SK154299A3 - N-triazolyl-2-indolecarboxamides and their use as cck-a agonists - Google Patents

N-triazolyl-2-indolecarboxamides and their use as cck-a agonists Download PDF

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Publication number
SK154299A3
SK154299A3 SK1542-99A SK154299A SK154299A3 SK 154299 A3 SK154299 A3 SK 154299A3 SK 154299 A SK154299 A SK 154299A SK 154299 A3 SK154299 A3 SK 154299A3
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SK
Slovakia
Prior art keywords
och
formula
group
compound
carbon atoms
Prior art date
Application number
SK1542-99A
Other languages
English (en)
Slovak (sk)
Inventor
Eric Bignon
Jean-Pierre Bras
Cointet Paul De
Pierre Despeyroux
Daniel Frehel
Danielle Gully
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of SK154299A3 publication Critical patent/SK154299A3/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
SK1542-99A 1997-05-13 1998-05-06 N-triazolyl-2-indolecarboxamides and their use as cck-a agonists SK154299A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9705850A FR2763337B1 (fr) 1997-05-13 1997-05-13 Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR1998/000905 WO1998051686A1 (fr) 1997-05-13 1998-05-06 N-triazolyl-2-indolecarboxamides et leur utilisation comme agonistes de cck-a

Publications (1)

Publication Number Publication Date
SK154299A3 true SK154299A3 (en) 2000-05-16

Family

ID=9506830

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1542-99A SK154299A3 (en) 1997-05-13 1998-05-06 N-triazolyl-2-indolecarboxamides and their use as cck-a agonists

Country Status (35)

Country Link
EP (1) EP0984960B1 (de)
JP (1) JP2001524980A (de)
KR (1) KR20010012541A (de)
CN (1) CN1263528A (de)
AR (1) AR011729A1 (de)
AT (1) ATE232207T1 (de)
AU (1) AU725530B2 (de)
BR (1) BR9811465A (de)
CA (1) CA2289573A1 (de)
CO (1) CO4940485A1 (de)
CZ (1) CZ289484B6 (de)
DE (1) DE69811223T2 (de)
DK (1) DK0984960T3 (de)
DZ (1) DZ2486A1 (de)
EE (1) EE9900524A (de)
ES (1) ES2190081T3 (de)
FR (1) FR2763337B1 (de)
GT (1) GT199800068A (de)
HR (1) HRP980258B1 (de)
HU (1) HUP0002763A3 (de)
ID (1) ID22911A (de)
IL (1) IL132903A0 (de)
IS (1) IS5235A (de)
NO (1) NO995513L (de)
NZ (1) NZ500637A (de)
PL (1) PL336772A1 (de)
RU (1) RU2175323C2 (de)
SI (1) SI0984960T1 (de)
SK (1) SK154299A3 (de)
TR (1) TR199902795T2 (de)
TW (1) TW396155B (de)
UY (1) UY24997A1 (de)
WO (1) WO1998051686A1 (de)
YU (1) YU57999A (de)
ZA (1) ZA983997B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2802530B1 (fr) * 1999-12-17 2002-02-22 Sanofi Synthelabo Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant
KR20030042035A (ko) * 2000-10-26 2003-05-27 사노피-신델라보 트리아졸 유도체 및 이들을 포함하는 제약 조성물
FR2815963B1 (fr) * 2000-10-26 2003-02-28 Sanofi Synthelabo Nouveaux derives du triazole et les compositions pharmaceutiques les contenant
HUP0004741A2 (hu) * 2000-11-28 2002-12-28 Sanofi-Synthelabo Kémiai eljárás tiazolszármazékok előállítására és új intermedier
CA2463441A1 (en) * 2001-10-12 2003-05-08 Bayer Pharmaceuticals Corporation Phenyl substituted 5-membered nitrogen containing heterocycles for the treatment of obesity
EP1314733A1 (de) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indol-2-carbonsäureamide als Faktor-Xa-Hemmer
EP1479677A1 (de) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Neue Indolderivate als Faktor Xa-Inhibitoren
EP1532980A1 (de) * 2003-11-24 2005-05-25 Novo Nordisk A/S N-Heteroaryl Indol-Carboxamide und deren analoga zur Vewendung als glucokinase Aktivatoren zur Behandlung von Diabetes
GB0403038D0 (en) * 2004-02-11 2004-03-17 Novartis Ag Organic compounds
JP2010516768A (ja) * 2007-01-26 2010-05-20 メルク・シャープ・エンド・ドーム・コーポレイション コレシストキニン−１レセプターモジュレーターとしての置換アミノピリミジン
EA201100189A1 (ru) 2008-07-15 2011-08-30 Новартис Аг Гетероарильные производные в качестве ингибиторов dgat1
EP2440555B1 (de) * 2009-06-09 2016-05-18 Actelion Pharmaceuticals Ltd Fluorierte aminotriazolderivate
EP2490659B1 (de) * 2009-10-22 2017-03-01 Henkel AG & Co. KGaA Mittel zur temporären verformung keratinhaltiger fasern, enthaltend eine nichtionische, mittels propylenoxid modifizierte stärke und ein chitosan
CN106928147A (zh) * 2017-03-14 2017-07-07 华东师范大学 三环二萜类似物及其制备方法、及其在制备抗前列腺癌药物中的应用
CN107271623A (zh) * 2017-07-27 2017-10-20 青岛啤酒股份有限公司 基于人体饱腹感的啤酒可饮性评价方法
WO2021071837A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701708B1 (fr) * 1993-02-19 1995-05-19 Sanofi Elf Dérivés de 2-amido-4-phénylthiazoles polysubstitués, procédé de préparation, composition pharmaceutique et utilisation de ces dérivés pour la préparation d'un médicament.
FR2703995B1 (fr) * 1993-04-16 1995-07-21 Sanofi Elf 5-acylamino 1,2,4-thiadiazoles, leur preparation et compositions pharmaceutiques en contenant.

