SK13822003A3 - Polymorfné formy chloridu fexofenadínu - Google Patents
Polymorfné formy chloridu fexofenadínu Download PDFInfo
- Publication number
- SK13822003A3 SK13822003A3 SK1382-2003A SK13822003A SK13822003A3 SK 13822003 A3 SK13822003 A3 SK 13822003A3 SK 13822003 A SK13822003 A SK 13822003A SK 13822003 A3 SK13822003 A3 SK 13822003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- fexofenadine
- chloride
- precipitate
- solution
- preparing
- Prior art date
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- 150000001805 chlorine compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 90
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- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims description 308
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- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000001757 thermogravimetry curve Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 229940117960 vanillin Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28252101P | 2001-04-09 | 2001-04-09 | |
| US30775201P | 2001-07-25 | 2001-07-25 | |
| US31439601P | 2001-08-23 | 2001-08-23 | |
| US33693001P | 2001-11-08 | 2001-11-08 | |
| US33904101P | 2001-12-07 | 2001-12-07 | |
| US34411401P | 2001-12-28 | 2001-12-28 | |
| US36178002P | 2002-03-04 | 2002-03-04 | |
| US36348202P | 2002-03-11 | 2002-03-11 | |
| PCT/US2002/011251 WO2002080857A2 (en) | 2001-04-09 | 2002-04-08 | Polymorphs of fexofenadine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK13822003A3 true SK13822003A3 (sk) | 2004-09-08 |
Family
ID=27575329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1382-2003A SK13822003A3 (sk) | 2001-04-09 | 2002-04-08 | Polymorfné formy chloridu fexofenadínu |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20020177608A1 (cs) |
| EP (1) | EP1392303A4 (cs) |
| KR (1) | KR20040012747A (cs) |
| AU (1) | AU2002305162A1 (cs) |
| CA (1) | CA2444456A1 (cs) |
| CZ (1) | CZ20033019A3 (cs) |
| HR (1) | HRP20030900A2 (cs) |
| HU (1) | HUP0400299A2 (cs) |
| IL (1) | IL158334A0 (cs) |
| MX (1) | MXPA03009259A (cs) |
| PL (1) | PL366576A1 (cs) |
| SK (1) | SK13822003A3 (cs) |
| WO (1) | WO2002080857A2 (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227676B1 (en) * | 1994-05-18 | 2011-11-28 | Aventisub Ii Inc | Process for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
| US7700779B2 (en) * | 2001-06-18 | 2010-04-20 | Dr. Reddy's Laboratories Limited | Crystalline forms of fexofenadine and its hydrochloride |
| CA2481377A1 (en) * | 2002-04-04 | 2003-10-16 | Dr. Reddy's Laboratories Ltd. | Antihistamine-decongestant pharmaceutical compositions |
| US20040044038A1 (en) * | 2002-06-10 | 2004-03-04 | Barnaba Krochmal | Polymorphic form XVI of fexofenadine hydrochloride |
| GB0319935D0 (en) * | 2003-08-26 | 2003-09-24 | Cipla Ltd | Polymorphs |
| JP2007532687A (ja) * | 2004-04-26 | 2007-11-15 | テバ ファーマシューティカル インダストリーズ リミティド | フェキソフェナジン塩酸塩の結晶形およびその製造方法 |
| US20060148851A1 (en) * | 2004-09-28 | 2006-07-06 | Shlomit Wizel | Fexofenadine crystal form and processes for its preparation thereof |
| WO2007052310A2 (en) * | 2005-11-03 | 2007-05-10 | Morepen Laboratories Limited | Polymorphs of fexofenadine hydrochloride and process for their preparation |
| MX2009000320A (es) * | 2006-07-11 | 2009-06-05 | Mutual Pharmaceutical Co | Formulaciones de liberacion controlada. |
| EP2105134A1 (en) | 2008-03-24 | 2009-09-30 | Ranbaxy Laboratories Limited | Stable amorphous fexofenadine hydrochloride |
