ES2129010B1 - Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion. - Google Patents

Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion.

Info

Publication number
ES2129010B1
ES2129010B1 ES009702307A ES9702307A ES2129010B1 ES 2129010 B1 ES2129010 B1 ES 2129010B1 ES 009702307 A ES009702307 A ES 009702307A ES 9702307 A ES9702307 A ES 9702307A ES 2129010 B1 ES2129010 B1 ES 2129010B1
Authority
ES
Spain
Prior art keywords
granules
composition
nitro
preparation procedure
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES009702307A
Other languages
English (en)
Other versions
ES2129010A1 (es
Inventor
Miguel Rubinstein
Pablo Wexler
Elias Bernardo Gutman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES2129010A1 publication Critical patent/ES2129010A1/es
Application granted granted Critical
Publication of ES2129010B1 publication Critical patent/ES2129010B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Composición de acción prolongada en gránulos que contienen 4-nitro-2-fenoximetansulfonanilida y su procedimiento de preparación, estando la composición formulada mediante una asociación de liberación sostenida en gránulos que mantiene la acción terapéutica del 4-nitro-2-fenoximetansulfonanilida y con disminución de las oscilaciones de las concentraciones plasmáticas; según el procedimiento de preparación de dicha composición, el principio activo es micronizado junto a un desintegrante y adherido por medio de unos polímeros ligantes a unos gránulos neutros compuestos de azúcar, formando gránulos de acción rápida, convencional o inmediata, incorporándose una fracción de los gránulos adheridos y recubiertos con el principio activo con unos polímeros que le confieren una acción controlada y prolongada del principio activo y se la asocia o mezcla a los restantes gránulos que contienen el principio activo (gránulos de acción inmediata), para preparar y administrar diferentes dosificaciones.
ES009702307A 1997-01-02 1997-11-06 Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion. Expired - Lifetime ES2129010B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AR9700002 1997-01-02

Publications (2)

Publication Number Publication Date
ES2129010A1 ES2129010A1 (es) 1999-05-16
ES2129010B1 true ES2129010B1 (es) 2000-01-16

Family

ID=3460992

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009702307A Expired - Lifetime ES2129010B1 (es) 1997-01-02 1997-11-06 Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion.

Country Status (4)

Country Link
US (1) US6187343B1 (es)
ES (1) ES2129010B1 (es)
IT (1) IT1297032B1 (es)
PT (1) PT102095B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL148864A0 (en) * 1999-09-28 2002-09-12 Panacea Biotec Ltd Pharmaceutical compositions containing nimesulide
EP1258241A1 (en) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Method of increasing the bioavailability of nimesulide
AR029548A1 (es) * 2001-06-29 2003-07-02 Bindecor S A Composicion de liberacion prolongada en forma de granulos multiples que permiten mantener la accion terapeutica de su principio activo, el 4-nitro-2-fenoximetansulfonanilida
MX2008000967A (es) * 2005-07-20 2008-03-26 Panacea Biotec Ltd Nueva composicion farmaceutica de forma de dosis de liberacion modificada que comprende inhibidor de enzima ciclooxigenasa.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56122311A (en) * 1980-02-29 1981-09-25 Eisai Co Ltd Lasting theophylline pharmaceutical composition
JPS6144811A (ja) * 1984-08-10 1986-03-04 Ss Pharmaceut Co Ltd 徐放性ジクロフエナクナトリウム製剤
JPS6339814A (ja) * 1986-08-01 1988-02-20 Teisan Seiyaku Kk トラニラストの経口用持続性製剤
US5622716A (en) * 1987-02-20 1997-04-22 Farmarc Nederland B.V. Process for preparing a retard product containing diltiazem for a single daily administration
JPH01287020A (ja) * 1988-05-13 1989-11-17 Shin Etsu Chem Co Ltd ワックス被覆徐放性製剤
SE509029C2 (sv) * 1988-08-16 1998-11-30 Ss Pharmaceutical Co Långtidsverkande diklofenak-natriumpreparat
EP0616841B1 (en) * 1992-10-09 1998-12-23 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Production method for fine granulate
HU210922B (en) * 1993-05-24 1995-09-28 Europharmaceuticals Sa Nimesulide alkali salt cyclodextrin inclusion complexes their preparation and pharmaceutical compositions containing them
BE1008307A3 (fr) * 1994-06-16 1996-04-02 Europharmaceuticals Sa Sel de nimesulide hydrosoluble, solution aqueuse le contenant, sa preparation et son utilisation.
IT1274034B (it) * 1994-07-26 1997-07-14 Applied Pharma Res Composizioni farmaceutiche a base di gomma da masticare e procedimento per la loro preparazione

