SK129598A3 - 5-membered heterocyclic compounds, preparation method thereof, their use and pharmaceutical compositions containing such compounds - Google Patents
5-membered heterocyclic compounds, preparation method thereof, their use and pharmaceutical compositions containing such compounds Download PDFInfo
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- SK129598A3 SK129598A3 SK1295-98A SK129598A SK129598A3 SK 129598 A3 SK129598 A3 SK 129598A3 SK 129598 A SK129598 A SK 129598A SK 129598 A3 SK129598 A3 SK 129598A3
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- alkyl
- group
- optionally substituted
- aryl
- radical
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 142
- 238000002360 preparation method Methods 0.000 title claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 title description 3
- 150000000565 5-membered heterocyclic compounds Chemical class 0.000 title description 2
- 150000003839 salts Chemical class 0.000 claims abstract description 51
- 239000000203 mixture Substances 0.000 claims abstract description 48
- -1 heteroaryl radical Chemical class 0.000 claims description 217
- 125000000217 alkyl group Chemical group 0.000 claims description 113
- 150000005840 aryl radicals Chemical class 0.000 claims description 66
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 54
- 108010008212 Integrin alpha4beta1 Proteins 0.000 claims description 50
- 229910052757 nitrogen Inorganic materials 0.000 claims description 47
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 39
- 125000001424 substituent group Chemical group 0.000 claims description 39
- 239000002253 acid Substances 0.000 claims description 38
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 32
- 125000005842 heteroatom Chemical group 0.000 claims description 30
- 229920006395 saturated elastomer Polymers 0.000 claims description 29
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 28
- 210000000265 leukocyte Anatomy 0.000 claims description 24
- 229910052717 sulfur Inorganic materials 0.000 claims description 24
- 229910052739 hydrogen Inorganic materials 0.000 claims description 23
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 22
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 22
- 125000002619 bicyclic group Chemical group 0.000 claims description 21
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- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000006493 trifluoromethyl benzyl group Chemical group 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
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- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
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-
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- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Application Number | Priority Date | Filing Date | Title |
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DE19741873A DE19741873A1 (de) | 1997-09-23 | 1997-09-23 | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
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US (1) | US6034238A (pt) |
EP (1) | EP0905139B1 (pt) |
JP (1) | JP4603104B2 (pt) |
KR (1) | KR19990030046A (pt) |
CN (1) | CN1216767A (pt) |
AT (1) | ATE421524T1 (pt) |
AU (1) | AU748579B2 (pt) |
BR (1) | BR9803969A (pt) |
CA (1) | CA2247735A1 (pt) |
CZ (1) | CZ303198A3 (pt) |
DE (2) | DE19741873A1 (pt) |
HR (1) | HRP980519A2 (pt) |
HU (1) | HUP9802143A3 (pt) |
ID (1) | ID20915A (pt) |
IL (1) | IL126278A0 (pt) |
MY (1) | MY134191A (pt) |
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NZ (1) | NZ331983A (pt) |
PL (1) | PL191149B1 (pt) |
RU (1) | RU2240326C2 (pt) |
SK (1) | SK129598A3 (pt) |
TR (1) | TR199801870A2 (pt) |
TW (1) | TW588051B (pt) |
ZA (1) | ZA988668B (pt) |
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DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
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DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19922462A1 (de) * | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
KR20020067050A (ko) | 1999-12-28 | 2002-08-21 | 화이자 프로덕츠 인코포레이티드 | 염증성, 자기면역 및 호흡기 질환의 치료에 유용한브이엘에이-4 의존성 세포 결합의 비펩티드계 억제제 |
DE10111876A1 (de) * | 2001-03-10 | 2002-09-19 | Aventis Pharma Gmbh | Bis(trifluormethyl)hydantoine als Zwischenprodukte für pharmazeutische Wirkstoffe |
DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE10137595A1 (de) | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
US7053112B2 (en) * | 2002-09-24 | 2006-05-30 | Schering Aktiengesellschaft | Imidazolidinedione analogs useful as anticoagulants and antithrombotics |
EA009646B1 (ru) | 2003-05-30 | 2008-02-28 | Рэнбакси Лабораториз Лтд. | Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa |
