SK15692002A3 - 3-Amino-6,7-dioxygénované steroidy a s nimi súvisiace použitie - Google Patents

3-Amino-6,7-dioxygénované steroidy a s nimi súvisiace použitie Download PDF

Info

Publication number
SK15692002A3
SK15692002A3 SK1569-2002A SK15692002A SK15692002A3 SK 15692002 A3 SK15692002 A3 SK 15692002A3 SK 15692002 A SK15692002 A SK 15692002A SK 15692002 A3 SK15692002 A3 SK 15692002A3
Authority
SK
Slovakia
Prior art keywords
compound
substituted
hydrogen
groups
group
Prior art date
Application number
SK1569-2002A
Other languages
English (en)
Slovak (sk)
Inventor
Jeffrey R. Raymond
Claudia E. Kasserra
Yaping Shen
Original Assignee
Inflazyme Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inflazyme Pharmaceuticals Limited filed Critical Inflazyme Pharmaceuticals Limited
Publication of SK15692002A3 publication Critical patent/SK15692002A3/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011Unsubstituted amino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only
    • C07J71/0047Nitrogen only at position 2(3)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0057Nitrogen and oxygen
    • C07J71/0063Nitrogen and oxygen at position 2(3)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK1569-2002A 2000-04-28 2001-04-30 3-Amino-6,7-dioxygénované steroidy a s nimi súvisiace použitie SK15692002A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20061700P 2000-04-28 2000-04-28
PCT/CA2001/000581 WO2001083512A1 (en) 2000-04-28 2001-04-30 3-nitrogen-6,7-dioxygen steroids and uses related thereto

Publications (1)

Publication Number Publication Date
SK15692002A3 true SK15692002A3 (sk) 2003-11-04

Family

ID=22742458

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1569-2002A SK15692002A3 (sk) 2000-04-28 2001-04-30 3-Amino-6,7-dioxygénované steroidy a s nimi súvisiace použitie

Country Status (34)