| WO2009136412A2 (en) * | 2008-04-25 | 2009-11-12 | Matrix Laboratories Limited | PROCESS FOR PREPARATION OF 4-[4-(4-(HYDROXYDIPHENYLMETHYL)- 1-PIPERIDINYL]-1-OXOBUTYL]-α,α-DIMETHYLBENZENE ACETIC ACID METHYL ESTER AND USE THEREOF |
| US20100183717A1 (en) * | 2009-01-16 | 2010-07-22 | Kristin Arnold | Controlled-release formulations |
| US9216955B2 (en) * | 2010-06-15 | 2015-12-22 | Chemelectiva S.R.L. | Polymorphic form of Fexofenadine hydrochloride, intermediates and process for its preparation |
| EP3068394A4 (en) | 2013-11-15 | 2017-04-26 | Akebia Therapeutics Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
| CN104072402B (zh) * | 2014-07-16 | 2016-08-17 | 昆山龙灯瑞迪制药有限公司 | 一种新结晶形式的盐酸非索非那定化合物及其制备方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| US4285957A (en) * | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
| WO1985003707A1 (en) * | 1984-02-15 | 1985-08-29 | Schering Corporation | 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
| SE8403179D0 (sv) * | 1984-06-13 | 1984-06-13 | Haessle Ab | New compounds |
| US4929605A (en) * | 1987-10-07 | 1990-05-29 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol derivatives |
| US5631375A (en) * | 1992-04-10 | 1997-05-20 | Merrell Pharmaceuticals, Inc. | Process for piperidine derivatives |
| NZ251132A (en) * | 1992-04-10 | 1996-12-20 | Merrell Dow Pharma | 4-diphenylmethyl piperidine derivatives and their preparation |
| AU679910B2 (en) * | 1992-05-11 | 1997-07-17 | Merrell Pharmaceuticals Inc. | Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient |
| DK0815860T3 (da) * | 1992-08-03 | 2006-08-14 | Sepracor Inc | Terfenadincarboxylat og behandlingen af allergiske lidelser |
| US5654433A (en) * | 1993-01-26 | 1997-08-05 | Merrell Pharmaceuticals Inc. | Process for piperidine derivatives |
| HU226559B1 (en) * | 1993-06-24 | 2009-03-30 | Amr Technology | Process for the production of piperidine derivatives |
| EP2261208A1 (en) * | 1993-06-25 | 2010-12-15 | Aventisub II Inc. | Intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives |
| US6147216A (en) * | 1993-06-25 | 2000-11-14 | Merrell Pharmaceuticals Inc. | Intermediates useful for the preparation of antihistaminic piperidine derivatives |
| HU227676B1 (en) * | 1994-05-18 | 2011-11-28 | Aventisub Ii Inc | Process for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
| JP4105762B2 (ja) * | 1995-02-28 | 2008-06-25 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | ピペリジノアルカノール化合物のための医薬組成物 |
| US6153754A (en) * | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US6201124B1 (en) * | 1995-12-21 | 2001-03-13 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US5925761A (en) * | 1997-02-04 | 1999-07-20 | Sepracor Inc. | Synthesis of terfenadine and derivatives |
| PT864653E (pt) * | 1997-03-11 | 2004-08-31 | Aventis Pharma Inc | Processo para preparacao de acido 4-(4-(4-(hidroxidifenil)-1-piperidinil)-1-hidroxibutil)-alfa,alfa-dimetilfenilacetico e derivados fosforilados |
| US6451815B1 (en) * | 1997-08-14 | 2002-09-17 | Aventis Pharmaceuticals Inc. | Method of enhancing bioavailability of fexofenadine and its derivatives |
| TR200000517T2 (tr) * | 1997-08-26 | 2000-08-21 | Hoechst Marion Roussel, Inc. | Piperidinoalkanol-Konjesyon azaltıcıdan oluşan kombinasyona yönelik farmasötik kompozisyon. |
| US5885912A (en) * | 1997-10-08 | 1999-03-23 | Bumbarger; Thomas H. | Protective multi-layered liquid retaining composite |
| IN191492B (cs) * | 1999-05-25 | 2003-12-06 | Ranbaxy Lab Ltd | |
