pharma Chemical Aktiengesellschaft A watersoluble nimesulide adduct also for injectable use
US20040013613A1 (en) * 2001-05-18 2004-01-22 Jain Rajeev A Rapidly disintegrating solid oral dosage form
US8236352B2 (en) * 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US20080213378A1 (en) * 1998-10-01 2008-09-04 Elan Pharma International, Ltd. Nanoparticulate statin formulations and novel statin combinations
EP1117384A1 (en) * 1998-10-01 2001-07-25 Elan Pharma International Limited Controlled release nanoparticulate compositions
US8293277B2 (en) * 1998-10-01 2012-10-23 Alkermes Pharma Ireland Limited Controlled-release nanoparticulate compositions
US20040141925A1 (en) * 1998-11-12 2004-07-22 Elan Pharma International Ltd. Novel triamcinolone compositions
US6969529B2 (en) * 2000-09-21 2005-11-29 Elan Pharma International Ltd. Nanoparticulate compositions comprising copolymers of vinyl pyrrolidone and vinyl acetate as surface stabilizers
US6428814B1 (en) * 1999-10-08 2002-08-06 Elan Pharma International Ltd. Bioadhesive nanoparticulate compositions having cationic surface stabilizers
US20040115134A1 (en) * 1999-06-22 2004-06-17 Elan Pharma International Ltd. Novel nifedipine compositions
CN101804041A (zh) * 1999-09-28 2010-08-18 灵药生物技术有限公司 含有尼美舒利的控释组合物
US20040156872A1 (en) * 2000-05-18 2004-08-12 Elan Pharma International Ltd. Novel nimesulide compositions
PE20020300A1 (es) * 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
US7198795B2 (en) 2000-09-21 2007-04-03 Elan Pharma International Ltd. In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
MY137736A (en) * 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
BR0102252B1 (pt) * 2001-04-10 2013-10-22 Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso
US20040101566A1 (en) * 2002-02-04 2004-05-27 Elan Pharma International Limited Novel benzoyl peroxide compositions
PT1471887E (pt) 2002-02-04 2010-07-16 Elan Pharma Int Ltd ComposiãŽes de nanopartculas com lisozima como um estabilizador superficial
TW200303749A (en) * 2002-02-22 2003-09-16 Pharmacia Corp Ophthalmic antibiotic drug formulations containing a cyclodextrin compound and cetyl pyridinium chloride
CA2479383A1 (en) * 2002-03-20 2003-10-02 Pharmacia Corporation Storage stable eplerenone formulation
EP1551457A1 (en) * 2002-07-16 2005-07-13 Elan Pharma International Limited Liquid dosage compositions of stable nanoparticulate active agents
CN1511828A (zh) * 2002-12-31 2004-07-14 �й������ž�����ҽѧ��ѧԺ����ҽ 磺酰苯胺类衍生物及其医药用途
ITMI20041121A1 (it) * 2004-06-03 2004-09-03 Advance Holdings Ltd Derivato della nimesulide metodo per prepararlo e composizione farmaceutica che lo comprende
US7576222B2 (en) * 2004-12-28 2009-08-18 Wyeth Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase
EP1902705A1 (en) * 2006-09-22 2008-03-26 Pharmatex Italia Srl Injectable pharmaceutical nimesulide solutions
BE1018279A3 (fr) * 2008-09-09 2010-08-03 Squarepoint Pointcarre Sprl Composition de nimesulide orodispersible.
BE1018280A3 (fr) * 2008-09-09 2010-08-03 Squarepoint Pointcarre Sprl Composition de nimesulide a liberation prolongee.
US20120171184A1 (en) 2010-12-31 2012-07-05 Lajos Szente Cellular hydration compositions
JP2015044850A (ja) * 2014-11-07 2015-03-12 イーストポンド・ラボラトリーズ・リミテッド シクロデキストリンを含有する細胞水和組成物

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IT1248475B (it) * 1990-05-22 1995-01-19 Angeli Inst Spa Composti di inclusione di nimesulide con ciclodestrine

Also Published As

Publication number Publication date
EP0714386A1 (fr) 1996-06-05
AU693901B2 (en) 1998-07-09
CZ289746B6 (cs) 2002-03-13
EP0714386B1 (fr) 1999-03-10
JPH09503002A (ja) 1997-03-25
US5756546A (en) 1998-05-26
DE69508192D1 (de) 1999-04-15
HU9600654D0 (en) 1996-05-28
DK0714386T3 (da) 1999-09-27
PL179789B1 (pl) 2000-10-31
GR3030437T3 (en) 1999-09-30
AU2708595A (en) 1996-01-05
NZ288150A (en) 1998-09-24
DE69508192T2 (de) 1999-10-14
HUT76475A (en) 1997-09-29
BE1008307A3 (fr) 1996-04-02
PL313031A1 (en) 1996-05-27
UA42734C2 (uk) 2001-11-15
ES2132678T3 (es) 1999-08-16
MX9600642A (es) 1997-07-31
CZ79296A3 (en) 1996-10-16
RU2151764C1 (ru) 2000-06-27
ATE177421T1 (de) 1999-03-15
CA2169747A1 (fr) 1995-12-21
SK35696A3 (en) 1996-12-04
WO1995034533A1 (fr) 1995-12-21

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