HRP20030900A2 - Polymorphs of fexofenadine hydrochloride - Google Patents

Polymorphs of fexofenadine hydrochloride

Info

Publication number
HRP20030900A2
HRP20030900A2 HR20030900A HRP20030900A HRP20030900A2 HR P20030900 A2 HRP20030900 A2 HR P20030900A2 HR 20030900 A HR20030900 A HR 20030900A HR P20030900 A HRP20030900 A HR P20030900A HR P20030900 A2 HRP20030900 A2 HR P20030900A2
Authority
HR
Croatia
Prior art keywords
polymorphs
fexofenadine hydrochloride
fexofenadine
hydrochloride
Prior art date
Application number
HR20030900A
Other languages
English (en)
Inventor
Diller Dov
Gross Irwin
Wizel Shlomit
Dolitzky Ben-Zion
Krochmal Barnaba
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of HRP20030900A2 publication Critical patent/HRP20030900A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20030900A 2001-04-09 2002-04-08 Polymorphs of fexofenadine hydrochloride HRP20030900A2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US28252101P 2001-04-09 2001-04-09
US30775201P 2001-07-25 2001-07-25
US31439601P 2001-08-23 2001-08-23
US33693001P 2001-11-08 2001-11-08
US33904101P 2001-12-07 2001-12-07
US34411401P 2001-12-28 2001-12-28
US36178002P 2002-03-04 2002-03-04
US36348202P 2002-03-11 2002-03-11
PCT/US2002/011251 WO2002080857A2 (en) 2001-04-09 2002-04-08 Polymorphs of fexofenadine hydrochloride

Publications (1)

Publication Number Publication Date
HRP20030900A2 true HRP20030900A2 (en) 2005-08-31

Family

ID=27575329

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030900A HRP20030900A2 (en) 2001-04-09 2002-04-08 Polymorphs of fexofenadine hydrochloride

Country Status (13)

Country Link
US (3) US20020177608A1 (cs)
EP (1) EP1392303A4 (cs)
KR (1) KR20040012747A (cs)
AU (1) AU2002305162A1 (cs)
CA (1) CA2444456A1 (cs)
CZ (1) CZ20033019A3 (cs)
HR (1) HRP20030900A2 (cs)
HU (1) HUP0400299A2 (cs)
IL (1) IL158334A0 (cs)
MX (1) MXPA03009259A (cs)
PL (1) PL366576A1 (cs)
SK (1) SK13822003A3 (cs)
WO (1) WO2002080857A2 (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227676B1 (en) * 1994-05-18 2011-11-28 Aventisub Ii Inc Process for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
US7700779B2 (en) * 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
DE60220953T2 (de) * 2002-04-04 2008-02-28 Dr. Reddy's Laboratories Ltd. Pharmazeutische zusammensetzungen enthaltend eine antihistaminische abschwellende arzneistoffkombination und ein verfahren zur herstellung davon
JP2005532356A (ja) * 2002-06-10 2005-10-27 テバ ファーマシューティカル インダストリーズ リミティド 塩酸フェキソフェナジンの多型体ｘｖｉ
GB0319935D0 (en) 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
JP2007532687A (ja) * 2004-04-26 2007-11-15 テバ ファーマシューティカル インダストリーズ リミティド フェキソフェナジン塩酸塩の結晶形およびその製造方法
JP2008514641A (ja) * 2004-09-28 2008-05-08 テバ ファーマシューティカル インダストリーズ リミティド 結晶形フェキソフェナジン、およびその調製方法
WO2007052310A2 (en) * 2005-11-03 2007-05-10 Morepen Laboratories Limited Polymorphs of fexofenadine hydrochloride and process for their preparation
CA2658170A1 (en) * 2006-07-11 2008-01-17 Mutual Pharmaceutical Company, Inc. Controlled-release formulations
US20090306135A1 (en) * 2008-03-24 2009-12-10 Mukesh Kumar Sharma Stable amorphous fexofenadine hydrochloride
WO2009136412A2 (en) * 2008-04-25 2009-11-12 Matrix Laboratories Limited PROCESS FOR PREPARATION OF 4-[4-(4-(HYDROXYDIPHENYLMETHYL)- 1-PIPERIDINYL]-1-OXOBUTYL]-α,α-DIMETHYLBENZENE ACETIC ACID METHYL ESTER AND USE THEREOF
WO2010083360A2 (en) * 2009-01-16 2010-07-22 Mutual Pharmaceutical Company, Inc. Controlled-release formulations
ES2403130B1 (es) * 2010-06-15 2014-09-29 Chemelectiva S.R.L. Forma polimórfica de clorhidrato de fexofenadina, compuestos intermedios y procedimiento para su preparación
MA39033A1 (fr) 2013-11-15 2017-11-30 Akebia Therapeutics Inc Formes solides d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino}acétique, compositions et leurs utilisations
CN104072402B (zh) * 2014-07-16 2016-08-17 昆山龙灯瑞迪制药有限公司 一种新结晶形式的盐酸非索非那定化合物及其制备方法

