HUP9802143A2 - 5-Tagú heterociklusos vegyületek, eljárás előállításukra és e vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
5-Tagú heterociklusos vegyületek, eljárás előállításukra és e vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9802143A2 HUP9802143A2 HU9802143A HUP9802143A HUP9802143A2 HU P9802143 A2 HUP9802143 A2 HU P9802143A2 HU 9802143 A HU9802143 A HU 9802143A HU P9802143 A HUP9802143 A HU P9802143A HU P9802143 A2 HUP9802143 A2 HU P9802143A2
- Authority
- HU
- Hungary
- Prior art keywords
- powder
- pipe
- alkyl
- general formula
- pipe powder
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000428 dust Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005099 aryl alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- -1 cyclic alkyl Chemical group 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
Abstract
A találmány tárgya (I) általánős képletű, új vegyületek - ahől Wjelentése R1-A-C(R13) vagy R1-A-CH=C általánős képletű csőpőrt, Yjelentése karbőnilcsőpőrt, tiőkarbőnilcsőpőrt vagy metiléncsőpőrt, Zjelentése N(R0) általánős képletű csőpőrt, őxigén-, kénatőm vagymetiléncsőpőrt, A jelentése kétértékű csőpőrt, amely alkilén-,ciklőalkilén-, fenilén-alkil-, alkilén-fenil-, fenilén-alkenil-csőpőrtvagy egy 5- vagy 6-tagú telített vagy telítetlen heterőciklűsőscsőpőrtból képzett csőpőrt, amely egy vagy két nitrőgénatőmőttartalmazhat, B jelentése kétértékű alkiléncsőpőrt, amelyszűbsztitűálatlan vagy szűbsztitűált, E és Ea jelentése egymástólfüggetlenül tetrazőlilcsőpőrt vagy (RdO)2P(O), HOS(O)2, R9NHS(O)2 vagyR10CO általánős képletű csőpőrt, R0, R13 jelentése a leírásbanmegadőtt, R, Ra és Rd jelentése egymástól függetlenül hidrőgénatőm,alkil-, ciklőalkil-, ciklőalkil-alkil-, adőtt esetben szűbsztitűáltaril- vagy az arilrészben adőtt esetben szűbsztitűált aril-alkil-csőpőrt; R1 jelentése X-NH-C(=NH)-(CH2)p vagy X1-NH-(CH2)p általánősképletű csőpőrt, ahől p értéke 0, 1, 2 vagy 3; X jelentésehidrőgénatőm, alkil-, alkil-karbőnil-, alkőxi-karbőnil-, alkil-karbőnil-őxi-alkőxi-karbőnil-, adőtt esetben szűbsztitűált aril-karbőnil-, adőtt esetben szűbsztitűált arilőxi-karbőnil-, aril-alkőxi)-karbőnil-csőpőrt, vagy aminőcsőpőrt, X1 jelentése megegyezik Xjelentésével vagy R'-NH-C(=N-R") általánős képletű csőpőrt, ahől R' ésR" jelentése egymástól függetlenül megegyezik X jelentésével, R2, R2aés R2b jelentése egymástól függetlenül hidrőgénatőm, alkil-, adőttesetben szűbsztitűált aril-, az arilrészben adőtt esetbenszűbsztitűált aril-alkil-, ciklőalkil- vagy ciklőalkil-alkil-csőpőrt;R3 jelentése R11NH általánős képletű csőpőrt, ciklőalkil-, ciklőalkil-alkil-, biciklőalkil-, biciklőalkil-alkil-, triciklőalkil-,triciklőalkil-alkil-csőpőrt, -CO-N(Ra)-R4-Ea vagy -CO-R5-R6-R7általánős képletű csőpőrt; a töb bi szűbsztitűens jelentése aleírásban megadőtt, valamennyi sztereőizőmer alakban és ezektetszőleges arányú keveréke főrmájában, tővábbá fiziőlógiailagalkalmazható sóik. A találmány a vegyületek előállítására és avegyületeket tartalmazó gyógyszerkészítményekre is vőnatkőzik. Agyógyszerkészítmények többek között gyűlladásős megbetegedésekkezelésére és megelőzésére használhatók. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19741873A DE19741873A1 (de) | 1997-09-23 | 1997-09-23 | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9802143D0 HU9802143D0 (en) | 1998-11-30 |