Country Link
US (4) US20040034216A1 (sh)
EP (1) EP1278763B1 (sh)
JP (1) JP2003531916A (sh)
KR (1) KR20030045671A (sh)
CN (1) CN1214039C (sh)
AP (1) AP1825A (sh)
AT (1) ATE353909T1 (sh)
AU (2) AU2001252084B2 (sh)
BG (1) BG107289A (sh)
BR (1) BR0110419A (sh)
CA (1) CA2418748A1 (sh)
CO (1) CO5590904A2 (sh)
DE (1) DE60126597T2 (sh)
DK (1) DK1278763T3 (sh)
DZ (1) DZ3355A1 (sh)
EE (1) EE200200613A (sh)
ES (1) ES2282247T3 (sh)
HK (1) HK1050694A1 (sh)
HR (1) HRP20020944A2 (sh)
HU (1) HUP0300908A2 (sh)
IL (2) IL152448A0 (sh)
MA (1) MA25808A1 (sh)
MX (1) MXPA02010645A (sh)
NO (1) NO324873B1 (sh)
NZ (1) NZ522181A (sh)
OA (1) OA12255A (sh)
PL (1) PL365798A1 (sh)
PT (1) PT1278763E (sh)
RU (1) RU2291873C2 (sh)
SK (1) SK15692002A3 (sh)
UA (1) UA79229C2 (sh)
WO (1) WO2001083512A1 (sh)
YU (1) YU88102A (sh)
ZA (1) ZA200208631B (sh)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
AU2001252084B2 (en) * 2000-04-28 2006-07-06 Inflazyme Pharmaceuticals Limited 3-nitrogen-6,7-dioxygen steroids and uses related thereto
US20050070487A1 (en) * 2001-04-24 2005-03-31 Nyce Jonathan W. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
JP2004534042A (ja) 2001-05-22 2004-11-11 インフラジム ファーマシューティカルズ リミテッド ステロイド−5−エン化合物のステロイド−5−エン−7−オン化合物へのアリル酸化、続くヒドロホウ素化および酸化による、6,7−ジヒドロキシステロイドの生成のための方法およびこの方法の中間体
ES2314252T3 (es) 2002-08-01 2009-03-16 Astellas Pharma Inc. Intercambiador de sodio-calcio dependiente del potasio.
US20090285900A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20110209699A1 (en) * 2003-07-31 2011-09-01 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090263381A1 (en) * 2003-07-31 2009-10-22 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050043282A1 (en) * 2003-07-31 2005-02-24 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026884A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026881A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050113318A1 (en) * 2003-07-31 2005-05-26 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090317476A1 (en) * 2003-07-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20080051382A1 (en) * 2003-10-20 2008-02-28 Inflazyme Pharmaceuticals Ltd. Crystalline Forms of 3-Beta-Amino 17-Methylene Androstane-6-Alpha 7-Beta-Diol Hydrochloride
KR20070007766A (ko) * 2003-10-20 2007-01-16 인플라자임 파마슈티칼즈 리미티드 3-베타-아미노 17-메틸렌 안드로스테인-6-알파 7-베타-디올하이드로클로라이드의 결정질 형태
FR2861077B1 (fr) * 2003-10-20 2006-03-03 Aventis Pharma Sa Formes cristallines du chlorydrate de 3-beta-amino, 17-methylene, androstane-6-alpha, 7-beta-diol
US20050227927A1 (en) * 2004-03-31 2005-10-13 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20050222049A1 (en) * 2004-03-31 2005-10-06 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20090317477A1 (en) * 2004-03-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US9149429B2 (en) * 2007-11-21 2015-10-06 The Procter & Gamble Company Preparations, methods and kits useful for the treatment of cough
JP5655243B2 (ja) * 2009-10-19 2015-01-21 国立大学法人 熊本大学 インドキシル硫酸の産生の阻害剤のスクリーニング方法、インドキシル硫酸代謝産生阻害剤、及び腎障害軽減剤
CA2786465C (en) 2010-01-15 2018-09-25 Suzhou Neupharma Co., Ltd. Bufalin derivatives for the treatment of cancer
US9670475B2 (en) 2010-07-09 2017-06-06 Bioverativ Therapeutics Inc. Factor IX polypeptides and methods of use thereof
WO2012103810A1 (en) 2011-02-02 2012-08-09 Suzhou Neupharma Co., Ltd Certain chemical entities, compositions, and methods
WO2013165924A1 (en) * 2012-04-29 2013-11-07 Neupharma, Inc. Certain chemical entities, compositions, and methods
EP3542861A1 (en) 2012-09-25 2019-09-25 Bioverativ Therapeutics Inc. Methods of using fix polypeptides
EP2970100A1 (en) 2013-03-14 2016-01-20 Aquinox Pharmaceuticals (Canada) Inc. Ship1 modulators and methods related thereto
JP6407951B2 (ja) 2013-03-14 2018-10-17 アクイノックス ファーマシューティカルズ (カナダ) インコーポレイテッド Ship1モジュレーターおよびそれに関連する組成物および方法
SG10201707600XA (en) 2013-03-15 2017-11-29 Biogen Ma Inc Factor ix polypeptide formulations
CN104744547B (zh) * 2013-12-27 2017-02-15 天津医科大学 一种抗乳腺癌转移作用的孕甾烷生物碱衍生物及医药用途
WO2016210146A1 (en) 2015-06-26 2016-12-29 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
WO2017127753A1 (en) 2016-01-20 2017-07-27 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
CN112543753A (zh) 2018-04-06 2021-03-23 塔罗制药公司 可用于治疗疼痛和炎症的茚衍生物
ES2960542T3 (es) * 2018-04-06 2024-03-05 Taro Pharmaceuticals Inc Derivados de hexadecahidro-1H-ciclopenta[a]fenantreno útiles en el tratamiento del dolor y la inflamación
JP2021526545A (ja) 2018-04-06 2021-10-07 アキノックス ファーマシューティカルス(カナダ)インク. 疼痛及び炎症を治療するのに有用なインデン誘導体

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682983A (en) * 1969-11-12 1972-08-08 Klaus Prezewowsky Preparation of {66 {11 {11 -17 ethinyl steroids
SG50585A1 (en) 1990-01-18 1998-07-20 Cura Nominees Pty Ltd Glycoalkaloids
US5877185A (en) 1991-10-22 1999-03-02 Octamer, Inc. Synergistic compositions useful as anti-tumor agents
CA2086221C (en) * 1992-12-23 2003-07-15 Raymond J. Andersen Contignasterol, and related 3-alpha hydroxy-6-alpha hydroxy-7-beta hydroxy-15-keto-14-beta steroids useful as anti-inflammatory and anti-thrombosis agent
DE69412596T2 (de) 1993-03-10 1999-03-04 Magainin Pharmaceuticals Inc., Plymouth Meeting, Pa. Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5856535A (en) 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
US6083532A (en) * 1995-03-01 2000-07-04 Duramed Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers and tablet formed therefrom
WO1996036230A1 (en) 1995-05-16 1996-11-21 The Salk Institute For Biological Studies Modulators for new members of the steroid/thyroid superfamily of receptors
US5874597A (en) * 1995-06-07 1999-02-23 Magainin Pharmaceuticals, Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US6046185A (en) 1996-07-11 2000-04-04 Inflazyme Pharmaceuticals Ltd. 6,7-oxygenated steroids and uses related thereto
US6060465A (en) * 1997-02-06 2000-05-09 Miljkovic; Dusan Bile acids and their derivatives as glycoregulatory agents
BR9815711B1 (pt) 1998-03-06 2014-10-29 Univ Brigham Young Composto antibiótico derivado de esteróide
AU2001252084B2 (en) * 2000-04-28 2006-07-06 Inflazyme Pharmaceuticals Limited 3-nitrogen-6,7-dioxygen steroids and uses related thereto