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US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
WO1985003707A1 (en) * 1984-02-15 1985-08-29 Schering Corporation 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
SE8403179D0 (sv) * 1984-06-13 1984-06-13 Haessle Ab New compounds
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
US5631375A (en) * 1992-04-10 1997-05-20 Merrell Pharmaceuticals, Inc. Process for piperidine derivatives
JP3686950B2 (ja) * 1992-04-10 2005-08-24 メレル ファーマスーティカルズ インコーポレイテッド ピペリジン誘導体類の新規な方法
CA2134211C (en) * 1992-05-11 1999-06-29 James K. Woodward Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient
AU675240B2 (en) * 1992-08-03 1997-01-30 Sepracor, Inc. Terfenadine metabolites and their optically pure isomers for treating allergic disorders
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
ES2129130T3 (es) * 1993-06-24 1999-06-01 Albany Molecular Res Inc Derivados de piperidina y proceso para su produccion.
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
CN1275916C (zh) * 1993-06-25 2006-09-20 阿温蒂斯公司 用于制备抗组胺哌啶衍生物的新中间体
HU227676B1 (en) * 1994-05-18 2011-11-28 Aventisub Ii Inc Process for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
MX9706449A (es) * 1995-02-28 1997-11-29 Hoechst Marion Roussel Inc Composicion farmaceutica para compuestos de piperidinalcanol.
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
ES2216191T3 (es) * 1997-03-11 2004-10-16 Aventis Pharmaceuticals Inc. Procedimiento para preparar acido 4-(4-(hidroxidifenil)-1-piperidinil)-1-hidroxibutil)-alfa,alfa-dimetilfenilacetico y derivados fosforilados.
US6451815B1 (en) * 1997-08-14 2002-09-17 Aventis Pharmaceuticals Inc. Method of enhancing bioavailability of fexofenadine and its derivatives
EE04294B1 (et) * 1997-08-26 2004-06-15 Hoechst Marion Roussel, Inc. Farmatseutiline kompositsioon piperidinoalkanooldekongestandi kombineerimiseks
US5885912A (en) * 1997-10-08 1999-03-23 Bumbarger; Thomas H. Protective multi-layered liquid retaining composite
IN191492B (cs) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
US6613906B1 (en) * 2000-06-06 2003-09-02 Geneva Pharmaceuticals, Inc. Crystal modification
CA2436418A1 (en) * 2001-01-30 2002-08-08 Board Of Regents, The University Of Texas Systems Process for production of nanoparticles and microparticles by spray freezing into liquid
CH695216A5 (de) * 2001-02-23 2006-01-31 Cilag Ag Verfahren zur Herstellung eines nicht hydratisierten Salzes eines Piperidinderivats und eine so erhältliche neue kristalline Form eines solchen Salzes.
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
KR20040015734A (ko) * 2001-06-18 2004-02-19 닥터 레디스 레보러터리즈 리미티드 4-[4-[4-(히드록실디페닐메틸)-1-피페리디닐]-1-히드록시부틸]-α,α-디메틸벤젠 아세트산 및 그 염산염의 신규 결정형태
US20040248935A1 (en) * 2001-07-31 2004-12-09 Milla Frederico Junquera Fexofenadine polymorph
DE60220953T2 (de) * 2002-04-04 2008-02-28 Dr. Reddy's Laboratories Ltd. Pharmazeutische zusammensetzungen enthaltend eine antihistaminische abschwellende arzneistoffkombination und ein verfahren zur herstellung davon
JP2005532356A (ja) * 2002-06-10 2005-10-27 テバ ファーマシューティカル インダストリーズ リミティド 塩酸フェキソフェナジンの多型体ｘｖｉ
US20050065183A1 (en) * 2003-07-31 2005-03-24 Indranil Nandi Fexofenadine composition and process for preparing
US20050069590A1 (en) * 2003-09-30 2005-03-31 Buehler Gail K. Stable suspensions for medicinal dosages
EP1713757A2 (en) * 2004-02-10 2006-10-25 Union Carbide Chemicals & Plastics Technology Corporation Hydroaminomethylation of olefins
US20050220877A1 (en) * 2004-03-31 2005-10-06 Patel Ashish A Bilayer tablet comprising an antihistamine and a decongestant

Also Published As

Publication number Publication date
KR20040012747A (ko) 2004-02-11
EP1392303A2 (en) 2004-03-03
US20020177608A1 (en) 2002-11-28
AU2002305162A1 (en) 2002-10-21
CZ20033019A3 (cs) 2004-07-14
US20090149497A1 (en) 2009-06-11
EP1392303A4 (en) 2005-01-26
IL158334A0 (en) 2004-05-12
MXPA03009259A (es) 2004-06-03
WO2002080857A3 (en) 2003-12-18
SK13822003A3 (sk) 2004-09-08
US20040058955A1 (en) 2004-03-25
WO2002080857A2 (en) 2002-10-17
CA2444456A1 (en) 2002-10-17
PL366576A1 (en) 2005-02-07
WO2002080857A8 (en) 2004-05-27
HUP0400299A2 (en) 2007-08-28

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