SK129598A3 - 5-membered heterocyclic compounds, preparation method thereof, their use and pharmaceutical compositions containing such compounds - Google Patents

Info

Publication number

SK129598A3

SK129598A3 SK1295-98A SK129598A SK129598A3 SK 129598 A3 SK129598 A3 SK 129598A3 SK 129598 A SK129598 A SK 129598A SK 129598 A3 SK129598 A3 SK 129598A3

Authority

SK

Slovakia

Prior art keywords

alkyl

group

optionally substituted

aryl

radical

Prior art date

1997-09-23

Links

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• 238000002360 preparation method Methods 0.000 title claims description 13
• 239000008194 pharmaceutical composition Substances 0.000 title description 3
• 150000000565 5-membered heterocyclic compounds Chemical class 0.000 title description 2
• 150000003839 salts Chemical class 0.000 claims abstract description 51
• 239000000203 mixture Substances 0.000 claims abstract description 48
• -1 heteroaryl radical Chemical class 0.000 claims description 217
• 125000000217 alkyl group Chemical group 0.000 claims description 113
• 150000005840 aryl radicals Chemical class 0.000 claims description 66
• 150000003254 radicals Chemical class 0.000 claims description 58
• 125000001072 heteroaryl group Chemical group 0.000 claims description 54
• 108010008212 Integrin alpha4beta1 Proteins 0.000 claims description 50
• 229910052757 nitrogen Inorganic materials 0.000 claims description 47
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 39
• 125000001424 substituent group Chemical group 0.000 claims description 39
• 239000002253 acid Substances 0.000 claims description 38
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 32
• 125000005842 heteroatom Chemical group 0.000 claims description 30
• 229920006395 saturated elastomer Polymers 0.000 claims description 29
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 28
• 210000000265 leukocyte Anatomy 0.000 claims description 24
• 229910052717 sulfur Inorganic materials 0.000 claims description 24
• 229910052739 hydrogen Inorganic materials 0.000 claims description 23
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 22
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 22
• 125000002619 bicyclic group Chemical group 0.000 claims description 21
• 125000000623 heterocyclic group Chemical group 0.000 claims description 20
• 239000001257 hydrogen Substances 0.000 claims description 20
• 125000002950 monocyclic group Chemical group 0.000 claims description 20
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• 125000003118 aryl group Chemical group 0.000 claims description 18
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• ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims description 2
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• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
• 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims description 2
• 230000004614 tumor growth Effects 0.000 claims description 2
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• 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
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• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
• 210000003954 umbilical cord Anatomy 0.000 description 1
• 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
• 229960004295 valine Drugs 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 229910052720 vanadium Inorganic materials 0.000 description 1
• 210000003556 vascular endothelial cell Anatomy 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
• 229920002554 vinyl polymer Polymers 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 239000003643 water by type Substances 0.000 description 1
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• 239000000080 wetting agent Substances 0.000 description 1