SK164795A3 - Benzene derivatives - Google Patents

Benzene derivatives Download PDF

Info

Publication number
SK164795A3
SK164795A3 SK1647-95A SK164795A SK164795A3 SK 164795 A3 SK164795 A3 SK 164795A3 SK 164795 A SK164795 A SK 164795A SK 164795 A3 SK164795 A3 SK 164795A3
Authority
SK
Slovakia
Prior art keywords
group
butyl
carbon atoms
optionally substituted
methyl
Prior art date
Application number
SK1647-95A
Other languages
English (en)
Slovak (sk)
Inventor
Ohi Nobuhiro
Kato Tatsuya
Ozaki Tomokazu
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of SK164795A3 publication Critical patent/SK164795A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SK1647-95A 1993-06-23 1994-06-23 Benzene derivatives SK164795A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15224893 1993-06-23
PCT/JP1994/001009 WO1995000471A1 (fr) 1993-06-23 1994-06-23 Derive du benzene utile contre les ischemies

Publications (1)

Publication Number Publication Date
SK164795A3 true SK164795A3 (en) 1996-10-02

Family

ID=15536338

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1647-95A SK164795A3 (en) 1993-06-23 1994-06-23 Benzene derivatives

Country Status (18)

Country Link
EP (1) EP0705816B1 (ro)
KR (1) KR100262419B1 (ro)
CN (1) CN1038582C (ro)
AT (1) ATE196464T1 (ro)
CA (1) CA2165662A1 (ro)
CZ (1) CZ289716B6 (ro)
DE (1) DE69425970T2 (ro)
ES (1) ES2152319T3 (ro)
FI (1) FI956151A (ro)
HU (1) HUT75102A (ro)
NO (1) NO305956B1 (ro)
PL (1) PL176687B1 (ro)
RO (1) RO115518B1 (ro)
RU (1) RU2127254C1 (ro)
SK (1) SK164795A3 (ro)
TW (1) TW403734B (ro)
UA (1) UA43338C2 (ro)
WO (1) WO1995000471A1 (ro)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998452A (en) * 1993-06-23 1999-12-07 Chugai Seiyaku Kabushiki Kaisha Benzene derivatives, compositions and methods for treating ischemic diseases
EP0799614A4 (en) * 1994-12-22 2000-03-22 Chugai Pharmaceutical Co Ltd ISCHEMIC DISEASE MEDICINE
WO1998021584A1 (en) * 1996-11-12 1998-05-22 Eli Lilly And Company Combinatorial process for preparing thiazolidinone libraries
US6174908B1 (en) 1999-05-10 2001-01-16 Icagen, Inc. Potassium channel inhibitors
EP1082315A1 (en) 1998-06-05 2001-03-14 Icagen, Inc. Potassium channel inhibitors
JP2004002206A (ja) * 2000-07-26 2004-01-08 Chugai Pharmaceut Co Ltd 光学活性なチアゾリジノン誘導体の製造方法
MXPA04000411A (es) 2001-07-16 2004-03-18 Euro Celtique Sa Tiazolidinonas arilo sustituidas y uso de las mismas.
AU2003255843A1 (en) * 2002-08-23 2004-03-11 Ionix Pharmaceuticals Limited 1,3-thiazolin-4-ones as therapeutic compounds in the treatment of pain
FR3120368B1 (fr) * 2021-03-02 2024-01-19 Michelin & Cie Monomères contenant un motif 4-thiazolidinone et leurs polycondensats polyamide, polyester et polyuréthane.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2623048A (en) * 1948-04-05 1952-12-23 Parke Davis & Co 4-thiazolidone derivatives and process for preparing the same
US2520179A (en) * 1949-02-02 1950-08-29 Sterling Drug Inc 4-thiazolidones and a method for preparation thereof
US3309377A (en) * 1964-10-19 1967-03-14 Sterling Drug Inc 3-[(2-oxazolidinone-3-yl)-alkyl]-4-thiazolidinones and their preparation
FR2504528A1 (fr) * 1981-04-23 1982-10-29 Choay Sa Dialcoxy (2,4) benzenesulfonamides n-substitues
US4820715A (en) * 1984-06-28 1989-04-11 Bristol-Myers Company Anti-emetic quinuclidinyl benzamides
PT83152B (pt) * 1985-08-09 1989-03-30 Lilly Co Eli Processo para a preparacao de compostos di-t-butilfenoicos
GB8820442D0 (en) * 1988-08-30 1988-09-28 Usherwood P N R Therapeutic polyamine amides
AU7317391A (en) * 1990-02-14 1991-09-03 Chugai Seiyaku Kabushiki Kaisha Inhibitor of denatured ldl formation