US7577605B2 (en) * | 2004-08-04 | 2009-08-18 | Bgc Partners, Inc. | System and method for managing trading using alert messages for outlying trading orders |
AU2006313430B2 (en) | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
US20120258093A1 (en) | 2009-08-20 | 2012-10-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
WO2012061074A1 (en) | 2010-10-25 | 2012-05-10 | Elan Pharmaceuticals, Inc. | METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN sVCAM AND/OR sMAdCAM LEVELS |
JP2021066690A (ja) * | 2019-10-24 | 2021-04-30 | 国立大学法人室蘭工業大学 | オピオイドペプチド誘導体及びこれを含む医薬組成物 |
WO2022162164A1 (en) | 2021-01-29 | 2022-08-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists |
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DE19515177A1 (de) * | 1995-04-28 | 1996-10-31 | Cassella Ag | Hydantoinderivate als Zwischenprodukte für pharmazeutische Wirkstoffe |
US5612363A (en) * | 1995-06-02 | 1997-03-18 | Berlex Laboratories, Inc. | N,N-di(aryl) cyclic urea derivatives as anti-coagulants |
US6248713B1 (en) * | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
EP0796855B1 (de) * | 1996-03-20 | 2002-02-06 | Hoechst Aktiengesellschaft | Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
EP0917462B1 (en) * | 1996-07-25 | 2006-09-13 | Biogen Idec MA Inc. | Cell adhesion inhibitors |
PL323130A1 (en) * | 1996-11-15 | 1998-05-25 | Hoechst Ag | Application of heterocyclic compounds in production of a pharmaceutic agent, novel heterocyclic compounds and pharmaceutic agent as such |
DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
DE19647381A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
WO1998042656A1 (en) * | 1997-03-21 | 1998-10-01 | Cytel Corporation | Novel compounds |
DE19741235A1 (de) * | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
-
1997
- 1997-09-23 DE DE19741873A patent/DE19741873A1/de not_active Withdrawn
-
1998
- 1998-09-17 DE DE59814334T patent/DE59814334D1/de not_active Expired - Lifetime
- 1998-09-17 IL IL12627898A patent/IL126278A0/xx not_active IP Right Cessation
- 1998-09-17 EP EP98117660A patent/EP0905139B1/de not_active Expired - Lifetime
- 1998-09-17 AT AT98117660T patent/ATE421524T1/de not_active IP Right Cessation
- 1998-09-21 SK SK1295-98A patent/SK129598A3/sk unknown
- 1998-09-21 ID IDP981265A patent/ID20915A/id unknown
- 1998-09-21 MY MYPI98004339A patent/MY134191A/en unknown
- 1998-09-21 CA CA002247735A patent/CA2247735A1/en not_active Abandoned
- 1998-09-21 CZ CZ983031A patent/CZ303198A3/cs unknown
- 1998-09-21 NZ NZ331983A patent/NZ331983A/en unknown
- 1998-09-21 TR TR1998/01870A patent/TR199801870A2/xx unknown
- 1998-09-22 NO NO984414A patent/NO984414L/no not_active Application Discontinuation
- 1998-09-22 HR HR19741873.2A patent/HRP980519A2/hr not_active Application Discontinuation
- 1998-09-22 BR BR9803969-5A patent/BR9803969A/pt not_active Application Discontinuation
- 1998-09-22 CN CN98119544A patent/CN1216767A/zh active Pending
- 1998-09-22 AU AU86148/98A patent/AU748579B2/en not_active Ceased
- 1998-09-22 JP JP26835298A patent/JP4603104B2/ja not_active Expired - Fee Related
- 1998-09-22 RU RU98117626/04A patent/RU2240326C2/ru not_active IP Right Cessation
- 1998-09-22 ZA ZA988668A patent/ZA988668B/xx unknown
- 1998-09-23 KR KR1019980039351A patent/KR19990030046A/ko not_active Application Discontinuation
- 1998-09-23 PL PL328789A patent/PL191149B1/pl unknown
- 1998-09-23 HU HU9802143A patent/HUP9802143A3/hu unknown
- 1998-09-23 US US09/158,772 patent/US6034238A/en not_active Expired - Lifetime
- 1998-09-25 TW TW087115671A patent/TW588051B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PL191149B1 (pl) | 2006-03-31 |
NO984414L (no) | 1999-03-24 |
MY134191A (en) | 2007-11-30 |
HUP9802143A2 (hu) | 1999-06-28 |
CN1216767A (zh) | 1999-05-19 |
JP4603104B2 (ja) | 2010-12-22 |
HUP9802143A3 (en) | 1999-11-29 |
CZ303198A3 (cs) | 1999-04-14 |
ZA988668B (en) | 1999-03-23 |
EP0905139B1 (de) | 2009-01-21 |
EP0905139A2 (de) | 1999-03-31 |
PL328789A1 (en) | 1999-03-29 |
IL126278A0 (en) | 1999-05-09 |
ID20915A (id) | 1999-03-25 |
AU748579B2 (en) | 2002-06-06 |
NZ331983A (en) | 2000-02-28 |
DE59814334D1 (de) | 2009-03-12 |
US6034238A (en) | 2000-03-07 |
HU9802143D0 (en) | 1998-11-30 |
NO984414D0 (no) | 1998-09-22 |
ATE421524T1 (de) | 2009-02-15 |
EP0905139A3 (de) | 2002-12-18 |
RU2240326C2 (ru) | 2004-11-20 |
DE19741873A1 (de) | 1999-03-25 |
CA2247735A1 (en) | 1999-03-23 |
AU8614898A (en) | 1999-04-15 |
TW588051B (en) | 2004-05-21 |
KR19990030046A (ko) | 1999-04-26 |
JPH11180960A (ja) | 1999-07-06 |
TR199801870A2 (xx) | 1999-04-21 |
BR9803969A (pt) | 2000-05-02 |
HRP980519A2 (en) | 1999-06-30 |
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