| US6613906B1 (en) * | 2000-06-06 | 2003-09-02 | Geneva Pharmaceuticals, Inc. | Crystal modification |
| AU2002243760A1 (en) * | 2001-01-30 | 2002-08-12 | Board Of Regents University Of Texas System | Process for production of nanoparticles and microparticles by spray freezing into liquid |
| CH695216A5 (de) * | 2001-02-23 | 2006-01-31 | Cilag Ag | Verfahren zur Herstellung eines nicht hydratisierten Salzes eines Piperidinderivats und eine so erhältliche neue kristalline Form eines solchen Salzes. |
| US20030021849A1 (en) * | 2001-04-09 | 2003-01-30 | Ben-Zion Dolitzky | Polymorphs of fexofenadine hydrochloride |
| BR0117054A (pt) * | 2001-06-18 | 2004-07-27 | Reddys Lab Ltd Dr | Formas cristalinas do ácido 4-[4-[4-hidroxidifenilmetil)-1-piperidinil]-1-hidroxibuti l]-alfa, alfa-dimetilbenzeno acético e seu cloridrato |
| DE60225694T2 (de) * | 2001-07-31 | 2008-06-26 | Texcontor Etablissement | Neues polymorph von fexo-fenadin |
| CA2481377A1 (en) * | 2002-04-04 | 2003-10-16 | Dr. Reddy's Laboratories Ltd. | Antihistamine-decongestant pharmaceutical compositions |
| US20040044038A1 (en) * | 2002-06-10 | 2004-03-04 | Barnaba Krochmal | Polymorphic form XVI of fexofenadine hydrochloride |
| US20050065183A1 (en) * | 2003-07-31 | 2005-03-24 | Indranil Nandi | Fexofenadine composition and process for preparing |
| US20050069590A1 (en) * | 2003-09-30 | 2005-03-31 | Buehler Gail K. | Stable suspensions for medicinal dosages |
| US7220884B2 (en) * | 2004-02-10 | 2007-05-22 | Dow Global Technologies, Inc. | Hydroaminomethylation of olefins |
| US20050220877A1 (en) * | 2004-03-31 | 2005-10-06 | Patel Ashish A | Bilayer tablet comprising an antihistamine and a decongestant |
-
2002
- 2002-04-08 PL PL02366576A patent/PL366576A1/xx unknown
- 2002-04-08 CZ CZ20033019A patent/CZ20033019A3/cs unknown
- 2002-04-08 AU AU2002305162A patent/AU2002305162A1/en not_active Abandoned
- 2002-04-08 HU HU0400299A patent/HUP0400299A2/hu unknown
- 2002-04-08 HR HR20030900A patent/HRP20030900A2/xx not_active Application Discontinuation
- 2002-04-08 CA CA002444456A patent/CA2444456A1/en not_active Abandoned
- 2002-04-08 KR KR10-2003-7013226A patent/KR20040012747A/ko not_active Ceased
- 2002-04-08 EP EP02733966A patent/EP1392303A4/en not_active Withdrawn
- 2002-04-08 SK SK1382-2003A patent/SK13822003A3/sk unknown
- 2002-04-08 IL IL15833402A patent/IL158334A0/xx unknown
- 2002-04-08 US US10/118,807 patent/US20020177608A1/en not_active Abandoned
- 2002-04-08 MX MXPA03009259A patent/MXPA03009259A/es not_active Application Discontinuation
- 2002-04-08 WO PCT/US2002/011251 patent/WO2002080857A2/en not_active Application Discontinuation
-
2003
- 2003-09-12 US US10/661,259 patent/US20040058955A1/en not_active Abandoned
-
2008
- 2008-09-09 US US12/207,372 patent/US20090149497A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PL366576A1 (en) | 2005-02-07 |
| AU2002305162A1 (en) | 2002-10-21 |
| KR20040012747A (ko) | 2004-02-11 |
| WO2002080857A2 (en) | 2002-10-17 |
| WO2002080857A3 (en) | 2003-12-18 |
| US20020177608A1 (en) | 2002-11-28 |
| US20090149497A1 (en) | 2009-06-11 |
| HUP0400299A2 (en) | 2007-08-28 |
| HRP20030900A2 (en) | 2005-08-31 |
| EP1392303A2 (en) | 2004-03-03 |
| EP1392303A4 (en) | 2005-01-26 |
| CA2444456A1 (en) | 2002-10-17 |
| IL158334A0 (en) | 2004-05-12 |
| CZ20033019A3 (cs) | 2004-07-14 |
| WO2002080857A8 (en) | 2004-05-27 |
| US20040058955A1 (en) | 2004-03-25 |
| MXPA03009259A (es) | 2004-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB9A | Suspension of patent application procedure |