Also Published As

Publication number Publication date
ES2282247T3 (es) 2007-10-16
US7112580B2 (en) 2006-09-26
CN1430625A (zh) 2003-07-16
BR0110419A (pt) 2004-02-25
ATE353909T1 (de) 2007-03-15
PL365798A1 (en) 2005-01-10
AP1825A (en) 2008-02-03
HK1050694A1 (en) 2003-07-04
AU2001252084B2 (en) 2006-07-06
AU5208401A (en) 2001-11-12
HRP20020944A2 (en) 2004-02-29
US20050215534A9 (en) 2005-09-29
JP2003531916A (ja) 2003-10-28
RU2291873C2 (ru) 2007-01-20
KR20030045671A (ko) 2003-06-11
PT1278763E (pt) 2007-05-31
DE60126597D1 (de) 2007-03-29
NO20025106L (no) 2002-12-18
BG107289A (bg) 2003-07-31
DZ3355A1 (fr) 2001-11-08
EP1278763A1 (en) 2003-01-29
US20070060553A1 (en) 2007-03-15
US6635629B2 (en) 2003-10-21
DE60126597T2 (de) 2007-10-31
EP1278763B1 (en) 2007-02-14
US20040138186A1 (en) 2004-07-15
ZA200208631B (en) 2004-02-23
AP2002002659A0 (en) 2002-12-31
OA12255A (en) 2006-05-11
WO2001083512A1 (en) 2001-11-08
US20020072510A1 (en) 2002-06-13
CA2418748A1 (en) 2001-11-08
NZ522181A (en) 2005-04-29
DK1278763T3 (da) 2007-06-11
NO324873B1 (no) 2007-12-17
HUP0300908A2 (hu) 2003-07-28
NO20025106D0 (no) 2002-10-24
CO5590904A2 (es) 2005-12-30
EE200200613A (et) 2004-04-15
IL152448A0 (en) 2003-05-29
US20040034216A1 (en) 2004-02-19
MA25808A1 (fr) 2003-07-01
IL152448A (en) 2006-12-31
MXPA02010645A (es) 2004-04-20
UA79229C2 (en) 2007-06-11
YU88102A (sh) 2006-01-16
CN1214039C (zh) 2005-08-10

Similar Documents

Publication Publication Date Title
SK15692002A3 (sk) 3-Amino-6,7-dioxygénované steroidy a s nimi súvisiace použitie
AU2001252084A1 (en) 3-nitrogen-6,7-dioxygen steroids and uses related thereto
JP4606408B2 (ja) 選択的グルココルチコイド受容体調節物質としての17−カルバモイルオキシコルチゾル誘導体
PH12015500491B1 (en) C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof
BR112014026640B1 (pt) compostos derivados de 2,2-difluoropropionamida de metil bardoxolona, formas polimórficas, composição farmacêutica, e uso dos mesmos
DE69703228T2 (de) Neue 6-Hydroxy und 6-Oxo-Androstan Verbindungen mit Kardioaktivität und pharmazeutische Präparate davon
US8563742B2 (en) Substituted aminothiazole derivatives, pharmaceutical compositions, and methods of use
PT85337B (pt) Processo para a preparacao de derivados cicloalquilicos 4-piridil-substituidos e de composicoes farmaceuticas que os contem
EP0412907A2 (fr) Nouveaux esters d'acides organiques avec des alcools dérivés de 19-nor stéroides et leurs sels, leur procédé de préparation et les intermédiaires de ce procédé, leur application à titre de médicaments et les compositions les renfermant
DE4227605A1 (de) Neue Hydroxyimino-5µ,14µ-androstan-Derivate, die auf das kardiovaskuläre System wirken, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten
JPS6212796A (ja) 11−β置換ステロイドおよびその製法
DE69409774T2 (de) Neue kardioaktive 17-Iminomethylalkenyl-5-beta-14-beta-androstan und 17-Iminoalkyl-5-beta, 14-beta-androstan Derivate, ein Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon
EP0210832A1 (en) Steroidic aromatase inhibitors
DE19961219A1 (de) 11beta-Phenylestratrien-Derivate mit Fluoralkylgruppen in der aromatischen Seitenkette, deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4232656A1 (de) Neue Cyclopentanperhydrophenanthren-17beta-(hydroxy oder alkoxy)-17alpha-(aryl oder heterocyclyl)-3beta-derivate, die auf das kardiovaskuläre System wirken, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
JPH0912593A (ja) 心臓血管系に活性な新規17−ヒドロキシイミノアルキルおよび17−ヒドロキシイミノメチルアルケニルシクロペンタンペルヒドロフェナントレン誘導体、それらの製造方法およびそれらの化合物を含む医薬組成物