HUP9802143A2 true HUP9802143A2 (hu) | 1999-06-28 |
HUP9802143A3 HUP9802143A3 (en) | 1999-11-29 |
Family
ID=7843291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9802143A HUP9802143A3 (en) | 1997-09-23 | 1998-09-23 | Heterocyclic compounds of 5 members in the ring, process for producing them and pharmaceutical compositions containing them |
Country Status (24)
Country | Link |
---|---|
US (1) | US6034238A (hu) |
EP (1) | EP0905139B1 (hu) |
JP (1) | JP4603104B2 (hu) |
KR (1) | KR19990030046A (hu) |
CN (1) | CN1216767A (hu) |
AT (1) | ATE421524T1 (hu) |
AU (1) | AU748579B2 (hu) |
BR (1) | BR9803969A (hu) |
CA (1) | CA2247735A1 (hu) |
CZ (1) | CZ303198A3 (hu) |
DE (2) | DE19741873A1 (hu) |
HR (1) | HRP980519A2 (hu) |
HU (1) | HUP9802143A3 (hu) |
ID (1) | ID20915A (hu) |
IL (1) | IL126278A0 (hu) |
MY (1) | MY134191A (hu) |
NO (1) | NO984414L (hu) |
NZ (1) | NZ331983A (hu) |
PL (1) | PL191149B1 (hu) |
RU (1) | RU2240326C2 (hu) |
SK (1) | SK129598A3 (hu) |
TR (1) | TR199801870A2 (hu) |
TW (1) | TW588051B (hu) |
ZA (1) | ZA988668B (hu) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
DE19741235A1 (de) * | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19922462A1 (de) * | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
JP2003519697A (ja) | 1999-12-28 | 2003-06-24 | ファイザー・プロダクツ・インク | 炎症性疾患、自己免疫疾患および呼吸器疾患の処置に有用な非ペプチド系のvla−4依存性細胞結合阻害薬 |
DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE10111876A1 (de) | 2001-03-10 | 2002-09-19 | Aventis Pharma Gmbh | Bis(trifluormethyl)hydantoine als Zwischenprodukte für pharmazeutische Wirkstoffe |
DE10137595A1 (de) | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
US7053112B2 (en) * | 2002-09-24 | 2006-05-30 | Schering Aktiengesellschaft | Imidazolidinedione analogs useful as anticoagulants and antithrombotics |
GEP20084406B (en) | 2003-05-30 | 2008-06-25 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as hmg-co inhibitors |
US7577605B2 (en) * | 2004-08-04 | 2009-08-18 | Bgc Partners, Inc. | System and method for managing trading using alert messages for outlying trading orders |
AU2006313430B2 (en) | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
WO2011020874A1 (en) | 2009-08-20 | 2011-02-24 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
EP2632492B1 (en) | 2010-10-25 | 2017-10-04 | Biogen MA Inc. | METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN sVCAM AND/OR sMAdCAM LEVELS |
JP2021066690A (ja) * | 2019-10-24 | 2021-04-30 | 国立大学法人室蘭工業大学 | オピオイドペプチド誘導体及びこれを含む医薬組成物 |
EP4284947A1 (en) | 2021-01-29 | 2023-12-06 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists |
Family Cites Families (49)
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---|---|---|---|---|
DE235866C (hu) * | ||||
DE2937779A1 (de) * | 1979-09-19 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
DE3044236A1 (de) * | 1980-11-25 | 1982-06-16 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
FR2487829A2 (fr) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