Also Published As

Publication number Publication date
CN1127502A (zh) 1996-07-24
TW403734B (en) 2000-09-01
EP0705816A1 (en) 1996-04-10
ES2152319T3 (es) 2001-02-01
AU674239B2 (en) 1996-12-12
CN1038582C (zh) 1998-06-03
DE69425970D1 (de) 2000-10-26
RO115518B1 (ro) 2000-03-30
PL176687B1 (pl) 1999-07-30
AU6982994A (en) 1995-01-17
ATE196464T1 (de) 2000-10-15
RU2127254C1 (ru) 1999-03-10
CZ345095A3 (en) 1996-12-11
EP0705816A4 (en) 1997-05-28
WO1995000471A1 (fr) 1995-01-05
HU9503775D0 (en) 1996-02-28
UA43338C2 (uk) 2001-12-17
NO955176L (no) 1996-02-23
CA2165662A1 (en) 1995-01-05
NO305956B1 (no) 1999-08-23
NO955176D0 (no) 1995-12-20
HUT75102A (en) 1997-04-28
DE69425970T2 (de) 2001-01-18
CZ289716B6 (cs) 2002-03-13
KR100262419B1 (ko) 2000-09-01
EP0705816B1 (en) 2000-09-20
FI956151A (fi) 1996-02-19
FI956151A0 (fi) 1995-12-20
PL312471A1 (en) 1996-04-29

Similar Documents

Publication Publication Date Title
EP1786773B1 (en) Isoindolin-1-one derivatives
JP2703408B2 (ja) １，４‐ベンゾチアゼピン誘導体
US5037984A (en) 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone compounds
US4166907A (en) 3,3-Dichloro-2-azetidinone derivatives having antiinflammatory activity
GB2146333A (en) Piperazine derivatives
FR2569404A1 (fr) Nouveaux derives de 1,2-benzisothiazol-3-ylpiperazine, compositions pharmaceutiques contenant de tels composes et leurs procedes de preparation
US4613600A (en) Antidepressant 1,2,4-triazolone compounds
SK164795A3 (en) Benzene derivatives
US4652561A (en) Naphtho[1,2-b]-1,4-thiazepinones
HUT73526A (en) Benzazepine derivative, pharmaceutical composition containing the same, and intermediate for the same
JPH0641095A (ja) 置換トリアゾロンおよびトリアゾールジオンの抗うつ性３−ハロフェニルピペラジニル−プロピル誘導体
US4115382A (en) 3,3-Dichloro-2-azetidinone derivatives having basic substituents
JPH0228176A (ja) ピリジルチアゾリジンカルボン酸アミド誘導体及び中間体
US4174317A (en) 3,3-Dichloro-2-azetidinone derivatives
JP2006500376A (ja) ヒスタミンｈ３受容体アンタゴニストとしての置換アゼピン、製造および治療上の使用
US5574033A (en) Heterocyclic compound and cardiotonic agent containing the same as effective component
US4808580A (en) Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treatment of ischemia and blood pressure lowering
US6297267B1 (en) 4,5-diaryloxazole compounds
JP3263241B2 (ja) 虚血性疾患に有用なベンゼン誘導体
US4959359A (en) Phenyl-thiazepinones as calcium regulating agents
CA2208508A1 (en) Therapeutic agent for ischemic diseases
Liang et al. Synthesis and Biological Activity of Some 1, 3‐Dihydro‐2H‐3‐benzazepin‐2‐ones with a Piperazine Moiety as Bradycardic Agents
Cascio et al. N-Phenylpiperazine derivatives with hypocholesterolemic activity
JPH03133970A (ja) ベンゾチアゼピン―４―オン誘導体
WO1986003200A1 (en) 1,4-benzothiazine derivatives