Also Published As

Publication number Publication date
TW396155B (en) 2000-07-01
AU7659998A (en) 1998-12-08
CA2289573A1 (fr) 1998-11-19
DK0984960T3 (da) 2003-05-26
ES2190081T3 (es) 2003-07-16
JP2001524980A (ja) 2001-12-04
IS5235A (is) 1999-10-29
CZ289484B6 (cs) 2002-01-16
HUP0002763A3 (en) 2002-05-28
KR20010012541A (ko) 2001-02-15
HRP980258A2 (en) 1999-02-28
DE69811223T2 (de) 2003-11-27
BR9811465A (pt) 2000-09-12
NO995513D0 (no) 1999-11-11
FR2763337A1 (fr) 1998-11-20
ATE232207T1 (de) 2003-02-15
DE69811223D1 (de) 2003-03-13
CO4940485A1 (es) 2000-07-24
YU57999A (sh) 2002-06-19
PL336772A1 (en) 2000-07-17
HUP0002763A2 (hu) 2001-06-28
EE9900524A (et) 2000-06-15
CZ400699A3 (cs) 2000-02-16
RU2175323C2 (ru) 2001-10-27
ID22911A (id) 1999-12-16
EP0984960B1 (de) 2003-02-05
UY24997A1 (es) 2000-10-31
AR011729A1 (es) 2000-08-30
AU725530B2 (en) 2000-10-12
NO995513L (no) 2000-01-12
WO1998051686A1 (fr) 1998-11-19
HRP980258B1 (en) 2002-08-31
GT199800068A (es) 1999-11-11
EP0984960A1 (de) 2000-03-15
ZA983997B (en) 1999-11-12
IL132903A0 (en) 2001-03-19
SI0984960T1 (en) 2003-06-30
CN1263528A (zh) 2000-08-16
TR199902795T2 (xx) 2000-02-21
FR2763337B1 (fr) 1999-08-20
NZ500637A (en) 2000-11-24
DZ2486A1 (fr) 2003-02-01

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