Also Published As

Publication number Publication date
ITMI972893A1 (it) 1999-06-30
ES2129010A1 (es) 1999-05-16
PT102095A (pt) 1998-07-31
US6187343B1 (en) 2001-02-13
PT102095B (pt) 2002-04-29
IT1297032B1 (it) 1999-08-03

Similar Documents

Publication Publication Date Title
PA8575701A1 (es) Preparaciones acidas de insulina con estabilidad mejorada
CR6210A (es) Composiciones de celecoxib
BG66093B1 (bg) Състави с контролирано освобождаване, съдържащи нимесулид
CO5160272A1 (es) Combinacion de cerivastatina y fibratos
DK0740650T3 (da) Codrugs som metode til styret transport af lægemiddel
ES2129048T3 (es) Composicion estabilizada de hormona paratiroide.
ATE344022T1 (de) Proinsulin c-peptid enthaltende arzneizubereitung mit verzögerter wirkstofffreigabe
ES2178048T3 (es) Uso de rifaximina como medicamento para el tratamiento de diarrea por criptosporidiosis.
YU75093A (sh) Transdermalni sistem za davanje koji sadrži acetilsalicilnu kiselinu za antitromboznu terapiju i profilaksu raka
ES2130152T3 (es) Medicamentos para tratar dolencias inflamatorias o para analgesia que contienen un nsaid y ranitidina/citrato de bismuto.
AR006401A1 (es) Compuestos de pirrolopirrolona, una composicion farmaceutica que los contiene, su uso en la fabricacion de un medicamento y en terapia, procesospara su preparación y compuestos intermediarios para dichos procesos.
AU2002214389A1 (en) Pharmaceutical composition containing honey for the treatment of wounds
BR0012951A (pt) Agonistas de retinóides seletivos
DE59907481D1 (de) Kontrolliert freisetzende pharmazeutische zusammensetzung mit tilidinmesylat als wirkstoff
IL139318A0 (en) Sugar alcohol mixtures as therapeutic agents and pharmaceutical compositions containing the same
ES2129010B1 (es) Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion.
ES2134237T3 (es) Composiciones farmaceuticas que contienen acido ursodesoxicolico.
ES2156220T3 (es) Preparacion transdermica que contiene un metabolito de loratidina con accion antihistaminica.
MX9300558A (es) Nueva sulfonilurea, procedimiento para su preparacion y formulado farmaceutico que la contiene.
BR0013582A (pt) Agonistas retinóides seletivos para rar
DE50105710D1 (de) Pharmazeutische, ramipril enthaltende brauseformulierung
ES2129563T3 (es) Empleo de una combinacion de un inhibidor de la enzima convertidora de angiotensina y un antagonista del calcio para el tratamiento de una proteinuria.
ES2172179T3 (es) Composiciones farmaceuticas de liberacion controlada que contienen tiagabina.
AR003656A1 (es) Procedimiento de preparacion de una combinacion de accion prolongada de granulos conteniendo 4-nitro-2-fenoximetanosulfonanilida
SE0000303D0 (sv) Novel compounds

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 19990216

Kind code of ref document: A1

Effective date: 19990216

EC2A Search report published

Date of ref document: 19990516

Kind code of ref document: A1

Effective date: 19990516

PC2A Transfer of patent