US4350704A (en) * | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
EP0278530A3 (de) * | 1980-08-30 | 1989-08-02 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
EP0050800B2 (en) * | 1980-10-23 | 1995-06-07 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
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-
1997
- 1997-09-23 DE DE19741873A patent/DE19741873A1/de not_active Withdrawn
-
1998
- 1998-09-17 IL IL12627898A patent/IL126278A0/xx not_active IP Right Cessation
- 1998-09-17 AT AT98117660T patent/ATE421524T1/de not_active IP Right Cessation
- 1998-09-17 EP EP98117660A patent/EP0905139B1/de not_active Expired - Lifetime
- 1998-09-17 DE DE59814334T patent/DE59814334D1/de not_active Expired - Lifetime
- 1998-09-21 NZ NZ331983A patent/NZ331983A/en unknown
- 1998-09-21 SK SK1295-98A patent/SK129598A3/sk unknown
- 1998-09-21 TR TR1998/01870A patent/TR199801870A2/xx unknown
- 1998-09-21 CZ CZ983031A patent/CZ303198A3/cs unknown
- 1998-09-21 ID IDP981265A patent/ID20915A/id unknown
- 1998-09-21 CA CA002247735A patent/CA2247735A1/en not_active Abandoned
- 1998-09-21 MY MYPI98004339A patent/MY134191A/en unknown
- 1998-09-22 RU RU98117626/04A patent/RU2240326C2/ru not_active IP Right Cessation
- 1998-09-22 HR HR19741873.2A patent/HRP980519A2/hr not_active Application Discontinuation
- 1998-09-22 NO NO984414A patent/NO984414L/no not_active Application Discontinuation
- 1998-09-22 BR BR9803969-5A patent/BR9803969A/pt not_active Application Discontinuation
- 1998-09-22 AU AU86148/98A patent/AU748579B2/en not_active Ceased
- 1998-09-22 JP JP26835298A patent/JP4603104B2/ja not_active Expired - Fee Related
- 1998-09-22 CN CN98119544A patent/CN1216767A/zh active Pending
- 1998-09-22 ZA ZA988668A patent/ZA988668B/xx unknown
- 1998-09-23 HU HU9802143A patent/HUP9802143A3/hu unknown
- 1998-09-23 PL PL328789A patent/PL191149B1/pl unknown
- 1998-09-23 KR KR1019980039351A patent/KR19990030046A/ko not_active Application Discontinuation
- 1998-09-23 US US09/158,772 patent/US6034238A/en not_active Expired - Lifetime
- 1998-09-25 TW TW087115671A patent/TW588051B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0905139A3 (de) | 2002-12-18 |
NO984414L (no) | 1999-03-24 |
DE59814334D1 (de) | 2009-03-12 |
EP0905139A2 (de) | 1999-03-31 |
PL191149B1 (pl) | 2006-03-31 |
CA2247735A1 (en) | 1999-03-23 |
JP4603104B2 (ja) | 2010-12-22 |
DE19741873A1 (de) | 1999-03-25 |
NZ331983A (en) | 2000-02-28 |
EP0905139B1 (de) | 2009-01-21 |
BR9803969A (pt) | 2000-05-02 |
RU2240326C2 (ru) | 2004-11-20 |
HRP980519A2 (en) | 1999-06-30 |
ID20915A (id) | 1999-03-25 |
TR199801870A2 (xx) | 1999-04-21 |
MY134191A (en) | 2007-11-30 |
ATE421524T1 (de) | 2009-02-15 |
JPH11180960A (ja) | 1999-07-06 |
ZA988668B (en) | 1999-03-23 |
AU748579B2 (en) | 2002-06-06 |
CN1216767A (zh) | 1999-05-19 |
NO984414D0 (no) | 1998-09-22 |
IL126278A0 (en) | 1999-05-09 |
TW588051B (en) | 2004-05-21 |
KR19990030046A (ko) | 1999-04-26 |
HUP9802143A3 (en) | 1999-11-29 |
PL328789A1 (en) | 1999-03-29 |
US6034238A (en) | 2000-03-07 |
SK129598A3 (en) | 1999-04-13 |
AU8614898A (en) | 1999-04-15 |
HU9802143D0 (en) | 1998-11-30 |
CZ303198A3 (cs) | 1999-04-14 |
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